Keyphrases
N-myristoyltransferase
100%
Human African Trypanosomiasis
97%
Trypanosoma Brucei
94%
N-Myristoyltransferase Inhibitors
80%
T. Brucei
55%
Trypanosoma Cruzi (T. cruzi)
42%
Trypanothione Synthetase
42%
Mycobacterium Tuberculosis (M. tb)
42%
Pyrazole Sulfonamides
37%
Chagas Disease
32%
Central Nervous System
32%
Trypanocidal Activity
32%
Drug Target
32%
Sulfonamide Antibiotics
26%
Glutathione
25%
Protozoan Parasites
23%
Inhibitor Identification
21%
Mercapto
21%
Aspergillus Fumigatus
21%
Cell Wall
21%
Uridine Diphosphate N-acetylglucosamine
21%
Causative Agents
21%
Relationship Mechanism
21%
Type II NADH Dehydrogenase
21%
Absorption Mechanism
21%
Absorption Distribution
21%
Potential Treatments
21%
Glutamate
21%
Biological Evaluation
21%
Synthetic Evaluation
21%
Allosteric Inhibitor
21%
Structure-activity Relationship
21%
Potential Drugs
21%
Penetrant
21%
Design Evaluation
21%
Proline
21%
Cyclin-dependent Kinase
21%
Inhibitor Evaluation
21%
Brain Penetrant
21%
Mouse Model
21%
Orally Active
21%
Molecular Hybridization
21%
Pyrophosphatase
21%
Metabolism
21%
Nutrient Transport
21%
Novel Class
21%
Mechanism of Action
21%
Diaminothiazoles
21%
Highly Selective
21%
Outer Membrane
21%
Pharmacology, Toxicology and Pharmaceutical Science
Trypanosoma Brucei
67%
African Trypanosomiasis
64%
Sulfonamide
42%
Chagas Disease
42%
Trypanosoma Cruzi
42%
Mycobacterium Tuberculosis
42%
Synthetase
42%
Trypanothione
42%
Disease
39%
Pyrazole
32%
Structure Activity Relationship
28%
Protozoon
26%
Glutathione
25%
Proline
21%
Glutamic Acid
21%
Chemotherapy
21%
Trypanosomatidae
21%
Trypanosomiasis
21%
Quinazolinone Derivative
21%
Cyclin Dependent Kinase
21%
Nagana
21%
Oxidoreductase
21%
Transferase Inhibitor
21%
Target Activity
17%
Pharmacokinetics
16%
Spermidine
14%
Bovine
14%
High-Throughput Screening
14%
Lead Compound
14%
Adenosine Triphosphate
14%
Infection
14%
EC50
14%
Azide
10%
Mouse Model
10%
Myristic Acid
10%
Amastigote
10%
Trypomastigote
10%
Leishmania Major
10%
Tropical Disease
10%
IC50
7%
Ligase
7%
Trypanosoma Vivax
7%
Adenosine Diphosphate
7%
Kinetoplastida
7%
Pharmaceutical Chemistry
7%
Trypanosoma Congolense
7%
Drug Resistance
7%
Molecular Target
7%
Intramuscular Injection
7%
Efficacy Study
5%