De Rycker, Manu

Dr, Head of Translational Parasitology

  • 643 Citations
  • 15 h-Index
20002019
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Research Output 2000 2019

  • 643 Citations
  • 15 h-Index
  • 28 Article
  • 3 Review article
  • 2 Comment/debate
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Article
2019
4 Citations (Scopus)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 others, Lowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Leishmania major
Leishmania donovani
Standard of Care
Solubility
49 Downloads (Pure)

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Torrie, L., Zuccotto, F., Robinson, D., Gray, D., Gilbert, I. & De Rycker, M., 31 May 2019, In : PLoS ONE. 14, 5, p. 1-16 16 p., e0217828.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Trypanosoma brucei
kinetochores
Trypanosoma brucei brucei
phosphotransferases (kinases)
1 Citation (Scopus)
42 Downloads (Pure)

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

Zmuda, F., Sastry, L., Shepherd, S. M., Jones, D., Scott, A., Craggs, P. D., Cortes, A., Gray, D. W., Torrie, L. S. & De Rycker, M., Sep 2019, In : Antimicrobial Agents and Chemotherapy. 63, 9, p. 1-15 15 p., e00309-19.

Research output: Contribution to journalArticle

Open Access
File
High-Throughput Screening Assays
Proteasome Inhibitors
Trypanosoma cruzi
Proteasome Endopeptidase Complex
Luminescence
2 Citations (Scopus)
113 Downloads (Pure)
Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
7 Citations (Scopus)
75 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
Leishmania infantum
Visceral Leishmaniasis
Proteasome Endopeptidase Complex
Leishmania donovani
Parasites
Drug Discovery
Communicable Diseases
Infectious Disease Medicine
Pharmacokinetics
Learning
25 Downloads (Pure)

Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment

Zmuda, F., Shepherd, S. M., Ferguson, M. A. J., Gray, D. W., Torrie, L. S. & De Rycker, M., Oct 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, p. 1-11 11 p., e01082-19.

Research output: Contribution to journalArticle

Open Access
File
Guanosine Diphosphate Mannose
Trypanosoma cruzi
Chagas Disease
Enzymes
Glycoconjugates
2018

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease

Thomas, M. G., De Rycker, M., Cotillo Torrejon, I., Thomas, J., Riley, J., Spinks, D., Read, K. D., Miles, T. J., Gilbert, I. H. & Wyatt, P. G., 1 Oct 2018, In : Bioorganic & Medicinal Chemistry Letters. 28, 18, p. 3025-3030 6 p.

Research output: Contribution to journalArticle

Chagas Disease
Parasites
Nifurtimox
Trypanosoma cruzi
Screening
17 Citations (Scopus)
250 Downloads (Pure)

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 9 Aug 2018, In : Nature. 560, 7717, p. 192-197 6 p.

Research output: Contribution to journalArticle

Open Access
File
Visceral Leishmaniasis
Cyclin-Dependent Kinases
Pharmaceutical Preparations
Toxicology
Parasites
10 Citations (Scopus)
84 Downloads (Pure)

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery

MacLean, L., Thomas, J., Lewis, M. D., Cotillo, I., Gray, D. & De Rycker, M., 12 Jul 2018, In : PLoS Neglected Tropical Diseases. 12, 7, p. 1-22 22 p., e0006612.

Research output: Contribution to journalArticle

Open Access
File
Chagas Disease
Trypanosoma cruzi
Drug Discovery
Parasites
Ergosterol
2017
4 Citations (Scopus)
125 Downloads (Pure)

Chemical Validation of Methionyl tRNA Synthetase (MetRS) as a Druggable Target in Leishmania donovani

Torrie, L., Brand, S., Robinson, D., Ko, E. J., Stojanovski, L., Simeons, F. R. C., Wyllie, S., Thomas, J., Ellis, L., Osuna-Cabello, M., Epemolu, R., Nuehs, A., Riley, J., MacLean, L., Manthri, S., Read, K., Gilbert, I., Fairlamb, A. & De Rycker, M., Oct 2017, In : ACS Infectious Diseases. 3, 10, p. 718-727 10 p.

Research output: Contribution to journalArticle

Open Access
File
Methionine-tRNA Ligase
Leishmania donovani
Leishmania
Methionine
Animal Models
8 Citations (Scopus)
113 Downloads (Pure)

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

Brand, S., Ko, E. J., Viayna, E., Thompson, S., Spinks, D., Thomas, M., Sandberg, L., Francisco, A. F., Jayawardhana, S., Smith, V. C., Jansen, C., De Rycker, M., Thomas, J., MacLean, L., Osuna-Cabello, M., Riley, J., Scullion, P., Stojanovski, L., Simeons, F. R. C., Epemolu, O. & 16 others, Shishikura, Y., Crouch, S. D., Bakshi, T. S., Nixon, C. J., Reid, I. H., Hill, A. P., Underwood, T. Z., Hindley, S. J., Robinson, S. A., Kelly, J. M., Fiandor, J. M., Wyatt, P. G., Marco, M., Miles, T. J., Read, K. D. & Gilbert, I. H., 14 Sep 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7284-7299 16 p.

Research output: Contribution to journalArticle

Open Access
File
Triazoles
Trypanosoma cruzi
Parasites
Chagas Disease
Nifurtimox
2016
15 Citations (Scopus)

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

Russell, S., Rahmani, R., Jones, A. J., Newson, H. L., Neilde, K., Cotillo, I., Rahmani Khajouei, M., Ferrins, L., Qureishi, S., Nguyen, N., Martinez-Martinez, M. S., Weaver, D. F., Kaiser, M., Riley, J., Thomas, J., De Rycker, M., Read, K. D., Flematti, G. R., Ryan, E., Tanghe, S. & 6 others, Rodriguez, A., Charman, S. A., Kessler, A., Avery, V. M., Baell, J. B. & Piggott, M. J., 10 Nov 2016, In : Journal of Medicinal Chemistry. 59, 21, p. 9686-9720 35 p.

Research output: Contribution to journalArticle

Trypanosomiasis
Neglected Diseases
African Trypanosomiasis
Trypanosoma brucei brucei
Chagas Disease
22 Citations (Scopus)
101 Downloads (Pure)

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade

De Rycker, M., Thomas, J., Riley, J., Brough, S. J., Miles, T. J. & Gray, D. W., 15 Apr 2016, In : PLoS Neglected Tropical Diseases. 10, 4, 19 p., e0004584.

Research output: Contribution to journalArticle

Open Access
File
Chagas Disease
Trypanosoma cruzi
azelastine
Libraries
Clemastine
2015
23 Citations (Scopus)
Leishmania donovani
Parasites
Leishmania
Drug Discovery
Pharmaceutical Preparations
19 Citations (Scopus)

Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei

Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H., 8 Oct 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.

Research output: Contribution to journalArticle

African Trypanosomiasis
Trypanosoma brucei brucei
Brain
Peptide Hydrolases
Central Nervous System
8 Citations (Scopus)

Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H., Nov 2015, In : ChemMedChem. 10, 11, p. 1809-1820 12 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Scaffolds
Protein Kinases
Screening
Growth
2013
76 Citations (Scopus)

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W., Jul 2013, In : Antimicrobial Agents and Chemotherapy. 57, 7, p. 2913-2922 10 p.

Research output: Contribution to journalArticle

Leishmania donovani
Parasites
Neglected Diseases
Visceral Leishmaniasis
Leishmania
33 Citations (Scopus)

ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines

Radtke, S., Milanovic, M., Rossé, C., De Rycker, M., Lachmann, S., Hibbert, A., Kermorgant, S. & Parker, P. J., 12 Jun 2013, In : Journal of Cell Science. 126, 11, p. 2381-2391 11 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Paxillin
Non-Small Cell Lung Carcinoma
Phosphotransferases
Cell Line
28 Citations (Scopus)
Antitubercular Agents
Visceral Leishmaniasis
Leishmania
Nitroreductases
Mycobacterium tuberculosis
2012
20 Citations (Scopus)
Trypanosoma brucei brucei
Trypanosomiasis
Drug Discovery
African Trypanosomiasis
Disease Vectors
2011
38 Citations (Scopus)
103 Downloads (Pure)

Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration

Lachmann, S., Jevons, A., de Rycker, M., Casamassima, A., Radtke, S., Collazos, A. & Parker, P. J., 6 Jul 2011, In : PLoS ONE. 6, 7, 11 p., e21732.

Research output: Contribution to journalArticle

Open Access
File
cell movement
protein kinases
cell invasion
Cell Movement
Protein Isoforms
2009
11 Citations (Scopus)

A high-content, cell-based screen identifies micropolyin, a new inhibitor of microtubule dynamics

De Rycker, M., Rigoreau, L., Dowding, S. & Parker, P. J., Jun 2009, In : Chemical Biology and Drug Design. 73, 6, p. 599-610 12 p.

Research output: Contribution to journalArticle

Microtubules
Tubulin
Prometaphase
M Phase Cell Cycle Checkpoints
Biological Phenomena
2007
31 Citations (Scopus)

Protein kinases, from B to C

Cameron, A. J., De Rycker, M., Calleja, V., Alcor, D., Kjaer, S., Kostelecky, B., Saurin, A., Faisal, A., Laguerre, M., Hemmings, B. A., McDonald, N., Larijani, B. & Parker, P. J., 1 Nov 2007, In : Biochemical Society Transactions. 35, 5, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Catalytic Domain
Phosphorylation
Protein Kinase C
Ground state
2004
62 Citations (Scopus)

Tankyrase polymerization is controlled by its sterile alpha motif and poly(ADP-ribose) polymerase domains

De Rycker, M. & Price, C. M., 1 Nov 2004, In : Molecular and Cellular Biology. 24, 22, p. 9802-9812 11 p.

Research output: Contribution to journalArticle

Tankyrases
Poly(ADP-ribose) Polymerases
Polymerization
Telomere
Ankyrins
2003
63 Citations (Scopus)

Vertebrate tankyrase domain structure and sterile α motif (SAM)-mediated multimerization

De Rycker, M., Venkatesan, R. N., Wei, C. & Price, C. M., 15 May 2003, In : Biochemical Journal. 372, 1, p. 87-96 10 p.

Research output: Contribution to journalArticle

Tankyrases
Vertebrates
Telomere
Ankyrins
Nuclear Proteins
2000
3 Citations (Scopus)

Pressor and renal effects of cross-linked hemoglobin in anesthetized cirrhotic rats

Ortiz, M. C., Fortepiani, L. A., Rycker, M. D., Atucha, N. M., Romero, J. C. & García-Estañ, J., 1 Jan 2000, In : Journal of Hepatology. 32, 1, p. 32-37 6 p.

Research output: Contribution to journalArticle

Hemoglobins
Kidney
Bile Ducts
Blood Pressure
Ligation