Projects per year
Personal profile
Research
Imaging is one of the most innovative and widely used technologies in modern life sciences research. Since 2002, we have led the Open Microscopy Environment (OME), an open source technology development effort to build the data management and integration tools needed to make imaging data a first-class resource for the next generation of life sciences research. OME develops and releases data models, file format translators and data management software. OME’s Bio-Formats and OMERO are used in thousands of laboratories around the world. We have built a spinout, Glencoe Software, to deliver commercial data managements systems based on Bio-Formats and OMERO.
We have used Bio-Formats and OMERO to build the Image Data Resource (IDR), one of the largest public bioimaging data repositories in the world. IDR publishes bioimaging datasets associated with peer reviewed publications. The flexibility provided by Bio-Formats and OMERO means that IDR can handle a wide range of data types from research domains across the life and biomedical sciences. The IDR project collaborates with the EMBL-EBI’s Bioimage Archive and RIKEN’s SSBD database (link: ssbd.qbic.riken.jp) to construct a larger ecosystem for public bioimaging data. Several projects worldwide now use the technology constructed for IDR for publishing their own data.
Our technology development for OME feeds into several research threads. Our main research interest is in cell division where we study the requirements for segregation of mitotic chromosomes. Our discovery of Bod1, a critical modifier of protein phosphate activity is in mitosis has illuminated the key roles in modulating signalling pathways during chromosomes segregation. Our current focus in collaboration with Angus Lamond’s lab is exploring the role of oxygen-sensing enzymes in assembling components of the mitotic spindle. We also work with the SLS’s National Phenotypic Screening Facility to provide high throughput imaging and large-scale data analytics capabilities for development of new assays, small technologies and analytic tools at the interface of chemistry and biology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Program Director
15 Feb 2021 → 30 Sep 2024
CEO, Glencoe Software, Inc.
20 Nov 2005 → …
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Network
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Next Generation Data Formats for BioImaging (Technology Development)
1/02/21 → 31/01/24
Project: Research
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Providing an open collaborative space for digital biology in Europe (EOSC-Life) (Joint with European Molecular Biology Laboratory as lead, Biobanks and Biomolecular Resources Research Infrastructure Consortium, EATRIS ERIC and 35 others)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/03/19 → 31/08/23
Project: Research
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Male Contraceptive Drug Development Using a Novel Human Sperm Phenotypic Screening Platform (Grand Challenges Phase II)
Andrews, P., Barratt, C., Gilbert, I., Martins Da Silva, S., Read, K. & Swedlow, J.
Bill and Melinda Gates Foundation
1/11/18 → 1/04/23
Project: Research
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The Interplay Between Oxygen Sensors PHDs and the Cell Cycle (Joint with University of Liverpool)
Fleming, S., Lamond, A. & Swedlow, J.
1/09/17 → 31/08/24
Project: Research
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Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform
Gruber, F. S., Johnston, Z. C., Norcross, N. R., Georgiou, I., Wilson, C., Read, K. D., Gilbert, I. H., Swedlow, J. R., Martins da Silva, S. & Barratt, C. L. R., Mar 2022, In: Human Reproduction. 37, 3, p. 466-475 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Downloads (Pure) -
High Throughput Phenotypic Screening of The Human Spermatozoon
Johnston, Z. C., Gruber, F. S., Brown, S., Norcross, N. R., Swedlow, J. R., Gilbert, I. H. & Barratt, C., Jan 2022, In: Reproduction. 163, 1, p. R1-R9 9 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Citations (Scopus)35 Downloads (Pure) -
IMI European Lead Factory - democratizing access to high-throughput screening
Jones, P. S., Boucharens, S., McElroy, S. P., Morrison, A., Honarnejad, S., van Boeckel, S., van den Hurk, H., Basting, D., Hüser, J., Jaroch, S., Ottow, E., Benningshof, J., Folmer, R. H. A., Leemhuis, F., Kramer-Verhulst, P. M., Nies, V. J. M., Orrling, K. M., Rijnders, T., Pfander, C., Engkvist, O., & 49 others , Apr 2022, In: Nature reviews. Drug discovery. 21, p. 245-246 2 p.Research output: Contribution to journal › Comment/debate › peer-review
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Male contraceptive development: A medicinal chemistry perspective
Norcross, N. R., Georgiou, I., Johnston, Z. C., Gruber, F. S., Swedlow, J. R., Read, K. D., Barratt, C. L. R. & Gilbert, I. H., 5 Dec 2022, In: European Journal of Medicinal Chemistry. 243, p. 1-8 8 p., 114709.Research output: Contribution to journal › Review article › peer-review
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MITI minimum information guidelines for highly multiplexed tissue images
Schapiro, D., Yapp, C., Sokolov, A., Reynolds, S. M., Chen, Y-A., Sudar, D., Xie, Y., Muhlich, J., Arias-Camison, R., Arena, S., Taylor, A. J., Nikolov, M., Tyler, M., Lin, J-R., Burlingame, E. A., Chang, Y. H., Farhi, S. L., Thorsson, V., Venkatamohan, N., Drewes, J. L., & 18 others , 21 Mar 2022, In: Nature Methods. 19, 3, p. 262-267 6 p.Research output: Contribution to journal › Comment/debate › peer-review
Open AccessFile6 Citations (Scopus)9 Downloads (Pure)
Prizes
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Fellow of the Royal Society of Edinburgh
Swedlow, Jason (Recipient), Apr 2012
Prize: Election to learned society
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Honorary Officer of the Most Excellent Order of the British Empire (OBE)
Swedlow, Jason (Recipient), 6 May 2021
Prize: National/international honour
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Google/Nature O’Reilly Sci Foo 2021
Jason Swedlow (Participant)
21 Oct 2021 → 23 Oct 2021Activity: Participating in or organising an event types › Participation in conference
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SenNet 2021, NIH Common Fund, External Program Consultant
Jason Swedlow (Consultant)
4 Nov 2021 → 31 Dec 2022Activity: Consultancy types › Consultancy
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ELMI 2021
Jason Swedlow (Participant)
23 Jun 2021 → 25 Jun 2021Activity: Participating in or organising an event types › Participation in conference
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3D LM EM Symposium - Crick Institute / Zeiss
Jason Swedlow (Participant)
15 Feb 2021 → 16 Feb 2021Activity: Participating in or organising an event types › Participation in conference
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SLAS 2021
Jason Swedlow (Participant)
26 Jan 2021 → 27 Jan 2021Activity: Participating in or organising an event types › Participation in conference