Labib, Karim

Professor

  • Professor & Personal Chair Genome Integrity, MRC PPU
  • United Kingdom

1992 …2023
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Research Output 1992 2019

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Article
2019
32 Downloads (Pure)

In vitro reconstitution defines the minimal requirements for Cdc48-dependent disassembly of the CMG helicase in budding yeast

Mukherjee, P. & Labib, K., 10 Sep 2019, In : Cell Reports. 28, 11, p. 2777-2783.e4 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cullin Proteins
Saccharomycetales
Multicarrier modulation
Ligases
Ubiquitin
8 Citations (Scopus)

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

Deng, L., Wu, R. A., Sonneville, R., Kochenova, O. V., Labib, K., Pellman, D. & Walter, J. C., 7 Mar 2019, In : Molecular Cell. 73, 5, p. 915-929.e6 22 p.

Research output: Contribution to journalArticle

Gene Rearrangement
DNA Replication
Ubiquitination
Ovum
Xenopus
7 Citations (Scopus)
79 Downloads (Pure)

Pif1-family helicases support fork convergence during DNA replication termination in eukaryotes

Deegan, T., Baxter, J., Ortiz Bazan, M., Yeeles, J. T. P. & Labib, K., 18 Apr 2019, In : Molecular Cell. 74, 2, p. 231-244.e9 24 p.

Research output: Contribution to journalArticle

Open Access
File
Eukaryota
DNA Replication
Type II DNA Topoisomerase
DNA Helicases
Type I DNA Topoisomerase
1 Citation (Scopus)
27 Downloads (Pure)

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

Sonneville, R., Bhowmick, R., Hoffmann, S., Mailand, N., Hickson, I. D. & Labib, K., 23 Sep 2019, In : eLife. 8, p. 1-19 19 p., 48686.

Research output: Contribution to journalArticle

Open Access
File
DNA Replication
Mitosis
DNA Repair
Repair
DNA
2018
10 Citations (Scopus)
90 Downloads (Pure)

Histone H2A-H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin

Evrin, C., Maman, J., Diamante, A., Pellegrini, L. & Labib, K., 1 Oct 2018, In : EMBO Journal. 37, 19, p. 1-16 16 p., e99021.

Research output: Contribution to journalArticle

Open Access
File
Histones
Chromatin
Maintenance
Yeast
Mutation
8 Citations (Scopus)
142 Downloads (Pure)

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Hong, Y., Sonneville, R., Wang, B., Scheidt, V., Meier, B., Woglar, A., Demetriou, S., Labib, K., Jantsch, V. & Gartner, A., 20 Feb 2018, In : Nature Communications. 9, p. 1-11 11 p., 728.

Research output: Contribution to journalArticle

Open Access
File
Lunar Module
nuclease
mitosis
chromatin
Deoxyribonucleases
4 Citations (Scopus)
121 Downloads (Pure)

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

Hong, Y., Velkova, M., Silva, N., Jagut, M., Scheidt, V., Labib, K., Jantsch, V. & Gartner, A., 7 Jun 2018, In : PLoS Genetics. 14, 6, p. 1-22 22 p., e1007453.

Research output: Contribution to journalArticle

Open Access
File
3'-nucleotidase
Recombinational DNA Repair
Chromosome Segregation
chromosome segregation
nucleases
10 Citations (Scopus)
71 Downloads (Pure)

The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

Gan, H., Serra-Cardona, A., Hua, X., Zhou, H., Labib, K., Yu, C. & Zhang, Z., 4 Oct 2018, In : Molecular Cell. 72, 1, p. 140-151.e3 16 p.

Research output: Contribution to journalArticle

Open Access
File
Histones
Nucleosomes
Epigenomics
DNA
DNA Primase
2017
22 Citations (Scopus)
102 Downloads (Pure)

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis

Sonneville, R., Priego Moreno, S., Knebel, A., Johnson, C., Hastie, C. J., Gartner, A., Gambus, A. & Labib, K., 3 Apr 2017, In : Nature Cell Biology. 19, p. 468-479 11 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Replication
Mitosis
Chromatin
Ubiquitination
Centers for Disease Control and Prevention (U.S.)
13 Citations (Scopus)
105 Downloads (Pure)

Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design

Wu, Y., Villa, F., Maman, J., Lau, Y. H., Dobnikar, L., Simon, A. C., Labib, K., Spring, D. R. & Pellegrini, L., 9 Oct 2017, In : Angewandte Chemie International Edition. 56, p. 12866-12872 8 p.

Research output: Contribution to journalArticle

Open Access
File
Peptides
Genes
DNA
Molecules
DNA-Directed DNA Polymerase
7 Citations (Scopus)
170 Downloads (Pure)

Ufd1-Npl4 recruit Cdc48 for disassembly of ubiquitylated CMG helicase at the end of chromosome replication

Maric, M., Mukherjee, P., Tatham, M. H., Hay, R. & Labib, K., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3033-3042 10 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitination
Multicarrier modulation
Chromosomes
DNA Helicases
Saccharomycetales
2016
103 Citations (Scopus)
90 Downloads (Pure)

Chromosome Duplication in Saccharomyces cerevisiae

Bell, S. P. & Labib, K., 6 Jul 2016, In : Genetics. 203, 3, p. 1027-1067 41 p.

Research output: Contribution to journalArticle

Open Access
File
Chromosome Duplication
DNA Replication
DNA Helicases
Chromatids
Replication Origin
39 Citations (Scopus)
222 Downloads (Pure)

Ctf4 is a hub in the eukaryotic replisome that links multiple CIP-box proteins to the CMG helicase

Villa, F., Simon, A. C., Ortiz Bazan, M. A., Kilkenny, M. L., Wirthensohn, D., Wightman, M., Matak-Vinkovíc, D., Pellegrini, L. & Labib, K., 4 Aug 2016, In : Molecular Cell. 63, 3, p. 385-396 12 p.

Research output: Contribution to journalArticle

Open Access
File
Ribosomal DNA
DNA Helicases
Chromosomes, Human, Pair 12
Proteins
DNA
92 Citations (Scopus)
132 Downloads (Pure)

MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of Deubiquitinating enzymes

Rehman, S. A. A., Kristariyanto, Y., Choi, S. Y., Nkosi, P., Weidlich, S., Labib, K., Hofmann, K. & Kulathu, Y., 7 Jul 2016, In : Molecular Cell. 63, p. 146-155 10 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin
Ubiquitination
Eukaryota
Catalysis
Proteolysis
13 Citations (Scopus)
351 Downloads (Pure)

The replisome-coupled E3 ubiquitin ligase Rtt101Mms22 counteracts Mrc1 function to tolerate genotoxic stress

Buser, R., Kellner, V., Melnik, A., Wilson-Zbinden, C., Schellhaas, R., Kastner, L., Piwko, W., Dees, M., Picotti, P., Maric, M., Labib, K., Luke, B. & Peter, M., 5 Feb 2016, In : PLoS Genetics. 12, 2, 25 p., e1005843.

Research output: Contribution to journalArticle

Open Access
File
ubiquitin-protein ligase
Ubiquitin-Protein Ligases
DNA replication
DNA Replication
ligases
2015
26 Citations (Scopus)
99 Downloads (Pure)

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

García-Rodríguez, L. J., De Piccoli, G., Marchesi, V., Jones, R. C., Edmondson, R. D. & Labib, K., 15 Oct 2015, In : Nucleic Acids Research. 43, 18, p. 8830-8838

Research output: Contribution to journalArticle

Open Access
File
S Phase Cell Cycle Checkpoints
Saccharomycetales
Phosphotransferases
DNA Polymerase II
Mutation
14 Citations (Scopus)
151 Downloads (Pure)

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos

Sonneville, R., Craig, G., Labib, K., Gartner, A. & Blow, J. J., 21 Jul 2015, In : Cell Reports. 12, 3, p. 405-417 13 p.

Research output: Contribution to journalArticle

Open Access
File
Chromosomes
DNA Replication
Chromatin
Condensation
Embryonic Structures
20 Citations (Scopus)
101 Downloads (Pure)

Tethering of SCFDia2 to the replisome promotes efficient ubiquitylation and disassembly of the CMG helicase

Maculins, T., Nkosi, P. J., Nishikawa, H. & Labib, K., 31 Aug 2015, In : Current Biology. 25, 17, p. 2254-2259 6 p.

Research output: Contribution to journalArticle

Open Access
File
F-box proteins
Ubiquitination
Multicarrier modulation
DNA helicases
degradation
2014
96 Citations (Scopus)

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

Simon, A. C., Zhou, J. C., Perera, R. L., van Deursen, F., Evrin, C., Ivanova, M. E., Kilkenny, M. L., Renault, L., Kjaer, S., Matak-Vinković, D., Labib, K., Costa, A. & Pellegrini, L., 2014, In : Nature. 510, 7504, p. 293-297 5 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Eukaryota
DNA Helicases
Fungal Proteins
Genomic Instability
99 Citations (Scopus)

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

Maric, M., Maculins, T., De Piccoli, G. & Labib, K., 24 Oct 2014, In : Science. 346, 6208, 13 p., 1253596.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
DNA Replication
Chromosomes
DNA Helicases
2013
73 Citations (Scopus)

Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

Sengupta, S., van Deursen, F., de Piccoli, G. & Labib, K., 8 Apr 2013, In : Current Biology. 23, 7, p. 543-552 10 p.

Research output: Contribution to journalArticle

DNA Polymerase II
DNA-directed DNA polymerase
Multicarrier modulation
DNA-Directed DNA Polymerase
Genes
77 Citations (Scopus)

Eukaryotic replisome components cooperate to process histones during chromosome replication

Foltman, M., Evrin, C., De Piccoli, G., Jones, R. C., Edmondson, R. D., Katou, Y., Nakato, R., Shirahige, K. & Labib, K., 28 Mar 2013, In : Cell Reports. 3, 3, p. 892-904 13 p.

Research output: Contribution to journalArticle

Chromosomes
Histones
Chromatin
Transcription
DNA
8 Citations (Scopus)

Hof1 and Rvs167 Have Redundant Roles in Actomyosin Ring Function during Cytokinesis in Budding Yeast

Nkosi, P. J., Targosz, B-S., Labib, K. & Sanchez-Diaz, A., 28 Feb 2013, In : PLoS ONE. 8, 2, e57846.

Research output: Contribution to journalArticle

Actomyosin
Saccharomycetales
Cytokinesis
cytokinesis
Yeast
2012
22 Citations (Scopus)

A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome

Kilkenny, M. L., De Piccoli, G., Perera, R. L., Labib, K. & Pellegrini, L., 6 Jul 2012, In : Journal of Biological Chemistry. 287, 28, p. 23740-23747 8 p.

Research output: Contribution to journalArticle

DNA Primase
DNA-Directed DNA Polymerase
Tail
Yeast
Yeasts
22 Citations (Scopus)

Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts

Devrekanli, A., Foltman, M., Roncero, C., Sanchez-Diaz, A. & Labib, K., 15 Nov 2012, In : Journal of Cell Science. 125, 22, p. 5453-5466 14 p.

Research output: Contribution to journalArticle

Chitin Synthase
Saccharomycetales
Cytokinesis
Catalytic Domain
Alleles
86 Citations (Scopus)

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

van Deursen, F., Sengupta, S., De Piccoli, G., Sanchez-Diaz, A. & Labib, K., 2 May 2012, In : EMBO Journal. 31, 9, p. 2195-2206 12 p.

Research output: Contribution to journalArticle

DNA Helicases
Replication Origin
Chromosomes
DNA Polymerase I
Chemical activation
105 Citations (Scopus)

Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases

De Piccoli, G., Katou, Y., Itoh, T., Nakato, R., Shirahige, K. & Labib, K., 9 Mar 2012, In : Molecular Cell. 45, 5, p. 696-704 9 p.

Research output: Contribution to journalArticle

S Phase Cell Cycle Checkpoints
DNA Replication
Saccharomycetales
Phosphotransferases
DNA Helicases
17 Citations (Scopus)

The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth

Sanchez-Diaz, A., Nkosi, P. J., Murray, S. & Labib, K., 29 Aug 2012, In : EMBO Journal. 31, 17, p. 3620-3634 15 p.

Research output: Contribution to journalArticle

Phosphorylation
Cytokinesis
Cyclin-Dependent Kinases
Phosphoric Monoester Hydrolases
Growth
2011
7 Citations (Scopus)

Building a double hexamer of DNA helicase at eukaryotic replication origins

Labib, K., 14 Dec 2011, In : EMBO Journal. 30, 24, p. 4853-4855 3 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Surviving chromosome replication: The many roles of the S-phase checkpoint pathway

Labib, K. & de Piccoli, G., 27 Dec 2011, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 366, 1584, p. 3554-3561 8 p.

Research output: Contribution to journalArticle

S Phase Cell Cycle Checkpoints
Chromosomes
interphase
DNA damage
DNA Damage
2010
222 Citations (Scopus)

Howdo Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

Labib, K., 15 Jun 2010, In : Genes & Development. 24, 12, p. 1208-1219 12 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Eukaryotic Cells
Cell Cycle
Chromosomes
DNA Helicases
2009
168 Citations (Scopus)

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome

Gambus, A., van Deursen, F., Polychronopoulos, D., Foltman, M., Jones, R. C., Edmondson, R. D., Calzada, A. & Labib, K., 7 Oct 2009, In : EMBO Journal. 28, 19, p. 2992-3004 13 p.

Research output: Contribution to journalArticle

Minichromosome Maintenance Proteins
DNA Polymerase I
Chromosomes
DNA Polymerase II
Genomic Instability
49 Citations (Scopus)

The amino-terminal TPR domain of Dia2 tethers SCFDia2 to the replisome progression complex

Morohashi, H., Maculins, T. & Labib, K., 1 Dec 2009, In : Current Biology. 19, 22, p. 1943-1949 7 p.

Research output: Contribution to journalArticle

Cullin Proteins
F-box proteins
terminal repeat sequences
Terminal Repeat Sequences
DNA replication
2008
55 Citations (Scopus)

Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast

Sanchez-Diaz, A., Marchesi, V., Murray, S., Jones, R., Pereira, G., Edmondson, R., Allen, T. & Labib, K., Apr 2008, In : Nature Cell Biology. 10, 4, p. 395-406 12 p.

Research output: Contribution to journalArticle

Actomyosin
Saccharomycetales
Cytokinesis
Membranes
Cell Membrane
5 Citations (Scopus)

Making Connections at DNA Replication Forks: Mrc1 Takes the Lead

Labib, K., 24 Oct 2008, In : Molecular Cell. 32, 2, p. 166-168 3 p.

Research output: Contribution to journalArticle

Genomic Instability
DNA-Directed DNA Polymerase
DNA Replication
Proteins
Lead
1 Citation (Scopus)

New insights into the chromosome cycle. Conference on the Replication and Segregation of Chromosomes

de la Cueva-Mendez, G. & Labib, K., Dec 2008, In : EMBO Reports. 9, 12, p. 1177-1181 5 p.

Research output: Contribution to journalArticle

2007
89 Citations (Scopus)

Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S Phase

Hodgson, B., Calzada, A. & Labib, K., Oct 2007, In : Molecular Biology of the Cell. 18, 10, p. 3894-3902 9 p.

Research output: Contribution to journalArticle

2006
99 Citations (Scopus)

Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks

Kanemaki, M. & Labib, K., 19 Apr 2006, In : EMBO Journal. 25, 8, p. 1753-1763 11 p.

Research output: Contribution to journalArticle

515 Citations (Scopus)

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

Gambus, A., Jones, RC., Sanchez-Diaz, A., Kanemaki, M., van Deursen, F., Edmondson, RD. & Labib, K., Apr 2006, In : Nature Cell Biology. 8, 4, p. 358-U41 34 p.

Research output: Contribution to journalArticle

2005
202 Citations (Scopus)

Molecular anatomy and regulation of a stable replisome eukaryotic DNA at a paused replication fork

Calzada, A., Hodgson, B., Kanemaki, M., Bueno, A. & Labib, K., 2005, In : Genes & Development. 19, 16, p. 1905-1919 15 p.

Research output: Contribution to journalArticle

2003
206 Citations (Scopus)

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo

Kanemaki, M., Sanchez-Diaz, A., Gambus, A. & Labib, K., 12 Jun 2003, In : Nature. 423, 6941, p. 720-724 5 p.

Research output: Contribution to journalArticle

2002
97 Citations (Scopus)

The chromosome replication cycle

Diffley, JFX. & Labib, K., 1 Mar 2002, In : Journal of Cell Science. 115, 5, p. 869-872 4 p.

Research output: Contribution to journalArticle

2000
66 Citations (Scopus)

A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls

Grallert, B., Kearsey, SE., Lenhard, M., Carlson, CR., Nurse, P., Boye, E. & Labib, K., 2000, In : Journal of Cell Science. 113, 8, p. 1447-1458 12 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18

Kearsey, SE., Montgomery, S., Labib, K. & Lindner, K., 3 Apr 2000, In : EMBO Journal. 19, 7, p. 1681-1690 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast

Diffley, JFX., Bousset, K., Labib, K., Noton, EA., Santocanale, C. & Tercero, JA., 2000, In : Cold Spring Harbor Symposia on Quantitative Biology. 65, p. 333-342 10 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

Tercero, JA., Labib, K. & Diffley, JFX., 2 May 2000, In : EMBO Journal. 19, 9, p. 2082-2093 12 p.

Research output: Contribution to journalArticle

486 Citations (Scopus)

Uninterrupted MCM2-7 function required for DNA replication fork progression

Labib, K., Tercero, JA. & Diffley, JFX., 2 Jun 2000, In : Science. 288, 5471, p. 1643-1647 5 p.

Research output: Contribution to journalArticle

1999
159 Citations (Scopus)

G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus

Labib, K., Diffley, JFX. & Kearsey, SE., Nov 1999, In : Nature Cell Biology. 1, 7, p. 415-422 8 p.

Research output: Contribution to journalArticle

1996
84 Citations (Scopus)

B-type cyclins regulate G(1) progression in fission yeast in opposition to the p25(rum1) cdk inhibitor

Martin-Castellanos, C., Labib, K. & Moreno, S., 15 Feb 1996, In : EMBO Journal. 15, 4, p. 839-849 11 p.

Research output: Contribution to journalArticle