Bergkessel, Megan

Dr, Dr

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Research interests

My laboratory is interested in understanding how bacteria, especially the opportunistic pathogen Pseudomonas aeruginosa, are able to regulate their activities under conditions that prevent active growth. Often in natural environments, including infections, bacteria encounter resource limitation that prevents them from being able to grow and divide. However, sensitive measurements have shown that they are still able to produce proteins at low rates under these conditions. The regulatory mechanisms that are involved are not well understood. Gaining insight into this regulatory context is important because non-growing bacteria are highly tolerant of antibiotics, and can contribute to chronic infections. Understanding how these non-growing, antibiotic-tolerant bacteria are regulating their low levels of biosynthetic activity could give us new insight into strategies to treat chronic infection and combat the rise of antibiotic resistance.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 4 - Quality Education

Education/Academic qualification

Doctor of Philosophy, The regulation of pre-mRNA splicing in response to environmental stress in budding yeast, University of California at San Francisco

Award Date: 31 Dec 2010

Master in Science, Effects of the Hepatitis B virus X protein on cellular mRNA stability, University of Otago

Award Date: 9 May 2004

Bachelor of Science, A genetic and biochemical analysis of the role of TSG8 in the DNA damage response of budding yeast, Pennsylvania State University

Award Date: 5 May 2001


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