Rouse, John

Professor

  • Scientific Programme Leader (MRC) & Personal Chair of Chromosome Biology, MRC PPU
  • United Kingdom

1994 …2023
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Research Output 1994 2019

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Article
2018

Corrigendum to "Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR" [DNA Repair 6 (2007) 1536-1544]

Jowsey, P., Morrice, N. A., Hastie, C. J., MacLauchlan, H., Toth, R. & Rouse, J., May 2018, In : DNA Repair. 65, p. 80 1 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
91 Downloads (Pure)

Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase

Munoz, I., Morgan, M., Peltier, J., Weiland, F., Gregorczyk, M., Brown, F. C. M., Macartney, T., Toth, R., Trost, M. & Rouse, J., 14 Dec 2018, In : The EMBO Journal. 37, 24, p. 1-19 19 p., e99559.

Research output: Contribution to journalArticle

Open Access
File
Screening
Phosphotransferases
Serine
Mutation
Substrates
2017
79 Downloads (Pure)
Open Access
File
11 Citations (Scopus)
108 Downloads (Pure)

RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

Feeney, L., Munoz, I. M., Lachaud, C., Toth, R., Appleton, P. L., Schindler, D. & Rouse, J., 1 Jun 2017, In : Molecular Cell. 66, 5, p. 610-621.e4 16 p.

Research output: Contribution to journalArticle

Open Access
File
Replication Protein A
Ubiquitin-Protein Ligases
Health
Fanconi Anemia
Genomic Instability
2016
1 Citation (Scopus)
113 Downloads (Pure)

A route to new cancer therapies: the FA pathway is essential in BRCA1- or BRCA2-deficient cells

Lachaud, C. & Rouse, J., 3 Aug 2016, In : Nature Structural & Molecular Biology. 23, 8, p. 701-703 3 p.

Research output: Contribution to journalArticle

Open Access
File
BRCA2 Gene
BRCA1 Gene
Fanconi Anemia
Mutation
Ovarian Neoplasms
13 Citations (Scopus)
106 Downloads (Pure)

Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in fan1 nuclease-defective knock-in mice

Lachaud, C., Slean, M., Marchesi, F., Lock, C., Odell, E., Castor, D., Toth, R. & Rouse, J., 15 Mar 2016, In : Genes and Development. 30, 6, p. 639-644 6 p.

Research output: Contribution to journalArticle

Open Access
File
Interstitial Nephritis
Polyploidy
DNA Damage
Fanconi Anemia
Ploidies
53 Citations (Scopus)

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability

Lachaud, C., Moreno, A., Marchesi, F., Toth, R., Blow, J. J. & Rouse, J., 19 Feb 2016, In : Science. 351, 6275, p. 846-849 4 p.

Research output: Contribution to journalArticle

Open Access
Genomic Instability
DNA Replication
Personnel Selection
Ubiquitination
Pancreatic Neoplasms
2015
21 Citations (Scopus)

USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

Perez-Oliva, A. B., Lachaud, C., Szyniarowski, P., Muñoz, I., Macartney, T., Hickson, I., Rouse, J. & Alessi, D. R., 3 Feb 2015, In : EMBO Journal. 34, 3, p. 326-343 18 p.

Research output: Contribution to journalArticle

Open Access
Endonucleases
DNA Repair
DNA Damage
DNA
Repair
2014
9 Citations (Scopus)
104 Downloads (Pure)

FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain

Pennell, S., Déclais, A-C., Li, J., Haire, L. F., Berg, W., Saldanha, J. W., Taylor, I. A., Rouse, J., Lilley, D. M. J. & Smerdon, S. J., 10 Jul 2014, In : Cell Reports. 8, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

Open Access
File
Dimerization
Virus Replication
Viruses
DNA Repair
Holliday Junction Resolvases
13 Citations (Scopus)
86 Downloads (Pure)

Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein

Nair, N., Castor, D., Macartney, T. & Rouse, J., Dec 2014, In : DNA Repair. 24, p. 131-137 7 p.

Research output: Contribution to journalArticle

Open Access
File
Point Mutation
Scaffolds
Repair
Mitomycin
DNA Repair
26 Citations (Scopus)
71 Downloads (Pure)

Improved genome editing in human cell lines using the CRISPR method

Munoz, I. M., Szyniarowski, P., Toth, R., Rouse, J. & Lachaud, C., 10 Oct 2014, In : PLoS ONE. 9, 10, 6 p., e109752.

Research output: Contribution to journalArticle

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
human cell lines
gene targeting
Genes
Cells
2013
92 Citations (Scopus)

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

Castor, D., Nair, N., Déclais, A-C., Lachaud, C., Toth, R., Macartney, T. J., Lilley, D. M. J., Arthur, J. S. C. & Rouse, J., 24 Oct 2013, In : Molecular Cell. 52, 2, p. 221-233 13 p.

Research output: Contribution to journalArticle

Cruciform DNA
DNA Repair
Chromosome Segregation
Genetic Structures
Genomic Instability
40 Citations (Scopus)

Localization-dependent and -independent roles of SLX4 in regulating telomeres

Wilson, J. S. J., Tejera, A. M., Castor, D., Toth, R., Blasco, M. A. & Rouse, J., 12 Sep 2013, In : Cell Reports. 4, 5, p. 853-860 8 p.

Research output: Contribution to journalArticle

Telomere
Telomere Homeostasis
Repair
DNA
DNA Repair
2012
79 Citations (Scopus)

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

Davis, E. J., Lachaud, C., Appleton, P., MacArtney, T. J., Nathke, I. & Rouse, J., 2012, In : Nature Structural & Molecular Biology. 19, 11, p. 1093-1100 8 p.

Research output: Contribution to journalArticle

DNA Damage
Ubiquitin
Proteins
DNA Repair
Mutation
17 Citations (Scopus)

Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

Munoz, I. M., Macartney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S. & Rouse, J., 21 Sep 2012, In : Journal of Biological Chemistry. 287, 39, p. 32346-53 8 p.

Research output: Contribution to journalArticle

Sin3 Histone Deacetylase and Corepressor Complex
Histone Deacetylase 1
Histone Deacetylases
Cyclin D1
Cell Cycle
2011
205 Citations (Scopus)

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

Stoepker, C., Hain, K., Schuster, B., Hilhorst-Hofstee, Y., Rooimans, M. A., Steltenpool, J., Oostra, A. B., Eirich, K., Korthof, E. T., Nieuwint, A. W. M., Jaspers, N. G. J., Bettecken, T., Joenje, H., Schindler, D., Rouse, J. & de Winter, J. P., Feb 2011, In : Nature Genetics. 43, 2, p. 138-U85 6 p.

Research output: Contribution to journalArticle

2010
195 Citations (Scopus)

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

MacKay, C., Declais, A-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J., 9 Jul 2010, In : Cell. 142, 1, p. 65-76 12 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Identification of the MMS22L-TONSL complex that promotes homologous recombination

Duro, E., Lundin, C., Ask, K., Sanchez-Pulido, L., MacArtney, T. J., Toth, R., Ponting, C. P., Groth, A., Helleday, T. & Rouse, J., 24 Nov 2010, In : Molecular Cell. 40, 4, p. 632-644 13 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tails

Toh, G. W. -L., Sugawara, N., Dong, J., Toth, R., Lee, S. E., Haber, J. E. & Rouse, J., 4 Jun 2010, In : DNA Repair. 9, 6, p. 718-726 9 p.

Research output: Contribution to journalArticle

2009
25 Citations (Scopus)

Biochemical characterisation of the SWI/SNF family member HLTF

MacKay, C., Toth, R. & Rouse, J., 11 Dec 2009, In : Biochemical and Biophysical Research Communications. 390, 2, p. 187-191 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Control of genome stability by Slx protein complexes

Rouse, J., Jun 2009, In : Biochemical Society Transactions. 37, p. 495-510 16 p.

Research output: Contribution to journalArticle

223 Citations (Scopus)

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

Munoz, I. M., Hain, K., Declais, A-C., Gardiner, M., Toh, G. W., Sanchez-Pulido, L., Heuckmann, J. M., Toth, R., Macartney, T., Eppink, B., Kanaar, R., Ponting, C. P., Lilley, D. M. J. & Rouse, J., 10 Jul 2009, In : Molecular Cell. 35, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

2008
46 Citations (Scopus)

Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage

Duro, E., Vaisica, J. A., Brown, G. W. & Rouse, J., 3 May 2008, In : DNA Repair. 7, 5, p. 811-818 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage

Vazquez-Martin, C., Rouse, J. & Cohen, P. T. W., Aug 2008, In : FEBS Journal. 275, 16, p. 4211-4221 11 p.

Research output: Contribution to journalArticle

Erratum: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage

Vázquez-Martin, C., Rouse, J. & Cohen, P. T. W., Nov 2008, In : FEBS Journal. 275, 22, p. 5745 1 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Identification and characterization of FUS/TLS as a new target of ATM

Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A. & Rouse, J., 15 Oct 2008, In : Biochemical Journal. 415, p. 297-307 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

Goehler, T., Munoz, I. M., Rouse, J. & Blow, J. J., 2008, In : DNA Repair. 7, 5, p. 775-787 13 p.

Research output: Contribution to journalArticle

2007
44 Citations (Scopus)

Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR

Jowsey, P., Morrice, N. A., Hastie, C. J., McLauchlan, H., Toth, R. & Rouse, J., 2007, In : DNA Repair. 6, 10, p. 1536-1544 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Automatic teller machines
DNA Damage
DNA
Ionizing radiation
57 Citations (Scopus)
63 Downloads (Pure)

Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

Munoz, I. M., Jowsey, P. A., Toth, R. & Rouse, J., Aug 2007, In : Nucleic Acids Research. 35, 16, p. 5312-5322 11 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Damage
Epitopes
Proteins
Mutation
Neoplasms
75 Citations (Scopus)

Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast

Flott, S., Alabert, C., Toh, G. W., Toth, R., Sugawara, N., Campbell, D. G., Haber, J. E., Pasero, P. & Rouse, J., Sep 2007, In : Molecular and Cellular Biology. 27, 18, p. 6433-45 13 p.

Research output: Contribution to journalArticle

Saccharomycetales
Methyl Methanesulfonate
DNA Repair
Phosphorylation
DNA
2005
42 Citations (Scopus)
Alkylation
DNA Damage
Repair
RecQ Helicases
Cells
2004
75 Citations (Scopus)

Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage

Rouse, J., 2004, In : The EMBO Journal. 23, 5, p. 1188-1197 10 p.

Research output: Contribution to journalArticle

DNA Damage
S Phase Cell Cycle Checkpoints
DNA
DNA Replication
S Phase
55 Citations (Scopus)

Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation

Jowsey, P. A., Doherty, A. J. & Rouse, J., 2004, In : Journal of Biological Chemistry. 279, 53, p. 55562-55569 8 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Ionizing radiation
Ionizing Radiation
Chemical activation
Proteins
1999
59 Citations (Scopus)

Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38

Lal, A. S., Clifton, A. D., Rouse, J., Segal, A. W. & Cohen, P., 7 Jun 1999, In : Biochemical and Biophysical Research Communications. 259, 2, p. 465-470 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 11
Neutrophil Activation
NADPH Oxidase
Chemical activation
Tetradecanoylphorbol Acetate
1996
109 Citations (Scopus)

Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells

Meier, R., Rouse, J., Cuenda, A., Nebreda, A. R. & Cohen, P., Mar 1996, In : European Journal of Biochemistry. 236, 3, p. 796-805 10 p.

Research output: Contribution to journalArticle

Open Access
Mitogen-Activated Protein Kinase 8
KB Cells
Mitogen-Activated Protein Kinase 11
PC12 Cells
Mitogen-Activated Protein Kinase Kinases
544 Citations (Scopus)

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2

Tan, Y., Rouse, J., Zhang, A., Cariati, S., Cohen, P. & Comb, M. J., 2 Sep 1996, In : EMBO Journal. 15, 17, p. 4629-4642 14 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Mitogen-Activated Protein Kinase Kinases
p38 Mitogen-Activated Protein Kinases
Cyclic AMP
Phosphotransferases
1995
1899 Citations (Scopus)

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R. & Lee, J. C., 8 May 1995, In : FEBS Letters. 364, 2, p. 229-233 5 p.

Research output: Contribution to journalArticle

Interleukin-1
Phosphotransferases
HSP27 Heat-Shock Proteins
Imidazoles
MAP Kinase Kinase Kinases
1994
1433 Citations (Scopus)

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T. & Nebreda, A. R., 23 Sep 1994, In : Cell. 78, 6, p. 1027-1037 11 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
Phosphorylation
Protein Kinases
Shock
Phosphotransferases