Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Defining the Role of Interleukin-33 in Gastrointestinal Fibrosis as a New Treatment Target for Crohn's Disease (PhD Studentship)
McLean, M. H. (Investigator) & McSorley, H. (Investigator)
Project: Research
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Assessing Interleukin-33 Effects On Human Eosinophils - A Mechanism In Fibrotic Diseases - Vacation Studentship
McLean, M. H. (Investigator)
Project: Research
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Interleukin-33 is a Novel Treatment Target for Inflammatory Bowel Disease (Transfer)
McLean, M. H. (Investigator)
Project: Research
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Interleukin-27 as a New Therapy for Acute Severe Inflammatory Bowel Disease (PhD Studentship - Transfer)
McLean, M. H. (Investigator)
Project: Research
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Identifying Novel Treatment Targets For Bile Acid Diarrhoea Through Interrogation Of Targeted Epithelial Barrier Disease Mechanisms And Discovery Science Proteomics In Human Gut Organoid Models - Joint with Imperial College, London
Arthur, S. (Investigator) & McLean, M. H. (Investigator)
1/09/23 → 28/02/26
Project: Research
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Characterising interleukin-27 (IL-27) responses in human blood derived macrophage cells
Helps, T., Baker, C. P., Arthur, S., Murray, G. I., Wilson, H. M. & McLean, M. H. (Lead / Corresponding author), Feb 2026, In: Cytokine. 198, 12 p., 157097.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)11 Downloads (Pure) -
The secondary bile acid, lithocholic acid, inhibits cystic fibrosis transmembrane conductance regulator expression and activity in colonic epithelial cells
Curley, C. E., Mobbs, C. L., Mroz, M. S., McLean, M. H. & Keely, S. J. (Lead / Corresponding author), Feb 2026, In: American Journal of Physiology - Gastrointestinal and Liver Physiology (AJP - Gastrointestinal and Liver Physiology). 330, 2, p. G110-G122 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett’s esophagus through progression to cancer
Lin, M.-L., Hickey, J. W., Passman, A., Carlotti, E., Devkumar, S., Derwa, Y. H., ChinAleong, J., Hackett, R. J., Evans, J., Sangwan, V., Novelli, M. R., Justo, M. R., Wright, N. A., Jansen, M., Underwood, T. J., Huang, S., Gascard, P., McLean, M. H., Schürch, C. M. & Tlsty, T. D. & 3 others, , 12 Jun 2025, BioRxiv, 35 p.Research output: Working paper/Preprint › Preprint
File34 Downloads (Pure) -
British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025
IBD guideline development group, Moran, G. W., Gordon, M., Sinopolou, V., Radford, S. J., Darie, A. M., Vuyyuru, S. K., Alrubaiy, L., Arebi, N., Blackwell, J., Butler, T. D., Chew, T., Colwill, M., Cooney, R., De Marco, G., Din, S., Din, S., Feakins, R., Gasparetto, M. & Gordon, H. & 17 others, , 23 Jun 2025, In: Gut. 74, p. s1-s101 101 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile72 Link opens in a new tab Citations (Scopus)393 Downloads (Pure) -
An investigation of the clinical impact and therapeutic relevance of a DNA damage immune response (DDIR) signature in patients with advanced gastroesophageal adenocarcinoma
Baxter, M. A. (Lead / Corresponding author), Spender, L. C., Cairns, D., Walsh, S., Oparka, R., Porter, R. J., Bray, S., Skinner, G., King, S., Turbitt, J., Collinson, D., Miedzybrodzka, Z. H., Jellema, G., Logan, G., Kennedy, R. D., Turkington, R. C., McLean, M. H., Swinson, D., Grabsch, H. I. & Lord, S. & 3 others, , May 2024, In: ESMO open. 9, 5, 12 p., 103450.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)122 Downloads (Pure)
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Evotec and Bristol Myers Squibb Research Science day
McLean, M. H. (Speaker)
3 Jul 2024 → 5 Jul 2024Activity: Talk or presentation types › Oral presentation
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Glasgow Gastro Conference
McLean, M. H. (Chair)
13 Sept 2024Activity: Participating in or organising an event types › Participation in conference
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Cutaneous Crohn's disease
McLean, M. H. (Invited speaker)
9 May 2024Activity: Talk or presentation types › Oral presentation
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Pathology Grand Round Lectures - 'Organoid modelling of the gastrointestinal epithelial barrier in GI diseases – Mechanisms of injury and repair'
McLean, M. H. (Speaker)
19 Dec 2024Activity: Talk or presentation types › Invited talk
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Crohn's and Colitis UK Research Awards Committee (External organisation)
McLean, M. H. (Chair)
1 Feb 2024 → 1 Feb 2027Activity: Membership types › Membership of panel