Projects per year
Personal profile
Biography
Dr Kang gained her bachelor’s degree in Chemistry from University of Science and Technology of China in 2001 and moved to the US to continue her graduate school at Case Western Reserve University in Cleveland, Ohio. Dr Kang successfully defended her PhD thesis entitled “Chronic ethanol consumption disrupts both lipid and glucose homeostasis in rat adipose tissue” under the supervision of Professor Laura Nagy in 2007.
Dr Kang had her postdoctoral training with Professor David Wasserman at Vanderbilt University and was appointed as a research faculty member of Vanderbilt University Medical Centre in 2012. She was also the Managing Director of the Metabolic Pathophysiology Core of the Vanderbilt Mouse Metabolic Phenotyping Centre between 2012 and 2014.
Dr Kang moved to the UK and joined the faculty of the University of Dundee in April 2014. In this role, Dr Kang is establishing her independent research on understanding the pathogenesis of insulin resistance, focusing on studying the role of extracellular matrix (ECM) remodelling.
Research interests
My research focuses on understanding the pathogenesis of insulin resistance. Emerging evidence suggests that the extracellular matrix (ECM) is of great potential significance in metabolic regulation and possibly is of pivotal significance for all metabolic diseases. By studying mice with specific mutations or mice overexpressing specific genes, my primary research interest centres on understanding the role of ECM remodelling in the pathogenesis of insulin resistance and identifying novel and cost-effective ECM-centric therapeutic targets for insulin resistance and type 2 diabetes. Insulin action in conscious, unstressed mice is studied by the hyperinsulinemic-euglycemic clamp technique. The research that is ongoing in my lab will provide new opportunities to explore therapeutics for insulin resistance and type 2 diabetes.
Teaching
Lecture teaching:
- Parmacology of Diabetes Treatment
- BSc Medical Sciences
- BMSc Cardiovascular and Diabetes
Research projects:
- PhD/MSc student supervision
- BSc honour projects
- BMSc research projects
- Summer projects
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Defining Stromal Biology In The Pathogenesis Of Oesophageal Cancer To Create A Novel Biomarker Signature To Aid Diagnosis, Prognosis And Treatment Strategies
Kang, L. (Investigator), McLean, M. H. (Investigator) & Walsh, S. (Investigator)
15/05/23 → 14/07/25
Project: Research
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The Extracellular Matrix (ECM) Remodelling And Receptor Activation Drives Adipose Tissue Malfunction In Obesity (Lead: UoD other instn: University of Edinburgh)
Ashford, M. (Investigator) & Kang, L. (Investigator)
11/07/22 → 10/07/25
Project: Research
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Quantification of Cardiac Fibrosis by Stain-Free Histology in Obese Insulin Resistant Mice
Kang, L. (Investigator)
Project: Research
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Role Of Hyaluronan, CD44 And RHAMM In Obesity Related Kidney Disease - Summer Studentship
Kang, L. (Investigator)
Project: Research
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O-Linked β-N-acetylglucosamine (O-GlcNAc) modification: emerging pathogenesis and a therapeutic target of diabetic nephropathy
Qi, B., Chen, Y., Chai, S., Lu, X. & Kang, L., Feb 2025, In: Diabetic Medicine. 42, 2, 15 p., 15436.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)82 Downloads (Pure) -
(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway
Li, S., Zhang, J., Zhao, Y., Kang, L., Jie, H. (Lead / Corresponding author) & Dong, B. (Lead / Corresponding author), 31 Oct 2024, In: Frontiers in Pharmacology. 15, 1453647, 15 p., 1453647.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Downloads (Pure) -
Corrigendum: (Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway
Li, S., Zhang, J., Zhao, Y., Kang, L., Jie, H. (Lead / Corresponding author) & Dong, B. (Lead / Corresponding author), 13 Dec 2024, In: Frontiers in Pharmacology. 15, 2 p., 1532331.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Downloads (Pure) -
Deletion of CD44 promotes adipogenesis by regulating PPARγ and cell cycle-related pathways
Weng, X., Jiang, H., Walker, D. J., Zhou, H., Lin, D., Wang, J. & Kang, L. (Lead / Corresponding author), Jul 2024, In: Journal of Endocrinology. 262, 1, 15 p., e240079.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)156 Downloads (Pure) -
Downregulation of the (pro)renin receptor alleviates ferroptosis-associated cardiac pathological changes via the NCOA 4-mediated ferritinophagy pathway in diabetic cardiomyopathy
Zhang, X., Dong, X., Jie, H., Li, S., Li, H., Su, Y., Li, L., Kang, L., Dong, B. (Lead / Corresponding author) & Zhang, Y. (Lead / Corresponding author), 10 Sept 2024, In: International Immunopharmacology. 138, 15 p., 112605.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus)
Prizes
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School of Medicine Equality, Diversity and Inclusion Award 2023-24
Kang, L. (Recipient), 19 Mar 2024
Prize: Prize (including medals and awards)
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The Dundee Difference Awards 2023-24
Kang, L. (Recipient), 18 Jan 2024
Prize: Prize (including medals and awards)
Activities
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European Association for the Study of Diabetes Annual Scientific Meeting in Madrid, Spain (selected oral presentation)
Kang, L. (Speaker)
1 Sept 2024Activity: Talk or presentation types › Oral presentation
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Diabetes UK Grant Review Panel (External organisation)
Kang, L. (Member)
29 Nov 2024Activity: Membership types › Membership of panel