Projects per year
Laureano de la Vega is a biochemist graduate from the University of Cordoba (Spain), he finished his PhD in Biochemistry in 2007 obtaining the highest degree, Summa Cum Laude, for his work investigating the molecular mechanisms regulating HIV latency. Following this, he moved to Giessen (Germany) to join the team of Prof. Lienhard Schmitz as a postdoctoral researcher from 2007 to 2013. During that time his research was focused on post-translational modifications of HIPK2, an important regulator of cell growth, cell death and differentiation. In 2013 he moved to Dundee where he started his own group focused on the regulation of stress response pathways in cancer.
Organisms need to be able to adapt to change in order to survive, and certain cellular programs (stress response pathways) have evolved to respond to a dynamic environment. Example of stress responses pathways include p53, NRF2, and HSF1 pathways. Stress responses are by definition acute, and their transient activation help normal cells to cope with cellular stresses. Interestingly, there is a large body of evidence showing that, in contrast to normal cells, cancer cells are constitutively under cellular stress (i.e. DNA damage/replication stress, proteotoxic stress, mitotic stress, metabolic stress, and oxidative stress) and they depend on the sustained activation of cytoprotective stress response pathways to survive.
The essential nature of the stress response pathways in cancer cells makes them attractive targets, and thus, a better understanding of how these pathways are regulated could help identify new ways to modulate stress responses to impair cancer cell survival. In that sense, our lab is focused in obtaining a detailed understanding of stress response pathways and their aberrations in cancer. For that, we are interested not only on key master regulators of stress responses (e.g. NRF2, HSF1 or P53) but as well in the upstream regulatory pathways that modulate their activity (i.e. upstream kinases).
Homeodomain-Interacting Protein Kinases (HIPKs) are a subfamily of the Dual specificity tYrosine Regulated Kinase (DYRK) family of kinases. These kinases function as hubs for a wide variety of stress signals, ranging from DNA damage and hypoxia to reactive oxygen species and metabolic stress. HIPK/DYRKs function as integrators for these stress signals and modulate different downstream pathways in order to allow cells to cope with these situations. Different posttranslational modifications modulate the activity and physiological role of HIPK/DYRKs, and the study of how their activity is regulated in different pathophysiological scenarios is an important line of investigation in cancer research.
Based on the literature and on previous studies from the lab it has become apparent that HIPK/DYRKs can play a dual role in cancer; either inducing apoptosis or promoting cell survival. While the pathways involved in their tumour suppressor role are relatively well studied, the underlying mechanisms mediating their pro-survival function(s) are not well characterised. Specifically, we are interested in i) understanding how this family of kinases is regulated in cancer cells; ii) identifying novel HIPK/DYRK-regulated pro-survival/oncogenic pathways and iii) to identify the basis for such functional duality in cancer, as it will inform us in which type of cancer or under which conditions (i.e. initial stages of cancer versus well stablished cancers) these kinases can support cancer cell survival and tumour growth.
Laureano currently teaches on the MRes Cancer Biology Course as a module lead, and on the BSc (Hons) level 3 Molecular Biology module and as a Journal Club leader.
1/02/17 → 31/01/23
1/04/15 → 31/03/16
1/10/14 → 30/09/15
Casares Perez, L., García, V., Garrido-Rodríguez, M., Millán, E., Collado, J. A., García-Martín, A., Peñarando, J., Calzado, M. A., de la Vega, L. & Muñoz, E., Jan 2020, In : Redox Biology. 28, p. 1-15 15 p., 101321.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile14 Citations (Scopus)99 Downloads (Pure)
Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In : iScience. 23, 10, 48 p., 101638.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile13 Downloads (Pure)
High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In VitroTorrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In : Biomolecules. 10, 10, 16 p., 1365.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile9 Downloads (Pure)
Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In : Redox Biology. 37, p. 1-10 10 p., 101689.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile5 Downloads (Pure)
Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2Morrugares, R., Correa-Sáez, A., Moreno Dorta, R., Garrido-Rodríguez, M., Muñoz, E., de la Vega, L. & Calzado, M. A., Jul 2020, In : Cellular and Molecular Life Sciences. 77, 13, p. 2621-2639 19 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)100 Downloads (Pure)
Erin Hardee (Organiser), Amy Cameron (Contributor), Ali Floyd (Contributor), Senga Robertson-Albertyn (Contributor), Claire Gorby (Contributor), Helge Dorfmueller (Contributor), Julia Marchingo (Contributor), Graham Christie (Contributor), Megan Bergkessel (Contributor), Mathew Jones (Contributor), Jorunn Bos (Contributor), Sarah McKim (Contributor), Piers Hemsley (Contributor), Davide Bulgarelli (Contributor), Edgar Huitema (Contributor), Christopher Henstridge (Contributor), Laureano de la Vega (Contributor), Ros Langston (Contributor), Amy Rogers (Contributor), Charlotte Proby (Contributor), Olga Semenova (Contributor), Carmen Escudero-Martinez (Contributor), Colin Henderson (Contributor), Gillian Smith (Contributor), Dominic Grussu (Contributor), Robin Pflughaupt (Contributor), Giulia Saredi (Contributor), Vanesa Alvarez (Contributor), Beatrice Colon (Contributor), Sharon Matthews (Contributor), Diana Gudynaite (Contributor), Sascha Roth (Contributor), Laura Casares Perez (Contributor), Hugh Nicholson (Contributor), Morven Shuttleworth (Contributor), Vasudha Tandon (Contributor), Richard Smith (Contributor), Rita Moreno Dorta (Contributor), Ryan Kwan (Contributor), Chidozie Ogbonnaya (Contributor), Ayman Banah (Contributor), Claire Ross (Contributor), Fiona Ramage (Contributor) & Xiong Weng (Contributor)27 Jul 2020 → 31 Jul 2020
Activity: Other activity types › Schools engagement
Matthew Jarron (Organiser), Amy Cameron (Organiser), Nicola Morrice (Contributor), Chim Lang (Contributor), Agathe Lermant (Contributor), Cara Nicholson (Contributor), Colin Henderson (Contributor), Ros Langston (Member), Laureano de la Vega (Member), Gillian Smith (Contributor), Daniella Cavellini (Contributor), Andrew Evans (Contributor), Jane Dickson (Contributor), Jacqueline Eccles (Contributor), Ola Epemolu (Contributor), Kevin Read (Contributor), Mattie Pawlowic (Contributor), Matthew Taylor (Contributor), Sarah McKim (Contributor), Henry McSorley (Contributor), Peter Mossey (Contributor), Susan Wyllie (Contributor), Niamh Nic Daeid (Contributor), Seaneen McDougall (Contributor), Ailsa Mackintosh (Contributor), Ali Floyd (Contributor), Catharine Goddard (Contributor), Li Kang (Contributor), James Gemmill (Contributor) & Rolf Black (Contributor)Nov 2020
Activity: Other activity types › Other