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Sampaio Guther, Lucia

Dr

  • United Kingdom

  • 1586 Citations
  • 23 h-Index
1992 …2019

Research output per year

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Research Output

  • 1586 Citations
  • 23 h-Index
  • 36 Article
  • 3 Chapter (peer-reviewed)
  • 2 Meeting abstract
2019
Open Access
File
1 Citation (Scopus)
60 Downloads (Pure)
2018

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Kelner, A., Tinti, M., Guther, M., Foth, B. J., Chappell, L., Berriman, M., Cowling, V. & Ferguson, M., 24 Jul 2018, In : PLoS ONE. 13, 7, p. 1-14 14 p., e0201263.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
113 Downloads (Pure)
2017
Open Access
File
4 Citations (Scopus)
175 Downloads (Pure)
2016

A gene of the β3-glycosyltransferase family encodes N-acetylglucosaminyltransferase II function in Trypanosoma brucei

Damerow, M., Graalfs, F., Guther, M. L. S., Mehlert, A., Izquierdo, L. & Ferguson, M. A. J., 24 Jun 2016, In : Journal of Biological Chemistry. 291, 26, p. 13834-13845 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
146 Downloads (Pure)
2014
Open Access
File
53 Citations (Scopus)
127 Downloads (Pure)

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei

Damerow, M., Rodrigues, J. A., Wu, D., Güther, M. L. S., Mehlert, A. & Ferguson, M. A. J., 28 Mar 2014, In : Journal of Biological Chemistry. 289, 13, p. 9328-9339 12 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
120 Downloads (Pure)
2013

Creation and characterization of glycosyltransferase mutants of trypanosoma brucei

Izquierdo, L., Güther, M. L. S. & Ferguson, M. A. J., 2013, Glycosyltransferases. Brockhausen, I. (ed.). Humana Press, p. 249-275 27 p. (Methods in Molecular Biology; vol. 1022).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

6 Citations (Scopus)
2012

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

Urbaniak, M. D., Guther, M. L. S. & Ferguson, M. A. J., 2012, In : PLoS ONE. 7, 5, p. - 8 p., e36619.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase

Bandini, G., Marino, K., Güther, M. L. S., Wernimont, A. K., Kuettel, S., Qiu, W., Afzal, S., Kelner, A., Hui, R. & Ferguson, M. A. J., 2012, In : Molecular Microbiology. 85, 3, p. 513-534 22 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei

Kuettel, S., Wadum, M. C. T., Guther, M. L. S., Marino, K., Riemer, C. & Ferguson, M. A. J., Apr 2012, In : Molecular Microbiology. 84, 2, p. 340-351 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2011

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei

Marino, K., Guther, M. L. S., Wernimont, A. K., Qiu, W., Hui, R. & Ferguson, M. A. J., Jul 2011, In : Eukaryotic Cell. 10, 7, p. 985-997 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2010

Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase

Marino, K., Guther, M. L. S., Wernimont, A. K., Amani, M., Hui, R. & Ferguson, M. A. J., Dec 2010, In : Glycobiology. 20, 12, p. 1619-1630 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects

Price, H. P., Guther, M. L. S., Ferguson, M. A. J. & Smith, D. F., Jan 2010, In : Molecular and Biochemical Parasitology. 169, 1, p. 55-58 4 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M. F., Brenk, R. & 6 others, Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G., 1 Apr 2010, In : Nature. 464, 7289, p. 728-732 7 p.

Research output: Contribution to journalArticle

184 Citations (Scopus)
2009

Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases

Izquierdo, L., Schulz, B. L., Rodrigues, J. A., Guther, M. L. S., Procter, J. B., Barton, G. J., Aebi, M. & Ferguson, M. A. J., 2 Sep 2009, In : EMBO Journal. 28, 17, p. 2650-2661 12 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
2008

Deletion of the TbALG3 gene demonstrates site-specific N-glycosylation and N-glycan processing in Trypanosoma brucei

Manthri, S., Guther, M. L. S., Izquierdo, L., Acosta-Serrano, A. & Ferguson, M. A. J., May 2008, In : Glycobiology. 18, 5, p. 367-383 17 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Sugar nucleotide metabolism and compartmentation in Trypanosoma brucei: new insights from UDP-GlcNAc and UDP-Glc biosynthesis

Marino, K., Guther, M. L. S. & Ferguson, M., Nov 2008, In : Glycobiology. 18, 11, p. 946-946 1 p.

Research output: Contribution to journalMeeting abstract

2005
55 Citations (Scopus)

The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number

Roper, J. R., Guther, M. L. S., MacRae, J. I., Prescott, A. R., Hallyburton, I., Acosta-Serrano, A. & Ferguson, M. A. J., 20 May 2005, In : Journal of Biological Chemistry. 280, 20, p. 19728-19736 9 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)
2003
16 Citations (Scopus)
86 Citations (Scopus)
2001

Acyl-CoA binding protein is essential in bloodstream form Trypanosoma brucei

Milne, K. G., Guther, M. L. S. & Ferguson, M. A. J., Feb 2001, In : Molecular and Biochemical Parasitology. 112, 2, p. 301-304 4 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Purification, cloning and characterization of a GPI inositol deacylase from Trypanosoma brucei

Güther, M. L. S., Leal, S., Morrice, N. A., Cross, G. A. M. & Ferguson, M. A. J., 2001, In : The EMBO Journal. 20, 17, p. 4923-4934 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2000

Cloning, complementation and expression of UDP glucose 4 ' epimerase from Trypanosoma brucei and T-cruzi

Roper, J. R., Milne, K. G., Guther, M. L. S. & Ferguson, M. A. J., Oct 2000, In : Glycobiology. 10, 10 (Supplement), p. 1124-1124 1 p.

Research output: Contribution to journalMeeting abstract

1999

The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness

Ferguson, M. A. J., Brimacombe, J. S., Brown, J. R., Crossman, A., Dix, A., Field, R. A., Guther, M. L. S., Milne, K. G., Sharma, D. K. & Smith, T. K., 1999, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1455, 2-3, p. 327-340 14 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)
1998

Analysis of the carbohydrate and lipid components of glycosylphosphatidylinositol structures

Treumann, A., Güther, M. L., Schneider, P. & Ferguson, M. A. J., 1998, Glycoanalysis protocols . Hounsell, E. F. (ed.). Totowa: Humana Press, p. 213-235 23 p. (Methods in Molecular Biology; vol. 76).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

12 Citations (Scopus)
1997

Hydrophobic mannosides act as acceptors for trypanosome α-mannosyltransferases

Brown, J. R., Güther, M. L. S., Field, R. A. & Ferguson, M. A., Jun 1997, In : Glycobiology. 7, 4, p. 549-558 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1995
16 Citations (Scopus)

The role of inositol acylation and inositol deacylation in GPI biosynthesis in Trypanosoma brucei

Guther, M. L. S. & Ferguson, M. A. J., 1 Jan 1995, In : EMBO Journal. 14, 13, p. 3080-3093 14 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)
1994

Glycosyl-phosphatidylinositol molecules of the parasite and the host

Ferguson, M. A. J., Brimacombe, J. S., Cottaz, S., Field, R. A., Guther, L. S., Homans, S. W., McConville, M. J., Mehlert, A., Milne, K. G., Ralton, J. E., Roy, Y. A., Schneider, P. & Zitzmann, N., 1994, In : Parasitology. 108, Suppl. 1, p. S45-54 10 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

The detection of phospholipase-resistant and -sensitive glycosyl-phosphatidylinositol membrane anchors by Western blotting

Guther, M. L. S., de Almeida, M. L. C., Rosenberry, T. L. & Ferguson, M. A. J., 1994, In : Analytical Biochemistry. 219, 2, p. 249-255 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodeling in African trypanosomes

Güther, M. L. S., Masterson, W. J. & Ferguson, M. A. J., 15 Jul 1994, In : Journal of Biological Chemistry. 269, 28, p. 18694-18701 8 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
5 Citations (Scopus)
1993

The mechanism of inhibition of glycosylphosphatidylinositol anchor biosynthesis in Trypanosoma brucei by mannosamine

Ralton, J. E., Milne, K., Güther, M. L. S., Field, R. A. & Ferguson, M. A. J., 1993, In : Journal of Biological Chemistry. 268, 32, p. 24183-24189 7 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

The microanalysis of glycosyl-phosphatidylinositol glycans

Güther, M. L. & Ferguson, M. A. J., 1993, Glycoprotein analysis in biomedicine . Hounsell, E. F. (ed.). Totowa: Humana Press, p. 99-117 19 p. (Methods in Molecular Biology; vol. 14).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

8 Citations (Scopus)
1992

Structural studies on the glycosylphosphatidylinositol membrane anchor of Trypanosoma cruzi 1G7-antigen: The structure of the glycan core

Guther, M. L. S., de Almeida, M. L. C., Yoshida, N. & Ferguson, M. A. J., 5 Apr 1992, In : Journal of Biological Chemistry. 267, 10, p. 6820-6828 9 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)