Labib, Karim

Professor

  • Professor & Personal Chair Genome Integrity, MRC PPU
  • United Kingdom

1992 …2019

Research output per year

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Research Output

Article

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

Hong, Y., Velkova, M., Silva, N., Jagut, M., Scheidt, V., Labib, K., Jantsch, V. & Gartner, A., 7 Jun 2018, In : PLoS Genetics. 14, 6, p. 1-22 22 p., e1007453.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
164 Downloads (Pure)

The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

Gan, H., Serra-Cardona, A., Hua, X., Zhou, H., Labib, K., Yu, C. & Zhang, Z., 4 Oct 2018, In : Molecular Cell. 72, 1, p. 140-151.e3 16 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
136 Downloads (Pure)

The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth

Sanchez-Diaz, A., Nkosi, P. J., Murray, S. & Labib, K., 29 Aug 2012, In : EMBO Journal. 31, 17, p. 3620-3634 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The replisome-coupled E3 ubiquitin ligase Rtt101Mms22 counteracts Mrc1 function to tolerate genotoxic stress

Buser, R., Kellner, V., Melnik, A., Wilson-Zbinden, C., Schellhaas, R., Kastner, L., Piwko, W., Dees, M., Picotti, P., Maric, M., Labib, K., Luke, B. & Peter, M., 5 Feb 2016, In : PLoS Genetics. 12, 2, 25 p., e1005843.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
398 Downloads (Pure)

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

Sonneville, R., Bhowmick, R., Hoffmann, S., Mailand, N., Hickson, I. D. & Labib, K., 23 Sep 2019, In : eLife. 8, p. 1-19 19 p., e48686.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
69 Downloads (Pure)

Ufd1-Npl4 recruit Cdc48 for disassembly of ubiquitylated CMG helicase at the end of chromosome replication

Maric, M., Mukherjee, P., Tatham, M. H., Hay, R. & Labib, K., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3033-3042 10 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
212 Downloads (Pure)

Uninterrupted MCM2-7 function required for DNA replication fork progression

Labib, K., Tercero, JA. & Diffley, JFX., 2 Jun 2000, In : Science. 288, 5471, p. 1643-1647 5 p.

Research output: Contribution to journalArticle

486 Citations (Scopus)
Chapter

Regulating initiation events in yeasts

Schwob, E. & Labib, K., 2006, DNA replication and human disease. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, p. 295-312 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Editorial

Highlights of the 23rd Genes and Cancer meeting University of Warwick 11-13 December 2006

Labib, K., 26 Apr 2007, In : Oncogene. 26, 19, p. 2675-2677 3 p.

Research output: Contribution to journalEditorial

Letter

Don't leave dignity out of the cloning debate

Labib, K., 3 Jul 1997, In : Nature. 388, 6637, p. 15-15 1 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)
Review article

A key role for the GINS complex at DNA replication forks

Labib, K. & Gambus, A., Jun 2007, In : Trends in Cell Biology. 17, 6, p. 271-278 8 p.

Research output: Contribution to journalReview article

93 Citations (Scopus)

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

Labib, K. & Diffley, JF., Feb 2001, In : Current Opinion in Genetics & Development. 11, 1, p. 64-70 7 p.

Research output: Contribution to journalReview article

118 Citations (Scopus)

MCM proteins: evolution, properties, and role in DNA replication

Kearsey, SE. & Labib, K., 16 Jun 1998, In : Biochimica et Biophysica Acta-Gene Structure and Expression. 1398, 2, p. 113-136 24 p.

Research output: Contribution to journalReview article

218 Citations (Scopus)

Replication fork barriers: pausing for a break or stalling for time?

Labib, K. & Hodgson, B., Apr 2007, In : EMBO Reports. 8, 4, p. 346-353 8 p.

Research output: Contribution to journalReview article

100 Citations (Scopus)