Labib, Karim

Professor

  • Professor & Personal Chair Genome Integrity, MRC PPU
  • United Kingdom

1992 …2023

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Research Output

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2019

In vitro reconstitution defines the minimal requirements for Cdc48-dependent disassembly of the CMG helicase in budding yeast

Mukherjee, P. & Labib, K., 10 Sep 2019, In : Cell Reports. 28, 11, p. 2777-2783.e4 11 p.

Research output: Contribution to journalArticle

Open Access
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63 Downloads (Pure)

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

Deng, L., Wu, R. A., Sonneville, R., Kochenova, O. V., Labib, K., Pellman, D. & Walter, J. C., 7 Mar 2019, In : Molecular Cell. 73, 5, p. 915-929.e6 22 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
14 Downloads (Pure)

Pif1-family helicases support fork convergence during DNA replication termination in eukaryotes

Deegan, T., Baxter, J., Ortiz Bazan, M., Yeeles, J. T. P. & Labib, K., 18 Apr 2019, In : Molecular Cell. 74, 2, p. 231-244.e9 24 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
116 Downloads (Pure)

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

Sonneville, R., Bhowmick, R., Hoffmann, S., Mailand, N., Hickson, I. D. & Labib, K., 23 Sep 2019, In : eLife. 8, p. 1-19 19 p., e48686.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
62 Downloads (Pure)
2018

Histone H2A-H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin

Evrin, C., Maman, J., Diamante, A., Pellegrini, L. & Labib, K., 1 Oct 2018, In : EMBO Journal. 37, 19, p. 1-16 16 p., e99021.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
129 Downloads (Pure)

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Hong, Y., Sonneville, R., Wang, B., Scheidt, V., Meier, B., Woglar, A., Demetriou, S., Labib, K., Jantsch, V. & Gartner, A., 20 Feb 2018, In : Nature Communications. 9, p. 1-11 11 p., 728.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
177 Downloads (Pure)

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

Hong, Y., Velkova, M., Silva, N., Jagut, M., Scheidt, V., Labib, K., Jantsch, V. & Gartner, A., 7 Jun 2018, In : PLoS Genetics. 14, 6, p. 1-22 22 p., e1007453.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
158 Downloads (Pure)

The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

Gan, H., Serra-Cardona, A., Hua, X., Zhou, H., Labib, K., Yu, C. & Zhang, Z., 4 Oct 2018, In : Molecular Cell. 72, 1, p. 140-151.e3 16 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
123 Downloads (Pure)
2017

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis

Sonneville, R., Priego Moreno, S., Knebel, A., Johnson, C., Hastie, C. J., Gartner, A., Gambus, A. & Labib, K., 3 Apr 2017, In : Nature Cell Biology. 19, p. 468-479 11 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
150 Downloads (Pure)

Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design

Wu, Y., Villa, F., Maman, J., Lau, Y. H., Dobnikar, L., Simon, A. C., Labib, K., Spring, D. R. & Pellegrini, L., 9 Oct 2017, In : Angewandte Chemie International Edition. 56, p. 12866-12872 8 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
155 Downloads (Pure)

Ufd1-Npl4 recruit Cdc48 for disassembly of ubiquitylated CMG helicase at the end of chromosome replication

Maric, M., Mukherjee, P., Tatham, M. H., Hay, R. & Labib, K., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3033-3042 10 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
205 Downloads (Pure)
2016

Chromosome Duplication in Saccharomyces cerevisiae

Bell, S. P. & Labib, K., 6 Jul 2016, In : Genetics. 203, 3, p. 1027-1067 41 p.

Research output: Contribution to journalArticle

Open Access
File
109 Citations (Scopus)
130 Downloads (Pure)

Ctf4 is a hub in the eukaryotic replisome that links multiple CIP-box proteins to the CMG helicase

Villa, F., Simon, A. C., Ortiz Bazan, M. A., Kilkenny, M. L., Wirthensohn, D., Wightman, M., Matak-Vinkovíc, D., Pellegrini, L. & Labib, K., 4 Aug 2016, In : Molecular Cell. 63, 3, p. 385-396 12 p.

Research output: Contribution to journalArticle

Open Access
File
43 Citations (Scopus)
260 Downloads (Pure)

MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of Deubiquitinating enzymes

Rehman, S. A. A., Kristariyanto, Y., Choi, S. Y., Nkosi, P., Weidlich, S., Labib, K., Hofmann, K. & Kulathu, Y., 7 Jul 2016, In : Molecular Cell. 63, p. 146-155 10 p.

Research output: Contribution to journalArticle

Open Access
File
108 Citations (Scopus)
167 Downloads (Pure)

The replisome-coupled E3 ubiquitin ligase Rtt101Mms22 counteracts Mrc1 function to tolerate genotoxic stress

Buser, R., Kellner, V., Melnik, A., Wilson-Zbinden, C., Schellhaas, R., Kastner, L., Piwko, W., Dees, M., Picotti, P., Maric, M., Labib, K., Luke, B. & Peter, M., 5 Feb 2016, In : PLoS Genetics. 12, 2, 25 p., e1005843.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
387 Downloads (Pure)
2015

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

García-Rodríguez, L. J., De Piccoli, G., Marchesi, V., Jones, R. C., Edmondson, R. D. & Labib, K., 15 Oct 2015, In : Nucleic Acids Research. 43, 18, p. 8830-8838

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
139 Downloads (Pure)

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos

Sonneville, R., Craig, G., Labib, K., Gartner, A. & Blow, J. J., 21 Jul 2015, In : Cell Reports. 12, 3, p. 405-417 13 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
185 Downloads (Pure)

Tethering of SCFDia2 to the replisome promotes efficient ubiquitylation and disassembly of the CMG helicase

Maculins, T., Nkosi, P. J., Nishikawa, H. & Labib, K., 31 Aug 2015, In : Current Biology. 25, 17, p. 2254-2259 6 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
134 Downloads (Pure)
2014

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

Simon, A. C., Zhou, J. C., Perera, R. L., van Deursen, F., Evrin, C., Ivanova, M. E., Kilkenny, M. L., Renault, L., Kjaer, S., Matak-Vinković, D., Labib, K., Costa, A. & Pellegrini, L., 2014, In : Nature. 510, 7504, p. 293-297 5 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

Maric, M., Maculins, T., De Piccoli, G. & Labib, K., 24 Oct 2014, In : Science. 346, 6208, 13 p., 1253596.

Research output: Contribution to journalArticle

104 Citations (Scopus)
2013

Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

Sengupta, S., van Deursen, F., de Piccoli, G. & Labib, K., 8 Apr 2013, In : Current Biology. 23, 7, p. 543-552 10 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Eukaryotic replisome components cooperate to process histones during chromosome replication

Foltman, M., Evrin, C., De Piccoli, G., Jones, R. C., Edmondson, R. D., Katou, Y., Nakato, R., Shirahige, K. & Labib, K., 28 Mar 2013, In : Cell Reports. 3, 3, p. 892-904 13 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Hof1 and Rvs167 Have Redundant Roles in Actomyosin Ring Function during Cytokinesis in Budding Yeast

Nkosi, P. J., Targosz, B-S., Labib, K. & Sanchez-Diaz, A., 28 Feb 2013, In : PLoS ONE. 8, 2, e57846.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2012

A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome

Kilkenny, M. L., De Piccoli, G., Perera, R. L., Labib, K. & Pellegrini, L., 6 Jul 2012, In : Journal of Biological Chemistry. 287, 28, p. 23740-23747 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts

Devrekanli, A., Foltman, M., Roncero, C., Sanchez-Diaz, A. & Labib, K., 15 Nov 2012, In : Journal of Cell Science. 125, 22, p. 5453-5466 14 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

van Deursen, F., Sengupta, S., De Piccoli, G., Sanchez-Diaz, A. & Labib, K., 2 May 2012, In : EMBO Journal. 31, 9, p. 2195-2206 12 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases

De Piccoli, G., Katou, Y., Itoh, T., Nakato, R., Shirahige, K. & Labib, K., 9 Mar 2012, In : Molecular Cell. 45, 5, p. 696-704 9 p.

Research output: Contribution to journalArticle

108 Citations (Scopus)

The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth

Sanchez-Diaz, A., Nkosi, P. J., Murray, S. & Labib, K., 29 Aug 2012, In : EMBO Journal. 31, 17, p. 3620-3634 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2011

Building a double hexamer of DNA helicase at eukaryotic replication origins

Labib, K., 14 Dec 2011, In : EMBO Journal. 30, 24, p. 4853-4855 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Surviving chromosome replication: The many roles of the S-phase checkpoint pathway

Labib, K. & de Piccoli, G., 27 Dec 2011, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 366, 1584, p. 3554-3561 8 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
2010

Howdo Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

Labib, K., 15 Jun 2010, In : Genes & Development. 24, 12, p. 1208-1219 12 p.

Research output: Contribution to journalArticle

226 Citations (Scopus)
2009

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome

Gambus, A., van Deursen, F., Polychronopoulos, D., Foltman, M., Jones, R. C., Edmondson, R. D., Calzada, A. & Labib, K., 7 Oct 2009, In : EMBO Journal. 28, 19, p. 2992-3004 13 p.

Research output: Contribution to journalArticle

171 Citations (Scopus)

The amino-terminal TPR domain of Dia2 tethers SCFDia2 to the replisome progression complex

Morohashi, H., Maculins, T. & Labib, K., 1 Dec 2009, In : Current Biology. 19, 22, p. 1943-1949 7 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2008

Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast

Sanchez-Diaz, A., Marchesi, V., Murray, S., Jones, R., Pereira, G., Edmondson, R., Allen, T. & Labib, K., Apr 2008, In : Nature Cell Biology. 10, 4, p. 395-406 12 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Making Connections at DNA Replication Forks: Mrc1 Takes the Lead

Labib, K., 24 Oct 2008, In : Molecular Cell. 32, 2, p. 166-168 3 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

New insights into the chromosome cycle. Conference on the Replication and Segregation of Chromosomes

de la Cueva-Mendez, G. & Labib, K., Dec 2008, In : EMBO Reports. 9, 12, p. 1177-1181 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2007

Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S Phase

Hodgson, B., Calzada, A. & Labib, K., Oct 2007, In : Molecular Biology of the Cell. 18, 10, p. 3894-3902 9 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)
2006

Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks

Kanemaki, M. & Labib, K., 19 Apr 2006, In : EMBO Journal. 25, 8, p. 1753-1763 11 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

Gambus, A., Jones, RC., Sanchez-Diaz, A., Kanemaki, M., van Deursen, F., Edmondson, RD. & Labib, K., Apr 2006, In : Nature Cell Biology. 8, 4, p. 358-U41 34 p.

Research output: Contribution to journalArticle

522 Citations (Scopus)
2005

Molecular anatomy and regulation of a stable replisome eukaryotic DNA at a paused replication fork

Calzada, A., Hodgson, B., Kanemaki, M., Bueno, A. & Labib, K., 2005, In : Genes & Development. 19, 16, p. 1905-1919 15 p.

Research output: Contribution to journalArticle

204 Citations (Scopus)
2003

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo

Kanemaki, M., Sanchez-Diaz, A., Gambus, A. & Labib, K., 12 Jun 2003, In : Nature. 423, 6941, p. 720-724 5 p.

Research output: Contribution to journalArticle

208 Citations (Scopus)
2002

The chromosome replication cycle

Diffley, JFX. & Labib, K., 1 Mar 2002, In : Journal of Cell Science. 115, 5, p. 869-872 4 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)
2000

A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls

Grallert, B., Kearsey, SE., Lenhard, M., Carlson, CR., Nurse, P., Boye, E. & Labib, K., 2000, In : Journal of Cell Science. 113, 8, p. 1447-1458 12 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18

Kearsey, SE., Montgomery, S., Labib, K. & Lindner, K., 3 Apr 2000, In : EMBO Journal. 19, 7, p. 1681-1690 10 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast

Diffley, JFX., Bousset, K., Labib, K., Noton, EA., Santocanale, C. & Tercero, JA., 2000, In : Cold Spring Harbor Symposia on Quantitative Biology. 65, p. 333-342 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

Tercero, JA., Labib, K. & Diffley, JFX., 2 May 2000, In : EMBO Journal. 19, 9, p. 2082-2093 12 p.

Research output: Contribution to journalArticle

148 Citations (Scopus)

Uninterrupted MCM2-7 function required for DNA replication fork progression

Labib, K., Tercero, JA. & Diffley, JFX., 2 Jun 2000, In : Science. 288, 5471, p. 1643-1647 5 p.

Research output: Contribution to journalArticle

486 Citations (Scopus)
1999

G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus

Labib, K., Diffley, JFX. & Kearsey, SE., Nov 1999, In : Nature Cell Biology. 1, 7, p. 415-422 8 p.

Research output: Contribution to journalArticle

161 Citations (Scopus)
1996

B-type cyclins regulate G(1) progression in fission yeast in opposition to the p25(rum1) cdk inhibitor

Martin-Castellanos, C., Labib, K. & Moreno, S., 15 Feb 1996, In : EMBO Journal. 15, 4, p. 839-849 11 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)