• 701 Citations
  • 11 h-Index
20042019
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Personal profile

Research interests

My laboratory is interested in understanding how bacteria, especially the opportunistic pathogen Pseudomonas aeruginosa, are able to regulate their activities under conditions that prevent active growth. Often in natural environments, including infections, bacteria encounter resource limitation that prevents them from being able to grow and divide. However, sensitive measurements have shown that they are still able to produce proteins at low rates under these conditions. The regulatory mechanisms that are involved are not well understood. Gaining insight into this regulatory context is important because non-growing bacteria are highly tolerant of antibiotics, and can contribute to chronic infections. Understanding how these non-growing, antibiotic-tolerant bacteria are regulating their low levels of biosynthetic activity could give us new insight into strategies to treat chronic infection and combat the rise of antibiotic resistance.

Education/Academic qualification

Doctor of Philosophy, University of California at San Francisco

Master in Science, University of Otago

Bachelor of Science, Pennsylvania State University

Fingerprint Dive into the research topics where Megan Bergkessel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Pseudomonas aeruginosa Medicine & Life Sciences
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Research Output 2004 2019

1 Citation (Scopus)
27 Downloads (Pure)

Aggregation of nontuberculous mycobacteria is regulated by carbon-nitrogen balance

Depas, W. H., Bergkessel, M. & Newman, D. K., Aug 2019, In : MBio. 10, 4, p. 1-17 17 p., e01715-19.

Research output: Contribution to journalArticle

Open Access
File
Nontuberculous Mycobacteria
Nitrogen
Carbon
Biofilms
Mycobacterium smegmatis

Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance

DePas, W., Bergkessel, M. & Newman, D. K., Oct 2019, In : Pediatric Pulmonology. 54, S2, p. S310 1 p., 411.

Research output: Contribution to journalConference article

Nontuberculous Mycobacteria
Zebrafish
Mycobacterium
Phagocytes
Biofilms

The dormancy-specific regulator, SutA, is intrinsically disordered and modulates transcription initiation in Pseudomonas aeruginosa

Bergkessel, M., Babin, B. M., VanderVelde, D., Sweredoski, M. J., Moradian, A., Eggleston-Rangel, R., Hess, S., Tirrell, D. A., Artsimovitch, I. & Newman, D. K., 10 Sep 2019, In : Molecular Microbiology. 112, 3, p. 992-1009 18 p.

Research output: Contribution to journalArticle

DNA-Directed RNA Polymerases
Pseudomonas aeruginosa
Sigma Factor
Holoenzymes
Housekeeping
19 Downloads (Pure)

Erratum for Basta et al., "Identification of Fitness Determinants during Energy-Limited Growth Arrest in Pseudomonas aeruginosa"

Basta, D. W., Bergkessel, M. & Newman, D. K., 10 Apr 2018, In : MBio. 9, 2, 1 p., e00576-18.

Research output: Contribution to journalComment/debate

Open Access
File

Aggregation of Nontuberculous Mycobacteria in Vitro and in Situ

DePas, W., Bergkessel, M. & Newman, D. K., Sep 2017, In : Pediatric Pulmonology. 52, S47, p. S342 1 p., 336.

Research output: Contribution to journalConference article

Nontuberculous Mycobacteria
Mycobacterium smegmatis
Cystic Fibrosis
Glycerol
Infection