Harrison, Justin

Dr

  • 234 Citations
  • 8 h-Index
20092018
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Fingerprint Dive into the research topics where Justin Harrison is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 32 Similar Profiles
Trypanosoma brucei brucei Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Quinazolinones Medicine & Life Sciences
Sulfonamides Medicine & Life Sciences
Uridine Diphosphate N-Acetylglucosamine Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Uridine Triphosphate Chemical Compounds
Aspergillus fumigatus Medicine & Life Sciences

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Research Output 2009 2018

  • 234 Citations
  • 8 h-Index
  • 9 Article
  • 1 Patent
7 Citations (Scopus)
99 Downloads (Pure)

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

Murugesan, D., Ray, P. C., Bayliss, T., Prosser, G. A., Harrison, J. R., Green, K., Soares De Melo, C., Feng, T. S., Street, L. J., Chibale, K., Warner, D. F., Mizrahi, V., Epemolu, O., Scullion, P., Ellis, L., Riley, J., Shishikura, Y., Ferguson, L., Osuna-Cabello, M., Read, K. D. & 10 others, Green, S. R., Lamprecht, D. A., Steyn, A. J. C., Ioerger, T. R., Sacchettini, J., Rhee, K. Y., Arora, K., Barry, C. E., Wyatt, P. G. & Boshoff, H. I. M., 8 Jun 2018, In : ACS Infectious Diseases. 4, 6, p. 954-969 16 p.

Research output: Contribution to journalArticle

Open Access
File
Quinazolinones
Structure-Activity Relationship
Mycobacterium tuberculosis
Adenosine Triphosphate
Allosteric Site
8 Citations (Scopus)
100 Downloads (Pure)

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

Harrison, J. R., Brand, S., Smith, V., Robinson, D. A., Thompson, S., Smith, A., Davies, K., Mok, N., Torrie, L. S., Collie, I., Hallyburton, I., Norval, S., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Brenk, R., Wyatt, P. G., Gilbert, I. H. & Read, K. D., 12 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8374–8389 16 p.

Research output: Contribution to journalArticle

Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Crystallography
Central Nervous System Diseases
Peripheral Nervous System
13 Citations (Scopus)
206 Downloads (Pure)

Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi

Herrera, L. J., Brand, S., Santos, A., Nohara, L. L., Harrison, J., Norcross, N. R., Thompson, S., Smith, V., Lema, C., Varela-Ramirez, A., Gilbert, I. H., Almeida, I. C. & Maldonado, R. A., 29 Apr 2016, In : PLoS Neglected Tropical Diseases. 10, 4, 20 p., e0004540.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma cruzi
Mammals
Chagas Disease
Parasites
Neglected Diseases
14 Citations (Scopus)

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

Fang, W., Robinson, D. A., Raimi, O. G., Blair, D. E., Harrison, J. R., Lockhart, D. E. A., Torrie, L. S., Ruda, G. F., Wyatt, P. G., Gilbert, I. H. & van Aalten, D. M. F., 19 Jun 2015, In : ACS Chemical Biology. 10, 6, p. 1425-1434 10 p.

Research output: Contribution to journalArticle

Open Access
Aspergillus fumigatus
Aspergillus
Cell Wall
Cells
Enzymes
30 Citations (Scopus)
54 Downloads (Pure)
Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Sulfonamides
Central Nervous System
Neurologic Mutant Mice