Ashford, Michael

Projects

Projects per year 2009 2011 2012 2013 2014 2028

• 5 Not started
• 6 Active
• 43 Finished

Projects per year

Search results

• Active

  Brain Endothelial Cell Dysfunction Links Type 2 Diabetes And Alzheimer's Disease. An Ironclad Mechanism - Joint with University of Oxford

  Ashford, M. (Investigator) & McLean, F. (Investigator)

  Diabetes UK

  2/01/24 → 1/01/25

  Project: Research

• Interrogating Tankyrase-mediated Control of Neuronal Degeneration in Frontotemporal Dementia (Dementia Research Leader Fellowship) (Outline) & Full

  Alessi, D. (Investigator), Ashford, M. (Investigator), Davies, P. (Investigator), McGurk, L. (Investigator) & Storey, K. (Investigator)

  Alzheimer's Society

  2/10/23 → 1/10/28

  Project: Research

• Environmental Nanoplastics - Is Our Brain Becoming A Dumping Ground For Plastic Waste

  Ashford, M. (Investigator) & McLean, F. (Investigator)

  24/07/23 → 23/01/25

  Project: Research

• The Extracellular Matrix (ECM) Remodelling And Receptor Activation Drives Adipose Tissue Malfunction In Obesity (Lead: UoD other instn: University of Edinburgh)

  Ashford, M. (Investigator) & Kang, L. (Investigator)

  Diabetes UK

  11/07/22 → 10/07/25

  Project: Research

  • Insulin Resistance 100%
  • Obesity 98%
  • CD44 96%
  • Cluster of Differentiation 44 (CD44) 86%
  • Extracellular Matrix 72%

• Is Blood-Brain Barrier Dysfunction In Alzheimer's Disease Driven By Altered Cellular Metabolism (Lead Dundee, joint with University Oxford, Cardiff University, University Edinburgh) - Fellowship

  Ashford, M. (Investigator), McLean, F. (Investigator) & McNeilly, A. (Investigator)

  15/06/22 → 14/06/25

  Project: Research

  • Network Building 100%
  • Mentorship 100%
  • Online Spaces 100%
  • Mentee 100%
  • Dementia Research 100%

• Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain (Joint with 26 other institutions, University of Oxford as lead)

  Ashford, M. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/01/19 → 31/12/25

  Project: Research

• Not started

  Development of a Sporadic Alzheimer's Disease Model (Vacation Scholarship)

  Ashford, M. (Investigator) & Meakin, P. (Investigator)

  Project: Research

• SUMMIT WP3 EDTA samples

  Ashford, M. (Investigator), Kennedy, G. (Investigator) & Khan, F. (Investigator)

  Project: Research

• The Effects of Beta-Amyloid on Cerebral Endothelial Cell Function (Undergraduate Bursary Student : Chaweewan (Verna) Sirakawin)

  Ashford, M. (Investigator)

  Project: Research

• Changes in Metabolic Signalling in a Mouse model of Alzheimer's Disease

  Ashford, M. (Investigator)

  Project: Research

• A Pathological Role for BACE1 Actibity in Metabolic Disease?

  Ashford, M. (Investigator) & Meakin, P. (Investigator)

  Project: Research

• Finished

  The Assessment of Bioenergetic Dysfunction in Chronic Disease

  Ashford, M. (Investigator), Cantley, J. (Investigator) & McNeilly, A. (Investigator)

  1/11/20 → 31/10/22

  Project: Research

  • Loss Function 100%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
  • Kelch-like 100%
  • Associated Proteins 100%
  • Synapsin I 100%

• COVID-19 Recuperation Costs

  Ashford, M. (Investigator) & McLean, F. (Investigator)

  26/08/20 → 25/08/21

  Project: Research

• An Investigation of How Insulin Receptor Function Could Influence the Development of Insulin Resistance and Type 2 Diabestes

  Ashford, M. (Investigator) & Sutherland, C. (Investigator)

  1/02/20 → 31/01/22

  Project: Research

• The Role of NCX1 Palmitoylation in Cardiac Function

  Ashford, M. (Investigator) & Fuller, W. (Investigator)

  British Heart Foundation

  25/09/17 → 24/09/21

  Project: Research

  • Palmitoylation 100%
  • Depalmitoylation 50%
  • Control Channel 50%
  • Calcium Transient 50%
  • Voltage Sensitivity 50%

• Establishing the mechanism underlying the genetic association of a glucose transporter to metformin response to improve its use in the clinic.

  Ashford, M. (Investigator), McCrimmon, R. (Investigator), Pearson, E. (Investigator) & Sutherland, C. (Investigator)

  Diabetes UK

  1/06/17 → 31/03/21

  Project: Research

  • Slc2a2 100%
  • Male Mice 100%
  • Whole-body 100%
  • High-fat Diet 100%
  • Metformin 100%

• Is Plasma Amyloid A Useful Biomarker For Metabolic Disease?

  Ashford, M. (Investigator), Khan, F. (Investigator) & Meakin, P. (Investigator)

  13/02/17 → 12/08/17

  Project: Research

• Extracellular and Endothelial Regulation of Muscle Glucose Uptake in Insulin Resistance In Vivo

  Ashford, M. (Investigator), Kang, L. (Investigator), Khan, F. (Investigator) & McCrimmon, R. (Investigator)

  Diabetes UK

  9/01/17 → 8/01/20

  Project: Research

  • Insulin Resistance 100%
  • CD44 82%
  • Cluster of Differentiation 44 (CD44) 77%
  • Obesity 67%
  • Extracellular Matrix 43%

• Cavins: Mobile Regulators of Adrenoceptor Signalling in the Cardiac Cell (Joint with University of Leeds)

  Ashford, M. (Investigator)

  British Heart Foundation

  1/01/16 → 31/12/18

  Project: Research

  • Palmitoylation 100%
  • Protein Palmitoylation 78%
  • Post-translational Modification 61%
  • Cysteine 56%
  • Posttranslational Modification 48%

• BACE1 and Endothelial Dysfunction in Diabetes (Project Grant scheme)

  Ashford, M. (Investigator) & Khan, F. (Investigator)

  British Heart Foundation

  1/10/15 → 30/09/18

  Project: Research

  • β-site APP-cleaving Enzyme 1 (BACE1) 100%
  • Amyloid Protein 56%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 53%
  • Kelch-like ECH-associated Protein 1 (Keap1) 53%
  • Transcription Factor Nrf2 53%

• Characterisation of the Role of NPAT in Metformin Regulation of Body Weight and Glycaemic Control: Moving GWAS Data to Biological Function

  Ashford, M. (Investigator), McCrimmon, R. (Investigator), Palmer, C. (Investigator), Pearson, E. (Investigator) & Sutherland, C. (Investigator)

  Medical Research Council

  1/10/15 → 30/09/18

  Project: Research

  • Nuclear Proteins 100%
  • Genetic Association 100%
  • Glycemic Response 100%
  • Fuel Choice 100%
  • Transcription Factor 100%

• NRF-2 Based Approaches to Preventing Cognitive Impairment in Diabetes

  Ashford, M. (Investigator), Dinkova-Kostova, A. (Investigator), Hayes, J. (Investigator) & McCrimmon, R. (Investigator)

  Diabetes UK

  1/10/15 → 30/09/18

  Project: Research

• Metabolic and Vascular Contributors to Dementia (Joint with Universities of Edinburgh, Aberdeen and St Andrews)

  Ashford, M. (Investigator)

  Alzheimer's Society

  1/09/15 → 31/08/20

  Project: Research

  • Biotin Identification 100%
  • Interactome 100%
  • Beta-Secretase 1 100%
  • Proximity-dependent Biotin Identification 100%
  • β-site APP-cleaving Enzyme 1 (BACE1) 100%

• Unravelling the Tangled Molecular Connections of BACE1 and GSK3

  Ashford, M. (Investigator) & Sutherland, C. (Investigator)

  1/08/14 → 31/07/15

  Project: Research

• Optogenetic Manipulation of Astrocytes During Metabolic Stress

  Ashford, M. (Investigator), Beall, C. (Investigator) & McCrimmon, R. (Investigator)

  Anonymous Trust

  1/07/14 → 31/08/17

  Project: Research

• Investigation of Metabolic Reprogramming Following Recurrent Hypoglycaemia in Glucose-Sensing Neurons

  Ashford, M. (Investigator) & McCrimmon, R. (Investigator)

  Anonymous Trust

  1/07/14 → 30/06/15

  Project: Research

• Can Amyloid Processing be Used as a Biomarker for Obesity-Driven Metabolic Disease in Humans

  Ashford, M. (Investigator), Dillon, J. (Investigator), Meakin, P. (Investigator) & Palmer, C. (Investigator)

  1/06/14 → 1/06/15

  Project: Research

• Extracellular Matrix Remodelling and Muscle Insulin Resistance: Role of Hyaluronan-CD44 Interaction

  Ashford, M. (Investigator) & Kang, L. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/06/14 → 31/05/16

  Project: Research

  • CD44 100%
  • Cluster of Differentiation 44 (CD44) 89%
  • Obesity 83%
  • Insulin Resistance 70%
  • Extracellular Matrix 70%

• Are Adenosine Receptors a Potential Therapeutic Target for Hypoglycaemia Avoidance in Diabetes?

  Ashford, M. (Investigator), Beall, C. (Investigator) & McCrimmon, R. (Investigator)

  1/01/14 → 31/12/14

  Project: Research

• Targeting the Hypothalamic Purinergic System for the Regulation Whole Body Glucose Homeostasis (RD Lawrence Fellowship)

  Ashford, M. (Investigator), Beall, C. (Investigator) & McCrimmon, R. (Investigator)

  Diabetes UK

  1/09/13 → 31/08/18

  Project: Research

• Cellular Reprogramming as a Tool to Characterise the Cellular Electrophysiology of Familial Arrhythmia

  Ashford, M. (Investigator), Berg, J. (Investigator), Choy, A.-M. (Investigator) & Stavridis, M. (Investigator)

  1/06/13 → 31/07/15

  Project: Research

• The Role of BACE1 in Cardiovascular Health and Disease

  Ashford, M. (Investigator), Khan, F. (Investigator) & Meakin, P. (Investigator)

  Anonymous Trust

  1/06/13 → 31/05/14

  Project: Research

• Cellular Reprogramming as a Tool to Characterise the Cellular Electrophysiology of Familial Arrhythmia Syndromes

  Ashford, M. (Investigator), Berg, J. (Investigator), Choy, A.-M. (Investigator), Stavrakis, S. (Investigator) & Stavridis, M. (Investigator)

  Anonymous Trust

  1/05/13 → 30/04/14

  Project: Research

• Creation of a Complete Workstation for the XF24 Extracellular Flux Analyser

  Ashford, M. (Investigator) & Milne, A. (Investigator)

  Anonymous Trust

  1/05/13 → 30/04/14

  Project: Research

• Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity

  Ashford, M. (Investigator)

  Medical Research Council

  1/01/13 → 31/12/15

  Project: Research

  • β-site APP-cleaving Enzyme 1 (BACE1) 100%
  • Insulin Resistance 74%
  • Liver 52%
  • Amyloid Protein 48%
  • High-fat Diet 46%

• Regulation of the Cardiac Sodium Pump by Palmitoylation

  Ashford, M. (Investigator) & Fuller, W. (Investigator)

  British Heart Foundation

  15/11/12 → 14/11/13

  Project: Research

  • Palmitoylation 100%
  • Phospholemman 61%
  • NCX1 55%
  • Cysteine 34%
  • Na+-K+ Pump 31%

• Pivotal Role of the Keap1-Nrf2 Pathway in the Pathogenesis and Prevention of Non Alcoholic Steatohepatitis Induced Cirrhosis

  Ashford, M. (Investigator), Dillon, J. (Investigator), Hayes, J. (Investigator) & McCrimmon, R. (Investigator)

  Medical Research Council

  1/11/12 → 31/03/16

  Project: Research

  • Prothrombin 100%
  • NFE2L2 97%
  • Nonalcoholic Steatohepatitis 72%
  • Oxidative Stress 65%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 65%

• Application of Selected-Reaction Monitoring (SRM) Mass Spectrometry for the Global Analysis of the Phosphorylation Status of Protein Kinases

  Ashford, M. (Investigator), Dillon, J. (Investigator), Hayes, J. (Investigator), McCrimmon, R. (Investigator) & Trost, M. (Investigator)

  Medical Research Council

  1/11/12 → 31/03/16

  Project: Research

  • Prothrombin 100%
  • NFE2L2 97%
  • Nonalcoholic Steatohepatitis 72%
  • Oxidative Stress 65%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 65%

• Beta-secretase Inhibition as a Novel Approach to Treat Type 2 Diabetes

  Ashford, M. (Investigator) & McCrimmon, R. (Investigator)

  Diabetes UK

  1/10/12 → 30/09/15

  Project: Research

  • Vascular Dysfunction 100%
  • Diabetes 100%
  • Obesity 100%
  • Nitric Oxide 100%
  • Amyloid Precursor Protein 100%

• Understanding Hypothalmic Glucose Sensing Mechanisms and their Role in Diabetes

  Ashford, M. (Investigator) & McCrimmon, R. (Investigator)

  Diabetes UK

  1/08/12 → 31/07/15

  Project: Research

• Role of Amyloid Processing and Oxidative Stress on Cellular Bioenergetics

  Ashford, M. (Investigator)

  1/08/12 → 31/07/13

  Project: Research

• Improvement in Live Cell Imaging Facilities

  Ashford, M. (Investigator), McCrimmon, R. (Investigator), Milne, A. (Investigator) & Sutherland, C. (Investigator)

  Anonymous Trust

  1/07/12 → 30/06/13

  Project: Research

• Investigation into the Role of Keap1 in Pancreatic B-Cell Function

  Ashford, M. (Investigator), Hayes, J. (Investigator), McCrimmon, R. (Investigator) & Meakin, P. (Investigator)

  Anonymous Trust

  1/06/12 → 31/05/13

  Project: Research

• A Perfusion System for Fluorescent Live Cell Imaging

  Ashford, M. (Investigator), Beall, C. (Investigator), McCrimmon, R. (Investigator), Milne, A. (Investigator), Sutherland, C. (Investigator) & Watterson, K. (Investigator)

  Anonymous Trust

  1/05/12 → 30/04/13

  Project: Research

• Astrocyte Regulation of Neuronal Function: Analysing Their Contribution to Oxidative and Metabolic Stress in Neurodegeneration (PhD Studentship)

  Ashford, M. (Investigator)

  Alzheimer's Society

  1/10/11 → 30/09/14

  Project: Research

• Characterisation of the Actions of Leptin Memetics on Hypothalamic Neurons (Industrial Case Studentship)

  Ashford, M. (Investigator)

  AstraZeneca

  1/10/11 → 1/10/15

  Project: Research

• Preconditioning and the Development of Hypoglycemia Tolerance

  Ashford, M. (Investigator) & McCrimmon, R. (Investigator)

  Juvenile Diabetes Research Foundation

  1/10/11 → 30/09/14

  Project: Research

• East Central Scotland Network Centre

  Ashford, M. (Investigator), Harvey, J. (Investigator) & Simpson, S. (Investigator)

  1/09/11 → 30/06/24

  Project: Research

• Understanding AMPKs Role in the Detection of Hypoglycaemia

  Ashford, M. (Investigator) & McCrimmon, R. (Investigator)

  European Foundation for the Study of Diabetes

  1/08/11 → 31/07/13

  Project: Research

• Antioxidant Response and Neurodegeneration Progression in Mice

  Ashford, M. (Investigator) & Stewart, C. (Investigator)

  1/06/11 → 31/12/13

  Project: Research