Hiom, Kevin

Professor, Head of Division of Cellular Medicine

  • 2746 Citations
  • 18 h-Index
1992 …2022
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Research Output 1992 2018

  • 2746 Citations
  • 18 h-Index
  • 20 Article
  • 3 Editorial
  • 2 Review article
  • 1 Letter
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Article
Article
209 Citations (Scopus)

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

Mallery, D. L., Vandenberg, C. J. & Hiom, K., 16 Dec 2002, In : EMBO Journal. 21, 24, p. 6755-6762 8 p.

Research output: Contribution to journalArticle

Polyubiquitin
Ubiquitin-Protein Ligases
Chemical activation
Histones
Ubiquitin Thiolesterase
18 Citations (Scopus)

Alleviation of EcoK DNA restriction in Escherichia coli and involvement of umuDC activity

Hiom, K. J. & Sedgwick, S. G., Jan 1992, In : Molecular & General Genetics : MGG. 231, 2, p. 265-275 11 p.

Research output: Contribution to journalArticle

Plasmids
Escherichia coli
Bacteriophage lambda
DNA
Bacteriophages
93 Citations (Scopus)

A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin

Elderkin, S., Maertens, G. N., Endoh, M., Mallery, D. L., Morrice, N., Koseki, H., Peters, G., Brockdorff, N. & Hiom, K., 2007, In : Molecular Cell. 28, 1, p. 107-20 14 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Histones
Lysine
Chromatin
195 Citations (Scopus)

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

Hiom, K. & Gellert, M., Jun 1998, In : Molecular Cell. 1, 7, p. 1011-1019 9 p.

Research output: Contribution to journalArticle

V(D)J Recombination
HMGB1 Protein
DNA Cleavage
Proteins
DNA
179 Citations (Scopus)

A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

Hiom, K. & Gellert, M., 10 Jan 1997, In : Cell. 88, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

V(D)J Recombination
DNA
Protein Sorting Signals
Genetic Recombination
Proteins
57 Citations (Scopus)

Branch migration during homologous recombination: assembly of a RuvAB-Holliday junction complex in vitro

Hiom, K. & West, S. C., 10 Mar 1995, In : Cell. 80, 5, p. 787-793 7 p.

Research output: Contribution to journalArticle

Cruciform DNA
Homologous Recombination
DNA
Recombinational DNA Repair
Deoxyribonuclease I
115 Citations (Scopus)

BRCA1-independent ubiquitination of FANCD2

Vandenberg, C. J., Gergely, F., Ong, C. Y., Pace, P., Mallery, D. L., Hiom, K. & Patel, K. J., Jul 2003, In : Molecular Cell. 12, 1, p. 247-254 8 p.

Research output: Contribution to journalArticle

Ubiquitination
Fanconi Anemia Complementation Group D2 Protein
DNA Damage
RING Finger Domains
BRCA1 Protein
51 Citations (Scopus)
132 Downloads (Pure)

BRCA1 is a histone-H2A-specific ubiquitin ligase

Kalb, R., Mallery, D. L., Larkin, C., Huang, J. T. J. & Hiom, K., 21 Aug 2014, In : Cell Reports. 8, 4, p. 999-1005 7 p.

Research output: Contribution to journalArticle

Open Access
File
Ligases
Ubiquitin
Histones
Chromatin
Ubiquitin-Protein Ligases
8 Citations (Scopus)
88 Downloads (Pure)

BRCA1 is required for maintenance of phospho-Chk1 and G2/M arrest during DNA cross-link repair in DT40 cells

Draga, M., Madgett, E. B., Vandenberg, C. J., du Plessis, D., Kaufmann, A., Werler, P., Chakraborty, P., Lowndes, N. F. & Hiom, K., Nov 2015, In : Molecular and Cellular Biology. 35, 22, p. 3829-3840 12 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Death
G2 Phase
Maintenance
DNA Repair
DNA
7 Citations (Scopus)

Characterisation of RuvAB-Holliday junction complexes by glycerol gradient sedimentation

Hiom, K. & West, S. C., 25 Sep 1995, In : Nucleic Acids Research. 23, 18, p. 3621-3626 6 p.

Research output: Contribution to journalArticle

Cruciform DNA
Glycerol
Adenosine Triphosphate
Centrifugation
Recombinational DNA Repair
306 Citations (Scopus)

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, M. H. & Hiom, K., 21 May 2009, In : Nature. 459, 7245, p. 460-U184 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
82 Downloads (Pure)

DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing

Chakraborty, P., Huang, J. & Hiom, K., 19 Oct 2018, In : Nature Communications. 9, 9, p. 1-14 14 p., 4346.

Research output: Contribution to journalArticle

Open Access
File
RNA Splicing
splicing
RNA
cells
Chromosome Fragility
400 Citations (Scopus)

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

Hiom, K., Melek, M. & Gellert, M., 21 Aug 1998, In : Cell. 94, 4, p. 463-470 8 p.

Research output: Contribution to journalArticle

V(D)J Recombination
DNA
Genetic Recombination
Proteins
Antigen Receptors
31 Citations (Scopus)

FANCJ: solving problems in DNA replication

Hiom, K., 2 Mar 2010, In : DNA Repair. 9, 3, p. 250-256 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells

Kitao, H., Nanda, I., Sugino, R. P., Kinomura, A., Yamazoe, M., Arakawa, H., Schmid, M., Innan, H., Hiom, K. & Takata, M., Jun 2011, In : Genes to Cells. 16, 6, p. 714-727 14 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts

London, T. B. C., Barber, L. J., Mosedale, G., Kelly, G. P., Balasubramanian, S., Hickson, I. D., Boulton, S. J. & Hiom, K., 26 Dec 2008, In : Journal of Biological Chemistry. 283, 52, p. 36132-36139 8 p.

Research output: Contribution to journalArticle

204 Citations (Scopus)

Stimulation of V(D)J cleavage by high mobility group proteins

van Gent, D. C., Hiom, K., Paull, T. T. & Gellert, M., 15 May 1997, In : EMBO Journal. 16, 10, p. 2665-2670 6 p.

Research output: Contribution to journalArticle

High Mobility Group Proteins
Protein Sorting Signals
HMGB2 Protein
V(D)J Recombination
HMGB1 Protein
18 Citations (Scopus)

The directionality of RuvAB-mediated branch migration: in vitro studies with three-armed junctions

Hiom, K., Tsaneva, I. R. & West, S. C., May 1996, In : Genes to Cells. 1, 5, p. 443-451 9 p.

Research output: Contribution to journalArticle

DNA
Cruciform DNA
Deoxyribonucleases
In Vitro Techniques
Oligonucleotides
338 Citations (Scopus)

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

Levitus, M., Waisfisz, Q., Godthelp, B. C., de Vries, Y., Hussain, S., Wiegant, W. W., Elghalbzouri-Maghrani, E., Steltenpool, J., Rooimans, M. A., Pals, G., Arwert, F., Mathew, C. G., Zdzienicka, M. Z., Hiom, K., De Winter, J. P. & Joenje, H., Sep 2005, In : Nature Genetics. 37, 9, p. 934-935 2 p.

Research output: Contribution to journalArticle

DNA Helicases
Fanconi Anemia
Maintenance
Genome
Mutation
91 Citations (Scopus)

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

Maertens, G. N., El Messaoudi-Aubert, S., Elderkin, S., Hiom, K. & Peters, G., 4 Aug 2010, In : EMBO Journal. 29, 15, p. 2553-2565 13 p.

Research output: Contribution to journalArticle