Swedlow, Jason

Professor

  • United Kingdom

20012023
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Personal profile

Research

Mitotic chromosome dynamics

During cell division, the two copies of a cell's genetic material are completely  separated and delivered to a pair of new daughter cells. Proper chromosome segregation requires the formation of correct attachments between the genetic material, assembled into chromosomes, and ends of microtubules. Our research is focussed on establishing the molecular mechanisms that mediate and monitor the correct attachment of chromosomes to microtubule at a special structure known as the kinetochore. To achieve this, we make use of advanced tools for imaging the components of cell division, especially in living cells and specialised mass spectrometry methods to probe the molecular machinery of cell division. Recently, we used these tools to discover a new protein, Bod1, that plays a critical role in the formation of correct attachments between microtubules and chromosomes by modulating the activity of Aurora B protein kinase. We recently installed a newly developed OMX microscope and are using this system to probe the inner workings of the centromere and kinetochore of the mitotic chromosome.

Like many cell biology labs, we generate large sets of image data. To manage, analyse and understand this data, we, long with our collaborators, formed the Open Microscopy Environment ConsortiumOME develops data specificationsfile format translators and data management software for imaging applications. OME tools are used in thousands of labs around the world. For more info on OME, see the Consortium's web site.

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  • 12 Similar Profiles
Kinetochores Medicine & Life Sciences
Cell Cycle Medicine & Life Sciences
Proteins Medicine & Life Sciences
Imaging techniques Chemical Compounds
Microtubules Medicine & Life Sciences
Chromosomes Chemical Compounds
Microscopy Medicine & Life Sciences
Cells Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2010 2023

Research Output 2001 2019

38 Downloads (Pure)

Bringing Open Data to Whole Slide Imaging

Besson, S., Leigh, R., Linkert, M., Allan, C., Burel, J-M., Carroll, M., Gault, D., Gozim, R., Li, S., Lindner, D., Moore, J., Moore, W., Walczysko, P., Wong, F. & Swedlow, J., 2019, Digital Pathology: 15th European Congress, ECDP 2019, Warwick, UK, April 10–13, 2019, Proceedings. Reyes-Aldasoro, C. C., Veta, M., Janowczyk, A., Bankhead, P. & Sirinukunwattana, K. (eds.). Switzerland: Springer , p. 3-10 8 p. (Lecture Notes in Computer Science; vol. 11435).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
Libraries
Reading
Pathology
2 Citations (Scopus)
61 Downloads (Pure)

Full volume super-resolution imaging of thick mitotic spindle using 3D AO STED microscope

McGloin, D., Swedlow, J. & Zdankowski, P., 1 Apr 2019, In : Biomedical Optics Express. 10, 4, p. 1999-2009 11 p., #352466.

Research output: Contribution to journalArticle

Open Access
File
Spindle Apparatus
spindles
Masks
stimulated emission
depletion
2 Citations (Scopus)
61 Downloads (Pure)

A call for public archives for biological image data

Ellenberg, J., Swedlow, J. R., Barlow, M., Cook, C. E., Sarkans, U., Patwardhan, A., Brazma, A. & Birney, E., 30 Oct 2018, In : Nature Methods. 15, 11, p. 849-854 6 p.

Research output: Contribution to journalArticle

Open Access
File
Bioinformatics
Imaging techniques
Computational Biology
Databases
Technology

An adaptive optics 3D STED microscope for super-resolution imaging of thick samples with background noise suppression using digital image processing

Zdankowski, P., Trusiak, M., Cywinska, M. & Swedlow, J. R., 1 Jan 2018, Speckle 2018: VII International Conference on Speckle Metrology. Jaroszewicz, L. R. & Kujawinska, M. (eds.). Washington: SPIE-International Society for Optical Engineering, Vol. 10834. 9 p. 108342G. (SPIE Proceedings; vol. 10834).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Noise Suppression
Digital Image Processing
Stimulated emission
Adaptive optics
Super-resolution
7 Citations (Scopus)
72 Downloads (Pure)

Killing with proficiency: integrated post-translational regulation of an offensive Type VI secretion system

Ostrowski, A., Cianfanelli, F. R., Porter, M., Mariano, G., Peltier, J., Wong, J. J., Swedlow, J. R., Trost, M. & Coulthurst, S. J., 27 Jul 2018, In : PLoS Pathogens. 14, 7, p. 1-25 25 p., e1007230.

Research output: Contribution to journalArticle

Open Access
File
Threonine
Phosphorylation
Serratia marcescens
Proteins
Weapons

Activities 2010 2010

  • 1 Participation in conference

Cancer Forum

Jason R. Swedlow (Invited speaker)
5 Mar 2010

Activity: Participating in or organising an event typesParticipation in conference

Thesis

Adaptive optics stimulated emission depletion microscope for thick sample imaging

Author: Zdankowski, P., 2018

Supervisor: Swedlow, J. (Supervisor) & McGloin, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Functional & Molecular Analysis of Bod1in Mitotic Chromosome Segregation

Author: Schleicher, K., 2014

Supervisor: Swedlow, J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

The functional and molecular characterisation of the novel DNA damage repair protein Bod1L

Author: Davies, A. M., 2015

Supervisor: Swedlow, J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File