Projects per year
Fingerprint Dive into the research topics where Kwok Ho Chan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 4 Similar Profiles
Proteolysis
Medicine & Life Sciences
Ubiquitin-Protein Ligases
Medicine & Life Sciences
WEB 2086
Medicine & Life Sciences
Epigenomics
Medicine & Life Sciences
Hydroxyproline
Engineering & Materials Science
Proteins
Chemical Compounds
Degradation
Chemical Compounds
Ligands
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2014 2018
17
Citations
(Scopus)
79
Downloads
(Pure)
3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation
Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.Research output: Contribution to journal › Article
Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation
Impact of target warhead and linkage vector on inducing protein degradation: comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds
Chan, K. H., Zengerle, M., Testa, A. & Ciulli, A., 25 Jan 2018, In : Journal of Medicinal Chemistry. 61, 2, p. 504-513 10 p.Research output: Contribution to journal › Article
Open Access
File
WEB 2086
Proteolysis
Ligands
Ubiquitin-Protein Ligases
Myeloid Cells
5
Citations
(Scopus)
120
Downloads
(Pure)
Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition
Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 7 Mar 2018, In : Chemical Science. 9, 9, p. 2452-2468 17 p., 2452.Research output: Contribution to journal › Article
Open Access
File
Benzodiazepines
Leucine
Proteins
Cell proliferation
Valine
Structural basis of PROTAC cooperative recognition for selective protein degradation
Gadd, M., Testa, A., Lucas, X., Chan, K. H., Chen, W., Lamont, D., Zengerle, M. & Ciulli, A., May 2017, In : Nature Chemical Biology. 13, 5, p. 514-521 11 p.Research output: Contribution to journal › Article
Open Access
File
Proteolysis
Ubiquitin-Protein Ligases
Calorimetry
Ligases
Mutagenesis
11
Citations
(Scopus)
120
Downloads
(Pure)
Chemical genetics approaches for selective intervention in epigenetics
Runcie, A. C., Chan, K. H., Zengerle, M. & Ciulli, A., Aug 2016, In : Current Opinion in Chemical Biology. 33, p. 186-194 9 p.Research output: Contribution to journal › Review article
Open Access
File
Epigenomics
Genetics
Genes
Modulation
Molecules