• 497 Citations
  • 6 h-Index
20142018
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Fingerprint Dive into the research topics where Kwok Ho Chan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Proteolysis Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
WEB 2086 Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Hydroxyproline Engineering & Materials Science
Proteins Chemical Compounds
Degradation Chemical Compounds
Ligands Medicine & Life Sciences

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Projects 2015 2017

Research Output 2014 2018

  • 497 Citations
  • 6 h-Index
  • 6 Article
  • 1 Review article
17 Citations (Scopus)
79 Downloads (Pure)

3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation

Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation
44 Citations (Scopus)
105 Downloads (Pure)
Open Access
File
WEB 2086
Proteolysis
Ligands
Ubiquitin-Protein Ligases
Myeloid Cells
5 Citations (Scopus)
120 Downloads (Pure)

Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition

Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 7 Mar 2018, In : Chemical Science. 9, 9, p. 2452-2468 17 p., 2452.

Research output: Contribution to journalArticle

Open Access
File
Benzodiazepines
Leucine
Proteins
Cell proliferation
Valine
136 Citations (Scopus)
298 Downloads (Pure)

Structural basis of PROTAC cooperative recognition for selective protein degradation

Gadd, M., Testa, A., Lucas, X., Chan, K. H., Chen, W., Lamont, D., Zengerle, M. & Ciulli, A., May 2017, In : Nature Chemical Biology. 13, 5, p. 514-521 11 p.

Research output: Contribution to journalArticle

Open Access
File
Proteolysis
Ubiquitin-Protein Ligases
Calorimetry
Ligases
Mutagenesis
11 Citations (Scopus)
120 Downloads (Pure)

Chemical genetics approaches for selective intervention in epigenetics

Runcie, A. C., Chan, K. H., Zengerle, M. & Ciulli, A., Aug 2016, In : Current Opinion in Chemical Biology. 33, p. 186-194 9 p.

Research output: Contribution to journalReview article

Open Access
File
Epigenomics
Genetics
Genes
Modulation
Molecules