Projects per year
Personal profile
Biography
Dr Kang gained her bachelor’s degree in Chemistry from University of Science and Technology of China in 2001 and moved to the US to continue her graduate school at Case Western Reserve University in Cleveland, Ohio. Dr Kang successfully defended her PhD thesis entitled “Chronic ethanol consumption disrupts both lipid and glucose homeostasis in rat adipose tissue” under the supervision of Professor Laura Nagy in 2007.
Dr Kang had her postdoctoral training with Professor David Wasserman at Vanderbilt University and was appointed as a research faculty member of Vanderbilt University Medical Centre in 2012. She was also the Managing Director of the Metabolic Pathophysiology Core of the Vanderbilt Mouse Metabolic Phenotyping Centre between 2012 and 2014.
Dr Kang moved to the UK and joined the faculty of the University of Dundee in April 2014. In this role, Dr Kang is establishing her independent research on understanding the pathogenesis of insulin resistance, focusing on studying the role of extracellular matrix (ECM) remodelling.
Research interests
My research focuses on understanding the pathogenesis of insulin resistance. Emerging evidence suggests that the extracellular matrix (ECM) is of great potential significance in metabolic regulation and possibly is of pivotal significance for all metabolic diseases. By studying mice with specific mutations or mice overexpressing specific genes, my primary research interest centres on understanding the role of ECM remodelling in the pathogenesis of insulin resistance and identifying novel and cost-effective ECM-centric therapeutic targets for insulin resistance and type 2 diabetes. Insulin action in conscious, unstressed mice is studied by the hyperinsulinemic-euglycemic clamp technique. The research that is ongoing in my lab will provide new opportunities to explore therapeutics for insulin resistance and type 2 diabetes.
Teaching
Lecture teaching:
- Parmacology of Diabetes Treatment
- BSc Medical Sciences
- BMSc Cardiovascular and Diabetes
Research projects:
- PhD/MSc student supervision
- BSc honour projects
- BMSc research projects
- Summer projects
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Ultra-High Definition Imaging - MRC Equipment Grant
Alessi, D., Banerjee, S., Cantley, J., Corner, G., Hayes, J., Hoskins, P., Kang, L., McNeilly, A., McSorley, H., Murdoch, C. & Rena, G.
1/11/22 → 31/03/23
Project: Research
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Institutional Strategic Support Fund (2016)
Cantrell, D., Dinkova-Kostova, A., Kang, L., Murray, P. & Pearson, E.
1/10/16 → 31/05/23
Project: Research
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The membrane receptor CD44: novel insights into metabolism
Weng, X., Maxwell-Warburton, S., Hasib, A., Ma, L. & Kang, L., 1 May 2022, In: Trends in Endocrinology and Metabolism. 33, 5, p. 318-332 15 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile9 Citations (Scopus)21 Downloads (Pure) -
Adipocyte Integrin-Linked Kinase Plays a Key Role in the Development of Diet-Induced Adipose Insulin Resistance in Male Mice
Bugler-Lamb, A. R., Hasib, A., Weng, X., Hennayake, C. K., Lin, C., McCrimmon, R. J., Stimson, R. H., Ashford, M. L. J., Wasserman, D. H. & Kang, L., Jul 2021, In: Molecular Metabolism. 49, 13 p., 101197.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)83 Downloads (Pure) -
Chronic effects of an antifibrotic agent pirfenidone on insulin sensitivity and cardiac function in high-fat diet induced insulin-resistant mice
Musale, V., Hennayake, C. K., Murdoch, C. E. & Kang, L., 29 Sep 2021, In: Diabetologia. 64, SUPPL 1, p. 212-213 413.Research output: Contribution to journal › Meeting abstract › peer-review
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Deletion of CD44 promotes adipogenesis and insulin signalling in adipocytes
Weng, X., Hennayake, C. K. & Kang, L., 1 Sep 2021, In: Diabetologia. 64, suppl. 1, p. 67-68 2 p., 124.Research output: Contribution to journal › Meeting abstract › peer-review
2 Citations (Scopus) -
A big-data approach to understanding metabolic rate and response to obesity in laboratory mice
Corrigan, J. K., Ramachandran, D., He, Y., Palmer, C. J., Jurczak, M. J., Chen, R., Li, B., Friedline, R. H., Kim, J. K., Ramsey, J. J., Lantier, L., McGuinness, O. P. & Banks, A. S., 1 May 2020, In: eLife. 9, 28 p., e53560.Research output: Contribution to journal › Article › peer-review
Open Access29 Citations (Scopus)
Activities
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Equality Diversity and Inclusion (Organisational unit)
Li Kang (Chair)
1 Apr 2022 → …Activity: Membership types › Membership of committee
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European Association for the Study of Diabetes conference 2022
Li Kang (Speaker)
19 Sep 2022 → 23 Sep 2022Activity: Participating in or organising an event types › Participation in conference
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PEGPH20 Attenuates Hyaluronan-CD44 Mediated Renal Injury in Obesity-Related Glomerulopathy
Li Kang (Speaker)
22 Sep 2022Activity: Talk or presentation types › Oral presentation