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Read, Kevin

Professor

20082022
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Research Output 2008 2019

2012
383 Citations (Scopus)

Automated design of ligands to polypharmacological profiles

Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Gilbert, I. H., Roth, B. L. & 1 others, Hopkins, A. L., 13 Dec 2012, In : Nature. 492, 7428, p. 215-+ 8 p.

Research output: Contribution to journal › Article

33 Citations (Scopus)

Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs

Gunn, R. N., Summerfield, S. G., Salinas, C. A., Read, K. D., Guo, Q., Searle, G. E., Parker, C. A., Jeffrey, P. & Laruelle, M., May 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 5, p. 874-883 10 p.

Research output: Contribution to journal › Article

28 Citations (Scopus)
6 Downloads (Pure)

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Spinks, D., Torrie, L. S., Thompson, S., Harrison, J. R., Frearson, J. A., Read, K. D., Fairlamb, A. H., Wyatt, P. G. & Gilbert, I. H., 2 Jan 2012, In : ChemMedChem. 7, 1, p. 95-106 12 p.

Research output: Contribution to journal › Article

72 Citations (Scopus)
374 Downloads (Pure)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

Research output: Contribution to journal › Article

Open Access
File
24 Citations (Scopus)
330 Downloads (Pure)

Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo

Hack, K., Reilly, L., Palmer, C., Read, K., Norval, S., Kime, R., Booth, K. & Foerster, J., May 2012, In : PLoS ONE. 7, 5

Research output: Contribution to journal › Article

Open Access
File
psoriasis
Peroxisome Proliferator-Activated Receptors
skin diseases
Psoriasis
Skin Diseases
22 Citations (Scopus)

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Read, K. D., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H., 2012, In : Journal of Medicinal Chemistry. 55, 24, p. 10948-57 10 p.

Research output: Contribution to journal › Article

Antimalarials
Thymidine
dTMP kinase
Urea
Pyrimidine Nucleotides
75 Citations (Scopus)

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

Wyllie, S., Patterson, S., Stojanovski, L., Simeons, F. R. C., Norval, S., Kime, R., Read, K. D. & Fairlamb, A. H., 1 Feb 2012, In : Science Translational Medicine. 4, 119, p. - 7 p., 119re1.

Research output: Contribution to journal › Article

2011
15 Citations (Scopus)

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Dow, G. S., Milner, E., Bathurst, I., Bhonsle, J., Caridha, D., Gardner, S., Gerena, L., Kozar, M., Lanteri, C., Mannila, A., McCalmont, W., Moon, J., Read, K. D., Norval, S., Roncal, N., Shackleford, D. M., Sousa, J., Steuten, J., White, K. L., Zeng, Q. & 1 others, Charman, S. A., 6 Jun 2011, In : Malaria Journal. 10, p. - 11 p., 150.

Research output: Contribution to journal › Article

9 Citations (Scopus)

Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum

Milner, E., Sousa, J., Pybus, B., Melendez, V., Gardner, S., Grauer, K., Moon, J., Carroll, D., Auschwitz, J., Gettayacamin, M., Lee, P., Leed, S., McCalmont, W., Norval, S., Tungtaeng, A., Zeng, Q., Kozar, M., Read, K. D., Li, Q. & Dow, G., 2011, In : European Journal of Drug Metabolism and Pharmacokinetics. 36, 3, p. 151-158 8 p.

Research output: Contribution to journal › Article

25 Citations (Scopus)
2 Downloads (Pure)

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

Spinks, D., Ong, H. B., Mpamhanga, C. P., Shanks, E. J., Robinson, D. A., Collie, I. T., Read, K. D., Frearson, J. A., Wyatt, P. G., Brenk, R., Fairlamb, A. H. & Gilbert, I. H., 7 Feb 2011, In : ChemMedChem. 6, 2, p. 302-308 7 p.

Research output: Contribution to journal › Article

5 Citations (Scopus)
13 Downloads (Pure)

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

Smith, V. C., Cleghorn, L. A. T., Woodland, A., Spinks, D., Hallyburton, I., Collie, I. T., Mok, N. Y., Norval, S., Brenk, R., Fairlamb, A. H., Frearson, J. A., Read, K. D., Gilbert, I. H. & Wyatt, P. G., 4 Oct 2011, In : ChemMedChem. 6, 10, p. 1832-1840 9 p.

Research output: Contribution to journal › Article

56 Citations (Scopus)

Target Validation: Linking Target and Chemical Properties to Desired Product Profile

Wyatt, P. G., Gilbert, I. H., Read, K. D. & Fairlamb, A. H., May 2011, In : Current Topics in Medicinal Chemistry. 11, 10, p. 1275-1283 9 p.

Research output: Contribution to journal › Review article

18 Citations (Scopus)

The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia

Large, C. H., Bison, S., Sartori, I., Read, K. D., Gozzi, A., Quarta, D., Antolini, M., Hollands, E., Gill, C. H., Gunthorpe, M. J., Idris, N., Neill, J. C. & Alvaro, G. S., Jul 2011, In : Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 100-113 14 p.

Research output: Contribution to journal › Article

2010
32 Citations (Scopus)

1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors

Micheli, F., Cavanni, P., Arban, R., Benedetti, R., Bertani, B., Bettati, M., Bettelini, L., Bonanomi, G., Braggio, S., Checchia, A., Davalli, S., Di Fabio, R., Fazzolari, E., Fontana, S., Marchioro, C., Minick, D., Negri, M., Oliosi, B., Read, K. D., Sartori, I. & 6 others, Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A. & Zonzini, L., 25 Mar 2010, In : Journal of Medicinal Chemistry. 53, 6, p. 2534-2551 18 p.

Research output: Contribution to journal › Article

42 Citations (Scopus)

6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor

Micheli, F., Cavanni, P., Andreotti, D., Arban, R., Benedetti, R., Bertani, B., Bettati, M., Bettelini, L., Bonanomi, G., Braggio, S., Carletti, R., Checchia, A., Corsi, M., Fazzolari, E., Fontana, S., Marchioro, C., Merlo-Pich, E., Negri, M., Oliosi, B., Ratti, E. & 11 others, Read, K. D., Roscic, M., Sartori, I., Spada, S., Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A., Zonzini, L. & Di Fabio, R., 8 Jul 2010, In : Journal of Medicinal Chemistry. 53, 13, p. 4989-5001 13 p.

Research output: Contribution to journal › Article

39 Citations (Scopus)
198 Downloads (Pure)

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

Ruda, G. F., Wong, P. E., Alibu, V. P., Norval, S., Read, K. D., Barrett, M. P. & Gilbert, I. H., 2010, In : Journal of Medicinal Chemistry. 53, 16, p. 6071-6078 8 p.

Research output: Contribution to journal › Article

Open Access
File
52 Citations (Scopus)

Assessing brain free fraction in early drug discovery

Read, K. D. & Braggio, S., Mar 2010, In : Expert Opinion on Drug Metabolism & Toxicology. 6, 3, p. 337-344 8 p.

Research output: Contribution to journal › Review article

32 Citations (Scopus)

Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

Dorfmueller, H. C., Borodkin, V. S., Schimpl, M., Zheng, X., Kime, R., Read, K. D. & van Aalten, D. M. F., 24 Nov 2010, In : Chemistry & Biology. 17, 11, p. 1250-1255 6 p.

Research output: Contribution to journal › Article

Central nervous system (CNS) exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous (IV) dosing in mice

Dow, G. S., Milner, E., Caridha, D., Gardner, S., Lanteri, C., Kozar, M., Mannila, A., McCalmont, W., Melendez, V., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Stouten, J., White, K., Zeng, Q. & Charman, S., Nov 2010, p. 213-213. 1 p.

Research output: Contribution to conference › Abstract

65 Citations (Scopus)

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

Sokolova, A. Y., Wyllie, S., Patterson, S., Oza, S. L., Read, K. D. & Fairlamb, A. H., Jul 2010, In : Antimicrobial Agents and Chemotherapy. 54, 7, p. 2893-2900 8 p.

Research output: Contribution to journal › Article

53 Citations (Scopus)

Identification of a kappa-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Jones, D. C., Hallyburton, I., Stojanovski, L., Read, K. D., Frearson, J. A. & Fairlamb, A. H., 15 Nov 2010, In : Biochemical Pharmacology. 80, 10, p. 1478-1486 9 p.

Research output: Contribution to journal › Article

178 Citations (Scopus)

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M. F., Brenk, R. & 6 others, Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G., 1 Apr 2010, In : Nature. 464, 7289, p. 728-732 7 p.

Research output: Contribution to journal › Article

9 Citations (Scopus)

Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat

Kalinichev, M., Bradford, A., Bison, S., Lucas, A., Sartori, I., Garbati, N., Andreetta, F., Bate, S., Austin, N. E., Jones, D. N. C., Read, K. D., Alvaro, G. & Large, C. H., Aug 2010, In : Epilepsia. 51, 8, p. 1543-1551 9 p.

Research output: Contribution to journal › Article

2009
74 Citations (Scopus)

Receptor occupancy and brain free fraction

Watson, J., Wright, S., Lucas, A., Clarke, K. L., Viggers, J., Cheetham, S., Jeffrey, P., Porter, R. & Read, K. D., Apr 2009, In : Drug Metabolism and Disposition. 37, 4, p. 753-760 8 p.

Research output: Contribution to journal › Article

33 Citations (Scopus)

The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat

Large, C. H., Kalinichev, M., Lucas, A., Carignani, C., Bradford, A., Garbati, N., Sartori, I., Austin, N. E., Ruffo, A., Jones, D. N. C., Alvaro, G. & Read, K. D., Jul 2009, In : Epilepsy Research. 85, 1, p. 96-106 11 p.

Research output: Contribution to journal › Article

2008
39 Citations (Scopus)

Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model

Charlton, S. T., Whetstone, J., Fayinka, S. T., Read, K. D., Illum, L. & Davis, S. S., Jul 2008, In : Pharmaceutical Research. 25, 7, p. 1531-1543 13 p.

Research output: Contribution to journal › Article

69 Citations (Scopus)

Toward an improved prediction of human in vivo brain penetration

Summerfield, S. G., Lucas, A. J., Porter, R. A., Jeffrey, P., Gunn, R. N., Read, K. R., Stevens, A. J., Metcalf, A. C., Osuna-Cabello, M. C., Kilford, P. J., Passchier, J. & Ruffo, A. D., 2008, In : Xenobiotica. 38, 12, p. 1518-1535 18 p.

Research output: Contribution to journal › Article