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Research

Mitotic chromosome dynamics

During cell division, the two copies of a cell's genetic material are completely  separated and delivered to a pair of new daughter cells. Proper chromosome segregation requires the formation of correct attachments between the genetic material, assembled into chromosomes, and ends of microtubules. Our research is focussed on establishing the molecular mechanisms that mediate and monitor the correct attachment of chromosomes to microtubule at a special structure known as the kinetochore. To achieve this, we make use of advanced tools for imaging the components of cell division, especially in living cells and specialised mass spectrometry methods to probe the molecular machinery of cell division. Recently, we used these tools to discover a new protein, Bod1, that plays a critical role in the formation of correct attachments between microtubules and chromosomes by modulating the activity of Aurora B protein kinase. We recently installed a newly developed OMX microscope and are using this system to probe the inner workings of the centromere and kinetochore of the mitotic chromosome.

Like many cell biology labs, we generate large sets of image data. To manage, analyse and understand this data, we, long with our collaborators, formed the Open Microscopy Environment ConsortiumOME develops data specificationsfile format translators and data management software for imaging applications. OME tools are used in thousands of labs around the world. For more info on OME, see the Consortium's web site.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Research Output 2001 2018

A call for public archives for biological image data

Ellenberg, J., Swedlow, J. R., Barlow, M., Cook, C. E., Sarkans, U., Patwardhan, A., Brazma, A. & Birney, E., 30 Oct 2018, In : Nature Methods. 15, 11, p. 849-854 6 p.

Research output: Contribution to journalArticle

Open Access
File
Bioinformatics
Imaging techniques
Computational Biology
Databases
Technology

Killing with proficiency: integrated post-translational regulation of an offensive Type VI secretion system

Ostrowski, A., Cianfanelli, F. R., Porter, M., Mariano, G., Peltier, J., Wong, J. J., Swedlow, J. R., Trost, M. & Coulthurst, S. J., 27 Jul 2018, In : PLoS Pathogens. 14, 7, e1007230.

Research output: Contribution to journalArticle

Open Access
File
Threonine
Phosphorylation
Serratia marcescens
Proteins
Weapons

Publisher Correction: Image Data Resource: a bioimage data integration and publication platform

Williams, E., Moore, J., Li, S. W., Rustici, G., Tarkowska, A., Chessel, A., Leo, S., Antal, B., Ferguson, R. K., Sarkans, U., Brazma, A., Carazo Salas, R. E. & Swedlow, J. R., 4 Oct 2018, In : Nature Methods. 1 p.

Research output: Contribution to journalArticle

Open Access
Data integration
Publications
Licensure

Visualization of Biomedical Data

O'Donoghue, S. I., Baldi, B. F., Clark, S. J., Darling, A. E., Hogan, J. M., Kaur, S., Maier-Hein, L., McCarthy, D. J., Moore, W., Stenau, E., Swedlow, J., Vuong, J. & Procter, J., 20 Jul 2018, In : Annual Review of Biomedical Data Science. 1

Research output: Contribution to journalArticle

Open Access
Learning
Metagenomics
Foster Home Care
Genomics
Research
3 Citations

Cutting Edge: Building bridges between cellular and molecular structural biology

Patwardhan, A., Brandt, R., Butcher, S. J., Collinson, L., Gault, D., Grünewald, K., Hecksel, C., Huiskonen, J. T., Iudin, A., Jones, M. L., Korir, P. K., Koster, A. J., Lagerstedt, I., Lawson, C. L., Mastronarde, D., McCormick, M., Parkinson, H. E., Rosenthal, P. B., Saalfeld, S., Saibil, H. R. & 7 othersSarntivijai, S., Solanes Valero, I., Subramaniam, S., Swedlow, J. R., Tudose, I., Winn, M. & Kleywegt, G. J., 24 Jul 2017, In : eLife. 6, p. 1-11 11 p., e25835.

Research output: Contribution to journalArticle

Open Access
File
Molecular Biology
Macromolecular Substances
Education
Decomposition

Activities 2010 2010

  • 1 Participation in conference

Cancer Forum

Jason R. Swedlow (Invited speaker)
5 Mar 2010

Activity: Participating in or organising an event typesParticipation in conference

Thesis

Adaptive optics stimulated emission depletion microscope for thick sample imaging

Author: Zdankowski, P., 2018

Supervisor: Swedlow, J. (Supervisor) & McGloin, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Functional & Molecular Analysis of Bod1in Mitotic Chromosome Segregation

Author: Schleicher, K., 2014

Supervisor: Swedlow, J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

The functional and molecular characterisation of the novel DNA damage repair protein Bod1L

Author: Davies, A. M., 2015

Supervisor: Swedlow, J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File