Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Manu De Rycker is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Wellcome Centre for Anti-Infectives Research
Cook, S. (Investigator), De Rycker, M. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator), Pawlowic, M. C. (Investigator), Read, K. (Investigator), Wyatt, P. (Investigator) & Wyllie, S. (Investigator)
1/04/17 → 31/03/25
Project: Research
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Development of a Preclinical Candidate for Chagas Disease That Acts Through Inhibition of Trypanosoma Cruzi Squalene Synthase
Bodkin, M. (Investigator), De Rycker, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator) & Read, K. (Investigator)
Project: Research
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Enabling Cryptococcal Meningitis Drug Discovery: Development Of Cryptococcus Screening Cascade And Identification Of High Quality Starting Points For Drug Discovery (Joint with GSK Tres Cantos Open Lab Foundation)
De Rycker, M. (Investigator) & Gilbert, I. (Investigator)
16/01/23 → 15/01/25
Project: Research
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Organoid High-Throughput Screening Platform For Cryptosporidiosis (Lead: UoD other instns: University of Arizona)
De Rycker, M. (Investigator), Gilbert, I. (Investigator) & Pawlowic, M. C. (Investigator)
1/04/22 → 31/12/24
Project: Research
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Elucidating molecular determinants of Trypanosoma cruzi persisters (New Investigator Research Grant) (Joint with the University of Glasgow)
De Rycker, M. (Investigator)
1/12/20 → 30/11/24
Project: Research
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Short-course combination treatment for experimental chronic Chagas disease
González, S., Wall, R. J., Thomas, J., Braillard, S., Brunori, G., Camino Díaz, I., Cantizani, J., Carvalho, S., Castañeda Casado, P., Chatelain, E., Cotillo, I., Fiandor, J. M., Francisco, A. F., Grimsditch, D., Keenan, M., Kelly, J. M., Kessler, A., Luise, C., Lyon, J. J. & MacLean, L. & 10 others, , 13 Dec 2023, In: Science Translational Medicine. 15, 726, 17 p., adg8105.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)93 Downloads (Pure) -
Structure Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors
Thomas, M. G., McGonagle, K., Rowland, P., Robinson, D. A., Dodd, P. G., Camino-Díaz, I., Campbell, L., Cantizani, J., Castañeda, P., Conn, D., Craggs, P. D., Edwards, D., Ferguson, L., Fosberry, A., Frame, L., Goswami, P., Hu, X., Korczynska, J., MacLean, L. & Martin, J. & 21 others, , 10 Aug 2023, In: Journal of Medicinal Chemistry. 66, 15, p. 10413-10431 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)111 Downloads (Pure) -
Anti-trypanosomatid drug discovery: progress and challenges
De Rycker, M., Wyllie, S., Horn, D., Read, K. D. & Gilbert, I. H. (Lead / Corresponding author), 31 Jan 2023, In: Nature Reviews Microbiology. 21, p. 35-50 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile85 Citations (Scopus)160 Downloads (Pure) -
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity
Izquierdo, M., Lin, D., O'Neill, S., Webster, L. A., Paterson, C., Thomas, J., Aguado, M. E., Colina Araújo, E., Alpízar-Pedraza, D., Joji, H., MacLean, L., Hope, A., Gray, D. W., Zoltner, M., Field, M. C., González-Bacerio, J. (Lead / Corresponding author) & De Rycker, M. (Lead / Corresponding author), 15 Feb 2024, In: PLoS Neglected Tropical Diseases. 18, 2, 20 p., e0011956.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)61 Downloads (Pure) -
Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors
Eadsforth, T., Torrie, L., Rowland, P., Edgar, E. V., MacLean, L., Paterson, C., Robinson, D. A., Shepherd, S. M., Thomas, J., Thomas, M., Gray, D., Postis, V. & De Rycker, M. (Lead / Corresponding author), 3 Dec 2024, (E-pub ahead of print) In: Journal of Biological Chemistry. 108049.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Modelling data for: Short-course combination treatment for experimental chronic Chagas disease
González Del Valle, S. (Creator), Zuccotto, F. (Creator), Luise, C. (Creator), Wyllie, S. (Creator) & De Rycker, M. (Creator), Dryad, 14 Dec 2023
DOI: 10.5061/dryad.95x69p8r7, https://datadryad.org/stash/dataset/doi:10.5061/dryad.95x69p8r7
Dataset
Prizes
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Industry and Academic Collaboration Award
De Rycker, M. (Recipient), Gilbert, I. (Recipient), Read, K. (Recipient), Wyllie, S. (Recipient), Wyatt, P. (Recipient), Gray, D. (Recipient), Thomas, M. (Recipient), Brand, S. (Recipient), McGonagle, K. (Recipient), Dodd, P. (Recipient), Dunne, J. (Recipient), MacLean, L. (Recipient), Thomas, J. (Recipient), Manthri, S. (Recipient), Paterson, C. (Recipient), Stojanovski, L. (Recipient), Pinto, E. (Recipient), Ferguson, L. (Recipient), Simeons, F. (Recipient), Torrie, L. (Recipient), Robinson, D. (Recipient), Riley, J. (Recipient), Frame, L. (Recipient), Garcia Sanchez, M. (Recipient), Da Silva Pacheco, J. (Recipient), Miles, T. (Recipient), Fiandor, J. M. (Recipient), Martin, J. J. (Recipient), Marco, M. (Recipient), Gonzalez, S. (Recipient), Cantizani, J. (Recipient), Cotillo, I. (Recipient) & Manzano, M. P. (Recipient), 12 Apr 2023
Prize: Prize (including medals and awards)
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DNDi Project of the Year 2023
De Rycker, M. (Recipient), Bell, S. (Recipient), Cookson, A. (Recipient), MacLean, L. (Recipient), Paterson, C. (Recipient), Riley, J. (Recipient), Thomas, J. (Recipient), Thompson, S. (Recipient), Torrie, L. (Recipient), Wyllie, S. (Recipient), De Sousa Paradela, L. (Recipient), Cookson, K. (Recipient), Gardner, E. (Recipient), Hughes, F. (Recipient), Sharma, K. (Recipient) & Swan, L. (Recipient), 6 Oct 2023
Prize: Prize (including medals and awards)
Activities
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Short-course combination treatment for experimental chronic Chagas disease.
De Rycker, M. (Speaker)
27 Feb 2024Activity: Talk or presentation types › Invited talk
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CIFAR Fungal Kingdom (FKG) Antifungal Workshop
De Rycker, M. (Participant)
6 Oct 2024Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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eLife (Journal)
De Rycker, M. (Peer reviewer)
8 Aug 2024Activity: Publication peer-review and editorial work types › Publication peer-review
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Cell Chemical Biology (Journal)
De Rycker, M. (Peer reviewer)
4 Apr 2024Activity: Publication peer-review and editorial work types › Publication peer-review
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Drug Discovery in Academic-industry partnership
De Rycker, M. (Speaker)
17 Sept 2024Activity: Talk or presentation types › Invited talk