Labib, Karim

Professor

  • Professor & Personal Chair Genome Integrity, MRC PPU
  • United Kingdom

1992 …2023
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Personal profile

Biography

2006-2013  Senior Group Leader, Paterson Institute for Cancer Research (Cancer Research U.K.), University of Manchester.

2001-2007  Cancer Research U.K. Senior Cancer Research Fellow, Paterson Institute for Cancer Research, University of Manchester.

2001-2006  Junior Group Leader, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, University of Manchester.

1997-2001  Post-doctoral fellowship from the ICRF to work with John Diffley, Clare Hall research laboratories, London.

1995-1997  Post-doctoral fellow with Stephen Kearsey, Department of Zoology, University of Oxford.

1993-1994  EMBO Long-term fellowship to work with Sergio Moreno, University of Salamanca, Spain

Education/Academic qualification

Doctor of Philosophy, University of Oxford

Master of Arts, University of Cambridge

Bachelor of Arts, University of Cambridge

Fingerprint Dive into the research topics where Karim Labib is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
DNA Replication Medicine & Life Sciences
Saccharomycetales Medicine & Life Sciences
Chromosomes Chemical Compounds
DNA Helicases Medicine & Life Sciences
Chromatin Medicine & Life Sciences
DNA-Directed DNA Polymerase Medicine & Life Sciences
Cytokinesis Medicine & Life Sciences
Eukaryota Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2023

Research Output 1992 2019

3 Citations (Scopus)

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

Deng, L., Wu, R. A., Sonneville, R., Kochenova, O. V., Labib, K., Pellman, D. & Walter, J. C., 7 Mar 2019, In : Molecular Cell. 73, 5, p. 915-929.e6 22 p.

Research output: Contribution to journalArticle

Gene Rearrangement
DNA Replication
Ubiquitination
Ovum
Xenopus
2 Citations (Scopus)
43 Downloads (Pure)

Pif1-family helicases support fork convergence during DNA replication termination in eukaryotes

Deegan, T., Baxter, J., Ortiz Bazan, M., Yeeles, J. T. P. & Labib, K., 18 Apr 2019, In : Molecular Cell. 74, 2, p. 231-244.e9 24 p.

Research output: Contribution to journalArticle

Open Access
File
Eukaryota
DNA Replication
Type II DNA Topoisomerase
DNA Helicases
Type I DNA Topoisomerase
5 Citations (Scopus)
49 Downloads (Pure)

Histone H2A-H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin

Evrin, C., Maman, J., Diamante, A., Pellegrini, L. & Labib, K., 13 Aug 2018, In : EMBO Journal. 37, 19, p. 1-16 16 p., e99021.

Research output: Contribution to journalArticle

Open Access
File
Histones
Chromatin
Maintenance
Yeast
Mutation
6 Citations (Scopus)
109 Downloads (Pure)

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Hong, Y., Sonneville, R., Wang, B., Scheidt, V., Meier, B., Woglar, A., Demetriou, S., Labib, K., Jantsch, V. & Gartner, A., 20 Feb 2018, In : Nature Communications. 9, p. 1-11 11 p., 728.

Research output: Contribution to journalArticle

Open Access
File
Lunar Module
nuclease
mitosis
chromatin
Deoxyribonucleases
3 Citations (Scopus)
78 Downloads (Pure)

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

Hong, Y., Velkova, M., Silva, N., Jagut, M., Scheidt, V., Labib, K., Jantsch, V. & Gartner, A., 7 Jun 2018, In : PLoS Genetics. 14, 6, p. 1-22 22 p., e1007453.

Research output: Contribution to journalArticle

Open Access
File
3'-nucleotidase
Recombinational DNA Repair
Chromosome Segregation
chromosome segregation
nucleases

Prizes

Elected member

Karim Labib (Recipient), 2010

Prize: Election to learned society

Hooke Medal

Karim Labib (Recipient), 2010

Prize: Prize (including medals and awards)

Long-term Doctoral Fellowship (1993-1994)

Karim Labib (Recipient), 1993

Prize: Fellowship awarded competitively

Senior Cancer Research Fellowship, 2001-2007

Karim Labib (Recipient), 2001

Prize: Fellowship awarded competitively

Young Investigator Programme

Karim Labib (Recipient), 2004

Prize: Fellowship awarded competitively

time

Activities 2003 2014

  • 45 Participation in conference
  • 4 Editorial activity

2014 Ramon Areces Foundation Symposium on ‘Cell Proliferation and Genome Integrity’, University of Santander, Spain

Karim Labib (Organiser)
2014

Activity: Participating in or organising an event typesParticipation in conference

2014 FASEB Yeast Chromosome Structure, Replication and Segregation meeting, Stemboat Springs, CO, USA

Karim Labib (Invited speaker)
2014

Activity: Participating in or organising an event typesParticipation in conference

2013 ASBMB annual meeting, Boston, MA, USA

Karim Labib (Invited speaker)
2013

Activity: Participating in or organising an event typesParticipation in conference

2013 Conference to celebrate 50th anniversary of the replicon theory, Pasteur Institute, Paris, France

Karim Labib (Invited speaker)
2013

Activity: Participating in or organising an event typesParticipation in conference

2013 Eukaryotic DNA replication meeting, Cold Spring Harbor, NY, USA

Karim Labib (Chair)
2013

Activity: Participating in or organising an event typesParticipation in conference

Thesis

In vitro reconstitution of the ubiquitylation and disassembly of the eukaryotic replisome

Author: Mukherjee, P., 2018

Supervisor: Labib, K. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy