Rouse, John

Professor

  • Scientific Programme Leader (MRC) & Personal Chair of Chromosome Biology, MRC PPU
  • United Kingdom

1994 …2020

Research output per year

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Research Output

2020
Open Access
File
2 Downloads (Pure)

Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease

Álvarez-Quilón, A., Wojtaszek, J. L., Mathieu, M-C., Patel, T., Appel, C. D., Hustedt, N., Rossi, S. E., Wallace, B. D., Setiaputra, D., Adam, S., Ohashi, Y., Melo, H., Cho, T., Gervais, C., Muñoz, I. M., Grazzini, E., Young, J. T. F., Rouse, J., Zinda, M., Williams, R. S. & 1 others, Durocher, D., 18 Jun 2020, In : Molecular Cell. 78, p. 1152-1162.e1-e8 23 p.

Research output: Contribution to journalArticle

Expanding the phenotype of the CDKL5 deficiency disorder: Are seizures mandatory?

MacKay, C. I., Bick, D., Prokop, J. W., Muñoz, I., Rouse, J., Downs, J. & Leonard, H., 17 Apr 2020, In : American Journal of Medical Genetics Part A. 182, 5, p. 1217-1222 6 p.

Research output: Contribution to journalArticle

2019

Ways to unwind with HROB, a new player in homologous recombination

Saredi, G. & Rouse, J., 1 Oct 2019, In : Genes & Development. 33, 19-20, p. 1293-1294 2 p.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
15 Downloads (Pure)
2018

Corrigendum to "Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR" [DNA Repair 6 (2007) 1536-1544]

Jowsey, P., Morrice, N. A., Hastie, C. J., MacLauchlan, H., Toth, R. & Rouse, J., May 2018, In : DNA Repair. 65, p. 80 1 p.

Research output: Contribution to journalArticle

Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase

Munoz, I., Morgan, M., Peltier, J., Weiland, F., Gregorczyk, M., Brown, F. C. M., Macartney, T., Toth, R., Trost, M. & Rouse, J., 14 Dec 2018, In : The EMBO Journal. 37, 24, p. 1-19 19 p., e99559.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
207 Downloads (Pure)
2017
Open Access
File
117 Downloads (Pure)

RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

Feeney, L., Munoz, I. M., Lachaud, C., Toth, R., Appleton, P. L., Schindler, D. & Rouse, J., 1 Jun 2017, In : Molecular Cell. 66, 5, p. 610-621.e4 16 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
177 Downloads (Pure)
2016

A route to new cancer therapies: the FA pathway is essential in BRCA1- or BRCA2-deficient cells

Lachaud, C. & Rouse, J., 3 Aug 2016, In : Nature Structural & Molecular Biology. 23, 8, p. 701-703 3 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
198 Downloads (Pure)

Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in fan1 nuclease-defective knock-in mice

Lachaud, C., Slean, M., Marchesi, F., Lock, C., Odell, E., Castor, D., Toth, R. & Rouse, J., 15 Mar 2016, In : Genes and Development. 30, 6, p. 639-644 6 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
188 Downloads (Pure)

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability

Lachaud, C., Moreno, A., Marchesi, F., Toth, R., Blow, J. J. & Rouse, J., 19 Feb 2016, In : Science. 351, 6275, p. 846-849 4 p.

Research output: Contribution to journalArticle

Open Access
58 Citations (Scopus)
2015

USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

Perez-Oliva, A. B., Lachaud, C., Szyniarowski, P., Muñoz, I., Macartney, T., Hickson, I., Rouse, J. & Alessi, D. R., 3 Feb 2015, In : EMBO Journal. 34, 3, p. 326-343 18 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)
2014

FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain

Pennell, S., Déclais, A-C., Li, J., Haire, L. F., Berg, W., Saldanha, J. W., Taylor, I. A., Rouse, J., Lilley, D. M. J. & Smerdon, S. J., 10 Jul 2014, In : Cell Reports. 8, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
174 Downloads (Pure)

Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein

Nair, N., Castor, D., Macartney, T. & Rouse, J., Dec 2014, In : DNA Repair. 24, p. 131-137 7 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
158 Downloads (Pure)

Improved genome editing in human cell lines using the CRISPR method

Munoz, I. M., Szyniarowski, P., Toth, R., Rouse, J. & Lachaud, C., 10 Oct 2014, In : PLoS ONE. 9, 10, 6 p., e109752.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
129 Downloads (Pure)
2013

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

Castor, D., Nair, N., Déclais, A-C., Lachaud, C., Toth, R., Macartney, T. J., Lilley, D. M. J., Arthur, J. S. C. & Rouse, J., 24 Oct 2013, In : Molecular Cell. 52, 2, p. 221-233 13 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Localization-dependent and -independent roles of SLX4 in regulating telomeres

Wilson, J. S. J., Tejera, A. M., Castor, D., Toth, R., Blasco, M. A. & Rouse, J., 12 Sep 2013, In : Cell Reports. 4, 5, p. 853-860 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2012

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

Davis, E. J., Lachaud, C., Appleton, P., MacArtney, T. J., Nathke, I. & Rouse, J., 2012, In : Nature Structural & Molecular Biology. 19, 11, p. 1093-1100 8 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

Munoz, I. M., Macartney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S. & Rouse, J., 21 Sep 2012, In : Journal of Biological Chemistry. 287, 39, p. 32346-53 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2011

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

Stoepker, C., Hain, K., Schuster, B., Hilhorst-Hofstee, Y., Rooimans, M. A., Steltenpool, J., Oostra, A. B., Eirich, K., Korthof, E. T., Nieuwint, A. W. M., Jaspers, N. G. J., Bettecken, T., Joenje, H., Schindler, D., Rouse, J. & de Winter, J. P., Feb 2011, In : Nature Genetics. 43, 2, p. 138-U85 6 p.

Research output: Contribution to journalArticle

211 Citations (Scopus)
2010

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

MacKay, C., Declais, A-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J., 9 Jul 2010, In : Cell. 142, 1, p. 65-76 12 p.

Research output: Contribution to journalArticle

204 Citations (Scopus)

Identification of the MMS22L-TONSL complex that promotes homologous recombination

Duro, E., Lundin, C., Ask, K., Sanchez-Pulido, L., MacArtney, T. J., Toth, R., Ponting, C. P., Groth, A., Helleday, T. & Rouse, J., 24 Nov 2010, In : Molecular Cell. 40, 4, p. 632-644 13 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tails

Toh, G. W. -L., Sugawara, N., Dong, J., Toth, R., Lee, S. E., Haber, J. E. & Rouse, J., 4 Jun 2010, In : DNA Repair. 9, 6, p. 718-726 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2009

Biochemical characterisation of the SWI/SNF family member HLTF

MacKay, C., Toth, R. & Rouse, J., 11 Dec 2009, In : Biochemical and Biophysical Research Communications. 390, 2, p. 187-191 5 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Control of genome stability by Slx protein complexes

Rouse, J., Jun 2009, In : Biochemical Society Transactions. 37, p. 495-510 16 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Control of histone methylation and genome stability by PTIP

Munoz, I. M. & Rouse, J., Mar 2009, In : EMBO Reports. 10, 3, p. 239-245 7 p.

Research output: Contribution to journalReview article

25 Citations (Scopus)

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

Munoz, I. M., Hain, K., Declais, A-C., Gardiner, M., Toh, G. W., Sanchez-Pulido, L., Heuckmann, J. M., Toth, R., Macartney, T., Eppink, B., Kanaar, R., Ponting, C. P., Lilley, D. M. J. & Rouse, J., 10 Jul 2009, In : Molecular Cell. 35, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

233 Citations (Scopus)
2008

Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage

Duro, E., Vaisica, J. A., Brown, G. W. & Rouse, J., 3 May 2008, In : DNA Repair. 7, 5, p. 811-818 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage

Vazquez-Martin, C., Rouse, J. & Cohen, P. T. W., Aug 2008, In : FEBS Journal. 275, 16, p. 4211-4221 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Erratum: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage

Vázquez-Martin, C., Rouse, J. & Cohen, P. T. W., Nov 2008, In : FEBS Journal. 275, 22, p. 5745 1 p.

Research output: Contribution to journalArticle

Identification and characterization of FUS/TLS as a new target of ATM

Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A. & Rouse, J., 15 Oct 2008, In : Biochemical Journal. 415, p. 297-307 11 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

Goehler, T., Munoz, I. M., Rouse, J. & Blow, J. J., 2008, In : DNA Repair. 7, 5, p. 775-787 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2007

Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR

Jowsey, P., Morrice, N. A., Hastie, C. J., McLauchlan, H., Toth, R. & Rouse, J., 2007, In : DNA Repair. 6, 10, p. 1536-1544 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

Munoz, I. M., Jowsey, P. A., Toth, R. & Rouse, J., Aug 2007, In : Nucleic Acids Research. 35, 16, p. 5312-5322 11 p.

Research output: Contribution to journalArticle

Open Access
File
59 Citations (Scopus)
144 Downloads (Pure)

Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast

Flott, S., Alabert, C., Toh, G. W., Toth, R., Sugawara, N., Campbell, D. G., Haber, J. E., Pasero, P. & Rouse, J., Sep 2007, In : Molecular and Cellular Biology. 27, 18, p. 6433-45 13 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)
2005
44 Citations (Scopus)
2004

Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage

Rouse, J., 2004, In : The EMBO Journal. 23, 5, p. 1188-1197 10 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation

Jowsey, P. A., Doherty, A. J. & Rouse, J., 2004, In : Journal of Biological Chemistry. 279, 53, p. 55562-55569 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
1999

Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38

Lal, A. S., Clifton, A. D., Rouse, J., Segal, A. W. & Cohen, P., 7 Jun 1999, In : Biochemical and Biophysical Research Communications. 259, 2, p. 465-470 6 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
1996

Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells

Meier, R., Rouse, J., Cuenda, A., Nebreda, A. R. & Cohen, P., Mar 1996, In : European Journal of Biochemistry. 236, 3, p. 796-805 10 p.

Research output: Contribution to journalArticle

Open Access
111 Citations (Scopus)

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2

Tan, Y., Rouse, J., Zhang, A., Cariati, S., Cohen, P. & Comb, M. J., 2 Sep 1996, In : EMBO Journal. 15, 17, p. 4629-4642 14 p.

Research output: Contribution to journalArticle

547 Citations (Scopus)
1995

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R. & Lee, J. C., 8 May 1995, In : FEBS Letters. 364, 2, p. 229-233 5 p.

Research output: Contribution to journalArticle

1912 Citations (Scopus)
1994

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T. & Nebreda, A. R., 23 Sep 1994, In : Cell. 78, 6, p. 1027-1037 11 p.

Research output: Contribution to journalArticle

1447 Citations (Scopus)