Ashford, Michael

Professor

  • 7723 Citations
  • 45 h-Index
1978 …2023

Research output per year

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Personal profile

Research

Chronic obesity is currently at epidemic levels in the UK and many other countries worldwide and is having a major adverse impact on our society. It is estimated that more 25% of the adult population are obese and around two thirds are either overweight or obese.  Worryingly over the last 20 years there has been a ~3 fold increase in the number of children and adolescents who are obese or overweight. This trend is alarming, as chronic obesity is associated with increased risk of cardiovascular and liver disease and some cancers. Most notably however, obesity is a primary driver for induction of peripheral insulin resistance, which when coupled with pancreatic beta cell functional insufficiency, leads to diabetes. Recent work also indicates that the risk of Alzheimer’s disease is higher in patients with diabetes and obesity. Therefore it is clear that our society is on a trajectory that will see significant increases in the proportion of individuals entering or in old age with severe chronic health issues. This places an enormous burden on the NHS and society generally, which is likely to worsen over the next 10-20 years if effective actions are not taken soon.

 

The aim of our work is to understand, at a molecular level, why and how these diseases are linked, in order to find new ways to prevent their long-term harmful consequences. We currently use a number of different systems to study the interactions between the hormones, leptin and insulin, and glucose and fat metabolism. Our current research projects are addressing: (i) how the enzyme beta secretase (BACE1) influences nutrient metabolism and leptin and insulin sensitivity; (ii) the role of the transcription factor, Nrf2, on glucose and lipid metabolism; (iii) how different cellular stresses influence cell metabolism and function; and (iv) how hypothalamic neurons and pancreatic beta cells sense changes in glucose levels.

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Projects

Research Output

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 14 May 2020, In : Journal of Clinical Investigation.

Research output: Contribution to journalArticle

Open Access
File
  • 6 Downloads (Pure)

    CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high fat-fed C57BL/6 mice

    Hasib, A., Hennayake, C., Bracy, D. P., Bugler-Lamb, A-R., Lantier, L., Khan, F., Ashford, M., McCrimmon, R., Wasserman, D. H. & Kang, L., Dec 2019, In : American Journal of Physiology, Endocrinology and Metabolism. 317, 6, p. E973-E983 11 p.

    Research output: Contribution to journalArticle

  • Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75]

    Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Jul 2019, In : Metabolism: Clinical and Experimental. 96, p. 101-102 2 p.

    Research output: Contribution to journalArticle

  • Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

    Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, 1, p. 55 16 p., 55.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 8 Citations (Scopus)
    170 Downloads (Pure)

    Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

    Smith, M. A., Katsouri, L., Virtue, S., Choudhury, A. I., Vidal-Puig, A., Ashford, M. L. J. & Withers, D. J., 9 Oct 2018, In : Cell Reports. 25, 2, p. 278-287.e4 15 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    118 Downloads (Pure)

    Activities

    • 1 Participation in conference

    Diabetes UK Professional Conference 2013

    Michael L. J. Ashford (Participant)

    13 Mar 201315 Mar 2013

    Activity: Participating in or organising an event typesParticipation in conference

    Thesis

    Investigation of BACE1 as a stress-induced regulator of neuronal metabolism

    Author: Findlay, J. A., 2014

    Supervisor: Ashford, M. (Supervisor) & Sutherland, C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Investigation of KATP channel function in response to metabolic and pharmacological manipulation, in the hypothalamic GT1-7 cell line

    Author: Haythorne, E., 2014

    Supervisor: Ashford, M. (Supervisor) & McCrimmon, R. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Nrf2 in metabolic related inflammation in the brain

    Author: Liddell, M. K., 2015

    Supervisor: Ashford, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Palmitoylation of the Cardiac Sodium-Calcium Exchanger

    Author: Reilly, L., 2014

    Supervisor: Fuller, W. (Supervisor) & Ashford, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Recurrent Hypoglycaemia-examining Impact and Strategy

    Author: George, P., 2015

    Supervisor: McCrimmon, R. (Supervisor) & Ashford, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File