• 1897 Citations
  • 23 h-Index
19982019
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Personal profile

Biography

Jenni Harvey obtained a BSc honours degree in Pharmacology at the University of Edinburgh (1990) before receiving a Ph.D. in 1993 for work on metabotropic glutamate receptors and synaptic transmission under the supervision of Prof Graham Collingridge (University of Birmingham). She then undertook postdoctoral research positions with Dr Mike Lacey (University of Birmingham) and Prof Mike AShford (University of Aberdeen), before moving to Dundee to set up her own laboratory after being awarded a Wellcome Research Career Development Fellowship (2001). In 2005, she was awarded a Wellcome University Award to continue her studies into the role of leptin in hippocampal synaptic function.

Teaching

Undergraduate Science Teaching

5th Year MSCi in Pharmacology/Neuroscience

4th year BSc & BMSc Honours in Pharmacology

4th year BSc & BMSc Honours in Neuroscience

Module Course - Synaptic plasticity and cognition

Module Course Leader - Neurodegenerative Disorders

Supervision of 4th year BSc and BMSc Honours Student Projects

3rd year BSc

Quantitative Pharmacology module

Molecular Pharmacology module

Regulatory Physiology and Pharmacology module

Biomembranes module

Undergraduate Medical Student Teaching

1st year Medical Special Study Component (SSC)

1st year tutorials

Supervision of Medical Students in their 4th year laboratory-based assignment

Postgraduate Teaching

I have extensive experience of supervising both MSc and PhD students.

Research

Jenni Harvey’s research group has a long standing interest in neuronal synaptic mechanisms and in particular the cellular basis for activity-dependent synaptic plasticity in the CNS. Her research is focused on understanding how the molecular processes of synaptic plasticity are influenced by hormonal systems in health and disease. Recent studies by the group have highlighted a potential cognitive enhancing role for leptin as it regulates diverse aspects of synaptic function including glutamate receptor trafficking, neuronal morphology and activity dependent synaptic plasticity. A major focus of her current research is in determining the cellular and molecular processes underlying leptin’s effects in the brain and also how dysfunctions in the leptin system impact on brain function. Her group are utilizing a range of techniques including electrophysiology, digital epifluorescence imaging, transgenic mouse technologies, molecular biology and confocal microscopy to determine the neuronal function of the hormone leptin.

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Projects 2013 2019

Research Output 1998 2018

1 Citation (Scopus)
30 Downloads (Pure)

Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin

McGregor, G., Clements, L., Farah, A., Irving, A. & Harvey, J., Sep 2018, In : Neurobiology of Aging. 69, p. 76-93 18 p.

Research output: Contribution to journalArticle

Open Access
File
Leptin
Synaptic Transmission
Synapses
Depression
Hippocampus
1 Citation (Scopus)
25 Downloads (Pure)

Food for thought: Leptin regulation of hippocampal function and its role in Alzheimer's disease

McGregor, G. & Harvey, J., Jul 2018, In : Neuropharmacology. 136, p. 298-306 9 p.

Research output: Contribution to journalReview article

Open Access
File
Leptin
Alzheimer Disease
Body Weight
Neurobiology
Neurodegenerative Diseases
17 Downloads (Pure)
Open Access
File
Leptin
Neurodegenerative Diseases
Hormones
Health
Alzheimer Disease
7 Citations (Scopus)

Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors

Irving, A., Abdulrazzaq, G., Chan, S. L. F., Penman, J., Harvey, J. & Alexander, S. P. H., Jun 2017, Cannabinoid Pharmacology. Kendall, D. & Alexander, S. P. H. (eds.). Cambridge, MA: Academic Press, Vol. 80. p. 223-247 25 p. (Advances in Pharmacology; vol. 80).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Cannabinoid Receptor CB2
Cannabinoid Receptor CB1
Cannabinoid Receptors
G-Protein-Coupled Receptors
Ligands
4 Citations (Scopus)

Canonical JAK-STAT signaling is pivotal for long-term depression at adult hippocampal temporoammonic-CA1 synapses

McGregor, G., Irving, A. J. & Harvey, J., Aug 2017, In : FASEB Journal. 31, 8, p. 3449-3466 19 p.

Research output: Contribution to journalArticle

Janus Kinases
Transcription
Transducers
Synapses
Depression

Thesis

Characterisation of leptin mimetic agents as therapeutic targets in Alzheimer's disease

Author: Malekizadeh, Y., 2016

Supervisor: Harvey, J. (Supervisor) & Irving, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

GPR30: a role for a novel estrogen-sensing receptor in hippocampal function?

Author: Alexander, A., 2013

Supervisor: Irving, A. (Supervisor) & Harvey, J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Leptin induces a novel form of long-term potentiation at the direct cortical input to hippocampal CA1 synapses

Author: Luo, X., 2013

Supervisor: Irving, A. (Supervisor) & Harvey, J. (Supervisor)

Student thesis: Master's ThesisMaster of Science

File