Hayes, John

Projects

Projects per year 2011 2012 2014 2025

• 2 Active
• 7 Not started
• 13 Finished

Projects per year

Search results

• Active

  Role of the GSK-3NRF2 Axis In Beta Cell Decline In Type 2 Diabetes

  Cantley, J., Hayes, J., McNeilly, A. & Sutherland, C.

  Diabetes UK

  18/04/21 → 17/04/24

  Project: Research

• Defining the Oxidative Stress-Related Mechanisms by which Activation of the Transcription Factor Nrf2 Arrests and Resolves Liver Fibrosis

  Arthur, S., Dillon, J., Dinkova-Kostova, A., Hayes, J. & Henderson, C.

  Medical Research Council

  1/04/20 → 30/06/25

  Project: Research

  • Oxidative Stress 100%
  • NF-E2-Related Factor 2 53%
  • Basic-Leucine Zipper Transcription Factors 51%
  • Ubiquitin-Protein Ligases 42%
  • Transcription Factors 36%
• Not started

  LTQ Oritrap Velos Mass Spectrometer from Thermo-Fisher (Quantitative Proteomics for the Dundee Cancer Centre)

  Clarke, P., Dinkova-Kostova, A., Hay, R., Hayes, J., Hiom, K. & Keyse, S.

  Project: Research

• Aref#d: 20930. Integrative Toxicology Training Partnership (ITTP) Studentship

  Hayes, J.

  Project: Research

• Interplay Between Transcription Factors Nrf2 and PPAR During the Development of Non-Alcoholic Steatohepatitis

  Hayes, J.

  Project: Research

• Mechanism of Inhibition of Inflammation by the Antioxidant Transcription Factor Nrf2

  Hayes, J.

  Project: Research

• Aref#d: 20287. Specificity in the Modification of Cysteine Residues in Keap1 by Different Electrophiles and Oxidative Stressors (Industrial Partnership Studentship : J Hourihan) Archived by MC on 13/10/16 was CO0367

  Hayes, J.

  Project: Research

• Inhibition of Non-Alcoholic Steatohepatitis (NASH), and its Progression to Hepatocellular Carcinoma, in Mice Fed a High-Fat Plus Fructose Diet by Pharmacological Activation of Nrf2

  Hayes, J.

  Project: Research

• Inhibition of Non-Alcoholic Steatohepatitis (NASH) in Mice Fed a High-Fat Plus Fructose Diet by Pharmacological Activation of Nrf2 (Vacation Scholarship)

  Hayes, J.

  Project: Research

• Finished

  Ultra-High Definition Imaging - MRC Equipment Grant

  Alessi, D., Banerjee, S., Cantley, J., Corner, G., Hayes, J., Hoskins, P., Kang, L., McNeilly, A., McSorley, H., Murdoch, C. & Rena, G.

  Medical Research Council

  1/11/22 → 31/03/23

  Project: Research

• Nrf2 Antioxidant Gene Expression and Its Role in Combatting Oxidative Stress and Maintaining Vascular Function in Patients with Cardiovascular Disease

  Hayes, J., Khan, F. & Lang, C.

  3/09/18 → 2/09/21

  Project: Research

• Small Molecules Activating Nrf2 as a Therapeutic Approach to Prevent Cardiac Ischemia-reperfusion Injury (joint with University of Glasgow)

  Dinkova-Kostova, A., Fuller, W., Hayes, J., Lang, C. & Mordi, I.

  British Heart Foundation

  1/04/17 → 31/03/19

  Project: Research

  • Amyloid beta-Protein Precursor 100%
  • Heme 95%
  • Biotin 94%
  • Gonadal Steroid Hormones 94%
  • Progesterone Receptors 90%

• Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)

  Dinkova-Kostova, A., Hayes, J., Henderson, C., Keyse, S., Lamond, A. & Sutherland, C.

  Medical Research Council

  1/05/16 → 31/10/19

  Project: Research

  • NF-E2-Related Factor 2 100%
  • Kelch-Like ECH-Associated Protein 1 88%
  • Glycogen Synthase Kinase 3 43%
  • Glycogen 38%
  • Transcription Factors 36%

• NRF-2 Based Approaches to Preventing Cognitive Impairment in Diabetes

  Ashford, M., Dinkova-Kostova, A., Hayes, J. & McCrimmon, R.

  Diabetes UK

  1/10/15 → 30/09/18

  Project: Research

• Physiological Significance of Loss of Transcription Factor Nrf2 with Age and its Positive Regulation by the Ubiquitin-Conjugating UBE2N Family Enzymes (iCASE Studentship with Industry)

  Dinkova-Kostova, A. & Hayes, J.

  1/10/14 → 30/09/18

  Project: Research

• Targeting TRIM Proteins as an Anti-inflammatory Strategy by Activating the Antioxidant Transcription Factor Nrf2

  Chowdhry, S. & Hayes, J.

  Anonymous Trust

  1/08/14 → 30/04/15

  Project: Research

• Mechanistic Insights into the Pathophysiology of CFS/ME A Study Examining Nrf2 Antioxidant Gene Expression and its Role in Combatting Oxidative Stress

  Belch, J., Dinkova-Kostova, A., Hayes, J. & Khan, F.

  ME Research UK

  1/07/14 → 1/09/19

  Project: Research

• Application of Selected-Reaction Monitoring (SRM) Mass Spectrometry for the Global Analysis of the Phosphorylation Status of Protein Kinases

  Ashford, M., Dillon, J., Hayes, J., McCrimmon, R. & Trost, M.

  Medical Research Council

  1/11/12 → 31/03/16

  Project: Research

  • NF-E2-Related Factor 2 100%
  • Non-alcoholic Fatty Liver Disease 50%
  • Fatty Liver 48%
  • TBE 31 45%
  • Oxidative Stress 38%

• Pivotal Role of the Keap1-Nrf2 Pathway in the Pathogenesis and Prevention of Non Alcoholic Steatohepatitis Induced Cirrhosis

  Ashford, M., Dillon, J., Hayes, J. & McCrimmon, R.

  Medical Research Council

  1/11/12 → 31/03/16

  Project: Research

  • NF-E2-Related Factor 2 100%
  • Non-alcoholic Fatty Liver Disease 50%
  • Fatty Liver 48%
  • TBE 31 45%
  • Oxidative Stress 38%

• Investigation into the Role of Keap1 in Pancreatic B-Cell Function

  Ashford, M., Hayes, J., McCrimmon, R. & Meakin, P.

  Anonymous Trust

  1/06/12 → 31/05/13

  Project: Research

• Molecular Mechanisms by which the Cancer Chemopreventive Properties of Transcription Factor Nrf2 are Regulated Through its Neh6 Redox-Independent Phosphodegrons as a Consequence of GSK3 Activity

  Hayes, J. & Sutherland, C.

  Cancer Research UK

  1/04/12 → 30/09/15

  Project: Research

• The Keap1-NRF2-ARE Pathway: A Tractable Target for the Amelioration of Alzheimer's Pathology

  Dinkova-Kostova, A., Hayes, J. & Sharkey, J.

  1/04/11 → 31/03/13

  Project: Research