Rouse, John

Professor

  • Scientific Programme Leader (MRC) & Personal Chair of Chromosome Biology, MRC PPU
  • United Kingdom

1994 …2023
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  • 4 Similar Profiles
DNA Damage Medicine & Life Sciences
DNA Repair Medicine & Life Sciences
Phosphorylation Chemical Compounds
DNA Chemical Compounds
Repair Chemical Compounds
Phosphotransferases Chemical Compounds
Mitogen-Activated Protein Kinase 11 Medicine & Life Sciences
Cells Chemical Compounds

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Projects 2013 2023

Research Output 1994 2018

Corrigendum to "Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR" [DNA Repair 6 (2007) 1536-1544]

Jowsey, P., Morrice, N. A., Hastie, C. J., MacLauchlan, H., Toth, R. & Rouse, J., May 2018, In : DNA Repair. 65, p. 80 1 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
52 Downloads (Pure)

Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase

Munoz, I., Morgan, M., Peltier, J., Weiland, F., Gregorczyk, M., Brown, F. C. M., Macartney, T., Toth, R., Trost, M. & Rouse, J., 1 Oct 2018, In : The EMBO Journal. 37, 19, p. 1-19 19 p., e99559.

Research output: Contribution to journalArticle

Open Access
File
60 Downloads (Pure)
Open Access
File
8 Citations (Scopus)
80 Downloads (Pure)

RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

Feeney, L., Munoz, I. M., Lachaud, C., Toth, R., Appleton, P. L., Schindler, D. & Rouse, J., 1 Jun 2017, In : Molecular Cell. 66, 5, p. 610-621.e4 16 p.

Research output: Contribution to journalArticle

Open Access
File
Replication Protein A
Ubiquitin-Protein Ligases
Health
Fanconi Anemia
Genomic Instability
1 Citation (Scopus)
79 Downloads (Pure)

A route to new cancer therapies: the FA pathway is essential in BRCA1- or BRCA2-deficient cells

Lachaud, C. & Rouse, J., 3 Aug 2016, In : Nature Structural & Molecular Biology. 23, 8, p. 701-703 3 p.

Research output: Contribution to journalArticle

Open Access
File
BRCA2 Gene
BRCA1 Gene
Fanconi Anemia
Mutation
Ovarian Neoplasms

Thesis

Analysis of the composition and regulation of the SLX4 complex

Author: Satriano, L., 2014

Supervisor: Rouse, J. (Supervisor)

Student thesis: Master's ThesisMaster of Science

File

Characterisation of human SLX4/FANCP, a coordinator of DNA repair nucleases

Author: Hain, K. O., 2012

Supervisor: Rouse, J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Identification of MMS22 as a regulator of DNA repair

Author: Duro, E., 2010

Supervisor: Rouse, J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Regulation of structure-selective nucleases by the SLX4 scaffold in ICL repair and HJ resolution

Author: Nair, N., 2014

Supervisor: Rouse, J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy