Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 4 Quality Education -
SDG 8 Decent Work and Economic Growth
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Dive into the research topics where Manu De Rycker is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Development of Novel Antifungal Agents
Bodkin, M. (Investigator), De Rycker, M. (Investigator), Gilbert, I. (Investigator), Read, K. (Investigator) & Wyllie, S. (Investigator)
1/05/25 → 30/04/30
Project: Research
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Development of a Preclinical Candidate for Chagas Disease That Acts Through Inhibition of Trypanosoma Cruzi Squalene Synthase
Bodkin, M. (Investigator), De Rycker, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator) & Read, K. (Investigator)
1/04/25 → 30/09/27
Project: Research
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Enabling Cryptococcal Meningitis Drug Discovery: Development Of Cryptococcus Screening Cascade And Identification Of High Quality Starting Points For Drug Discovery (Joint with GSK Tres Cantos Open Lab Foundation)
De Rycker, M. (Investigator) & Gilbert, I. (Investigator)
16/01/23 → 31/03/25
Project: Research
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Organoid High-Throughput Screening Platform For Cryptosporidiosis (Lead: UoD other instns: University of Arizona)
De Rycker, M. (Investigator), Gilbert, I. (Investigator) & Pawlowic, M. C. (Investigator)
1/04/22 → 31/12/24
Project: Research
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Elucidating molecular determinants of Trypanosoma cruzi persisters (New Investigator Research Grant) (Joint with the University of Glasgow)
De Rycker, M. (Investigator)
1/12/20 → 30/11/24
Project: Research
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Short-course combination treatment for experimental chronic Chagas disease
González, S., Wall, R. J., Thomas, J., Braillard, S., Brunori, G., Camino Díaz, I., Cantizani, J., Carvalho, S., Castañeda Casado, P., Chatelain, E., Cotillo, I., Fiandor, J. M., Francisco, A. F., Grimsditch, D., Keenan, M., Kelly, J. M., Kessler, A., Luise, C., Lyon, J. J. & MacLean, L. & 10 others, , 13 Dec 2023, In: Science Translational Medicine. 15, 726, 17 p., adg8105.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Link opens in a new tab Citations (Scopus)265 Downloads (Pure) -
Structure Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors
Thomas, M. G., McGonagle, K., Rowland, P., Robinson, D. A., Dodd, P. G., Camino-Díaz, I., Campbell, L., Cantizani, J., Castañeda, P., Conn, D., Craggs, P. D., Edwards, D., Ferguson, L., Fosberry, A., Frame, L., Goswami, P., Hu, X., Korczynska, J., MacLean, L. & Martin, J. & 21 others, , 10 Aug 2023, In: Journal of Medicinal Chemistry. 66, 15, p. 10413-10431 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Link opens in a new tab Citations (Scopus)354 Downloads (Pure) -
Anti-trypanosomatid drug discovery: progress and challenges
De Rycker, M., Wyllie, S., Horn, D., Read, K. D. & Gilbert, I. H. (Lead / Corresponding author), 31 Jan 2023, In: Nature Reviews Microbiology. 21, p. 35-50 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile153 Link opens in a new tab Citations (Scopus)388 Downloads (Pure) -
Decoding efficacy and resistance space at a drug binding site
Altmann, S., Mendoza Martinez, C., Ridgway, M., Tinti, M., Saini, J., Ibrahim, P. E. G. F., Thomas, M., De Rycker, M., Bodkin, M. J. & Horn, D. (Lead / Corresponding author), 11 Mar 2026, In: Nature Communications. 17, 14 p., 2337.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)19 Downloads (Pure) -
Trypanosoma cruzi cell atlas as a single-cell resource for understanding parasite population heterogeneity and differentiation
Laidlaw, R. F., García Sánchez, M., Da Silva Pacheco, J., Paradela, L. S., Otto, T. D. (Lead / Corresponding author) & De Rycker, M. (Lead / Corresponding author), Dec 2026, In: Nature Communications. 17, 17 p., 6801.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure)
Datasets
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BindingDB Entry 50017383: Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
, BindingDB, Thomas, M. (Creator), Brand, S. (Creator), De Rycker, M. (Creator), Zuccotto, F. (Creator), Lukac, I. (Creator), Dodd, P. (Creator), Ko, E. J. (Creator), Manthri, S. (Creator), McGonagle, K. (Creator), Osuna-Cabello, M. (Creator), Riley, J. (Creator), Pont Masanet, C. (Creator), Simeons, F. (Creator), Stojanovski, L. (Creator), Thomas, J. (Creator), Thompson, S. (Creator), Viayna Gaza, E. (Creator), Fiandor, J. M. (Creator), Martin, J. J. (Creator), Wyatt, P. (Creator), Miles, T. J. (Creator), Read, K. (Creator), Marco, M. (Creator) & Gilbert, I. (Creator), BindingDB, 24 Jun 2023
DOI: 10.7270/q2d79gg7
Dataset
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Modelling data for: Short-course combination treatment for experimental chronic Chagas disease
González Del Valle, S. (Creator), Zuccotto, F. (Creator), Luise, C. (Creator), Wyllie, S. (Creator) & De Rycker, M. (Creator), Dryad, 14 Dec 2023
DOI: 10.5061/dryad.95x69p8r7, https://datadryad.org/stash/dataset/doi:10.5061/dryad.95x69p8r7 and one more link, https://zenodo.org/records/10386313 (show fewer)
Dataset
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BindingDB Entry 50018902: Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
BindingDB, Brand, S. (Creator), Ko, E. J. (Creator), Viayna Gaza, E. (Creator), Thompson, S. (Creator), Spinks, D. (Creator), Thomas, M. (Creator), Sandberg, L. (Creator), Francisco, A. F. (Creator), Jayawardhana, S. (Creator), Smith, V. (Creator), Jansen, C. (Creator), De Rycker, M. (Creator), Thomas, J. (Creator), MacLean, L. (Creator), Osuna-Cabello, M. (Creator), Riley, J. (Creator), Scullion, P. (Creator), Stojanovski, L. (Creator), Simeons, F. (Creator), Epemolu, O. (Creator), Shishikura, Y. (Creator), Crouch, S. D. (Creator), Bakshi, T. S. (Creator), Nixon, C. J. (Creator), Reid, I. H. (Creator), Hill, A. P. (Creator), Underwood, T. Z. (Creator), Hindley, S. J. (Creator), Robinson, S. (Creator), Kelly, J. M. (Creator), Fiandor, J. M. (Creator), Wyatt, P. (Creator), Marco, M. (Creator), Miles, T. J. (Creator), Read, K. (Creator) & Gilbert, I. (Creator), BindingDB, 22 Apr 2024
DOI: 10.7270/q2zw1r50
Dataset
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BindingDB Entry 50008275: Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
BindingDB, Thomas, M. (Creator), De Rycker, M. (Creator), Ajakane, M. (Creator), Albrecht, S. (Creator), Álvarez-Pedraglio, A. I. (Creator), Boesche, M. (Creator), Brand, S. (Creator), Campbell, L. (Creator), Cantizani-Perez, J. (Creator), Cleghorn, L. (Creator), Copley, R. C. B. (Creator), Crouch, S. D. (Creator), Daugan, A. (Creator), Drewes, G. (Creator), Ferrer-Bazaga, S. (Creator), Ghidelli-Disse, S. (Creator), Gonzalez, S. (Creator), Gresham, S. L. (Creator), Hill, A. P. (Creator), Hindley, S. J. (Creator), Lowe, R. M. (Creator), Mackenzie, C. (Creator), MacLean, L. (Creator), Manthri, S. (Creator), Martin, F. (Creator), Miguel-Siles, J. (Creator), Norval, S. (Creator), Osuna-Cabello, M. (Creator), Woodland, A. (Creator), Patterson, S. (Creator), Pena, I. (Creator), Quesada-Campos, M. T. (Creator), Reid, I. H. (Creator), Revill, C. (Creator), Riley, J. (Creator), Ruiz-Gomez, J. R. (Creator), Shishikura, Y. (Creator), Simeons, F. (Creator), Smith, V. C. (Creator), Spinks, D. (Creator), Stojanovski, L. (Creator), Thomas, J. (Creator), Thompson, S. (Creator), Underwood, T. Z. (Creator), Gray, D. (Creator), Fiandor, J. M. (Creator), Gilbert, I. (Creator), Wyatt, P. (Creator), Read, K. (Creator) & Miles, T. J. (Creator), BindingDB, 22 Feb 2021
DOI: 10.7270/q2zc867r
Dataset
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BindingDB Entry 50011502: Identification of 6-amino-1
BindingDB, Thomas, M. (Creator), De Rycker, M. (Creator), Ajakane, M. (Creator), Crouch, S. D. (Creator), Campbell, L. (Creator), Daugan, A. (Creator), Fra, G. (Creator), Guerrero, C. (Creator), Mackenzie, C. (Creator), MacLean, L. (Creator), Manthri, S. (Creator), Martin, F. (Creator), Norval, S. (Creator), Osuna-Cabello, M. (Creator), Riley, J. (Creator), Shishikura, Y. (Creator), Miguel-Siles, J. (Creator), Simeons, F. (Creator), Stojanovski, L. (Creator), Thomas, J. (Creator), Thompson, S. (Creator), Velasco, R. F. (Creator), Fiandor, J. M. (Creator), Wyatt, P. (Creator), Read, K. (Creator), Gilbert, I. (Creator) & Miles, T. J. (Creator), BindingDB, 22 Mar 2022
DOI: 10.7270/q2qj7mwd
Dataset
Prizes
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Industry and Academic Collaboration Award
De Rycker, M. (Recipient), Gilbert, I. (Recipient), Read, K. (Recipient), Wyllie, S. (Recipient), Wyatt, P. (Recipient), Gray, D. (Recipient), Thomas, M. (Recipient), Brand, S. (Recipient), McGonagle, K. (Recipient), Dodd, P. (Recipient), Dunne, J. (Recipient), MacLean, L. (Recipient), Thomas, J. (Recipient), Manthri, S. (Recipient), Paterson, C. (Recipient), Stojanovski, L. (Recipient), Pinto, E. (Recipient), Ferguson, L. (Recipient), Simeons, F. (Recipient), Torrie, L. (Recipient), Robinson, D. (Recipient), Riley, J. (Recipient), Frame, L. (Recipient), Garcia Sanchez, M. (Recipient), Da Silva Pacheco, J. (Recipient), Miles, T. (Recipient), Fiandor, J. M. (Recipient), Martin, J. J. (Recipient), Marco, M. (Recipient), Gonzalez, S. (Recipient), Cantizani, J. (Recipient), Cotillo, I. (Recipient) & Manzano, M. P. (Recipient), 12 Apr 2023
Prize: Prize (including medals and awards)
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DNDi Project of the Year 2023
De Rycker, M. (Recipient), Bell, S. (Recipient), Cookson, A. (Recipient), MacLean, L. (Recipient), Paterson, C. (Recipient), Riley, J. (Recipient), Thomas, J. (Recipient), Thompson, S. (Recipient), Torrie, L. (Recipient), Wyllie, S. (Recipient), De Sousa Paradela, L. (Recipient), Cookson, K. (Recipient), Gardner, E. (Recipient), Hughes, F. (Recipient), Sharma, K. (Recipient) & Swan, L. (Recipient), 6 Oct 2023
Prize: Prize (including medals and awards)
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Premio Nacional de la Academia de Ciencias de Cuba (National Prize of the Cuban Academy of Sciences)
De Rycker, M. (Recipient), Paterson, C. (Recipient), Lin, D. (Recipient), Thomas, J. (Recipient), Joji, H. (Recipient), MacLean, L. (Recipient), O'Neill, S. (Recipient), Webster, L. (Recipient) & Gray, D. (Recipient), 2024
Prize: National/international honour
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WH Pierce Global Impact in Microbiology Prize
De Rycker, M. (Recipient), 2025
Prize: Prize (including medals and awards)
Activities
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Cross-Pathogen Insights: Leveraging Kinetoplastid Lessons for Antifungal Drug Discovery
De Rycker, M. (Speaker)
7 Apr 2026 → 9 Apr 2026Activity: Talk or presentation types › Invited talk
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Drug Discovery for Kinetoplastid Diseases; developing new treatments and approaches
De Rycker, M. (Speaker)
27 Apr 2026Activity: Talk or presentation types › Invited talk
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Developing new antifungals in an Academic – Industry partnership
De Rycker, M. (Invited speaker)
29 Jun 2026Activity: Talk or presentation types › Invited talk
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Scientific Advisory Committee (Event)
De Rycker, M. (Chair)
1 May 2025 → 30 Apr 2030Activity: Membership types › Membership of committee
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New approaches in Chagas disease drug discovery
De Rycker, M. (Speaker)
5 Oct 2025 → 8 Oct 2025Activity: Talk or presentation types › Invited talk
Press/Media
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Announcement of new antifungals drug discovery award
16/07/25
2 items of Media coverage
Press/Media: Research
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Launch of MRC DPFS programme to develop new treatments for Chagas disease.
1/04/25
1 item of Media coverage
Press/Media: Research
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