Chan, Kwok Ho

Associate Staff, Biological Chemistry and Drug Discovery

526 Citations
7 h-Index

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4 Similar Profiles

Proteolysis Medicine & Life Sciences

Ubiquitin-Protein Ligases Medicine & Life Sciences

WEB 2086 Medicine & Life Sciences

Epigenomics Medicine & Life Sciences

Hydroxyproline Engineering & Materials Science

Proteins Chemical Compounds

Degradation Chemical Compounds

Ligands Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2015 2017

1 Finished

Bump-BET; Bump and Hole Approach to Ellucidate Function of Individual Bromodomains of BET Proteins (Marie Curie Fellowship)

Chan, K. H. & Ciulli, A.

COMMISSION OF THE EUROPEAN COMMUNITIES

1/10/15 → 30/09/17

Project: Research

Research Output 2014 2018

526 Citations
7 h-Index
6 Article
1 Review article

18 Citations (Scopus)

90 Downloads (Pure)

3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation

Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.

Research output: Contribution to journal › Article

Open Access

File

Hydroxyproline

Ubiquitin-Protein Ligases

Proteolysis

Proteins

Degradation

46 Citations (Scopus)

115 Downloads (Pure)

Impact of target warhead and linkage vector on inducing protein degradation: comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds

Chan, K. H., Zengerle, M., Testa, A. & Ciulli, A., 25 Jan 2018, In : Journal of Medicinal Chemistry. 61, 2, p. 504-513 10 p.

Research output: Contribution to journal › Article

Open Access

File

WEB 2086

Proteolysis

Ligands

Ubiquitin-Protein Ligases

Myeloid Cells

8 Citations (Scopus)

131 Downloads (Pure)

Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition

Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 7 Mar 2018, In : Chemical Science. 9, 9, p. 2452-2468 17 p., 2452.

Research output: Contribution to journal › Article

Open Access

File

Benzodiazepines

Leucine

Proteins

Cell proliferation

Valine

146 Citations (Scopus)

309 Downloads (Pure)

Structural basis of PROTAC cooperative recognition for selective protein degradation

Gadd, M., Testa, A., Lucas, X., Chan, K. H., Chen, W., Lamont, D., Zengerle, M. & Ciulli, A., May 2017, In : Nature Chemical Biology. 13, 5, p. 514-521 11 p.

Research output: Contribution to journal › Article

Open Access

File

Proteolysis

Ubiquitin-Protein Ligases

Calorimetry

Ligases

Mutagenesis

12 Citations (Scopus)

132 Downloads (Pure)

Chemical genetics approaches for selective intervention in epigenetics

Runcie, A. C., Chan, K. H., Zengerle, M. & Ciulli, A., Aug 2016, In : Current Opinion in Chemical Biology. 33, p. 186-194 9 p.

Research output: Contribution to journal › Review article

Open Access

File

Epigenomics

Genetics

Genes

Modulation

Molecules