Kang, Li

Dr

  • 1712 Citations
  • 17 h-Index
20062025

Research output per year

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Personal profile

Biography

Dr Kang gained her bachelor’s degree in Chemistry from University of Science and Technology of China in 2001 and moved to the US to continue her graduate school at Case Western Reserve University in Cleveland, Ohio. Dr Kang successfully defended her PhD thesis entitled “Chronic ethanol consumption disrupts both lipid and glucose homeostasis in rat adipose tissue” under the supervision of Professor Laura Nagy in 2007.

Dr Kang had her postdoctoral training with Professor David Wasserman at Vanderbilt University and was appointed as a research faculty member of Vanderbilt University Medical Centre in 2012. She was also the Managing Director of the Metabolic Pathophysiology Core of the Vanderbilt Mouse Metabolic Phenotyping Centre between 2012 and 2014.

Dr Kang moved to the UK and joined the faculty of the University of Dundee in April 2014. In this role, Dr Kang is establishing her independent research on understanding the pathogenesis of insulin resistance, focusing on studying the role of extracellular matrix (ECM) remodelling.

Research interests

My research focuses on understanding the pathogenesis of insulin resistance. Emerging evidence suggests that the extracellular matrix (ECM) is of great potential significance in metabolic regulation and possibly is of pivotal significance for all metabolic diseases. By studying mice with specific mutations or mice overexpressing specific genes, my primary research interest centres on understanding the role of ECM remodelling in the pathogenesis of insulin resistance and identifying novel and cost-effective ECM-centric therapeutic targets for insulin resistance and type 2 diabetes. Insulin action in conscious, unstressed mice is studied by the hyperinsulinemic-euglycemic clamp technique. The research that is ongoing in my lab will provide new opportunities to explore therapeutics for insulin resistance and type 2 diabetes.

Teaching

Lecture teaching:

  • Parmacology of Diabetes Treatment
  • BSc Medical Sciences
  • BMSc Cardiovascular and Diabetes

Research projects:

  • PhD/MSc student supervision
  • BSc honour projects
  • BMSc research projects
  • Summer projects

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Projects

Research Output

  • 1712 Citations
  • 17 h-Index
  • 26 Article
  • 1 Comment/debate
  • 1 Review article

Circulating tissue factor-positive procoagulant microparticles in patients with type 1 diabetes

Zhang, C., Ou, Q., Gu, Y., Cheng, G., Du, R., Yuan, L., Cordiner, R., Kang, D., Zhang, J., Huang, Q., Yu, C., Kang, L., Wang, X., Sun, X., Mo, X., Tian, H., Pearson, E., Meng, W. & Li, S., 3 Jan 2020, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 2819-2828 10 p.

Research output: Contribution to journalArticle

Open Access
File
  • 25 Downloads (Pure)

    CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high fat-fed C57BL/6 mice

    Hasib, A., Hennayake, C., Bracy, D. P., Bugler-Lamb, A-R., Lantier, L., Khan, F., Ashford, M., McCrimmon, R., Wasserman, D. H. & Kang, L., Dec 2019, In : American Journal of Physiology, Endocrinology and Metabolism. 317, 6, p. E973-E983 11 p.

    Research output: Contribution to journalArticle

  • Cytochrome P450 Epoxygenase-Derived Epoxyeicosatrienoic Acids Contribute to Insulin Sensitivity in Mice and in Humans

    Gangadhariah, M. H., Dieckmann, B. W., Lantier, L., Kang, L., Wasserman, D. H., Chiusa, M., Caskey, C. F., Dickerson, J., Luo, P., Capdevila, J. H., Imig, J. D., Yu, C., Pozzi, A. & Luther, J. M., Jun 2017, In : Diabetologia. 60, 6, p. 1066-1075

    Research output: Contribution to journalArticle

    Open Access
    File
  • 11 Citations (Scopus)
    183 Downloads (Pure)

    Adipose extracellular matrix remodelling in obesity and insulin resistance

    Lin, D., Chun, T-H. & Kang, L., 1 Nov 2016, In : Biochemical Pharmacology. 119, p. 8-16 9 p.

    Research output: Contribution to journalComment/debate

    Open Access
    File
  • 46 Citations (Scopus)
    198 Downloads (Pure)

    Integrin-linked kinase in muscle is necessary for the development of insulin resistance in diet-induced obese mice

    Kang, L., Mokshagundam, S., Reuter, B., Lark, D. S., Sneddon, C. C., Hennayake, C., Williams, A. S., Bracy, D. P., James, F. D., Pozzi, A., Zent, R. & Wasserman, D. H., 1 Jun 2016, In : Diabetes. 65, 6, p. 1590-1600 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 14 Citations (Scopus)
    195 Downloads (Pure)

    Activities

    • 2 Examination
    • 2 Membership of committee
    • 1 Editorial activity
    • 1 Schools engagement

    Welfare and Ethical Use of Animals Committee, University of Dundee (External organisation)

    Li Kang (Member)

    2020 → …

    Activity: Membership typesMembership of committee

    Society for Endocrinology (External organisation)

    Li Kang (Chair)

    1 Jan 202031 Dec 2023

    Activity: Membership typesMembership of committee

    External examiner

    Li Kang (Examiner)

    7 Apr 2020

    Activity: Examination typesExamination

    External examiner

    Li Kang (Examiner)

    29 Nov 2019

    Activity: Examination typesExamination

    Biology (Journal)

    Li Kang (Editorial board member)

    2019 → …

    Activity: Publication peer-review and editorial work typesEditorial activity

    Thesis

    The role of Integrin-Linked Kinase in regulating glucose and lipid homeostasis in adipose tissue

    Author: Bugler-Lamb, A., 2020

    Supervisor: Kang, L. (Supervisor) & Ashford, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy