Labib, Karim

Professor

  • Professor & Personal Chair Genome Integrity, MRC PPU
  • United Kingdom

1992 …2020

Research output per year

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Research Output

Article

Regulation of the cell cycle timing of Start in fission yeast by the rum1+ gene

Moreno, S., Labib, K., Correa, J. & Nurse, P., 1994, In : Journal of Cell Science. p. 63-68 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases

De Piccoli, G., Katou, Y., Itoh, T., Nakato, R., Shirahige, K. & Labib, K., 9 Mar 2012, In : Molecular Cell. 45, 5, p. 696-704 9 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

rum1: A CDK inhibitor regulating G1 progression in fission yeast

Labib, K. & Moreno, S., Feb 1996, In : Trends in Cell Biology. 6, 2, p. 62-66 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Surviving chromosome replication: The many roles of the S-phase checkpoint pathway

Labib, K. & de Piccoli, G., 27 Dec 2011, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 366, 1584, p. 3554-3561 8 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design

Wu, Y., Villa, F., Maman, J., Lau, Y. H., Dobnikar, L., Simon, A. C., Labib, K., Spring, D. R. & Pellegrini, L., 9 Oct 2017, In : Angewandte Chemie International Edition. 56, p. 12866-12872 8 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
170 Downloads (Pure)

Tethering of SCFDia2 to the replisome promotes efficient ubiquitylation and disassembly of the CMG helicase

Maculins, T., Nkosi, P. J., Nishikawa, H. & Labib, K., 31 Aug 2015, In : Current Biology. 25, 17, p. 2254-2259 6 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
148 Downloads (Pure)

The amino-terminal TPR domain of Dia2 tethers SCFDia2 to the replisome progression complex

Morohashi, H., Maculins, T. & Labib, K., 1 Dec 2009, In : Current Biology. 19, 22, p. 1943-1949 7 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

The chromosome replication cycle

Diffley, JFX. & Labib, K., 1 Mar 2002, In : Journal of Cell Science. 115, 5, p. 869-872 4 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

Hong, Y., Velkova, M., Silva, N., Jagut, M., Scheidt, V., Labib, K., Jantsch, V. & Gartner, A., 7 Jun 2018, In : PLoS Genetics. 14, 6, p. 1-22 22 p., e1007453.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
172 Downloads (Pure)

The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

Gan, H., Serra-Cardona, A., Hua, X., Zhou, H., Labib, K., Yu, C. & Zhang, Z., 4 Oct 2018, In : Molecular Cell. 72, 1, p. 140-151.e3 16 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
142 Downloads (Pure)

The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth

Sanchez-Diaz, A., Nkosi, P. J., Murray, S. & Labib, K., 29 Aug 2012, In : EMBO Journal. 31, 17, p. 3620-3634 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The replisome-coupled E3 ubiquitin ligase Rtt101Mms22 counteracts Mrc1 function to tolerate genotoxic stress

Buser, R., Kellner, V., Melnik, A., Wilson-Zbinden, C., Schellhaas, R., Kastner, L., Piwko, W., Dees, M., Picotti, P., Maric, M., Labib, K., Luke, B. & Peter, M., 5 Feb 2016, In : PLoS Genetics. 12, 2, 25 p., e1005843.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
401 Downloads (Pure)

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

Sonneville, R., Bhowmick, R., Hoffmann, S., Mailand, N., Hickson, I. D. & Labib, K., 23 Sep 2019, In : eLife. 8, p. 1-19 19 p., e48686.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
73 Downloads (Pure)

Ufd1-Npl4 recruit Cdc48 for disassembly of ubiquitylated CMG helicase at the end of chromosome replication

Maric, M., Mukherjee, P., Tatham, M. H., Hay, R. & Labib, K., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3033-3042 10 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
215 Downloads (Pure)

Uninterrupted MCM2-7 function required for DNA replication fork progression

Labib, K., Tercero, JA. & Diffley, JFX., 2 Jun 2000, In : Science. 288, 5471, p. 1643-1647 5 p.

Research output: Contribution to journalArticle

488 Citations (Scopus)