Stojanovski, Laste

Research Output

Research Output per year

2010 2020

• 1442 Citations
• 16 h-Index
• 30 Article

Research Output per year

Research Output per year

Search results

• 2020

  Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

  Harrison, J. R., Sarkar, S., Hampton, S., Riley, J., Stojanovski, L., Sahlberg, C., Appelqvist, P., Erath, J., Mathan, V., Rodriguez, A., Kaiser, M., Pacanowska, D. G., Read, K. D., Johansson, N. G. & Gilbert, I. H., 26 Mar 2020, In : Journal of Medicinal Chemistry. 63, 6, p. 3066-3089 24 p.

  Research output: Contribution to journal › Article › peer-review

  • Trypanosoma cruzi
  • Chagas Disease
  • Central America
  • South America
  • Parasites

• Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

  Thomas, M., De Rycker, M., Wall, R. J., Spinks, D., Epemolu, O., Manthri, S., Norval, S., Osuna-Cabello, M., Patterson, S., Riley, J., Simeons, F. R. C., Stojanovski, L., Thomas, J., Thompson, S., Naylor, C., Fiandor, J. M., Wyatt, P. G., Marco, M., Wyllie, S., Read, K. D. & 2 others, Miles, T. J. & Gilbert, I. H., 10 Sep 2020, In : Journal of Medicinal Chemistry. 63, 17, p. 9523-9539 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Naphthyridines
  • Visceral Leishmaniasis
  • Neglected Diseases
  • Divalent Cations
  • Parasitic Diseases
  17 Downloads (Pure)

• Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

  Thomas, M. G., De Rycker, M., Ajakane, M., Crouch, S. D., Campbell, L., Daugan, A., Fra, G., Guerrero, C., Mackenzie, C. J., MacLean, L., Manthri, S., Martin, F., Norval, S., Osuna-Cabello, M., Riley, J., Shishikura, Y., Miguel-Siles, J., Simeons, F. R. C., Stojanovski, L., Thomas, J. & 7 others, Thompson, S., Velasco, R. F., Fiandor, J. M., Wyatt, P. G., Read, K. D., Gilbert, I. H. & Miles, T. J., 21 Oct 2020, In : RSC Medicinal Chemistry. 11, 10, p. 1168-1177 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • pyrazolo(3,4-d)pyrimidine
  • Visceral Leishmaniasis
  • Developing Countries
  19 Downloads (Pure)
• 2019

  Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

  Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 others, Lowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Visceral Leishmaniasis
  • Leishmania donovani
  • Leishmania major
  • Solubility
  • Standard of Care
  8 Citations (Scopus)

  66 Downloads (Pure)

• Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

  Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J., Edwards, T. E. & 57 others, Hallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H., 2 Apr 2019, In : Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lysine-tRNA Ligase
  • Cryptosporidiosis
  • cladosporin
  • Cryptosporidium parvum
  • Malaria
  20 Citations (Scopus)

  274 Downloads (Pure)

• Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani

  Corpas Lopez, V., Moniz, S., Thomas, M., Wall, R., Torrie, L., Zander-Dinse, D., Tinti, M., Brand, S., Stojanovski, L., Manthri, S., Hallyburton, I., Zuccotto, F., Wyatt, P., De Rycker, M., Horn, D., Ferguson, M., Clos, J., Read, K., Fairlamb, A., Gilbert, I. & 1 others, Wyllie, S., 11 Jan 2019, In : ACS Infectious Diseases. 5, 1, p. 111-122 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • glycylpeptide N-tetradecanoyltransferase
  • Leishmania donovani
  • 2,6-dichloro-N-(difluoromethyl)-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
  • Pharmacology
  • Parasites
  11 Citations (Scopus)

  189 Downloads (Pure)

• Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

  Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Leishmania infantum
  • Visceral Leishmaniasis
  • Proteasome Endopeptidase Complex
  • Leishmania donovani
  • Parasites
  27 Citations (Scopus)

  149 Downloads (Pure)
• 2018

  A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

  Harrison, J. R., Brand, S., Smith, V., Robinson, D. A., Thompson, S., Smith, A., Davies, K., Mok, N., Torrie, L. S., Collie, I., Hallyburton, I., Norval, S., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Brenk, R., Wyatt, P. G., Gilbert, I. H. & Read, K. D., 12 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8374–8389 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • glycylpeptide N-tetradecanoyltransferase
  • African Trypanosomiasis
  • Crystallography
  • Trypanosoma brucei brucei
  • Central Nervous System Diseases
  16 Citations (Scopus)

  192 Downloads (Pure)

• Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

  Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 9 Aug 2018, In : Nature. 560, 7717, p. 192-197 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Visceral Leishmaniasis
  • Cyclin-Dependent Kinases
  • Pharmaceutical Preparations
  • Toxicology
  • Parasites
  39 Citations (Scopus)

  523 Downloads (Pure)

• The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

  Barini, E., Miccoli, A., Tinarelli, F., Mulholland, K., Kadri, H., Khanim, F., Stojanovski, L., Read, K. D., Burness, K., Blow, J. J., Mehellou, Y. & Muqit, M. M. K., 2 Mar 2018, In : ChemBioChem. 19, 5, p. 425-429 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Parkinson Disease Associated Proteins
  • Niclosamide
  • Anthelmintics
  • Protein Kinases
  • Parkinson Disease
  11 Citations (Scopus)

  160 Downloads (Pure)
• 2017

  Chemical Validation of Methionyl tRNA Synthetase (MetRS) as a Druggable Target in Leishmania donovani

  Torrie, L., Brand, S., Robinson, D., Ko, E. J., Stojanovski, L., Simeons, F. R. C., Wyllie, S., Thomas, J., Ellis, L., Osuna-Cabello, M., Epemolu, R., Nuehs, A., Riley, J., MacLean, L., Manthri, S., Read, K., Gilbert, I., Fairlamb, A. & De Rycker, M., Oct 2017, In : ACS Infectious Diseases. 3, 10, p. 718-727 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Methionine-tRNA Ligase
  • Leishmania donovani
  • Leishmania
  • Methionine
  • Animal Models
  7 Citations (Scopus)

  168 Downloads (Pure)

• Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

  Bayliss, T., Robinson, D., Smith, V., Brand, S., McElroy, S., Torrie, L., Mpamhanga, C., Norval, S., Stojanovski, L., Brenk, R., Frearson, J., Read, K., Gilbert, I. & Wyatt, P., 14 Dec 2017, In : Journal of Medicinal Chemistry. 60, 23, p. 9790-9806 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • glycylpeptide N-tetradecanoyltransferase
  • African Trypanosomiasis
  • DDD 85646
  • Brain
  • Pharmaceutical Preparations
  7 Citations (Scopus)

  213 Downloads (Pure)

• Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

  Brand, S., Ko, E. J., Viayna, E., Thompson, S., Spinks, D., Thomas, M., Sandberg, L., Francisco, A. F., Jayawardhana, S., Smith, V. C., Jansen, C., De Rycker, M., Thomas, J., MacLean, L., Osuna-Cabello, M., Riley, J., Scullion, P., Stojanovski, L., Simeons, F. R. C., Epemolu, O. & 16 others, Shishikura, Y., Crouch, S. D., Bakshi, T. S., Nixon, C. J., Reid, I. H., Hill, A. P., Underwood, T. Z., Hindley, S. J., Robinson, S. A., Kelly, J. M., Fiandor, J. M., Wyatt, P. G., Marco, M., Miles, T. J., Read, K. D. & Gilbert, I. H., 14 Sep 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7284-7299 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Triazoles
  • Trypanosoma cruzi
  • Parasites
  • Chagas Disease
  • Nifurtimox
  14 Citations (Scopus)

  189 Downloads (Pure)

• Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis

  Park, Y., Pacitto, A., Bayliss, T., Cleghorn, L. A. T., Wang, Z., Hartman, T., Arora, K., Ioerger, T. R., Sacchettini, J., Rizzi, M., Donini, S., Blundell, T. L., Ascher, D. B., Rhee, K., Breda, A., Zhou, N., Dartois, V., Jonnala, S. R., Via, L. E., Mizrahi, V. & 35 others, Epemolu, O., Stojanovski, L., Simeons, F., Osuna-Cabello, M., Ellis, L., MacKenzie, C. J., Smith, A. R. C., Davis, S. H., Murugesan, D., Buchanan, K. I., Turner, P. A., Huggett, M., Zuccotto, F., Rebollo-Lopez, M. J., Lafuente-Monasterio, M. J., Sanz, O., Diaz, G. S., Lelièvre, J., Ballell, L., Selenski, C., Axtman, M., Ghidelli-Disse, S., Pflaumer, H., Bösche, M., Drewes, G., Freiberg, G. M., Kurnick, M. D., Srikumaran, M., Kempf, D. J., Green, S. R., Ray, P. C., Read, K., Wyatt, P., Barry, C. E. & Boshoff, H. I., 13 Jan 2017, In : ACS Infectious Diseases. 3, 1, p. 18-33 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Indazoles
  • Inosine Monophosphate
  • Sulfonamides
  • Mycobacterium tuberculosis
  • Oxidoreductases
  46 Citations (Scopus)
• 2016

  Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

  Baragaña, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Luksch, T. & 44 others, Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Jiménez-Díaz, M. B., Sanz, L. M., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H., 25 May 2016, In : Nature. 537, 7618, p. 122 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Antimalarials
  • Drug Discovery
  • Biological Science Disciplines
  • Proteins
  2 Citations (Scopus)

• Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

  Baragaña, B., Norcross, N. R., Wilson, C., Porzelle, A., Hallyburton, I., Grimaldi, R., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Wyatt, P. G., Delves, M. J., Meister, S., Duffy, S., Avery, V. M., Winzeler, E. A., Sinden, R. E., Wittlin, S., Frearson, J. A. & 7 others, Gray, D. W., Fairlamb, A. H., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 10 Nov 2016, In : Journal of Medicinal Chemistry. 59, 21, p. 9672-9685 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DDD107498
  • quinoline-4-carboxamide
  • Peptide Elongation Factor 2
  • Antimalarials
  • Plasmodium falciparum
  29 Citations (Scopus)

  209 Downloads (Pure)

• The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

  Patterson, S., Wyllie, S., Norval, S., Stojanovski, L., Simeons, F. R. C., Auer, J. L., Osuna-Cabello, M., Read, K. D. & Fairlamb, A. H., 24 May 2016, In : eLife. 5, p. 1-21 21 p., e09744.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • OPC-67683
  • Visceral Leishmaniasis
  • Hormesis
  • Parasites
  • Pharmaceutical Preparations
  41 Citations (Scopus)

  200 Downloads (Pure)

• Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials

  Norcross, N. R., Baragana, B., Wilson, C., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Porzelle, A., Grimaldi, R., Wittlin, S., Duffy, S., Avery, V. M., Meister, S., Sanz, L., Jimenez-Diaz, B., Angulo-Barturen, I., Ferrer, S., Santos Marinez, M. & 10 others, Javier Gamo, F., Frearson, J. A., Gray, D. W., Fairlamb, A. H., Winzeler, E. A., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 14 Jul 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6101-6120 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pyrimidines
  • Antimalarials
  • Plasmodium falciparum
  • Malaria
  • Cytochrome P-450 Enzyme Inhibitors
  5 Citations (Scopus)

  354 Downloads (Pure)
• 2015

  A novel multiple-stage antimalarial agent that inhibits protein synthesis

  Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Luksch, T. & 44 others, Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Belén Jiménez-Díaz, M., Maria Sanz, L., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H., 18 Jun 2015, In : Nature. 522, 7556, p. 315-320 6 p.

  Research output: Contribution to journal › Article › peer-review
  182 Citations (Scopus)

• Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode

  Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. & Gilbert, I. H., Nov 2015, In : ChemMedChem. 10, 11, p. 1821-1836 16 p.

  Research output: Contribution to journal › Article › peer-review

  • glycylpeptide N-tetradecanoyltransferase
  • Trypanosoma brucei brucei
  • Molecules
  • Scaffolds
  • X ray crystallography
  13 Citations (Scopus)

• Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei

  Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H., 8 Oct 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.

  Research output: Contribution to journal › Article › peer-review

  • indoline
  • African Trypanosomiasis
  • Trypanosoma brucei brucei
  • Brain
  • Peptide Hydrolases
  21 Citations (Scopus)

• Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

  Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H., Nov 2015, In : ChemMedChem. 10, 11, p. 1809-1820 12 p.

  Research output: Contribution to journal › Article › peer-review

  • 1H-pyrazolo(3,4-b)pyridine
  • Trypanosoma brucei brucei
  • Scaffolds
  • Screening
  • Protein Kinases
  9 Citations (Scopus)
• 2014

  Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N -myristoyltransferase inhibitors: Identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human african trypanosomiasis

  Brand, S., Norcross, N. R., Thompson, S., Harrison, J. R., Smith, V. C., Robinson, D. A., Torrie, L. S., McElroy, S. P., Hallyburton, I., Norval, S., Scullion, P., Stojanovski, L., Simeons, F. R. C., Van Aalten, D., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Wyatt, P. G., Gilbert, I. H. & 1 others, Read, K. D., 11 Dec 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 9855-9869 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • glycylpeptide N-tetradecanoyltransferase
  • pyrazole
  • African Trypanosomiasis
  • Trypanosoma brucei brucei
  • Sulfonamides
  34 Citations (Scopus)

  104 Downloads (Pure)
• 2013

  PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

  Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C., 3 Apr 2013, In : EMBO Journal. 32, 7, p. 1008-22 15 p.

  Research output: Contribution to journal › Article › peer-review

  • 1-Phosphatidylinositol 4-Kinase
  • V(D)J Recombination
  • Phosphatidylinositols
  • Cells
  • B-Lymphoid Precursor Cells
  24 Citations (Scopus)

• The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

  Patterson, S., Wyllie, S., Stojanovski, L., Perry, M. R., Simeons, F. R. C., Norval, S., Osuna-Cabello, M., De Rycker, M., Read, K. D. & Fairlamb, A. H., Oct 2013, In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 4699-4706 8 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazine
  • Antitubercular Agents
  • Visceral Leishmaniasis
  • fexinidazole
  • Leishmania
  35 Citations (Scopus)
• 2012

  Automated design of ligands to polypharmacological profiles

  Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Gilbert, I. H., Roth, B. L. & 1 others, Hopkins, A. L., 13 Dec 2012, In : Nature. 492, 7428, p. 215-+ 8 p.

  Research output: Contribution to journal › Article › peer-review
  429 Citations (Scopus)

• Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

  Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  78 Citations (Scopus)

  461 Downloads (Pure)

• The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

  Wyllie, S., Patterson, S., Stojanovski, L., Simeons, F. R. C., Norval, S., Kime, R., Read, K. D. & Fairlamb, A. H., 1 Feb 2012, In : Science Translational Medicine. 4, 119, p. - 7 p., 119re1.

  Research output: Contribution to journal › Article › peer-review
  84 Citations (Scopus)
• 2010

  Identification of a kappa-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

  Jones, D. C., Hallyburton, I., Stojanovski, L., Read, K. D., Frearson, J. A. & Fairlamb, A. H., 15 Nov 2010, In : Biochemical Pharmacology. 80, 10, p. 1478-1486 9 p.

  Research output: Contribution to journal › Article › peer-review
  57 Citations (Scopus)

• N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

  Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M. F., Brenk, R. & 6 others, Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G., 1 Apr 2010, In : Nature. 464, 7289, p. 728-732 7 p.

  Research output: Contribution to journal › Article › peer-review
  193 Citations (Scopus)