• 282 Citations
  • 5 h-Index
20142018
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Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 8 Similar Profiles
Proteolysis Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
WEB 2086 Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Proteins Chemical Compounds
Degradation Chemical Compounds
Hydroxyproline Medicine & Life Sciences
Ligands Medicine & Life Sciences

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Research Output 2014 2018

  • 282 Citations
  • 5 h-Index
  • 6 Article
  • 1 Review article
1 Citations

3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation

Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation
18 Citations
Open Access
File
WEB 2086
Proteolysis
Ligands
Ubiquitin-Protein Ligases
Myeloid Cells
3 Citations

Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition

Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 9 Mar 2018, In : Chemical Science. 2018, 9, p. 2387-2634 18 p., 2452.

Research output: Contribution to journalArticle

Open Access
File
Benzodiazepines
Leucine
Proteins
Cell proliferation
Valine
62 Citations

Structural basis of PROTAC cooperative recognition for selective protein degradation

Gadd, M., Testa, A., Lucas, X., Chan, K. H., Chen, W., Lamont, D., Zengerle, M. & Ciulli, A., May 2017, In : Nature Chemical Biology. 13, 5, p. 514-521 11 p.

Research output: Contribution to journalArticle

Open Access
File
Proteolysis
Ubiquitin-Protein Ligases
Calorimetry
Ligases
Mutagenesis
9 Citations

Chemical genetics approaches for selective intervention in epigenetics

Runcie, A. C., Chan, K. H., Zengerle, M. & Ciulli, A., Aug 2016, In : Current Opinion in Chemical Biology. 33, p. 186-194 9 p.

Research output: Contribution to journalReview article

Open Access
File
Epigenomics
Genetics
Genes
Modulation
Molecules