Read, Kevin

Professor

20082022
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Research Output 2008 2019

2008
39 Citations (Scopus)

Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model

Charlton, S. T., Whetstone, J., Fayinka, S. T., Read, K. D., Illum, L. & Davis, S. S., Jul 2008, In : Pharmaceutical Research. 25, 7, p. 1531-1543 13 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Toward an improved prediction of human in vivo brain penetration

Summerfield, S. G., Lucas, A. J., Porter, R. A., Jeffrey, P., Gunn, R. N., Read, K. R., Stevens, A. J., Metcalf, A. C., Osuna-Cabello, M. C., Kilford, P. J., Passchier, J. & Ruffo, A. D., 2008, In : Xenobiotica. 38, 12, p. 1518-1535 18 p.

Research output: Contribution to journalArticle

2009
74 Citations (Scopus)

Receptor occupancy and brain free fraction

Watson, J., Wright, S., Lucas, A., Clarke, K. L., Viggers, J., Cheetham, S., Jeffrey, P., Porter, R. & Read, K. D., Apr 2009, In : Drug Metabolism and Disposition. 37, 4, p. 753-760 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat

Large, C. H., Kalinichev, M., Lucas, A., Carignani, C., Bradford, A., Garbati, N., Sartori, I., Austin, N. E., Ruffo, A., Jones, D. N. C., Alvaro, G. & Read, K. D., Jul 2009, In : Epilepsy Research. 85, 1, p. 96-106 11 p.

Research output: Contribution to journalArticle

2010
32 Citations (Scopus)

1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors

Micheli, F., Cavanni, P., Arban, R., Benedetti, R., Bertani, B., Bettati, M., Bettelini, L., Bonanomi, G., Braggio, S., Checchia, A., Davalli, S., Di Fabio, R., Fazzolari, E., Fontana, S., Marchioro, C., Minick, D., Negri, M., Oliosi, B., Read, K. D., Sartori, I. & 6 others, Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A. & Zonzini, L., 25 Mar 2010, In : Journal of Medicinal Chemistry. 53, 6, p. 2534-2551 18 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor

Micheli, F., Cavanni, P., Andreotti, D., Arban, R., Benedetti, R., Bertani, B., Bettati, M., Bettelini, L., Bonanomi, G., Braggio, S., Carletti, R., Checchia, A., Corsi, M., Fazzolari, E., Fontana, S., Marchioro, C., Merlo-Pich, E., Negri, M., Oliosi, B., Ratti, E. & 11 others, Read, K. D., Roscic, M., Sartori, I., Spada, S., Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A., Zonzini, L. & Di Fabio, R., 8 Jul 2010, In : Journal of Medicinal Chemistry. 53, 13, p. 4989-5001 13 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
196 Downloads (Pure)

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

Ruda, G. F., Wong, P. E., Alibu, V. P., Norval, S., Read, K. D., Barrett, M. P. & Gilbert, I. H., 2010, In : Journal of Medicinal Chemistry. 53, 16, p. 6071-6078 8 p.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)

Assessing brain free fraction in early drug discovery

Read, K. D. & Braggio, S., Mar 2010, In : Expert Opinion on Drug Metabolism & Toxicology. 6, 3, p. 337-344 8 p.

Research output: Contribution to journalReview article

32 Citations (Scopus)

Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

Dorfmueller, H. C., Borodkin, V. S., Schimpl, M., Zheng, X., Kime, R., Read, K. D. & van Aalten, D. M. F., 24 Nov 2010, In : Chemistry & Biology. 17, 11, p. 1250-1255 6 p.

Research output: Contribution to journalArticle

Central nervous system (CNS) exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous (IV) dosing in mice

Dow, G. S., Milner, E., Caridha, D., Gardner, S., Lanteri, C., Kozar, M., Mannila, A., McCalmont, W., Melendez, V., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Stouten, J., White, K., Zeng, Q. & Charman, S., Nov 2010, p. 213-213. 1 p.

Research output: Contribution to conferenceAbstract

64 Citations (Scopus)

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

Sokolova, A. Y., Wyllie, S., Patterson, S., Oza, S. L., Read, K. D. & Fairlamb, A. H., Jul 2010, In : Antimicrobial Agents and Chemotherapy. 54, 7, p. 2893-2900 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Identification of a kappa-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Jones, D. C., Hallyburton, I., Stojanovski, L., Read, K. D., Frearson, J. A. & Fairlamb, A. H., 15 Nov 2010, In : Biochemical Pharmacology. 80, 10, p. 1478-1486 9 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M. F., Brenk, R. & 6 others, Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G., 1 Apr 2010, In : Nature. 464, 7289, p. 728-732 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat

Kalinichev, M., Bradford, A., Bison, S., Lucas, A., Sartori, I., Garbati, N., Andreetta, F., Bate, S., Austin, N. E., Jones, D. N. C., Read, K. D., Alvaro, G. & Large, C. H., Aug 2010, In : Epilepsia. 51, 8, p. 1543-1551 9 p.

Research output: Contribution to journalArticle

2011
15 Citations (Scopus)

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Dow, G. S., Milner, E., Bathurst, I., Bhonsle, J., Caridha, D., Gardner, S., Gerena, L., Kozar, M., Lanteri, C., Mannila, A., McCalmont, W., Moon, J., Read, K. D., Norval, S., Roncal, N., Shackleford, D. M., Sousa, J., Steuten, J., White, K. L., Zeng, Q. & 1 others, Charman, S. A., 6 Jun 2011, In : Malaria Journal. 10, p. - 11 p., 150.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum

Milner, E., Sousa, J., Pybus, B., Melendez, V., Gardner, S., Grauer, K., Moon, J., Carroll, D., Auschwitz, J., Gettayacamin, M., Lee, P., Leed, S., McCalmont, W., Norval, S., Tungtaeng, A., Zeng, Q., Kozar, M., Read, K. D., Li, Q. & Dow, G., 2011, In : European Journal of Drug Metabolism and Pharmacokinetics. 36, 3, p. 151-158 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2 Downloads (Pure)

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

Spinks, D., Ong, H. B., Mpamhanga, C. P., Shanks, E. J., Robinson, D. A., Collie, I. T., Read, K. D., Frearson, J. A., Wyatt, P. G., Brenk, R., Fairlamb, A. H. & Gilbert, I. H., 7 Feb 2011, In : ChemMedChem. 6, 2, p. 302-308 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
13 Downloads (Pure)

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

Smith, V. C., Cleghorn, L. A. T., Woodland, A., Spinks, D., Hallyburton, I., Collie, I. T., Mok, N. Y., Norval, S., Brenk, R., Fairlamb, A. H., Frearson, J. A., Read, K. D., Gilbert, I. H. & Wyatt, P. G., 4 Oct 2011, In : ChemMedChem. 6, 10, p. 1832-1840 9 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
18 Citations (Scopus)

The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia

Large, C. H., Bison, S., Sartori, I., Read, K. D., Gozzi, A., Quarta, D., Antolini, M., Hollands, E., Gill, C. H., Gunthorpe, M. J., Idris, N., Neill, J. C. & Alvaro, G. S., Jul 2011, In : Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 100-113 14 p.

Research output: Contribution to journalArticle

2012
14 Citations (Scopus)

A comparative study of the CYP450 inhibition potential of marketed drugs using two fluorescence based assay platforms routinely used in the pharmaceutical industry

Kajbaf, M., Longhi, R., Montanari, D., Vinco, F., Rigo, M., Fontano, S. & Read, K. D., 2012, In : Drug Metabolism Letters. 5, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

Drug Industry
Drug interactions
Assays
Microsomes
Fluorescence
383 Citations (Scopus)

Automated design of ligands to polypharmacological profiles

Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Gilbert, I. H., Roth, B. L. & 1 others, Hopkins, A. L., 13 Dec 2012, In : Nature. 492, 7428, p. 215-+ 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs

Gunn, R. N., Summerfield, S. G., Salinas, C. A., Read, K. D., Guo, Q., Searle, G. E., Parker, C. A., Jeffrey, P. & Laruelle, M., May 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 5, p. 874-883 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
6 Downloads (Pure)
72 Citations (Scopus)
373 Downloads (Pure)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
326 Downloads (Pure)

Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo

Hack, K., Reilly, L., Palmer, C., Read, K., Norval, S., Kime, R., Booth, K. & Foerster, J., May 2012, In : PLoS ONE. 7, 5

Research output: Contribution to journalArticle

Open Access
File
psoriasis
Peroxisome Proliferator-Activated Receptors
skin diseases
Psoriasis
Skin Diseases
22 Citations (Scopus)

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Read, K. D., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H., 2012, In : Journal of Medicinal Chemistry. 55, 24, p. 10948-57 10 p.

Research output: Contribution to journalArticle

Antimalarials
Thymidine
dTMP kinase
Urea
Pyrimidine Nucleotides
74 Citations (Scopus)

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

Wyllie, S., Patterson, S., Stojanovski, L., Simeons, F. R. C., Norval, S., Kime, R., Read, K. D. & Fairlamb, A. H., 1 Feb 2012, In : Science Translational Medicine. 4, 119, p. - 7 p., 119re1.

Research output: Contribution to journalArticle

2013
41 Citations (Scopus)

Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I., 2013, In : ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.

Research output: Contribution to journalArticle

Biosensing Techniques
G-Protein-Coupled Receptors
Biosensors
Adrenergic Receptors
Screening
18 Citations (Scopus)

Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents

Murugesan, D., Kaiser, M., White, K. L., Norval, S., Riley, J., Wyatt, P. G., Charman, S. A., Read, K. D., Yeates, C. & Gilbert, I. H., 2013, In : ChemMedChem.

Research output: Contribution to journalArticle

Antimalarials
Structure-Activity Relationship
Parasites
Derivatives
Humulus
28 Citations (Scopus)
Antitubercular Agents
Visceral Leishmaniasis
Leishmania
Nitroreductases
Mycobacterium tuberculosis
2014
16 Citations (Scopus)
85 Downloads (Pure)

C-reactive protein is essential for innate resistance to pneumococcal infection

Simons, J. P., Loeffler, J. M., Al-Shawi, R., Ellmerich, S., Hutchinson, W. L., Tennent, G. A., Petrie, A., Raynes, J. G., de Souza, J. B., Lawrence, R. A., Read, K. D. & Pepys, M. B., Jul 2014, In : Immunology. 142, 3, p. 414-420 7 p.

Research output: Contribution to journalArticle

Open Access
File
Pneumococcal Infections
C-Reactive Protein
Anti-Idiotypic Antibodies
Antibodies
2 Citations (Scopus)

In Vitro and In Vivo studies of trypanocidal activity of dietary isothiocyanates

Steverding, D., Michaels, S. & Read, K. D., 22 Jan 2014, In : Planta Medica.

Research output: Contribution to journalLetter

Isothiocyanates
Trypanosoma brucei brucei
Trypanosomiasis
HL-60 Cells
Parasitemia
30 Citations (Scopus)
53 Downloads (Pure)
Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Sulfonamides
Central Nervous System
Neurologic Mutant Mice
2015
157 Citations (Scopus)

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Luksch, T. & 44 others, Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Belén Jiménez-Díaz, M., Maria Sanz, L., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H., 18 Jun 2015, In : Nature. 522, 7556, p. 315-320 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Development of a fluorescence-based Trypanosoma cruzi CYP51 inhibition assay for effective compound triaging in drug discovery programmes for Chagas disease

Riley, J., Brand, S., Voice, M., Caballero, I., Calvo, D. & Read, K. D., 22 Sep 2015, In : PLoS Neglected Tropical Diseases. 9, 9, 12 p., e0004014.

Research output: Contribution to journalArticle

Chagas Disease
Trypanosoma cruzi
Drug Discovery
Fluorescence
Pharmaceutical Preparations
8 Citations (Scopus)

Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode

Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. & Gilbert, I. H., Nov 2015, In : ChemMedChem. 10, 11, p. 1821-1836 16 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Molecules
Scaffolds
Leishmania major
X ray crystallography
19 Citations (Scopus)

Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei

Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H., 8 Oct 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.

Research output: Contribution to journalArticle

African Trypanosomiasis
Trypanosoma brucei brucei
Brain
Peptide Hydrolases
Central Nervous System
8 Citations (Scopus)

Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H., Nov 2015, In : ChemMedChem. 10, 11, p. 1809-1820 12 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Scaffolds
Protein Kinases
Screening
Growth
2016
25 Citations (Scopus)
76 Downloads (Pure)

Activation of bicyclic nitro-drugs by a novel nitroreductase (NTR2) in Leishmania

Wyllie, S., Roberts, A. J., Norval, S., Patterson, S., Foth, B. J., Berriman, M., Read, K. D. & Fairlamb, A. H., 3 Nov 2016, In : PLoS Pathogens. 12, 11, p. 1-22 22 p., e1005971.

Research output: Contribution to journalArticle

Open Access
File
Nitroreductases
Leishmania
Nitro Compounds
Nifurtimox
Pharmaceutical Preparations
2 Citations (Scopus)

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragaña, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Luksch, T. & 44 others, Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Jiménez-Díaz, M. B., Sanz, L. M., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H., 25 May 2016, In : Nature. 537, 7618, p. 122 1 p.

Research output: Contribution to journalArticle

Antimalarials
Drug Discovery
Biological Science Disciplines
Proteins
corrigendum
21 Citations (Scopus)
114 Downloads (Pure)

Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

Baragaña, B., Norcross, N. R., Wilson, C., Porzelle, A., Hallyburton, I., Grimaldi, R., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Wyatt, P. G., Delves, M. J., Meister, S., Duffy, S., Avery, V. M., Winzeler, E. A., Sinden, R. E., Wittlin, S., Frearson, J. A. & 7 others, Gray, D. W., Fairlamb, A. H., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 10 Nov 2016, In : Journal of Medicinal Chemistry. 59, 21, p. 9672-9685 14 p.

Research output: Contribution to journalArticle

Open Access
File
Peptide Elongation Factor 2
Antimalarials
Plasmodium falciparum
Malaria
Pharmacokinetics
15 Citations (Scopus)

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

Russell, S., Rahmani, R., Jones, A. J., Newson, H. L., Neilde, K., Cotillo, I., Rahmani Khajouei, M., Ferrins, L., Qureishi, S., Nguyen, N., Martinez-Martinez, M. S., Weaver, D. F., Kaiser, M., Riley, J., Thomas, J., De Rycker, M., Read, K. D., Flematti, G. R., Ryan, E., Tanghe, S. & 6 others, Rodriguez, A., Charman, S. A., Kessler, A., Avery, V. M., Baell, J. B. & Piggott, M. J., 10 Nov 2016, In : Journal of Medicinal Chemistry. 59, 21, p. 9686-9720 35 p.

Research output: Contribution to journalArticle

Trypanosomiasis
Neglected Diseases
African Trypanosomiasis
Trypanosoma brucei brucei
Chagas Disease
9 Citations (Scopus)
105 Downloads (Pure)

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

Stoessel, D., Nowell, C. J., Jones, A. J., Ferrins, L., Ellis, K. M., Riley, J., Rahmani, R., Read, K. D., McConville, M. J., Avery, V. M., Baell, J. B. & Creek, D. J., Jul 2016, In : Metabolomics. 12, 7, 14 p., 126.

Research output: Contribution to journalArticle

Open Access
File
Anilides
Trypanosoma brucei brucei
Sphingolipids
Metabolomics
Ceramides
24 Citations (Scopus)
92 Downloads (Pure)

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

Francisco, A. F., Jayawardhana, S., Lewis, M. D., White, K. L., Shackleford, D. M., Chen, G., Saunders, J., Osuna-Cabello, M., Read, K. D., Charman, S. A., Chatelain, E. & Kelly, J. M., 17 Oct 2016, In : Scientific Reports. 6, p. 1-11 11 p., 35351.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma cruzi
Nifurtimox
Sulfones
Chagas Disease
Infection
44 Citations (Scopus)
109 Downloads (Pure)

Potent and selective chemical probe of hypoxic signaling downstream of HIF-α hydroxylation via VHL inhibition

Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. & Ciulli, A., 4 Nov 2016, In : Nature Communications. 7, p. 1-12 12 p., 13312.

Research output: Contribution to journalArticle

Open Access
File
Hydroxylation
hypoxia
probes
Prolyl-Hydroxylase Inhibitors
Prolyl Hydroxylases
30 Citations (Scopus)
111 Downloads (Pure)

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

Patterson, S., Wyllie, S., Norval, S., Stojanovski, L., Simeons, F. R. C., Auer, J. L., Osuna-Cabello, M., Read, K. D. & Fairlamb, A. H., 24 May 2016, In : eLife. 5, p. 1-21 21 p., e09744.

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Visceral Leishmaniasis
Hormesis
Pharmaceutical Preparations
Parasites
Nitroreductases
4 Citations (Scopus)
105 Downloads (Pure)

Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials

Norcross, N. R., Baragana, B., Wilson, C., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Porzelle, A., Grimaldi, R., Wittlin, S., Duffy, S., Avery, V. M., Meister, S., Sanz, L., Jimenez-Diaz, B., Angulo-Barturen, I., Ferrer, S., Santos Marinez, M. & 10 others, Javier Gamo, F., Frearson, J. A., Gray, D. W., Fairlamb, A. H., Winzeler, E. A., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 14 Jul 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6101-6120 20 p.

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Pyrimidines
Antimalarials
Plasmodium falciparum
Malaria
SCID Mice
2017
101 Citations (Scopus)
196 Downloads (Pure)
Open Access
File
Drug Discovery
Public Health
Neglected Diseases
Disease Eradication
African Trypanosomiasis
12 Citations (Scopus)
223 Downloads (Pure)

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

Nakazawa Hewitt, S., Dranow, D. M., Horst, B. G., Abendroth, J. A., Forte, B., Hallyburton, I., Jansen, C., Baragana, B., Choi, R., Rivas, K., Hulverson, M. A., Dumais, M., Edwards, T. E., Lorimer, D. D., Fairlamb, A., Gray, D., Read, K., Lehane, A. M., Kirk, K., Myler, P. J. & 6 others, Wernimont, A., Walpole, C., Stacy, R., Barrett, L., Gilbert, I. H. & Van Voorhis, W. C., 13 Jan 2017, In : ACS Infectious Diseases. 3, 1, p. 34-44 11 p.

Research output: Contribution to journalArticle

Open Access
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Pharmaceutical Chemistry
Plasmodium falciparum
Malaria
Crystallography
X Ray Crystallography