Labib, Karim

Professor

  • Professor & Personal Chair Genome Integrity, MRC PPU
  • United Kingdom

1992 …2023

Research output per year

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Personal profile

Biography

2006-2013  Senior Group Leader, Paterson Institute for Cancer Research (Cancer Research U.K.), University of Manchester.

2001-2007  Cancer Research U.K. Senior Cancer Research Fellow, Paterson Institute for Cancer Research, University of Manchester.

2001-2006  Junior Group Leader, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, University of Manchester.

1997-2001  Post-doctoral fellowship from the ICRF to work with John Diffley, Clare Hall research laboratories, London.

1995-1997  Post-doctoral fellow with Stephen Kearsey, Department of Zoology, University of Oxford.

1993-1994  EMBO Long-term fellowship to work with Sergio Moreno, University of Salamanca, Spain

Education/Academic qualification

Doctor of Philosophy, University of Oxford

Award Date: 1 Jan 1993

Master of Arts, University of Cambridge

Award Date: 1 Jan 1992

Bachelor of Arts, University of Cambridge

Award Date: 1 Jan 1989

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Projects

Research Output

In vitro reconstitution defines the minimal requirements for Cdc48-dependent disassembly of the CMG helicase in budding yeast

Mukherjee, P. & Labib, K., 10 Sep 2019, In : Cell Reports. 28, 11, p. 2777-2783.e4 11 p.

Research output: Contribution to journalArticle

Open Access
File
  • 55 Downloads (Pure)

    Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

    Deng, L., Wu, R. A., Sonneville, R., Kochenova, O. V., Labib, K., Pellman, D. & Walter, J. C., 7 Mar 2019, In : Molecular Cell. 73, 5, p. 915-929.e6 22 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 10 Citations (Scopus)
    9 Downloads (Pure)

    Pif1-family helicases support fork convergence during DNA replication termination in eukaryotes

    Deegan, T., Baxter, J., Ortiz Bazan, M., Yeeles, J. T. P. & Labib, K., 18 Apr 2019, In : Molecular Cell. 74, 2, p. 231-244.e9 24 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 8 Citations (Scopus)
    106 Downloads (Pure)

    TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

    Sonneville, R., Bhowmick, R., Hoffmann, S., Mailand, N., Hickson, I. D. & Labib, K., 23 Sep 2019, In : eLife. 8, p. 1-19 19 p., e48686.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 3 Citations (Scopus)
    54 Downloads (Pure)

    Histone H2A-H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin

    Evrin, C., Maman, J., Diamante, A., Pellegrini, L. & Labib, K., 1 Oct 2018, In : EMBO Journal. 37, 19, p. 1-16 16 p., e99021.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 12 Citations (Scopus)
    120 Downloads (Pure)

    Prizes

    Elected member

    Karim Labib (Recipient), 2010

    Prize: Election to learned society

    Hooke Medal

    Karim Labib (Recipient), 2010

    Prize: Prize (including medals and awards)

    Long-term Doctoral Fellowship (1993-1994)

    Karim Labib (Recipient), 1993

    Prize: Fellowship awarded competitively

    Senior Cancer Research Fellowship, 2001-2007

    Karim Labib (Recipient), 2001

    Prize: Fellowship awarded competitively

    Young Investigator Programme

    Karim Labib (Recipient), 2004

    Prize: Fellowship awarded competitively

  • Activities

    • 45 Participation in conference
    • 4 Editorial activity
    • 1 Public engagement and outreach - public lecture/debate/seminar

    Cafe Science Dundee: A BRIEF HISTORY OF LIFE

    Karim Labib (Speaker)
    5 Oct 2017

    Activity: Other activity typesPublic engagement and outreach - public lecture/debate/seminar

    2014 FASEB Yeast Chromosome Structure, Replication and Segregation meeting, Stemboat Springs, CO, USA

    Karim Labib (Invited speaker)
    2014

    Activity: Participating in or organising an event typesParticipation in conference

    2014 Ramon Areces Foundation Symposium on ‘Cell Proliferation and Genome Integrity’, University of Santander, Spain

    Karim Labib (Organiser)
    2014

    Activity: Participating in or organising an event typesParticipation in conference

    2013 Conference to celebrate 50th anniversary of the replicon theory, Pasteur Institute, Paris, France

    Karim Labib (Invited speaker)
    2013

    Activity: Participating in or organising an event typesParticipation in conference

    2013 Eukaryotic DNA replication meeting, Cold Spring Harbor, NY, USA

    Karim Labib (Chair)
    2013

    Activity: Participating in or organising an event typesParticipation in conference

    Thesis

    In vitro reconstitution of the ubiquitylation and disassembly of the eukaryotic replisome

    Author: Mukherjee, P., 2018

    Supervisor: Labib, K. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy