Swedlow, Jason

Professor

  • United Kingdom

20002020

Research output per year

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Personal profile

Research

Mitotic chromosome dynamics

During cell division, the two copies of a cell's genetic material are completely  separated and delivered to a pair of new daughter cells. Proper chromosome segregation requires the formation of correct attachments between the genetic material, assembled into chromosomes, and ends of microtubules. Our research is focussed on establishing the molecular mechanisms that mediate and monitor the correct attachment of chromosomes to microtubule at a special structure known as the kinetochore. To achieve this, we make use of advanced tools for imaging the components of cell division, especially in living cells and specialised mass spectrometry methods to probe the molecular machinery of cell division. Recently, we used these tools to discover a new protein, Bod1, that plays a critical role in the formation of correct attachments between microtubules and chromosomes by modulating the activity of Aurora B protein kinase. We recently installed a newly developed OMX microscope and are using this system to probe the inner workings of the centromere and kinetochore of the mitotic chromosome.

Like many cell biology labs, we generate large sets of image data. To manage, analyse and understand this data, we, long with our collaborators, formed the Open Microscopy Environment ConsortiumOME develops data specificationsfile format translators and data management software for imaging applications. OME tools are used in thousands of labs around the world. For more info on OME, see the Consortium's web site.

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Projects

Research Output

Community standards for open cell migration data

Gonzalez-Beltran, A. N., Masuzzo, P., Ampe, C., Bakker, G-J., Besson, S., Eibl, R. H., Friedl, P., Gunzer, M., Kittisopikul, M., Le Dévédec, S. E., Leo, S., Moore, J., Paran, Y., Prilusky, J., Rocca-Serra, P., Roudot, P., Schuster, M., Sergeant, G., Strömblad, S., Swedlow, J. R. & 5 others, van Erp, M., Van Troys, M., Zaritsky, A., Sansone, S-A. & Martens, L., May 2020, In : GigaScience. 9, 5, p. 1-11 11 p., giaa041.

Research output: Contribution to journalReview article

Open Access
File
  • 16 Downloads (Pure)

    Numerically Enhanced Stimulated Emission Depletion Microscopy with Adaptive Optics for Deep-Tissue Super-Resolved Imaging

    Zdańkowski, P., Trusiak, M., McGloin, D. & Swedlow, J. R., 28 Jan 2020, In : ACS Nano. 14, 1, p. 394-405 12 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)
  • Bringing Open Data to Whole Slide Imaging

    Besson, S., Leigh, R., Linkert, M., Allan, C., Burel, J-M., Carroll, M., Gault, D., Gozim, R., Li, S., Lindner, D., Moore, J., Moore, W., Walczysko, P., Wong, F. & Swedlow, J., 2019, Digital Pathology: 15th European Congress, ECDP 2019, Warwick, UK, April 10–13, 2019, Proceedings. Reyes-Aldasoro, C. C., Janowczyk, A., Veta, M., Bankhead, P. & Sirinukunwattana, K. (eds.). Switzerland: Springer , p. 3-10 8 p. (Lecture Notes in Computer Science; vol. 11435).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Open Access
    File
  • 154 Downloads (Pure)

    Full volume super-resolution imaging of thick mitotic spindle using 3D AO STED microscope

    McGloin, D., Swedlow, J. & Zdankowski, P., 1 Apr 2019, In : Biomedical Optics Express. 10, 4, p. 1999-2009 11 p., #352466.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 6 Citations (Scopus)
    145 Downloads (Pure)

    Activities

    • 1 Participation in conference
    • 1 Other

    BiteSize Bio Podcast interview with Jason Swedlow

    Jason Swedlow (Speaker)

    27 Aug 2020

    Activity: Other activity typesOther

    Cancer Forum

    Jason R. Swedlow (Invited speaker)

    5 Mar 2010

    Activity: Participating in or organising an event typesParticipation in conference