Jason Swedlow

Personal profile

Research

Mitotic chromosome dynamics

During cell division, the two copies of a cell's genetic material are completely separated and delivered to a pair of new daughter cells. Proper chromosome segregation requires the formation of correct attachments between the genetic material, assembled into chromosomes, and ends of microtubules. Our research is focussed on establishing the molecular mechanisms that mediate and monitor the correct attachment of chromosomes to microtubule at a special structure known as the kinetochore. To achieve this, we make use of advanced tools for imaging the components of cell division, especially in living cells and specialised mass spectrometry methods to probe the molecular machinery of cell division. Recently, we used these tools to discover a new protein, Bod1, that plays a critical role in the formation of correct attachments between microtubules and chromosomes by modulating the activity of Aurora B protein kinase. We recently installed a newly developed OMX microscope and are using this system to probe the inner workings of the centromere and kinetochore of the mitotic chromosome.

Like many cell biology labs, we generate large sets of image data. To manage, analyse and understand this data, we, long with our collaborators, formed the Open Microscopy Environment Consortium. OME develops data specifications, file format translators and data management software for imaging applications. OME tools are used in thousands of labs around the world. For more info on OME, see the Consortium's web site.

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Projects

4 Not started
5 Active
29 Finished

Providing an open collaborative space for digital biology in Europe (EOSC-Life) (Joint with European Molecular Biology Laboratory as lead, Biobanks and Biomolecular Resources Research Infrastructure Consortium, EATRIS ERIC and 35 others)

Swedlow, J.

COMMISSION OF THE EUROPEAN COMMUNITIES

1/03/19 → 28/02/23

Project: Research

The Image Data Resource: Making Biological Imaging Data FAIR (Joint with EMBL-EBI) (Biomedical Resources Grant)

Swedlow, J.

Wellcome Trust

1/10/18 → 1/04/22

Project: Research

BioStudies and the Image Data Resource: Expanding Imaging Datasets, Linkage, Metadata and Value (Joint with EMBL-EBI) (Bioinformatics and Biological Resources Fund - BBR)

Swedlow, J.

Biotechnology and Biological Sciences Research Council

1/07/18 → 30/06/21

Project: Research

The Interplay Between Oxygen Sensors PHDs and the Cell Cycle (Joint with University of Liverpool)

Fleming, S., Lamond, A. & Swedlow, J.

Wellcome Trust

1/09/17 → 31/08/22

Project: Research

Architecture of a Biofilm (Joint with University of Edinburgh)

Campbell, P., Davidson, F., Ferguson, M., Stanley-Wall, N. & Swedlow, J.

Biotechnology and Biological Sciences Research Council

1/02/17 → 31/07/22

Project: Research

Research Output

Community standards for open cell migration data

Gonzalez-Beltran, A. N., Masuzzo, P., Ampe, C., Bakker, G-J., Besson, S., Eibl, R. H., Friedl, P., Gunzer, M., Kittisopikul, M., Le Dévédec, S. E., Leo, S., Moore, J., Paran, Y., Prilusky, J., Rocca-Serra, P., Roudot, P., Schuster, M., Sergeant, G., Strömblad, S., Swedlow, J. R. & 5 others, van Erp, M., Van Troys, M., Zaritsky, A., Sansone, S-A. & Martens, L., May 2020, In : GigaScience. 9, 5, p. 1-11 11 p., giaa041.

Research output: Contribution to journal › Review article

Open Access

File

16 Downloads (Pure)

Numerically Enhanced Stimulated Emission Depletion Microscopy with Adaptive Optics for Deep-Tissue Super-Resolved Imaging

Zdańkowski, P., Trusiak, M., McGloin, D. & Swedlow, J. R., 28 Jan 2020, In : ACS Nano. 14, 1, p. 394-405 12 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Open Microscopy Environment: OME is a consortium of universities, research labs, industry and developers producing open-source software and format standards for microscopy data.

Swedlow, J., 2020

Research output: Non-textual form › Software

Bringing Open Data to Whole Slide Imaging

Besson, S., Leigh, R., Linkert, M., Allan, C., Burel, J-M., Carroll, M., Gault, D., Gozim, R., Li, S., Lindner, D., Moore, J., Moore, W., Walczysko, P., Wong, F. & Swedlow, J., 2019, Digital Pathology: 15th European Congress, ECDP 2019, Warwick, UK, April 10–13, 2019, Proceedings. Reyes-Aldasoro, C. C., Janowczyk, A., Veta, M., Bankhead, P. & Sirinukunwattana, K. (eds.). Switzerland: Springer , p. 3-10 8 p. (Lecture Notes in Computer Science; vol. 11435).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Open Access

File