Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors
Eadsforth, T. C., Torrie, L. S., Rowland, P., Edgar, E. V., MacLean, L. M., Paterson, C., Robinson, D. A., Shepherd, S. M., Thomas, J., Thomas, M., Gray, D., Postis, V. & De Rycker, M. (Lead / Corresponding author), Jan 2025, In: Journal of Biological Chemistry. 301, 1, 17 p., 108049.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)110 Downloads (Pure) -
Structure-activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi
Thomas, M., Dunne, J., Dodd, P. G., D’Oria, E., Frame, L., Garcia-Perez, A., McGonagle, K., Manzano-Chinchon, P., MacLean, L., Paterson, C., Riley, J., Thomas, J., Torrie, L. S., Wrobel, K., Read, K., Marco, M. (Lead / Corresponding author) & De Rycker, M. (Lead / Corresponding author), 1 Sept 2025, In: RSC Medicinal Chemistry. 16, 9, p. 4135-4153 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile106 Downloads (Pure) -
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity
Izquierdo, M., Lin, D., O'Neill, S., Webster, L. A., Paterson, C., Thomas, J., Aguado, M. E., Colina Araújo, E., Alpízar-Pedraza, D., Joji, H., MacLean, L., Hope, A., Gray, D. W., Zoltner, M., Field, M. C., González-Bacerio, J. (Lead / Corresponding author) & De Rycker, M. (Lead / Corresponding author), 15 Feb 2024, In: PLoS Neglected Tropical Diseases. 18, 2, 20 p., e0011956.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)133 Downloads (Pure) -
Validation of Trypanosoma cruzi inactivation techniques for laboratory use
MacLean, L. M. (Lead / Corresponding author), Ariyanayagam, M., Sastry, L., Paterson, C., De Rycker, M. & Fairlamb, A. H. (Lead / Corresponding author), 18 Apr 2024, In: PLoS ONE. 19, 4, 12 p., e0300021.Research output: Contribution to journal › Article › peer-review
Open AccessFile108 Downloads (Pure) -
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis (Nature, (2018), 560, 7717, (192-197), 10.1038/s41586-018-0356-z)
Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P. & Albrecht, S. & 12 others, , 4 Jul 2023, In: Nature. 619, p. E48 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access
Prizes
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DNDi Project of the Year 2023
De Rycker, M. (Recipient), Bell, S. (Recipient), Cookson, A. (Recipient), MacLean, L. (Recipient), Paterson, C. (Recipient), Riley, J. (Recipient), Thomas, J. (Recipient), Thompson, S. (Recipient), Torrie, L. (Recipient), Wyllie, S. (Recipient), De Sousa Paradela, L. (Recipient), Cookson, K. (Recipient), Gardner, E. (Recipient), Hughes, F. (Recipient), Sharma, K. (Recipient) & Swan, L. (Recipient), 6 Oct 2023
Prize: Prize (including medals and awards)
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Industry and Academic Collaboration Award
De Rycker, M. (Recipient), Gilbert, I. (Recipient), Read, K. (Recipient), Wyllie, S. (Recipient), Wyatt, P. (Recipient), Gray, D. (Recipient), Thomas, M. (Recipient), Brand, S. (Recipient), McGonagle, K. (Recipient), Dodd, P. (Recipient), Dunne, J. (Recipient), MacLean, L. (Recipient), Thomas, J. (Recipient), Manthri, S. (Recipient), Paterson, C. (Recipient), Stojanovski, L. (Recipient), Pinto, E. (Recipient), Ferguson, L. (Recipient), Simeons, F. (Recipient), Torrie, L. (Recipient), Robinson, D. (Recipient), Riley, J. (Recipient), Frame, L. (Recipient), Garcia Sanchez, M. (Recipient), Da Silva Pacheco, J. (Recipient), Miles, T. (Recipient), Fiandor, J. M. (Recipient), Martin, J. J. (Recipient), Marco, M. (Recipient), Gonzalez, S. (Recipient), Cantizani, J. (Recipient), Cotillo, I. (Recipient) & Manzano, M. P. (Recipient), 12 Apr 2023
Prize: Prize (including medals and awards)