Hobrath, Judith

Computational Chemist, Biological Chemistry and Drug Discovery

99 Citations
5 h-Index

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shikimate kinase Medicine & Life Sciences

Sulindac Medicine & Life Sciences

Amides Medicine & Life Sciences

Mycobacterium tuberculosis Medicine & Life Sciences

Anti-Inflammatory Agents Medicine & Life Sciences

Fenamates Medicine & Life Sciences

Screening Chemical Compounds

Libraries Medicine & Life Sciences

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Research Output 2016 2019

99 Citations
5 h-Index
11 Article
1 Review article

7 Citations (Scopus)

74 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journal › Article

Open Access

File

Leishmania infantum

Visceral Leishmaniasis

Proteasome Endopeptidase Complex

Leishmania donovani

Parasites

83 Downloads (Pure)

Amine Containing Analogs of Sulindac for Cancer Prevention

Mathew, B., Hobrath, J. V., Connelly, M. C., Guy, R. K. & Reynolds, R. C., 31 Jan 2018, In : Open Medicinal Chemistry Journal. 12, p. 1-12 12 p.

Research output: Contribution to journal › Article

Open Access

File

Sulindac

Amines

Libraries

Neoplasms

Adenomatous Polyps

2 Citations (Scopus)

76 Downloads (Pure)

A multifaceted approach to identify non-specific enzyme inhibition: Application to Mycobacterium tuberculosis shikimate kinase

Alturki, M. S., Fuanta, N. R., Jarrard, M. A., Hobrath, J. V., Goodwin, D. C., Rants'o, T. A. & Calderón, A. I., 15 Feb 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 4, p. 802-808 7 p.

Research output: Contribution to journal › Article

Open Access

File

shikimate kinase

Enzyme inhibition

Mycobacterium tuberculosis

Assays

Screening

2 Citations (Scopus)

109 Downloads (Pure)

Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone

Simithy, J., Fuanta, N. R., Hobrath, J. V., Kochanowska-Karamyan, A., Hamann, M. T., Goodwin, D. C. & Calderón, A. I., May 2018, In : Biochimica et Biophysica Acta: General Subjects. 1866, 5-6, p. 731-739 9 p.

Research output: Contribution to journal › Article

Open Access

File

shikimate kinase

Mycobacterium tuberculosis

ilimaquinone

3 Citations (Scopus)

86 Downloads (Pure)

Oxazole and thiazole analogs of sulindac for cancer prevention

Mathew, B., Hobrath, J. V., Connelly, M. C., Guy, R. K. & Reynolds, R. C., Apr 2018, In : Future Medicinal Chemistry. 10, 7, p. 743-753 12 p.

Research output: Contribution to journal › Article

Open Access

File

Oxazoles

Sulindac

Thiazoles

Amides

Colonic Neoplasms