Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 4 Quality Education -
SDG 8 Decent Work and Economic Growth
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Collaborations and top research areas from the last five years
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Development of a Preclinical Candidate for Chagas Disease That Acts Through Inhibition of Trypanosoma Cruzi Squalene Synthase
Bodkin, M. (Investigator), De Rycker, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator) & Read, K. (Investigator)
1/04/25 → 30/09/27
Project: Research
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Enabling Cryptococcal Meningitis Drug Discovery: Development Of Cryptococcus Screening Cascade And Identification Of High Quality Starting Points For Drug Discovery (Joint with GSK Tres Cantos Open Lab Foundation)
De Rycker, M. (Investigator) & Gilbert, I. (Investigator)
16/01/23 → 31/03/25
Project: Research
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Organoid High-Throughput Screening Platform For Cryptosporidiosis (Lead: UoD other instns: University of Arizona)
De Rycker, M. (Investigator), Gilbert, I. (Investigator) & Pawlowic, M. C. (Investigator)
1/04/22 → 31/12/24
Project: Research
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Elucidating molecular determinants of Trypanosoma cruzi persisters (New Investigator Research Grant) (Joint with the University of Glasgow)
De Rycker, M. (Investigator)
1/12/20 → 30/11/24
Project: Research
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Wellcome Centre for Anti-Infectives Research
Baragana, B. (Investigator), Cook, S. (Investigator), De Rycker, M. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator), Lee, M. (Investigator), Pawlowic, M. C. (Investigator), Read, K. (Investigator), Wyatt, P. (Investigator) & Wyllie, S. (Investigator)
1/04/17 → 1/04/25
Project: Research
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Short-course combination treatment for experimental chronic Chagas disease
González, S., Wall, R. J., Thomas, J., Braillard, S., Brunori, G., Camino Díaz, I., Cantizani, J., Carvalho, S., Castañeda Casado, P., Chatelain, E., Cotillo, I., Fiandor, J. M., Francisco, A. F., Grimsditch, D., Keenan, M., Kelly, J. M., Kessler, A., Luise, C., Lyon, J. J. & MacLean, L. & 10 others, , 13 Dec 2023, In: Science Translational Medicine. 15, 726, 17 p., adg8105.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Link opens in a new tab Citations (Scopus)185 Downloads (Pure) -
Structure Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors
Thomas, M. G., McGonagle, K., Rowland, P., Robinson, D. A., Dodd, P. G., Camino-Díaz, I., Campbell, L., Cantizani, J., Castañeda, P., Conn, D., Craggs, P. D., Edwards, D., Ferguson, L., Fosberry, A., Frame, L., Goswami, P., Hu, X., Korczynska, J., MacLean, L. & Martin, J. & 21 others, , 10 Aug 2023, In: Journal of Medicinal Chemistry. 66, 15, p. 10413-10431 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Link opens in a new tab Citations (Scopus)307 Downloads (Pure) -
Anti-trypanosomatid drug discovery: progress and challenges
De Rycker, M., Wyllie, S., Horn, D., Read, K. D. & Gilbert, I. H. (Lead / Corresponding author), 31 Jan 2023, In: Nature Reviews Microbiology. 21, p. 35-50 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile129 Link opens in a new tab Citations (Scopus)273 Downloads (Pure) -
Decoding efficacy and resistance space at a drug binding site
Altmann, S., Mendoza Martinez, C., Ridgway, M., Tinti, M., Saini, J., Ibrahim, P. E. G. F., Thomas, M., De Rycker, M., Bodkin, M. J. & Horn, D., 4 Feb 2026, (E-pub ahead of print) In: Nature Communications. 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Biophysical analysis of an oligomerization-attenuated variant of the Leishmania donovani dynamin-1-like protein
Wuyts, E., Sundaramoorthy, R., Tulloch, L., Monsieurs, P., Eadsforth, T., Pintelon, I., Timmermans, J.-P., Dujardin, J.-C., Domagalska, M. A., Caljon, G., De Rycker, M., Postis, V., Wyllie, S. & Sterckx, Y.G.-J. (Lead / Corresponding author), Sept 2025, In: Molecular and Biochemical Parasitology. 263, 111691.Research output: Contribution to journal › Article › peer-review
Open AccessFile124 Downloads (Pure)
Datasets
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Modelling data for: Short-course combination treatment for experimental chronic Chagas disease
González Del Valle, S. (Creator), Zuccotto, F. (Creator), Luise, C. (Creator), Wyllie, S. (Creator) & De Rycker, M. (Creator), Dryad, 14 Dec 2023
DOI: 10.5061/dryad.95x69p8r7, https://datadryad.org/stash/dataset/doi:10.5061/dryad.95x69p8r7 and one more link, https://zenodo.org/records/10386313 (show fewer)
Dataset
Prizes
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Industry and Academic Collaboration Award
De Rycker, M. (Recipient), Gilbert, I. (Recipient), Read, K. (Recipient), Wyllie, S. (Recipient), Wyatt, P. (Recipient), Gray, D. (Recipient), Thomas, M. (Recipient), Brand, S. (Recipient), McGonagle, K. (Recipient), Dodd, P. (Recipient), Dunne, J. (Recipient), MacLean, L. (Recipient), Thomas, J. (Recipient), Manthri, S. (Recipient), Paterson, C. (Recipient), Stojanovski, L. (Recipient), Pinto, E. (Recipient), Ferguson, L. (Recipient), Simeons, F. (Recipient), Torrie, L. (Recipient), Robinson, D. (Recipient), Riley, J. (Recipient), Frame, L. (Recipient), Garcia Sanchez, M. (Recipient), Da Silva Pacheco, J. (Recipient), Miles, T. (Recipient), Fiandor, J. M. (Recipient), Martin, J. J. (Recipient), Marco, M. (Recipient), Gonzalez, S. (Recipient), Cantizani, J. (Recipient), Cotillo, I. (Recipient) & Manzano, M. P. (Recipient), 12 Apr 2023
Prize: Prize (including medals and awards)
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DNDi Project of the Year 2023
De Rycker, M. (Recipient), Bell, S. (Recipient), Cookson, A. (Recipient), MacLean, L. (Recipient), Paterson, C. (Recipient), Riley, J. (Recipient), Thomas, J. (Recipient), Thompson, S. (Recipient), Torrie, L. (Recipient), Wyllie, S. (Recipient), De Sousa Paradela, L. (Recipient), Cookson, K. (Recipient), Gardner, E. (Recipient), Hughes, F. (Recipient), Sharma, K. (Recipient) & Swan, L. (Recipient), 6 Oct 2023
Prize: Prize (including medals and awards)
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WH Pierce Global Impact in Microbiology Prize
De Rycker, M. (Recipient), 2025
Prize: Prize (including medals and awards)
Activities
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The Biochemical Society's 2024 Industry and Academic Collaboration Award Lecture: Industry-academia collaboration to develop new treatments for neglected tropical diseases – targeting the kinetoplastid proteasome
De Rycker, M. (Speaker)
11 Sept 2024Activity: Talk or presentation types › Invited talk
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Applying AI to anti-parasitic drug discovery
De Rycker, M. (Speaker)
3 Apr 2024Activity: Talk or presentation types › Keynote
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CIFAR Fungal Kingdom (FKG) Antifungal Workshop
De Rycker, M. (Participant)
6 Oct 2024Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Short-course combination treatment for experimental chronic Chagas disease.
De Rycker, M. (Speaker)
27 Feb 2024Activity: Talk or presentation types › Invited talk
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Drug Discovery in Academic-industry partnership
De Rycker, M. (Speaker)
17 Sept 2024Activity: Talk or presentation types › Invited talk