Torrie, Leah

Dr

  • 638 Citations
  • 12 h-Index
20092019
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Research Output 2009 2019

  • 638 Citations
  • 12 h-Index
  • 21 Article
  • 2 Book/Film/Article review
  • 2 Comment/debate
  • 1 Review article
2019
17 Downloads (Pure)
Open Access
File
Burkholderia pseudomallei
Adenosine Monophosphate
Anti-Bacterial Agents
Ligands
Enzymes
26 Downloads (Pure)

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Torrie, L., Zuccotto, F., Robinson, D., Gray, D., Gilbert, I. & De Rycker, M., 31 May 2019, In : PLoS ONE. 14, 5, p. 1-16 16 p., e0217828.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Trypanosoma brucei
kinetochores
Trypanosoma brucei brucei
phosphotransferases (kinases)
19 Downloads (Pure)

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

Zmuda, F., Sastry, L., Shepherd, S. M., Jones, D., Scott, A., Craggs, P. D., Cortes, A., Gray, D. W., Torrie, L. S. & De Rycker, M., Sep 2019, In : Antimicrobial Agents and Chemotherapy. 63, 9, p. 1-15 15 p., e00309-19.

Research output: Contribution to journalArticle

Open Access
File
High-Throughput Screening Assays
Proteasome Inhibitors
Trypanosoma cruzi
Proteasome Endopeptidase Complex
Luminescence
1 Citation (Scopus)
102 Downloads (Pure)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J., Edwards, T. E. & 57 others, Hallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H., 2 Apr 2019, In : Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

Research output: Contribution to journalArticle

Open Access
File
Lysine-tRNA Ligase
Cryptosporidiosis
Cryptosporidium parvum
Malaria
Plasmodium falciparum
1 Citation (Scopus)
86 Downloads (Pure)
Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
8 Downloads (Pure)

Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment

Zmuda, F., Shepherd, S. M., Ferguson, M. A. J., Gray, D. W., Torrie, L. S. & De Rycker, M., Oct 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, p. 1-11 11 p., e01082-19.

Research output: Contribution to journalArticle

Open Access
File
Guanosine Diphosphate Mannose
Trypanosoma cruzi
Chagas Disease
Enzymes
Glycoconjugates
2018
6 Citations (Scopus)
75 Downloads (Pure)

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

Harrison, J. R., Brand, S., Smith, V., Robinson, D. A., Thompson, S., Smith, A., Davies, K., Mok, N., Torrie, L. S., Collie, I., Hallyburton, I., Norval, S., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Brenk, R., Wyatt, P. G., Gilbert, I. H. & Read, K. D., 12 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8374–8389 16 p.

Research output: Contribution to journalArticle

Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Crystallography
Central Nervous System Diseases
Peripheral Nervous System
2017
95 Citations (Scopus)
169 Downloads (Pure)
Open Access
File
Drug Discovery
Public Health
Neglected Diseases
Disease Eradication
African Trypanosomiasis
3 Citations (Scopus)
114 Downloads (Pure)

Chemical Validation of Methionyl tRNA Synthetase (MetRS) as a Druggable Target in Leishmania donovani

Torrie, L., Brand, S., Robinson, D., Ko, E. J., Stojanovski, L., Simeons, F. R. C., Wyllie, S., Thomas, J., Ellis, L., Osuna-Cabello, M., Epemolu, R., Nuehs, A., Riley, J., MacLean, L., Manthri, S., Read, K., Gilbert, I., Fairlamb, A. & De Rycker, M., Oct 2017, In : ACS Infectious Diseases. 3, 10, p. 718-727 10 p.

Research output: Contribution to journalArticle

Open Access
File
Methionine-tRNA Ligase
Leishmania donovani
Leishmania
Methionine
Animal Models
3 Citations (Scopus)
116 Downloads (Pure)

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

Bayliss, T., Robinson, D., Smith, V., Brand, S., McElroy, S., Torrie, L., Mpamhanga, C., Norval, S., Stojanovski, L., Brenk, R., Frearson, J., Read, K., Gilbert, I. & Wyatt, P., 14 Dec 2017, In : Journal of Medicinal Chemistry. 60, 23, p. 9790-9806 17 p.

Research output: Contribution to journalArticle

Open Access
File
African Trypanosomiasis
Brain
Pharmaceutical Preparations
glycylpeptide N-tetradecanoyltransferase
DDD 85646
2015
8 Citations (Scopus)

Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode

Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. & Gilbert, I. H., Nov 2015, In : ChemMedChem. 10, 11, p. 1821-1836 16 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Molecules
Scaffolds
Leishmania major
X ray crystallography
14 Citations (Scopus)

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

Fang, W., Robinson, D. A., Raimi, O. G., Blair, D. E., Harrison, J. R., Lockhart, D. E. A., Torrie, L. S., Ruda, G. F., Wyatt, P. G., Gilbert, I. H. & van Aalten, D. M. F., 19 Jun 2015, In : ACS Chemical Biology. 10, 6, p. 1425-1434 10 p.

Research output: Contribution to journalArticle

Open Access
Aspergillus fumigatus
Aspergillus
Cell Wall
Cells
Enzymes
2014
16 Citations (Scopus)
65 Downloads (Pure)

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

Roberts, A. J., Torrie, L. S., Wyllie, S. & Fairlamb, A. H., 15 Apr 2014, In : Biochemical Journal. 459, 2, p. 323-332 10 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma cruzi
Molecular Biology
Trypanosoma brucei brucei
Genes
Trypanosomiasis
28 Citations (Scopus)
43 Downloads (Pure)
Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Sulfonamides
Central Nervous System
Neurologic Mutant Mice
2013
77 Citations (Scopus)

A Lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays

McElroy, S. P., Nomura, T., Torrie, L. S., Warbrick, E., Gartner, U., Wood, G. & McLean, W. H. I., 2013, In : PLoS Biology. 11, 6, e1001593.

Research output: Contribution to journalArticle

nonsense mutation
stop codon
Nonsense Codon
Assays
luciferase
2012
14 Citations (Scopus)

Allosteric competitive inhibitors of the glucose-1-phosphate Thymidylyltransferase (RmlA) from  seudomonas aeruginosa

Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H., 2012, In : ACS Chemical Biology.

Research output: Contribution to journalArticle

glucose-1-phosphate thymidylyltransferase
Rhamnose
Mycobacterium tuberculosis
Pseudomonas aeruginosa
Catalytic Domain
28 Citations (Scopus)
6 Downloads (Pure)
72 Citations (Scopus)
357 Downloads (Pure)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)

IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening

Tidten-Luksch, N., Grimaldi, R., Torrie, L. S., Frearson, J. A., Hunter, W. N. & Brenk, R., 2012, In : PLoS ONE. 7, 4, p. - 16 p., e35792.

Research output: Contribution to journalArticle

2011

Developing small molecule drugs to rescue nonsense mutations in disease-causing genes

Nomura, T., Gartner, U., McElroy, S., Torrie, L., Pourreyron, C., South, A. P., Wood, G., Woodland, A., Frearson, J., Wyatt, P. & McLean, I., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S67-S67 1 p., 397.

Research output: Contribution to journalBook/Film/Article review

34 Citations (Scopus)
7 Downloads (Pure)

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

Cleghorn, L. A. T., Woodland, A., Collie, I. T., Torrie, L. S., Norcross, N., Luksch, T., Mpamhanga, C., Walker, R. G., Mottram, J. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G., 9 Dec 2011, In : ChemMedChem. 6, 12, p. 2214-2224 11 p.

Research output: Contribution to journalArticle

2010

A high-throughput in vitro screen to identify inhibitors of the trypanosoma brucei trypananthione synthethase activity

Kramer, M., Torrie, L., Booker, M., Spinks, D., Barker, R. H., Oza, S., Harris, M., Frearson, J., Collie, I. & Fairlamb, A., Nov 2010, In : American Journal of Tropical Medicine and Hygiene. 83, 5 (Suppl.), p. 323-323 1 p., 1083.

Research output: Contribution to journalBook/Film/Article review

173 Citations (Scopus)

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M. F., Brenk, R. & 6 others, Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G., 1 Apr 2010, In : Nature. 464, 7289, p. 728-732 7 p.

Research output: Contribution to journalArticle

2009
49 Citations (Scopus)

Chemical Validation of Trypanothione Synthetase a potential drug targer for human trypanosomiasis

Torrie, L. S., Wyllie, S., Spinks, D., Oza, S. L., Thompson, S., Harrison, J. R., Gilbert, I. H., Wyatt, P. G., Fairlamb, A. H. & Frearson, J. A., 25 Dec 2009, In : Journal of Biological Chemistry. 284, 52, p. 36137-36145 9 p.

Research output: Contribution to journalArticle