Research Output per year
Personal profile
Research interests
My laboratory is interested in understanding how bacteria, especially the opportunistic pathogen Pseudomonas aeruginosa, are able to regulate their activities under conditions that prevent active growth. Often in natural environments, including infections, bacteria encounter resource limitation that prevents them from being able to grow and divide. However, sensitive measurements have shown that they are still able to produce proteins at low rates under these conditions. The regulatory mechanisms that are involved are not well understood. Gaining insight into this regulatory context is important because non-growing bacteria are highly tolerant of antibiotics, and can contribute to chronic infections. Understanding how these non-growing, antibiotic-tolerant bacteria are regulating their low levels of biosynthetic activity could give us new insight into strategies to treat chronic infection and combat the rise of antibiotic resistance.
Education/Academic qualification
Doctor of Philosophy, University of California at San Francisco
Master in Science, University of Otago
Bachelor of Science, Pennsylvania State University
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Pseudomonas aeruginosa
Medicine & Life Sciences
Nontuberculous Mycobacteria
Medicine & Life Sciences
Yeasts
Medicine & Life Sciences
RNA Precursors
Medicine & Life Sciences
Bacteria
Medicine & Life Sciences
Genes
Medicine & Life Sciences
Messenger RNA
Medicine & Life Sciences
Growth
Medicine & Life Sciences
Network
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Research Output 2004 2019
1
Citation
(Scopus)
27
Downloads
(Pure)
Aggregation of nontuberculous mycobacteria is regulated by carbon-nitrogen balance
Depas, W. H., Bergkessel, M. & Newman, D. K., Aug 2019, In : MBio. 10, 4, p. 1-17 17 p., e01715-19.Research output: Contribution to journal › Article
Open Access
File
Nontuberculous Mycobacteria
Nitrogen
Carbon
Biofilms
Mycobacterium smegmatis
Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance
DePas, W., Bergkessel, M. & Newman, D. K., Oct 2019, In : Pediatric Pulmonology. 54, S2, p. S310 1 p., 411.Research output: Contribution to journal › Conference article
Nontuberculous Mycobacteria
Zebrafish
Mycobacterium
Phagocytes
Biofilms
The dormancy-specific regulator, SutA, is intrinsically disordered and modulates transcription initiation in Pseudomonas aeruginosa
Bergkessel, M., Babin, B. M., VanderVelde, D., Sweredoski, M. J., Moradian, A., Eggleston-Rangel, R., Hess, S., Tirrell, D. A., Artsimovitch, I. & Newman, D. K., 10 Sep 2019, In : Molecular Microbiology. 112, 3, p. 992-1009 18 p.Research output: Contribution to journal › Article
DNA-Directed RNA Polymerases
Pseudomonas aeruginosa
Sigma Factor
Holoenzymes
Housekeeping
Erratum for Basta et al., "Identification of Fitness Determinants during Energy-Limited Growth Arrest in Pseudomonas aeruginosa"
Basta, D. W., Bergkessel, M. & Newman, D. K., 10 Apr 2018, In : MBio. 9, 2, 1 p., e00576-18.Research output: Contribution to journal › Comment/debate
Open Access
File
Aggregation of Nontuberculous Mycobacteria in Vitro and in Situ
DePas, W., Bergkessel, M. & Newman, D. K., Sep 2017, In : Pediatric Pulmonology. 52, S47, p. S342 1 p., 336.Research output: Contribution to journal › Conference article
Nontuberculous Mycobacteria
Mycobacterium smegmatis
Cystic Fibrosis
Glycerol
Infection