Cleghorn, Laura

Dr

  • 455 Citations
  • 8 h-Index
20092019
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Fingerprint Dive into the research topics where Laura Cleghorn is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 85 Similar Profiles
Trypanosoma brucei brucei Medicine & Life Sciences
Mycobacterium tuberculosis Medicine & Life Sciences
Protein Kinases Chemical Compounds
African Trypanosomiasis Medicine & Life Sciences
Electron Transport Complex IV Medicine & Life Sciences
Indazoles Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Thiophenes Medicine & Life Sciences

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Research Output 2009 2019

  • 455 Citations
  • 8 h-Index
  • 13 Article
  • 1 Book/Film/Article review
  • 1 Patent
3 Citations (Scopus)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 othersLowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Leishmania major
Leishmania donovani
Standard of Care
Solubility
1 Citation (Scopus)
65 Downloads (Pure)

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Cleghorn, L., Ray, P., Odingo, J., Kumar, A., Wescott, H., Korkegian, A., Masquelin, T., Lopez Moure, A., Wilson, C., Davis, S., Huggett, M., Turner, P., Smith, A., Epemolu, R., Zuccotto, F., Riley, J., Scullion, S., Shishikura, Y., Ferguson, L., Rullas, J. & 6 othersGuijarro, L., Read, K., Green, S., Hipskind, P., Parish, T. & Wyatt, P., 9 Aug 2018, In : Journal of Medicinal Chemistry. 61, 15, p. 6592-6608 17 p.

Research output: Contribution to journalArticle

Open Access
File
Thiophenes
Morpholinos
Mycobacterium tuberculosis
Electron Transport Complex IV
Structure-Activity Relationship

Correction for Arora et al., "Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis"

Arora, K., Ochoa-Montaño, B., Tsang, P. S., Blundell, T. L., Dawes, S. S., Mizrahi, V., Bayliss, T., Mackenzie, C. J., Cleghorn, L. A. T., Ray, P. C., Wyatt, P. G., Uh, E., Lee, J., Barry, C. E. & Boshoff, H. I., Sep 2017, In : Antimicrobial Agents and Chemotherapy. 61, 9, 1 p., e01429-17 .

Research output: Contribution to journalArticle

29 Citations (Scopus)

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis

Park, Y., Pacitto, A., Bayliss, T., Cleghorn, L. A. T., Wang, Z., Hartman, T., Arora, K., Ioerger, T. R., Sacchettini, J., Rizzi, M., Donini, S., Blundell, T. L., Ascher, D. B., Rhee, K., Breda, A., Zhou, N., Dartois, V., Jonnala, S. R., Via, L. E., Mizrahi, V. & 35 othersEpemolu, O., Stojanovski, L., Simeons, F., Osuna-Cabello, M., Ellis, L., MacKenzie, C. J., Smith, A. R. C., Davis, S. H., Murugesan, D., Buchanan, K. I., Turner, P. A., Huggett, M., Zuccotto, F., Rebollo-Lopez, M. J., Lafuente-Monasterio, M. J., Sanz, O., Diaz, G. S., Lelièvre, J., Ballell, L., Selenski, C., Axtman, M., Ghidelli-Disse, S., Pflaumer, H., Bösche, M., Drewes, G., Freiberg, G. M., Kurnick, M. D., Srikumaran, M., Kempf, D. J., Green, S. R., Ray, P. C., Read, K., Wyatt, P., Barry, C. E. & Boshoff, H. I., 13 Jan 2017, In : ACS Infectious Diseases. 3, 1, p. 18-33 16 p.

Research output: Contribution to journalArticle

Indazoles
Inosine Monophosphate
Sulfonamides
Mycobacterium tuberculosis
Oxidoreductases
17 Citations (Scopus)

Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei

Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H., 8 Oct 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.

Research output: Contribution to journalArticle

African Trypanosomiasis
Trypanosoma brucei brucei
Brain
Peptide Hydrolases
Central Nervous System