• 554 Citations
  • 7 h-Index
20142018
If you made any changes in Pure these will be visible here soon.

Research Output 2014 2018

  • 554 Citations
  • 7 h-Index
  • 6 Article
  • 1 Review article
2018
18 Citations (Scopus)
102 Downloads (Pure)

3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation

Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation
49 Citations (Scopus)
129 Downloads (Pure)
Open Access
File
WEB 2086
Proteolysis
Ligands
Ubiquitin-Protein Ligases
Myeloid Cells
8 Citations (Scopus)
142 Downloads (Pure)

Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition

Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 7 Mar 2018, In : Chemical Science. 9, 9, p. 2452-2468 17 p., 2452.

Research output: Contribution to journalArticle

Open Access
File
Benzodiazepines
Leucine
Proteins
Cell proliferation
Valine
2017
155 Citations (Scopus)
321 Downloads (Pure)

Structural basis of PROTAC cooperative recognition for selective protein degradation

Gadd, M., Testa, A., Lucas, X., Chan, K. H., Chen, W., Lamont, D., Zengerle, M. & Ciulli, A., May 2017, In : Nature Chemical Biology. 13, 5, p. 514-521 11 p.

Research output: Contribution to journalArticle

Open Access
File
Proteolysis
Ubiquitin-Protein Ligases
Calorimetry
Ligases
Mutagenesis
2016
12 Citations (Scopus)
144 Downloads (Pure)

Chemical genetics approaches for selective intervention in epigenetics

Runcie, A. C., Chan, K. H., Zengerle, M. & Ciulli, A., Aug 2016, In : Current Opinion in Chemical Biology. 33, p. 186-194 9 p.

Research output: Contribution to journalReview article

Open Access
File
Epigenomics
Genetics
Genes
Modulation
Molecules
2015
234 Citations (Scopus)
171 Downloads (Pure)

Selective small molecule induced degradation of the BET bromodomain protein BRD4

Zengerle, M., Chan, K-H. & Ciulli, A., 21 Aug 2015, In : ACS Chemical Biology. 10, 8, p. 1770-1777 8 p.

Research output: Contribution to journalArticle

Open Access
File
Proteolysis
Degradation
Molecules
Ubiquitin-Protein Ligases
Neoplasm Genes
2014
78 Citations (Scopus)

A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Baud, M. G. J., Lin-Shiao, E., Cardote, T., Tallant, C., Pschibul, A., Chan, K-H., Zengerle, M., Garcia, J. R., Kwan, T. T-L., Ferguson, F. M. & Ciulli, A., 31 Oct 2014, In : Science. 346, 6209, p. 638-641 4 p.

Research output: Contribution to journalArticle

Proteins
Epigenomics
Lysine
Chromatin
Cell Culture Techniques