Projects per year
Personal profile
Research
Mitotic chromosome dynamics
During cell division, the two copies of a cell's genetic material are completely separated and delivered to a pair of new daughter cells. Proper chromosome segregation requires the formation of correct attachments between the genetic material, assembled into chromosomes, and ends of microtubules. Our research is focussed on establishing the molecular mechanisms that mediate and monitor the correct attachment of chromosomes to microtubule at a special structure known as the kinetochore. To achieve this, we make use of advanced tools for imaging the components of cell division, especially in living cells and specialised mass spectrometry methods to probe the molecular machinery of cell division. Recently, we used these tools to discover a new protein, Bod1, that plays a critical role in the formation of correct attachments between microtubules and chromosomes by modulating the activity of Aurora B protein kinase. We recently installed a newly developed OMX microscope and are using this system to probe the inner workings of the centromere and kinetochore of the mitotic chromosome.
Like many cell biology labs, we generate large sets of image data. To manage, analyse and understand this data, we, long with our collaborators, formed the Open Microscopy Environment Consortium. OME develops data specifications, file format translators and data management software for imaging applications. OME tools are used in thousands of labs around the world. For more info on OME, see the Consortium's web site.
Fingerprint Dive into the research topics where Jason Swedlow is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 2 Similar Profiles
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Providing an open collaborative space for digital biology in Europe (EOSC-Life) (Joint with European Molecular Biology Laboratory as lead, Biobanks and Biomolecular Resources Research Infrastructure Consortium, EATRIS ERIC and 35 others)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/03/19 → 28/02/23
Project: Research
The Image Data Resource: Making Biological Imaging Data FAIR (Joint with EMBL-EBI) (Biomedical Resources Grant)
1/10/18 → 30/09/21
Project: Research
The Interplay Between Oxygen Sensors PHDs and the Cell Cycle (Joint with University of Liverpool)
Fleming, S., Lamond, A. & Swedlow, J.
1/09/17 → 31/08/22
Project: Research
Research Output
Bringing Open Data to Whole Slide Imaging
Besson, S., Leigh, R., Linkert, M., Allan, C., Burel, J-M., Carroll, M., Gault, D., Gozim, R., Li, S., Lindner, D., Moore, J., Moore, W., Walczysko, P., Wong, F. & Swedlow, J., 2019, Digital Pathology: 15th European Congress, ECDP 2019, Warwick, UK, April 10–13, 2019, Proceedings. Reyes-Aldasoro, C. C., Janowczyk, A., Veta, M., Bankhead, P. & Sirinukunwattana, K. (eds.). Switzerland: Springer , p. 3-10 8 p. (Lecture Notes in Computer Science; vol. 11435).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Open Access
File
Full volume super-resolution imaging of thick mitotic spindle using 3D AO STED microscope
McGloin, D., Swedlow, J. & Zdankowski, P., 1 Apr 2019, In : Biomedical Optics Express. 10, 4, p. 1999-2009 11 p., #352466.Research output: Contribution to journal › Article
Open Access
File
5
Citations
(Scopus)
118
Downloads
(Pure)
Numerically Enhanced Stimulated Emission Depletion Microscopy with Adaptive Optics for Deep-Tissue Super-Resolved Imaging
Zdańkowski, P., Trusiak, M., McGloin, D. & Swedlow, J. R., 16 Dec 2019, In : ACS Nano. 12 p.Research output: Contribution to journal › Article
A call for public archives for biological image data
Ellenberg, J., Swedlow, J. R., Barlow, M., Cook, C. E., Sarkans, U., Patwardhan, A., Brazma, A. & Birney, E., 30 Oct 2018, In : Nature Methods. 15, 11, p. 849-854 6 p.Research output: Contribution to journal › Article
Open Access
File
3
Citations
(Scopus)
106
Downloads
(Pure)
An adaptive optics 3D STED microscope for super-resolution imaging of thick samples with background noise suppression using digital image processing
Zdankowski, P., Trusiak, M., Cywinska, M. & Swedlow, J. R., 1 Jan 2018, Speckle 2018: VII International Conference on Speckle Metrology. Jaroszewicz, L. R. & Kujawinska, M. (eds.). Washington: SPIE-International Society for Optical Engineering, Vol. 10834. 9 p. 108342G. (SPIE Proceedings; vol. 10834).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Activities
- 1 Participation in conference
Cancer Forum
Jason R. Swedlow (Invited speaker)5 Mar 2010
Activity: Participating in or organising an event types › Participation in conference
Thesis
Adaptive optics stimulated emission depletion microscope for thick sample imaging
Author: Zdankowski, P., 2018Supervisor: Swedlow, J. (Supervisor) & McGloin, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Functional & Molecular Analysis of Bod1in Mitotic Chromosome Segregation
Author: Schleicher, K., 2014Supervisor: Swedlow, J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
The functional and molecular characterisation of the novel DNA damage repair protein Bod1L
Author: Davies, A. M., 2015Supervisor: Swedlow, J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File