Keyphrases
Proteolysis Targeting chimera (PROTAC)
88%
Stereoselective Recognition
66%
Conformational Analysis
66%
E3 Ubiquitin Ligase
66%
Orthodontic Patients
66%
Von Hippel-Lindau
66%
Fluoro
66%
Structure-based Design
66%
Dentists
66%
Targeted Protein Degradation
66%
Hydroxyproline
66%
Bromodomain-containing Protein 4 (BRD4)
55%
Macrocyclization
44%
Bromodomain
44%
Referral Rate
33%
Co-crystal Structure
33%
Orthodontic Treatment
33%
Inappropriate Referrals
33%
Proline
33%
New Patients
33%
Orthodontics
33%
Functional Chemicals
22%
Bioactive Conformation
22%
Homologous Target
22%
Fluorination
22%
Linker
22%
Rational Design
22%
Peptide Ligand
22%
Cell Behavior
22%
PROTAC Degraders
22%
Biophysical Studies
22%
Binding Affinity
22%
BET Proteins
22%
Ternary Complex
22%
Enzyme Inhibitors
22%
Bifunctional Molecules
22%
Chemical Probes
22%
Degrader
22%
Receptor Antagonist
22%
Referral Guidelines
16%
Unnecessary Referrals
16%
Parts Information
16%
Healthcare Professionals
16%
Waiting List
16%
General Dental Practitioners
16%
Medical Consultation
16%
North of England
16%
Secondary Care
16%
Referral Patterns
16%
Bioisosteric
11%
Chemistry
Proteolysis Targeting Chimera
100%
4-Hydroxyproline
66%
Proline
50%
Kd
33%
Crystal Structure
33%
Hydroxyproline
33%
macrocyclization
33%
Chemistry
33%
Fluorination
33%
Epimer
16%
Agent Interacting With Transmitter, Hormone or Drug Receptor
16%
Molecular Property
16%
Molecular Recognition
16%
Pyrrolidine
16%
Carboxamide
16%
Stereochemistry
16%
Electrostatic Potential
16%
Donor
16%
Enzyme Inhibitor
16%
X-Ray Crystallography
16%
Hydroxyl
16%
NMR Spectroscopy
16%
hydroxylation
16%
Hydrogen Bond
16%
L-Proline Derivative
16%
4-Oxo-L-Proline
16%
Peptidomimetic
16%
Biochemistry, Genetics and Molecular Biology
Bromodomain
66%
Proline
66%
Ubiquitin-Conjugating Enzyme
66%
Protein Catabolism
66%
Crystal Structure
50%
Receptor Antagonist
33%
Fluorination
33%
Enzyme Inhibitor
33%
Binding Affinity
33%
Ternary Complex
33%
Conformation
33%
Hypoxia Inducible Factor 1
16%
X-Ray Crystallography
16%
Ligase
16%
Hydroxylation
16%
Hydrogen Bond
16%
Diastereoisomer
16%
Small Molecule
16%
Molecular Recognition
16%
Epimer
16%
Static Electricity
16%
Biochemistry
16%
Peptidomimetic
16%
