Swamy, Mahima

Dr

  • Principal Investigator and Sir Henry Dale Fellow, MRC PPU
20142022
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Research Output 2015 2019

2019

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Chen, Y., Vandereyken, M., Newton, I., Moraga Gonzalez, I., Nathke, I. & Swamy, M., 26 Nov 2019, In : PLoS Biology. 17, 11, 23 p., e3000540.

Research output: Contribution to journalArticle

Open Access
Adenomatous Polyposis Coli
interleukins
epithelial cells
cytokines
Epithelial Cells
2017
10 Citations (Scopus)
92 Downloads (Pure)

Control of amino-acid transport coordinates metabolic reprogramming in T cell malignancy

Grzes, K. M., Swamy, M., Hukelmann, J. L., Emslie, E., Sinclair, L. V. & Cantrell, D. A., 26 May 2017, In : Leukemia. 31, p. 2771-2779 9 p.

Research output: Contribution to journalArticle

Open Access
File
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphocytes
Amino Acids
Large Neutral Amino Acid-Transporter 1
Leucine
2016
50 Citations (Scopus)
162 Downloads (Pure)

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

Swamy, M., Beck-Garcia, K., Beck-Garcia, E., Hartl, F. A., Morath, A., Yousefi, O. S., Dopfer, E. P., Molnár, E., Schulze, A. K., Blanco, R., Borroto, A., Martín-Blanco, N., Alarcon, B., Höfer, T., Minguet, S. & Schamel, W. W. A., 17 May 2016, In : Immunity. 44, 5, p. 1091-1101 11 p.

Research output: Contribution to journalArticle

Open Access
File
T-Cell Antigen Receptor
Cholesterol
Phosphorylation
Allosteric Regulation
Adaptive Immunity
92 Citations (Scopus)
107 Downloads (Pure)

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F. & Cantrell, D. A., Jun 2016, In : Nature Immunology. 17, 6, p. 712-720 9 p.

Research output: Contribution to journalArticle

Open Access
File
Glutamine
T-Lymphocytes
Glucose
Glycosyltransferases
Neoplasms
2015
30 Citations (Scopus)

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

Swamy, M., Abeler-Dörner, L., Chettle, J., Mahlakõiv, T., Goubau, D., Chakravarty, P., Ramsay, G., Reis e Sousa, C., Staeheli, P., Blacklaws, B. A., Heeney, J. L. & Hayday, A. C., 19 May 2015, In : Nature Communications. 6, 12 p., 7090.

Research output: Contribution to journalArticle

Lymphocytes
lymphocytes
Lymphocyte Activation
Antiviral Agents
interferon