Hiom, Kevin

Professor, Head of Division of Cellular Medicine

  • 2729 Citations
  • 18 h-Index
1992 …2022
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Research Output 1992 2018

  • 2729 Citations
  • 18 h-Index
  • 20 Article
  • 3 Editorial
  • 2 Review article
  • 1 Letter
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Article
2018
1 Citation (Scopus)
72 Downloads (Pure)

DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing

Chakraborty, P., Huang, J. & Hiom, K., 19 Oct 2018, In : Nature Communications. 9, 9, p. 1-14 14 p., 4346.

Research output: Contribution to journalArticle

Open Access
File
RNA Splicing
splicing
RNA
cells
Chromosome Fragility
2015
8 Citations (Scopus)
82 Downloads (Pure)

BRCA1 is required for maintenance of phospho-Chk1 and G2/M arrest during DNA cross-link repair in DT40 cells

Draga, M., Madgett, E. B., Vandenberg, C. J., du Plessis, D., Kaufmann, A., Werler, P., Chakraborty, P., Lowndes, N. F. & Hiom, K., Nov 2015, In : Molecular and Cellular Biology. 35, 22, p. 3829-3840 12 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Death
G2 Phase
Maintenance
DNA Repair
DNA
2014
48 Citations (Scopus)
121 Downloads (Pure)

BRCA1 is a histone-H2A-specific ubiquitin ligase

Kalb, R., Mallery, D. L., Larkin, C., Huang, J. T. J. & Hiom, K., 21 Aug 2014, In : Cell Reports. 8, 4, p. 999-1005 7 p.

Research output: Contribution to journalArticle

Open Access
File
Ligases
Ubiquitin
Histones
Chromatin
Ubiquitin-Protein Ligases
2011
17 Citations (Scopus)

FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells

Kitao, H., Nanda, I., Sugino, R. P., Kinomura, A., Yamazoe, M., Arakawa, H., Schmid, M., Innan, H., Hiom, K. & Takata, M., Jun 2011, In : Genes to Cells. 16, 6, p. 714-727 14 p.

Research output: Contribution to journalArticle

2010
30 Citations (Scopus)

FANCJ: solving problems in DNA replication

Hiom, K., 2 Mar 2010, In : DNA Repair. 9, 3, p. 250-256 7 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

Maertens, G. N., El Messaoudi-Aubert, S., Elderkin, S., Hiom, K. & Peters, G., 4 Aug 2010, In : EMBO Journal. 29, 15, p. 2553-2565 13 p.

Research output: Contribution to journalArticle

2009
304 Citations (Scopus)

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, M. H. & Hiom, K., 21 May 2009, In : Nature. 459, 7245, p. 460-U184 5 p.

Research output: Contribution to journalArticle

2008
139 Citations (Scopus)

FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts

London, T. B. C., Barber, L. J., Mosedale, G., Kelly, G. P., Balasubramanian, S., Hickson, I. D., Boulton, S. J. & Hiom, K., 26 Dec 2008, In : Journal of Biological Chemistry. 283, 52, p. 36132-36139 8 p.

Research output: Contribution to journalArticle

2007
92 Citations (Scopus)

A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin

Elderkin, S., Maertens, G. N., Endoh, M., Mallery, D. L., Morrice, N., Koseki, H., Peters, G., Brockdorff, N. & Hiom, K., 2007, In : Molecular Cell. 28, 1, p. 107-20 14 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Histones
Lysine
Chromatin
2005
338 Citations (Scopus)

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

Levitus, M., Waisfisz, Q., Godthelp, B. C., de Vries, Y., Hussain, S., Wiegant, W. W., Elghalbzouri-Maghrani, E., Steltenpool, J., Rooimans, M. A., Pals, G., Arwert, F., Mathew, C. G., Zdzienicka, M. Z., Hiom, K., De Winter, J. P. & Joenje, H., Sep 2005, In : Nature Genetics. 37, 9, p. 934-935 2 p.

Research output: Contribution to journalArticle

DNA Helicases
Fanconi Anemia
Maintenance
Genome
Mutation
2003
114 Citations (Scopus)

BRCA1-independent ubiquitination of FANCD2

Vandenberg, C. J., Gergely, F., Ong, C. Y., Pace, P., Mallery, D. L., Hiom, K. & Patel, K. J., Jul 2003, In : Molecular Cell. 12, 1, p. 247-254 8 p.

Research output: Contribution to journalArticle

Ubiquitination
Fanconi Anemia Complementation Group D2 Protein
DNA Damage
RING Finger Domains
BRCA1 Protein
2002
208 Citations (Scopus)

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

Mallery, D. L., Vandenberg, C. J. & Hiom, K., 16 Dec 2002, In : EMBO Journal. 21, 24, p. 6755-6762 8 p.

Research output: Contribution to journalArticle

Polyubiquitin
Ubiquitin-Protein Ligases
Chemical activation
Histones
Ubiquitin Thiolesterase
1998
195 Citations (Scopus)

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

Hiom, K. & Gellert, M., Jun 1998, In : Molecular Cell. 1, 7, p. 1011-1019 9 p.

Research output: Contribution to journalArticle

V(D)J Recombination
HMGB1 Protein
DNA Cleavage
Proteins
DNA
399 Citations (Scopus)

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

Hiom, K., Melek, M. & Gellert, M., 21 Aug 1998, In : Cell. 94, 4, p. 463-470 8 p.

Research output: Contribution to journalArticle

V(D)J Recombination
DNA
Genetic Recombination
Proteins
Antigen Receptors
1997
179 Citations (Scopus)

A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

Hiom, K. & Gellert, M., 10 Jan 1997, In : Cell. 88, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

V(D)J Recombination
DNA
Protein Sorting Signals
Genetic Recombination
Proteins
204 Citations (Scopus)

Stimulation of V(D)J cleavage by high mobility group proteins

van Gent, D. C., Hiom, K., Paull, T. T. & Gellert, M., 15 May 1997, In : EMBO Journal. 16, 10, p. 2665-2670 6 p.

Research output: Contribution to journalArticle

High Mobility Group Proteins
Protein Sorting Signals
HMGB2 Protein
V(D)J Recombination
HMGB1 Protein
1996
18 Citations (Scopus)

The directionality of RuvAB-mediated branch migration: in vitro studies with three-armed junctions

Hiom, K., Tsaneva, I. R. & West, S. C., May 1996, In : Genes to Cells. 1, 5, p. 443-451 9 p.

Research output: Contribution to journalArticle

DNA
Cruciform DNA
Deoxyribonucleases
In Vitro Techniques
Oligonucleotides
1995
57 Citations (Scopus)

Branch migration during homologous recombination: assembly of a RuvAB-Holliday junction complex in vitro

Hiom, K. & West, S. C., 10 Mar 1995, In : Cell. 80, 5, p. 787-793 7 p.

Research output: Contribution to journalArticle

Cruciform DNA
Homologous Recombination
DNA
Recombinational DNA Repair
Deoxyribonuclease I
7 Citations (Scopus)

Characterisation of RuvAB-Holliday junction complexes by glycerol gradient sedimentation

Hiom, K. & West, S. C., 25 Sep 1995, In : Nucleic Acids Research. 23, 18, p. 3621-3626 6 p.

Research output: Contribution to journalArticle

Cruciform DNA
Glycerol
Adenosine Triphosphate
Centrifugation
Recombinational DNA Repair
1992
18 Citations (Scopus)

Alleviation of EcoK DNA restriction in Escherichia coli and involvement of umuDC activity

Hiom, K. J. & Sedgwick, S. G., Jan 1992, In : Molecular & General Genetics : MGG. 231, 2, p. 265-275 11 p.

Research output: Contribution to journalArticle

Plasmids
Escherichia coli
Bacteriophage lambda
DNA
Bacteriophages