Stavridis, Marios

Dr

20032020

Research output per year

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Personal profile

Research

Our work focuses on the biochemical properties of pluripotent cells such as embryonic stem cells (mouse and human) and cells of the early embryo. Work in recent years has identified the Erk1/2 classical MAPK signalling pathway as the one required to initiate the differentiation of mouse and rat ES cells. These findings have led to the proposition that pluripotency is a “ground state” maintained extrinsically by protecting cells from differentiation signals (e.g. Fibroblast growth factor or Erk) or their consequences. However, human pluripotent cells may require this pathway for cell survival and/or proliferation suggesting that there may be fundamental differences between the control of differentiation of human and rodent early embryo cells.

 

We are interested in exploring these apparent differences and understanding their cause. For this we study the signalling pathways controlling self-renewal and differentiation of mouse and human embryonic stem cell lines. In collaboration with the assisted conception unit in Ninewells Hospital we aim to study the same processes in human embryos donated for research. We envisage that a better understanding of early embryo development will lead to better conditions for IVF treatment and higher success rates. Additionally, elucidation of the precise mechanisms of pluripotent cell differentiation is a prerequisite for any potential use of such cells (ES or iPS) for therapeutic purposes.

Teaching

3rd year: Developmental Biology (BI3102)

Honours: Reproduction (4A15)

Honours: Stem Cells and Regeneration (Module leader) (4B10)

Post graduate: MRes Cancer Biology (Module 6 co-ordinator)

Biography

Marios got his first degree in genetics from the University of Wales,Cardiff in 1998. He then moved to Edinburgh to work with Austin Smith on the neural differentiation of embryonic stem cells where he completed his PhD studies in 2002. During that time he developed an interest in signal transduction and how it regulates stem cell behaviour. Following a short period with a small biotech company in Edinburgh where he worked on generating specific neural types from embryonic stem cells, he moved to Dundee to work with Kate Storey on the mechanisms controlling neural specification in vertebrate embryos and embryonic stem (ES) cells. He was awarded a MRC/BBSRC cross council career development fellowship in stem cell research which led to the identification of the Erk MAPK pathway as a critical early signal controlling ES cell differentiation. In 2009 he was appointed Lecturer in the College of Medicine, Dentistry and Nursing where his group continue the study of signals involved in ES cell differentiation onset. A recent interest in the group has been the regulation of signalling by O-GlcNAc modifications.

He is involved in various public engagement activities and has in the past given presentations to the general public and patient groups, co-ordinated pupil activities, organised a screening/discussion of a documentary on stem cell research and collaborated with a local artist for the production of stem cell-inspired paintings.

Keywords

  • Q Science (General)
  • Stem cell research
  • Biochemistry
  • signal transduction
  • cancer research
  • neural development

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Projects

Research Output

An intellectual disability syndrome with single nucleotide variants in O-GlcNAc Transferase

Pravata, V., Omelkova, M., Stavridis, M., Desbiens, C. M., Stephen, H. M., Lefeber, D. J., Gécz, J., Gundogdu, M., Õunap, K., Joss, S., Schwartz, C. E., Wells, L. & van Aalten, D., 1 Jun 2020, In : European Journal of Human Genetics. 28, p. 706-714 9 p.

Research output: Contribution to journalArticle

Open Access
File
  • 36 Downloads (Pure)

    A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability

    Pravata, V. M., Gundogdu, M., Bartual, S. G., Ferenbach, A. T., Stavridis, M., Õunap, K., Pajusalu, S., Žordania, R., Wojcik, M. H. & van Aalten, D. M. F., 7 Nov 2019, In : FEBS Letters.

    Research output: Contribution to journalArticle

  • 2 Citations (Scopus)

    Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability

    Pravata, V., Muha, V., Gundogdu, M., Ferenbach, A., Kakade, P., Vandadi, V., Wilmes, A. C., Borodkin, V., Joss, S., Stavridis, M. & van Aalten, D., 23 Jul 2019, In : Proceedings of the National Academy of Sciences. 116, 30, p. 14961-14970 10 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 5 Citations (Scopus)
    119 Downloads (Pure)

    mRNA Cap methylation in pluripotency and differentiation

    Grasso, L., Suska, O., Davidson, L., Gonatopoulos-Pournatzis, T., Williamson, R., Wasmus, L., Wiedlich, S., Peggie, M., Stavridis, M. P. & Cowling, V. H., 2 Aug 2016, In : Cell Reports. 16, 5, p. 1352-1365 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 12 Citations (Scopus)
    181 Downloads (Pure)

    Neural differentiation of mouse embryonic stem cells in serum-free monolayer culture

    Wongpaiboonwattana, W. & Stavridis, M. P., 14 May 2015, In : JoVE: Journal of Visualized Experiments. 99, e52823.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 11 Citations (Scopus)
    172 Downloads (Pure)

    Activities

    Cafe Science Dundee: STEM CELLS: HOPE, HYPE AND HUSTLERS

    Marios Stavridis (Speaker)

    12 Sep 2016

    Activity: Other activity typesPublic engagement and outreach - public lecture/debate/seminar

    External PhD examiner

    Marios Stavridis (Examiner)

    30 Jan 2013

    Activity: Examination typesExamination

    External Masters Examiner

    Marios Stavridis (Examiner)

    7 Oct 2013

    Activity: Examination typesExamination

    Journal of Biomarkers (Journal)

    Marios Stavridis (Editor)

    2012

    Activity: Publication peer-review and editorial work typesEditorial activity

    Dundee Science Festival 2011

    Marios Stavridis (Organiser)

    10 Nov 2011

    Activity: Participating in or organising an event typesFestival/Exhibition

    Thesis

    Construction and use of a Sox1 reporter line to study embryonic stem cell differentiation

    Author: Stavridis, M., 2002

    Supervisor: Smith, A. (External person) (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy