Hiom, Kevin

Professor, Head of Division of Cellular Medicine

  • 2720 Citations
  • 18 h-Index
1992 …2022
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Personal profile

Biography

Professor Kevin Hiom is the Pat McPherson Chair in Cancer Biology. Kevin did his undergraduate degree at the University of Liverpool and undertook his PhD at the MRC National institute for Medical Research where he studies the responses of bacterial cells to DNA damage caused by ultraviolet light. In 1991 Kevin moved to the Imperial Cancer Research Fund Clare Hall Lab’s to work with Dr Stephen West FRS on the biochemistry of genetic recombination and then in 1995 moved to the National Institutes of health, Bethesda Maryland USA to work on V(D)J recombination with Dr Martin Gellert. In 1998 Keven started his own group at the MRC Laboratory of Molecular Biology in Cambridge, working on the role of DNA repair in preventing human disease,. In 2009 Kevin relocated to the School of Medicine at the University of Dundee where he is now the Head of the Division of Cellular Medicine. During his career Kevin has been awarded a number of prizes including the NIH Fellows Award for Research Excellence (1998), Pfizer Academic Award for work on the mechanism of V(D)J recombination(1999), Fanconi Anemia Research Fund Discovery Award (2005) for the identification of the FANCJ gene and the European Association for Cancer Research Cancer Researcher Award Lecture (2009).

Research

Kevin Hiom’s group researches the mechanisms by which cells deal with damage to their genetic material DNA and how, when this goes wrong, it can lead to human disease. In particular Kevin’s group have an interest in the repair of DNA breaks. During his post-doctoral career Kevin showed how DNA breaks generated during the development of the immune system could result in the formation of cancer causing translocations in which DNA from two different chromosomes become fused. Since 1998 Kevin’s research has focused on the function of the important cancer causing gene BRCA1 which is defective in patients with a predisposition to early onset breast and ovarian cancer. His lab also identified a protein, related to BRCA1, was the cause of the human inherited blood disease Fanconi anaemia. In recent times the Hiom lab is focused on the role of RNA metabolism in the repair of DNA damage and how defects in this process lead to cancers in children and also to neurodegenerative diseases.

Teaching

Professor Hiom is an active participant in undergraduate and postgraduate teaching. He contributes lectures to module BS42007 (Cancer Biology), module BS42027 (Cancer Pharmacology and treatment) and BS32029 (Cell proliferation and survival mechanisms underlying disease) in Biological /Biomedical sciences. He also lectures on DNA repair in the BMSc module in Cancer and several lectures for the MRes Cancer Biology taught post-graduate masters course. His specialist teaching is in the mechanisms of genome stability and its role in disease.

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  • 10 Similar Profiles
DNA Medicine & Life Sciences
Fanconi Anemia Medicine & Life Sciences
V(D)J Recombination Medicine & Life Sciences
Cruciform DNA Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
Proteins Medicine & Life Sciences
Histones Medicine & Life Sciences
DNA Repair Medicine & Life Sciences

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Projects 2013 2022

Research Output 1992 2018

  • 2720 Citations
  • 18 h-Index
  • 20 Article
  • 3 Editorial
  • 2 Review article
  • 1 Letter
1 Citation (Scopus)
66 Downloads (Pure)

DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing

Chakraborty, P., Huang, J. & Hiom, K., 19 Oct 2018, In : Nature Communications. 9, 9, p. 1-14 14 p., 4346.

Research output: Contribution to journalArticle

Open Access
File
RNA Splicing
splicing
RNA
cells
Chromosome Fragility
8 Citations (Scopus)
79 Downloads (Pure)

BRCA1 is required for maintenance of phospho-Chk1 and G2/M arrest during DNA cross-link repair in DT40 cells

Draga, M., Madgett, E. B., Vandenberg, C. J., du Plessis, D., Kaufmann, A., Werler, P., Chakraborty, P., Lowndes, N. F. & Hiom, K., Nov 2015, In : Molecular and Cellular Biology. 35, 22, p. 3829-3840 12 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Death
G2 Phase
Maintenance
DNA Repair
DNA
48 Citations (Scopus)
115 Downloads (Pure)

BRCA1 is a histone-H2A-specific ubiquitin ligase

Kalb, R., Mallery, D. L., Larkin, C., Huang, J. T. J. & Hiom, K., 21 Aug 2014, In : Cell Reports. 8, 4, p. 999-1005 7 p.

Research output: Contribution to journalArticle

Open Access
File
Ligases
Ubiquitin
Histones
Chromatin
Ubiquitin-Protein Ligases
2 Citations (Scopus)

Homologous Recombination: How RecA Finds the Perfect Partner

Hiom, K., 24 Apr 2012, In : Current Biology. 22, 8, p. R275-R278 4 p.

Research output: Contribution to journalEditorial

17 Citations (Scopus)

FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells

Kitao, H., Nanda, I., Sugino, R. P., Kinomura, A., Yamazoe, M., Arakawa, H., Schmid, M., Innan, H., Hiom, K. & Takata, M., Jun 2011, In : Genes to Cells. 16, 6, p. 714-727 14 p.

Research output: Contribution to journalArticle

Thesis

The Non-Wnt Functions of APC: Unravelling the Link between APC and Apoptosis

Author: Cuddihy, J., 2016

Supervisor: Hiom, K. (Supervisor) & Nathke, I. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Medicine

File

The role of the BARD1 BRCT domains in the DNA damage response

Author: Kaufmann, A., 2014

Supervisor: Hiom, K. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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