Projects per year
Personal profile
Research interests
My laboratory is interested in understanding how bacteria, especially the opportunistic pathogen Pseudomonas aeruginosa, are able to regulate their activities under conditions that prevent active growth. Often in natural environments, including infections, bacteria encounter resource limitation that prevents them from being able to grow and divide. However, sensitive measurements have shown that they are still able to produce proteins at low rates under these conditions. The regulatory mechanisms that are involved are not well understood. Gaining insight into this regulatory context is important because non-growing bacteria are highly tolerant of antibiotics, and can contribute to chronic infections. Understanding how these non-growing, antibiotic-tolerant bacteria are regulating their low levels of biosynthetic activity could give us new insight into strategies to treat chronic infection and combat the rise of antibiotic resistance.
Education/Academic qualification
Doctor of Philosophy, University of California at San Francisco
Award Date: 31 Dec 2010
Master in Science, University of Otago
Award Date: 9 May 2004
Bachelor of Science, Pennsylvania State University
Award Date: 5 May 2001
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Projects
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Measuring Activity Dynamics in Non-growing Populations of Bacteria.
15/06/20 → 14/06/22
Project: Research
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Development Of A Drug Discovery Platform Targeting Salmonella Typhimurium PersisterCells
Bergkessel, M., Coulthurst, S., Gilbert, I. & Read, K.
1/06/21 → 31/05/23
Project: Research
Research output
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Regulation of Protein Biosynthetic Activity During Growth Arrest
Bergkessel, M., Oct 2020, In: Current Opinion in Microbiology. 57, p. 62-69 8 p.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus) -
Aggregation of nontuberculous mycobacteria is regulated by carbon-nitrogen balance
Depas, W. H., Bergkessel, M. & Newman, D. K., Aug 2019, In: MBio. 10, 4, p. 1-17 17 p., e01715-19.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)97 Downloads (Pure) -
Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance
DePas, W., Bergkessel, M. & Newman, D. K., Oct 2019, In: Pediatric Pulmonology. 54, S2, p. S310 1 p., 411.Research output: Contribution to journal › Conference article › peer-review
1 Citation (Scopus) -
The dormancy-specific regulator, SutA, is intrinsically disordered and modulates transcription initiation in Pseudomonas aeruginosa
Bergkessel, M., Babin, B. M., VanderVelde, D., Sweredoski, M. J., Moradian, A., Eggleston-Rangel, R., Hess, S., Tirrell, D. A., Artsimovitch, I. & Newman, D. K., 10 Sep 2019, In: Molecular Microbiology. 112, 3, p. 992-1009 18 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Erratum for Basta et al., "Identification of Fitness Determinants during Energy-Limited Growth Arrest in Pseudomonas aeruginosa"
Basta, D. W., Bergkessel, M. & Newman, D. K., 10 Apr 2018, In: MBio. 9, 2, 1 p., e00576-18.Research output: Contribution to journal › Comment/debate › peer-review
Open AccessFile
Activities
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Magnificent Microbes 2020 - Planning Meeting
Nicola Stanley-Wall (Participant), Erin Hardee (Organiser), Chris Earl (Participant), Margarita Kalamara (Participant), Saria Mansoor (Participant), Sofia Arnaouteli (Participant), Natalie Bamford (Participant), Martin Hagan (Participant), Gabriela Mol Avelar Tamaki (Participant), Thibault Rosazza (Participant), Azul Zorzoli (Participant), Kieron Lucas (Participant), Katharine Mathers (Participant), Helge Dorfmueller (Participant), Diana Gudynaite (Participant), Ben Wagstaff (Participant), Megan Bergkessel (Participant) & Hannah Donnelly (Participant)
17 Jan 2020Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Magnificent Microbes 2020 - Practise Event
Erin Hardee (Organiser), Nicola Stanley-Wall (Organiser), Margarita Kalamara (Member), Saria Mansoor (Member), Gabriela Mol Avelar Tamaki (Member), Thibault Rosazza (Member), Sofia Arnaouteli (Member), Azul Zorzoli (Member), Kieron Lucas (Member), Katharine Mathers (Member), Helge Dorfmueller (Member), Natalie Bamford (Member), Martin Hagan (Member), Diana Gudynaite (Member), Ben Wagstaff (Member), Chris Earl (Member), Barnaby Stonier (Member), Megan Bergkessel (Member), Sarah Coulthurst (Member) & Hannah Donnelly (Member)
12 Feb 2020Activity: Other activity types › Schools engagement
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Magnificent Microbes 2020
Nicola Stanley-Wall (Contributor), Erin Hardee (Organiser), Margarita Kalamara (Presenter), Natalie Bamford (Presenter), Martin Hagan (Member), Sofia Arnaouteli (Member), Saria Mansoor (Member), Gabriela Mol Avelar Tamaki (Member), Thibault Rosazza (Member), Azul Zorzoli (Member), Kieron Lucas (Member), Katharine Mathers (Member), Helge Dorfmueller (Member), Diana Gudynaite (Member), Ben Wagstaff (Member), Chris Earl (Member), Barnaby Stonier (Member), Sarah Coulthurst (Member), Megan Bergkessel (Member) & Hannah Donnelly (Member)
6 Mar 2020 → 7 Mar 2020Activity: Other activity types › Public engagement and outreach - festival/exhibition
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Life Sciences Virtual Work Experience Week
Erin Hardee (Organiser), Amy Cameron (Contributor), Ali Floyd (Contributor), Senga Robertson-Albertyn (Contributor), Claire Gorby (Contributor), Helge Dorfmueller (Contributor), Julia Marchingo (Contributor), Graham Christie (Contributor), Megan Bergkessel (Contributor), Mathew Jones (Contributor), Jorunn Bos (Contributor), Sarah McKim (Contributor), Piers Hemsley (Contributor), Davide Bulgarelli (Contributor), Edgar Huitema (Contributor), Christopher Henstridge (Contributor), Laureano de la Vega (Contributor), Ros Langston (Contributor), Amy Rogers (Contributor), Charlotte Proby (Contributor), Olga Semenova (Contributor), Carmen Escudero-Martinez (Contributor), Colin Henderson (Contributor), Gillian Smith (Contributor), Dominic Grussu (Contributor), Robin Pflughaupt (Contributor), Giulia Saredi (Contributor), Vanesa Alvarez (Contributor), Beatrice Colon (Contributor), Sharon Matthews (Contributor), Diana Gudynaite (Contributor), Sascha Roth (Contributor), Laura Casares Perez (Contributor), Hugh Nicholson (Contributor), Morven Shuttleworth (Contributor), Vasudha Tandon (Contributor), Richard Smith (Contributor), Rita Moreno Dorta (Contributor), Ryan Kwan (Contributor), Chidozie Ogbonnaya (Contributor), Ayman Banah (Contributor), Claire Ross (Contributor), Fiona Ramage (Contributor) & Xiong Weng (Contributor)
27 Jul 2020 → 31 Jul 2020Activity: Other activity types › Schools engagement
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Magnificent Microbes 2020 - Training
Nicola Stanley-Wall (Participant), Erin Hardee (Organiser), Margarita Kalamara (Participant), Diana Gudynaite (Participant), Thibault Rosazza (Participant), Katharine Mathers (Participant), Martin Hagan (Participant), Hannah Donnelly (Participant), Azul Zorzoli (Participant), Kieron Lucas (Participant), Saria Mansoor (Participant), Ben Wagstaff (Participant), Gabriela Mol Avelar Tamaki (Participant), Sofia Arnaouteli (Participant), Natalie Bamford (Participant), Chris Earl (Participant) & Megan Bergkessel (Participant)
11 Dec 2019Activity: Participating in or organising an event types › Participation in workshop, seminar, course