• 1859 Citations
  • 25 h-Index
1985 …2016
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Personal profile

Research

Molecular mechanisms and control in transcription by RNA polymerase I

Appropriately coordinated expression of genes is essential for normal cell growth, development and differentiation in all organisms. The control of expression of many genes in eukaryotes occurs at the level of transcription. The central objective in our laboratory is to achieve an understanding of the molecular mechanisms involved in transcription of the ribosomal RNA genes, mediated by RNA polymerase I, and the cellular control of this process (1,2). rRNA synthesis drives ribosome biogenesis and, therefore, is associated intricately with cell growth and proliferation. Deregulation of this process can lead to cell death, hyperproliferation or hypertrophy and has been linked to specific cancers and heart disease.

Our research is directed towards determination of: 

  • the role of the essential promoter selective TBP-TAF complex SL1 in coordinating the formation of transcription pre-initiation complexes (3,4);
  • the molecular mechanism of activation by UBF of promoter escape by Pol I (5,6)
  • the dynamics of the Pol I proteome (7)
  • the link between cell growth and proliferation and Pol I transcription (7,8)
  • the factors involved in promoting transcription elongation and re-initiation
  • the roles of novel growth-regulated and Pol I-associated factors in human cells (7,9,10)

Keywords

  • Q Science (General)
  • Molecular biology; Gene expression; Gene regulation; Ribosome biogenesis, Transcription, RNA polymerase I, ribosomal RNA, nucleolus, mammalian cells, cell growth and proliferation, cancer, transcription factors, transcription initiation, transcription elongation, rDNA chromatin

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 17 Similar Profiles
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Genetic Promoter Regions Medicine & Life Sciences
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Research Output 1985 2016

10 Citations

The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

Bailly, A., Perrin, A., Bou Malhab, L. J., Pion, E., Larance, M., Nagala, M., Smith, P., O'Donohue, M-F., Gleizes, P-E., Zomerdijk, J., Lamond, A. I. & Xirodimas, D. P. 28 Jan 2016 In : Oncogene. 35, 4, p. 415-426 12 p.

Research output: Contribution to journalArticle

Open Access
File
Proteome
Caenorhabditis elegans
Ubiquitin
Cell Cycle Checkpoints
Ribosomes
2 Citations

Structural biology: Pivotal findings for a transcription machine

Zomerdijk, J. 31 Oct 2013 In : Nature. 502, 7473, p. 629-630 2 p.

Research output: Contribution to journalArticle

2 Citations

Structural biology: Pivotal findings for a transcription machine

Zomerdijk, J. 2013 In : Nature. 502, 7473, p. 629-630 2 p.

Research output: Contribution to journalArticle

13 Citations

Topoisomerase IIα promotes activation of RNA polymerase i transcription by facilitating pre-initiation complex formation

Ray, S., Panova, T., Miller, G., Volkov, A., Porter, A. C. G., Russell, J., Panov, K. I. & Zomerdijk, J. C. B. M. 19 Mar 2013 In : Nature Communications. 4, 1598

Research output: Contribution to journalArticle

RNA Polymerase I
Type II DNA Topoisomerase
DNA-Directed RNA Polymerases
Transcription
Ribosomal DNA
31 Citations

RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle

Albert, B., Leger-Silvestre, I., Normand, C., Ostermaier, M. K., Perez-Fernandez, J., Panov, K. I., Zomerdijk, J. C. B. M., Schultz, P. & Gadal, O. 24 Jan 2011 In : Journal of Cell Biology. 192, 2, p. 277-293 17 p.

Research output: Contribution to journalArticle

Open Access
File

Activities 1987 2015

  • 4 Participation in conference
  • 1 Types of Public engagement and outreach - Schools engagement

Gene Expression Advanced Higher Lecture

Zomerdijk, J. (Presenter)
19 Mar 2015

Activity: Types of Public engagement and outreach - Schools engagement

Biochemical Society Annual Symposium ‘Transcription UK 2005’

Zomerdijk, J. (Participant)
13 Apr 200515 Apr 2005

Activity: Participation in conference

634th Meeting of the Biochemical Society

Zomerdijk, J. (Participant)
2 Apr 19906 Apr 1990

Activity: Participation in conference

UCLA Symposium on Host-Parasite Interactions

Zomerdijk, J. (Participant)
3 Apr 198910 Apr 1989

Activity: Participation in conference

Roche-UCLA Symposium on Mechanisms of Control of Gene Expression.

Zomerdijk, J. (Participant)
30 Mar 1987

Activity: Participation in conference

Thesis

A proteomic analysis of the dynamic RNA polymerase I complexes

Author: Ciesiolka, A., 2014

Supervisor: Zomerdijk, J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy