• 2068 Citations
  • 26 h-Index
1985 …2016

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Personal profile

Research

Molecular mechanisms and control in transcription by RNA polymerase I

Appropriately coordinated expression of genes is essential for normal cell growth, development and differentiation in all organisms. The control of expression of many genes in eukaryotes occurs at the level of transcription. The central objective in our laboratory is to achieve an understanding of the molecular mechanisms involved in transcription of the ribosomal RNA genes, mediated by RNA polymerase I, and the cellular control of this process (1,2). rRNA synthesis drives ribosome biogenesis and, therefore, is associated intricately with cell growth and proliferation. Deregulation of this process can lead to cell death, hyperproliferation or hypertrophy and has been linked to specific cancers and heart disease.

Our research is directed towards determination of: 

  • the role of the essential promoter selective TBP-TAF complex SL1 in coordinating the formation of transcription pre-initiation complexes (3,4);
  • the molecular mechanism of activation by UBF of promoter escape by Pol I (5,6)
  • the dynamics of the Pol I proteome (7)
  • the link between cell growth and proliferation and Pol I transcription (7,8)
  • the factors involved in promoting transcription elongation and re-initiation
  • the roles of novel growth-regulated and Pol I-associated factors in human cells (7,9,10)

Keywords

  • Q Science (General)
  • Molecular biology; Gene expression; Gene regulation; Ribosome biogenesis, Transcription, RNA polymerase I, ribosomal RNA, nucleolus, mammalian cells, cell growth and proliferation, cancer, transcription factors, transcription initiation, transcription elongation, rDNA chromatin

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  • 11 Similar Profiles

Research Output

The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

Bailly, A., Perrin, A., Bou Malhab, L. J., Pion, E., Larance, M., Nagala, M., Smith, P., O'Donohue, M-F., Gleizes, P-E., Zomerdijk, J., Lamond, A. I. & Xirodimas, D. P., 28 Jan 2016, In : Oncogene. 35, 4, p. 415-426 12 p.

Research output: Contribution to journalArticle

Open Access
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  • 21 Citations (Scopus)
    275 Downloads (Pure)

    Structural biology: Pivotal findings for a transcription machine

    Zomerdijk, J., 31 Oct 2013, In : Nature. 502, 7473, p. 629-630 2 p.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Structural biology: Pivotal findings for a transcription machine

    Zomerdijk, J., 2013, In : Nature. 502, 7473, p. 629-630 2 p.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Topoisomerase IIα promotes activation of RNA polymerase i transcription by facilitating pre-initiation complex formation

    Ray, S., Panova, T., Miller, G., Volkov, A., Porter, A. C. G., Russell, J., Panov, K. I. & Zomerdijk, J. C. B. M., 19 Mar 2013, In : Nature Communications. 4, 1598.

    Research output: Contribution to journalArticle

  • 17 Citations (Scopus)

    RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle

    Albert, B., Leger-Silvestre, I., Normand, C., Ostermaier, M. K., Perez-Fernandez, J., Panov, K. I., Zomerdijk, J. C. B. M., Schultz, P. & Gadal, O., 24 Jan 2011, In : Journal of Cell Biology. 192, 2, p. 277-293 17 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    39 Citations (Scopus)
    442 Downloads (Pure)

    Activities

    • 4 Participation in conference
    • 1 Schools engagement

    Gene Expression Advanced Higher Lecture

    Joost Zomerdijk (Presenter)
    19 Mar 2015

    Activity: Other activity typesSchools engagement

    Biochemical Society Annual Symposium ‘Transcription UK 2005’

    Joost Zomerdijk (Participant)
    13 Apr 200515 Apr 2005

    Activity: Participating in or organising an event typesParticipation in conference

    634th Meeting of the Biochemical Society

    Joost Zomerdijk (Participant)
    2 Apr 19906 Apr 1990

    Activity: Participating in or organising an event typesParticipation in conference

    UCLA Symposium on Host-Parasite Interactions

    Joost Zomerdijk (Participant)
    3 Apr 198910 Apr 1989

    Activity: Participating in or organising an event typesParticipation in conference

    Roche-UCLA Symposium on Mechanisms of Control of Gene Expression.

    Joost Zomerdijk (Participant)
    30 Mar 1987

    Activity: Participating in or organising an event typesParticipation in conference

    Thesis

    A proteomic analysis of the dynamic RNA polymerase I complexes

    Author: Ciesiolka, A., 2014

    Supervisor: Zomerdijk, J. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy