Projects per year
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
- 8 Similar Profiles
Proteolysis
Medicine & Life Sciences
Ubiquitin-Protein Ligases
Medicine & Life Sciences
WEB 2086
Medicine & Life Sciences
Epigenomics
Medicine & Life Sciences
Proteins
Chemical Compounds
Degradation
Chemical Compounds
Hydroxyproline
Medicine & Life Sciences
Ligands
Medicine & Life Sciences
Projects 2015 2017
- 1 Finished
Bump-BET; Bump and Hole Approach to Ellucidate Function of Individual Bromodomains of BET Proteins (Marie Curie Fellowship)
1/10/15 → 30/09/17
Project: Research
Research Output 2014 2018
8
Citations
(Scopus)
23
Downloads
(Pure)
3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation
Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.Research output: Contribution to journal › Article
Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation
Impact of target warhead and linkage vector on inducing protein degradation: comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds
Chan, K. H., Zengerle, M., Testa, A. & Ciulli, A., 25 Jan 2018, In : Journal of Medicinal Chemistry. 61, 2, p. 504-513 10 p.Research output: Contribution to journal › Article
Open Access
File
WEB 2086
Proteolysis
Ligands
Ubiquitin-Protein Ligases
Myeloid Cells
Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition
Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 9 Mar 2018, In : Chemical Science. 2018, 9, p. 2387-2634 18 p., 2452.Research output: Contribution to journal › Article
Open Access
File
Benzodiazepines
Leucine
Proteins
Cell proliferation
Valine
Structural basis of PROTAC cooperative recognition for selective protein degradation
Gadd, M., Testa, A., Lucas, X., Chan, K. H., Chen, W., Lamont, D., Zengerle, M. & Ciulli, A., May 2017, In : Nature Chemical Biology. 13, 5, p. 514-521 11 p.Research output: Contribution to journal › Article
Open Access
File
Proteolysis
Ubiquitin-Protein Ligases
Calorimetry
Ligases
Mutagenesis
10
Citations
(Scopus)
63
Downloads
(Pure)
Chemical genetics approaches for selective intervention in epigenetics
Runcie, A. C., Chan, K. H., Zengerle, M. & Ciulli, A., Aug 2016, In : Current Opinion in Chemical Biology. 33, p. 186-194 9 p.Research output: Contribution to journal › Review article
Open Access
File
Epigenomics
Genetics
Genes
Modulation
Molecules