Projects per year
Personal profile
Biography
Jenni Harvey obtained a BSc honours degree in Pharmacology at the University of Edinburgh (1990) before receiving a Ph.D. in 1993 for work on metabotropic glutamate receptors and synaptic transmission under the supervision of Prof Graham Collingridge (University of Birmingham). She then undertook postdoctoral research positions with Dr Mike Lacey (University of Birmingham) and Prof Mike AShford (University of Aberdeen), before moving to Dundee to set up her own laboratory after being awarded a Wellcome Research Career Development Fellowship (2001). In 2005, she was awarded a Wellcome University Award to continue her studies into the role of leptin in hippocampal synaptic function.
Teaching
Undergraduate Science Teaching
5th Year MSCi in Pharmacology/Neuroscience
4th year BSc & BMSc Honours in Pharmacology
4th year BSc & BMSc Honours in Neuroscience
Module Course - Synaptic plasticity and cognition
Module Course Leader - Neurodegenerative Disorders
Supervision of 4th year BSc and BMSc Honours Student Projects
3rd year BSc
Quantitative Pharmacology module
Molecular Pharmacology module
Regulatory Physiology and Pharmacology module
Biomembranes module
Undergraduate Medical Student Teaching
1st year Medical Special Study Component (SSC)
1st year tutorials
Supervision of Medical Students in their 4th year laboratory-based assignment
Postgraduate Teaching
I have extensive experience of supervising both MSc and PhD students.
Research
Jenni Harvey’s research group has a long standing interest in neuronal synaptic mechanisms and in particular the cellular basis for activity-dependent synaptic plasticity in the CNS. Her research is focused on understanding how the molecular processes of synaptic plasticity are influenced by hormonal systems in health and disease. Recent studies by the group have highlighted a potential cognitive enhancing role for leptin as it regulates diverse aspects of synaptic function including glutamate receptor trafficking, neuronal morphology and activity dependent synaptic plasticity. A major focus of her current research is in determining the cellular and molecular processes underlying leptin’s effects in the brain and also how dysfunctions in the leptin system impact on brain function. Her group are utilizing a range of techniques including electrophysiology, digital epifluorescence imaging, transgenic mouse technologies, molecular biology and confocal microscopy to determine the neuronal function of the hormone leptin.
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Projects
Does Leptin Have Pathway-Specific Effects on the Regulation of Hippocampal Excitatory Synaptic Transmission
Harvey, J., Irving, A. & Luo, X.
Project: Research
Evaluation of the Potential use of Leptin Mimetics in the Treatment of Neurodegenerative Disorders
Harvey, J. & Irving, A.
Project: Research
Research Output
Activation of oestrogen receptor α induces a novel form of LTP at hippocampal temporoammonic-CA1 synapses
Clements, L. & Harvey, J., Feb 2020, In : British Journal of Pharmacology. 177, 3, p. 642-655 14 p.Research output: Contribution to journal › Article
Leptin Regulation of Synaptic Function at Hippocampal TA-CA1 and SC-CA1 Synapses: Implications for Health and Disease
Mcgregor, G. & Harvey, J., Mar 2019, In : Neurochemical Research. 44, 3, p. 650-660 11 p.Research output: Contribution to journal › Article
Open Access
File
9
Citations
(Scopus)
138
Downloads
(Pure)
N‐Palmitoylglycine and other N‐acylamides activate the lipid receptor G2A/GPR132
Foster, J., Ueno, S., Chen, M. X., Harvey, J., Dowell, S. J., Irving, A. J. & Brown, A. J., Dec 2019, In : Pharmacology Research and Perspectives. 7, 6, p. 1-13 13 p., e00542.Research output: Contribution to journal › Article
Open Access
File
Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin
McGregor, G., Clements, L., Farah, A., Irving, A. & Harvey, J., Sep 2018, In : Neurobiology of Aging. 69, p. 76-93 18 p.Research output: Contribution to journal › Article
Open Access
File
5
Citations
(Scopus)
160
Downloads
(Pure)
Food for thought: Leptin regulation of hippocampal function and its role in Alzheimer's disease
McGregor, G. & Harvey, J., Jul 2018, In : Neuropharmacology. 136, p. 298-306 9 p.Research output: Contribution to journal › Review article
Open Access
File
6
Citations
(Scopus)
213
Downloads
(Pure)
Thesis
Age-dependent regulation of hippocampal excitatory synaptic transmission by leptin
Author: Mcgregor, G., 2018Supervisor: Harvey, J. (Supervisor) & Irving, A. J. (External person) (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
Characterisation of leptin mimetic agents as therapeutic targets in Alzheimer's disease
Author: Malekizadeh, Y., 2016Supervisor: Harvey, J. (Supervisor) & Irving, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
GPR30: a role for a novel estrogen-sensing receptor in hippocampal function?
Author: Alexander, A., 2013Supervisor: Irving, A. (Supervisor) & Harvey, J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Leptin induces a novel form of long-term potentiation at the direct cortical input to hippocampal CA1 synapses
Author: Luo, X., 2013Supervisor: Irving, A. (Supervisor) & Harvey, J. (Supervisor)
Student thesis: Master's Thesis › Master of Science
File