Projects per year
Personal profile
Biography
Jenni Harvey obtained a BSc honours degree in Pharmacology at the University of Edinburgh (1990) before receiving a Ph.D. in 1993 for work on metabotropic glutamate receptors and synaptic transmission under the supervision of Prof Graham Collingridge (University of Birmingham). She then undertook postdoctoral research positions with Dr Mike Lacey (University of Birmingham) and Prof Mike AShford (University of Aberdeen), before moving to Dundee to set up her own laboratory after being awarded a Wellcome Research Career Development Fellowship (2001). In 2005, she was awarded a Wellcome University Award to continue her studies into the role of leptin in hippocampal synaptic function.
Teaching
Undergraduate Science Teaching
5th Year MSCi in Pharmacology/Neuroscience
4th year BSc & BMSc Honours in Pharmacology
4th year BSc & BMSc Honours in Neuroscience
Module Course - Synaptic plasticity and cognition
Module Course Leader - Neurodegenerative Disorders
Supervision of 4th year BSc and BMSc Honours Student Projects
3rd year BSc
Quantitative Pharmacology module
Molecular Pharmacology module
Regulatory Physiology and Pharmacology module
Biomembranes module
Undergraduate Medical Student Teaching
1st year Medical Special Study Component (SSC)
1st year tutorials
Supervision of Medical Students in their 4th year laboratory-based assignment
Postgraduate Teaching
I have extensive experience of supervising both MSc and PhD students.
Research
Jenni Harvey’s research group has a long standing interest in neuronal synaptic mechanisms and in particular the cellular basis for activity-dependent synaptic plasticity in the CNS. Her research is focused on understanding how the molecular processes of synaptic plasticity are influenced by hormonal systems in health and disease. Recent studies by the group have highlighted a potential cognitive enhancing role for leptin as it regulates diverse aspects of synaptic function including glutamate receptor trafficking, neuronal morphology and activity dependent synaptic plasticity. A major focus of her current research is in determining the cellular and molecular processes underlying leptin’s effects in the brain and also how dysfunctions in the leptin system impact on brain function. Her group are utilizing a range of techniques including electrophysiology, digital epifluorescence imaging, transgenic mouse technologies, molecular biology and confocal microscopy to determine the neuronal function of the hormone leptin.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Evaluating The Neuroprotective Actions Of GPER1 In Tau Related Synaptic Dysfunction - Studentship
Harvey, J. (Investigator), Henstridge, C. (Investigator) & McNeilly, A. (Investigator)
Project: Research
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Evaluation of the Potential use of Leptin Mimetics in the Treatment of Neurodegenerative Disorders
Harvey, J. (Investigator) & Irving, A. (Investigator)
Project: Research
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Evaluation of the Potential Use of Leptin Mimetics in the treatment of Neurodegenerative Disease
Harvey, J. (Investigator)
Project: Research
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Targeting the Estrogen System to Treat CNS Disease (Vacation Scholarship : Rebecca Crook)
Harvey, J. (Investigator)
Project: Research
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Novel leptin-based therapeutic strategies to limit synaptic dysfunction in Alzheimer’s disease.
Harvey, J., 4 Jul 2024, In: International Journal of Molecular Sciences.Research output: Contribution to journal › Review article › peer-review
Open Access -
G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses
Clements, L., Alexander, A., Hamilton, K., Irving, A. & Harvey, J. (Lead / Corresponding author), 28 Jan 2023, In: Molecular Brain. 16, 18 p., 16.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)226 Downloads (Pure) -
Leptin-based hexamers facilitate memory and prevent amyloid-driven AMPA receptor internalisation and neuronal degeneration
Doherty, G. (Lead / Corresponding author), Holiday, A., Malekizadeh, Y., Manolescu, C., Duncan, S., Flewitt, I., Hamilton, K., MacLeod, B., Ainge, J. A. (Lead / Corresponding author) & Harvey, J. (Lead / Corresponding author), Jun 2023, In: Journal of Neurochemistry. 165, 6, p. 809-826 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)287 Downloads (Pure) -
Leptin prevents aberrant targeting of tau to hippocampal synapses via PI 3 kinase driven inhibition of GSK3β
Hamilton, K., Morrow, K., Markantoni, E. & Harvey, J. (Lead / Corresponding author), Nov 2023, In: Journal of Neurochemistry. 167, 4, p. 520-537 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)193 Downloads (Pure) -
Food for Thought: Leptin and Hippocampal Synaptic Function
Harvey, J. (Lead / Corresponding author), 17 Jun 2022, In: Frontiers in Pharmacology. 13, 8 p., 882158.Research output: Contribution to journal › Review article › peer-review
Open AccessFile10 Citations (Scopus)85 Downloads (Pure)
Datasets
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Data from: Leptin regulation of hippocampal synaptic function in health and disease
Irving, A. J. (Creator) & Harvey, J. (Creator), Dryad, 25 Oct 2014
DOI: 10.5061/dryad.n8f46, https://datadryad.org/stash/dataset/doi:10.5061/dryad.n8f46
Dataset
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Leptin-based hexamers facilitate memory and prevent amyloid-driven AMPA receptor internalisation and neuronal degeneration
Harvey, J. (Creator), University of Dundee, 5 Jan 2022
DOI: 10.15132/10000189, https://dmail.sharepoint.com/:f:/s/ResearchServicesPublicDocuments/EtPAHnOnUvJCqpJFbeal90wBxSK2XSRP8fk4Pacd-l0GXA?e=DYkXZJ and one more link, https://creativecommons.org/licenses/by/4.0/ (show fewer)
Dataset
File
Prizes
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Wellcome Trust Research Career Development Fellowship
Harvey, J. (Recipient), 1999
Prize: Fellowship awarded competitively
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Activities
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Discovery Days 2024
Urch, J. (Organiser), Wasim, S. (Organiser), Gillespie, I. (Chair), McBeth, D. (Presenter), Miller, L. (Presenter), Mu, X. (Presenter), Haque, S. (Presenter), Mcculloch, P. (Presenter), Brewer, N. (Presenter), Fenton, J. (Presenter), Harvey, J. (Presenter), Macluskey, M. (Presenter), Rena, G. (Presenter), Lee, M. (Presenter), Peter, M. (Presenter), Marton, G. (Presenter), Thomson, I. (Presenter), Daly, A. (Presenter), Dey, C. (Presenter), Hendry, S. (Presenter), Ingram, R. (Presenter), Young, L. (Presenter), Melinger, A. (Presenter), Giddens, T. (Presenter), Kinnear, S. (Presenter), Coxon, A. (Presenter), Booth, D. (Presenter), Paramati, S. R. (Presenter), Rinaldi, V. (Presenter), Duce, S. (Presenter), Patrick, S. (Presenter), Gibson, L. (Chair), McGeorge, J. (Chair), Alexander, W. (Chair) & Wasim, S. (Member)
10 Jan 2024 → 12 Jan 2024Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar
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School of Medicine: Women in Science Day
Harvey, J. (Organiser)
11 Feb 2021Activity: Participating in or organising an event types › Other event
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Alzheimer's Research UK (External organisation)
Harvey, J. (Member)
2020 → …Activity: Membership types › Membership of board