Li Kang

Personal profile

Biography

Dr Kang gained her bachelor’s degree in Chemistry from University of Science and Technology of China in 2001 and moved to the US to continue her graduate school at Case Western Reserve University in Cleveland, Ohio. Dr Kang successfully defended her PhD thesis entitled “Chronic ethanol consumption disrupts both lipid and glucose homeostasis in rat adipose tissue” under the supervision of Professor Laura Nagy in 2007.

Dr Kang had her postdoctoral training with Professor David Wasserman at Vanderbilt University and was appointed as a research faculty member of Vanderbilt University Medical Centre in 2012. She was also the Managing Director of the Metabolic Pathophysiology Core of the Vanderbilt Mouse Metabolic Phenotyping Centre between 2012 and 2014.

Dr Kang moved to the UK and joined the faculty of the University of Dundee in April 2014. In this role, Dr Kang is establishing her independent research on understanding the pathogenesis of insulin resistance, focusing on studying the role of extracellular matrix (ECM) remodelling.

Research interests

My research focuses on understanding the pathogenesis of insulin resistance. Emerging evidence suggests that the extracellular matrix (ECM) is of great potential significance in metabolic regulation and possibly is of pivotal significance for all metabolic diseases. By studying mice with specific mutations or mice overexpressing specific genes, my primary research interest centres on understanding the role of ECM remodelling in the pathogenesis of insulin resistance and identifying novel and cost-effective ECM-centric therapeutic targets for insulin resistance and type 2 diabetes. Insulin action in conscious, unstressed mice is studied by the hyperinsulinemic-euglycemic clamp technique. The research that is ongoing in my lab will provide new opportunities to explore therapeutics for insulin resistance and type 2 diabetes.

Teaching

Lecture teaching:

Parmacology of Diabetes Treatment
BSc Medical Sciences
BMSc Cardiovascular and Diabetes

Research projects:

PhD/MSc student supervision
BSc honour projects
BMSc research projects
Summer projects

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Projects

2 Not started
2 Active
7 Finished

Targeting Early Extracellular Matrix Abnormalities to Treat Cardiac Insulin Resistance and Associated Dysfunction (Joint with University of Glasgow)

Kang, L. & Lang, C.

British Heart Foundation

6/03/19 → 5/03/22

Project: Research

Institutional Strategic Support Fund (2016)

Cantrell, D., Dinkova-Kostova, A., Kang, L., Murray, P. & Pearson, E.

Wellcome Trust

1/10/16 → 31/03/25

Project: Research

Generating Evidence that RABEP2 is a Novel GSK3 Substrate that Represents a Single Therapeutic Target to Reduce Both Hyperglycemia and Microvascular Disease in Diabetes (joint with Glasgow Uni)

Kang, L., Khan, F., Murdoch, C. & Sutherland, C.

British Heart Foundation

1/06/20 → 31/05/23

Project: Research

Quantification of Cardiac Fibrosis by Stain-Free Histology in Obese Insulin Resistant Mice

Kang, L.

Project: Research

Meformin-Associated B12 Deficiency and Cognitive Function in Type 2 Diabetes

Doney, A., Kang, L., McCrimmon, R. & Pearson, E.

1/09/19 → 29/02/20

Project: Research

Research Output

1712 Citations
17 h-Index
26 Article
1 Comment/debate
1 Review article

Circulating tissue factor-positive procoagulant microparticles in patients with type 1 diabetes

Zhang, C., Ou, Q., Gu, Y., Cheng, G., Du, R., Yuan, L., Cordiner, R., Kang, D., Zhang, J., Huang, Q., Yu, C., Kang, L., Wang, X., Sun, X., Mo, X., Tian, H., Pearson, E., Meng, W. & Li, S., 3 Jan 2020, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 2819-2828 10 p.

Research output: Contribution to journal › Article

Open Access

File

25 Downloads (Pure)

CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high fat-fed C57BL/6 mice

Hasib, A., Hennayake, C., Bracy, D. P., Bugler-Lamb, A-R., Lantier, L., Khan, F., Ashford, M., McCrimmon, R., Wasserman, D. H. & Kang, L., Dec 2019, In : American Journal of Physiology, Endocrinology and Metabolism. 317, 6, p. E973-E983 11 p.

Research output: Contribution to journal › Article

Cytochrome P450 Epoxygenase-Derived Epoxyeicosatrienoic Acids Contribute to Insulin Sensitivity in Mice and in Humans

Gangadhariah, M. H., Dieckmann, B. W., Lantier, L., Kang, L., Wasserman, D. H., Chiusa, M., Caskey, C. F., Dickerson, J., Luo, P., Capdevila, J. H., Imig, J. D., Yu, C., Pozzi, A. & Luther, J. M., Jun 2017, In : Diabetologia. 60, 6, p. 1066-1075

Research output: Contribution to journal › Article

Open Access

File

11 Citations (Scopus)

183 Downloads (Pure)

Adipose extracellular matrix remodelling in obesity and insulin resistance

Lin, D., Chun, T-H. & Kang, L., 1 Nov 2016, In : Biochemical Pharmacology. 119, p. 8-16 9 p.

Research output: Contribution to journal › Comment/debate

Open Access

File

46 Citations (Scopus)

198 Downloads (Pure)

Integrin-linked kinase in muscle is necessary for the development of insulin resistance in diet-induced obese mice

Kang, L., Mokshagundam, S., Reuter, B., Lark, D. S., Sneddon, C. C., Hennayake, C., Williams, A. S., Bracy, D. P., James, F. D., Pozzi, A., Zent, R. & Wasserman, D. H., 1 Jun 2016, In : Diabetes. 65, 6, p. 1590-1600 11 p.

Research output: Contribution to journal › Article

Open Access

File