Thomas, John

Drug Discovery Unit

38 Citations
4 h-Index

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Research Output 2016 2018

38 Citations
4 h-Index
8 Article

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease

Thomas, M. G., De Rycker, M., Cotillo Torrejon, I., Thomas, J., Riley, J., Spinks, D., Read, K. D., Miles, T. J., Gilbert, I. H. & Wyatt, P. G., 1 Oct 2018, In : Bioorganic & Medicinal Chemistry Letters. 28, 18, p. 3025-3030 6 p.

Research output: Contribution to journal › Article

Chagas Disease

Parasites

Nifurtimox

Trypanosoma cruzi

Screening

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery

MacLean, L., Thomas, J., Lewis, M. D., Cotillo, I., Gray, D. & De Rycker, M., 12 Jul 2018, In : PLoS Neglected Tropical Diseases. 12, 7, p. 1-22 22 p., e0006612.

Research output: Contribution to journal › Article

Open Access

File

Chagas Disease

Trypanosoma cruzi

Drug Discovery

Parasites

Ergosterol

2 Citations

Chemical Validation of Methionyl tRNA Synthetase (MetRS) as a Druggable Target in Leishmania donovani

Torrie, L., Brand, S., Robinson, D., Ko, E. J., Stojanovski, L., Simeons, F. R. C., Wyllie, S., Thomas, J., Ellis, L., Osuna-Cabello, M., Epemolu, R., Nuehs, A., Riley, J., MacLean, L., Manthri, S., Read, K., Gilbert, I., Fairlamb, A. & De Rycker, M., Oct 2017, In : ACS Infectious Diseases. 3, 10, p. 718-727 10 p.

Research output: Contribution to journal › Article

Open Access

File

Methionine-tRNA Ligase

Leishmania donovani

Leishmania

Methionine

Animal Models

5 Citations

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

Brand, S., Ko, E. J., Viayna, E., Thompson, S., Spinks, D., Thomas, M., Sandberg, L., Francisco, A. F., Jayawardhana, S., Smith, V. C., Jansen, C., De Rycker, M., Thomas, J., MacLean, L., Osuna-Cabello, M., Riley, J., Scullion, P., Stojanovski, L., Simeons, F. R. C., Epemolu, O. & 16 othersShishikura, Y., Crouch, S. D., Bakshi, T. S., Nixon, C. J., Reid, I. H., Hill, A. P., Underwood, T. Z., Hindley, S. J., Robinson, S. A., Kelly, J. M., Fiandor, J. M., Wyatt, P. G., Marco, M., Miles, T. J., Read, K. D. & Gilbert, I. H., 14 Sep 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7284-7299 16 p.

Research output: Contribution to journal › Article

Open Access

File

Triazoles

Trypanosoma cruzi

Parasites

Chagas Disease

Nifurtimox

5 Citations

Association between underestimation of tumour size by imaging and incomplete excision in breast-conserving surgery for breast cancer

Dixon, J. M., Newlands, C., Dodds, C., Thomas, J., Williams, L. J., Kunkler, I. H., Bing, A. & MacAskill, E. J., 1 Jun 2016, In : British Journal of Surgery. 103, 7, p. 830-838 9 p.

Research output: Contribution to journal › Article

Segmental Mastectomy

Mammography

Ultrasonography

Breast Neoplasms

Odds Ratio