Tatham, Michael

Dr

  • United Kingdom

  • 2527 Citations
  • 20 h-Index
20052020

Research output per year

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Research Output

  • 2527 Citations
  • 20 h-Index
  • 31 Article
  • 1 Chapter (peer-reviewed)
  • 1 Book/Film/Article review
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Article
2020

Antibody RING-Mediated Destruction of Endogenous Proteins

Ibrahim, A. F. M., Shen, L., Tatham, M. H., Dickerson, D., Prescott, A. R., Abidi, N., Xirodimas, D. P. & Hay, R. T., 25 May 2020, In : Molecular Cell. 12 p.

Research output: Contribution to journalArticle

Open Access
File
17 Downloads (Pure)
2019

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

Schmidt, N., Domingues, P., Golebiowski, F., Patzina, C., Tatham, M. H., Hay, R. T. & Hale, B. G., 27 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17399-17408 10 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
73 Downloads (Pure)

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics

Popow, O., Paulo, J. A., Tatham, M., Volk, M., Rojas-Fernandez, A., Loyer, N., Newton, I., Januschke, J., Haigis, K. M. & Nathke, I., Sep 2019, In : Molecular Cancer Research. 17, 9, p. 1828-1841 14 p.

Research output: Contribution to journalArticle

Open Access
File
9 Downloads (Pure)

Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation

Wang, Y., Tatham, M. H., Schmidt-Heck, W., Swann, C., Singh-Dolt, K., Meseguer-Ripolles, J., Lucendo-Villarin, B., Kunath, T., Rudd, T. R., Smith, A. J. H., Hengstler, J. G., Godoy, P., Hay, R. T. & Hay, D. C., 28 Jun 2019, In : iScience. 16, p. 206-217 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
81 Downloads (Pure)

The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε

Winczura, A., Appanah, R., Tatham, M. H., Hay, R. T. & De Piccoli, G., 25 Nov 2019, In : PLoS Genetics. 15, 11, p. 1-26 26 p., e1008427.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
43 Downloads (Pure)
2018

Expanded Interactome of the Intrinsically Disordered Protein Dss1

Schenstrøm, S. M., Rebula, C. A., Tatham, M. H., Hendus-Altenburger, R., Jourdain, I., Hay, R. T., Kragelund, B. B. & Hartmann-Petersen, R., 23 Oct 2018, In : Cell Reports. 25, 4, p. 862-870 9 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
122 Downloads (Pure)
2017

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

Tatham, M. H., Cole, C., Scullion, P., Wilkie, R., Westwood, N. J., Stark, L. A. & Hay, R. T., 1 Feb 2017, In : Molecular & Cellular Proteomics. 16, 2, p. 310-326 17 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
179 Downloads (Pure)

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway

Ugun-Klusek, A., Tatham, M. H., Elkharaz, J., Constantin-Teodosiu, D., Lawler, K., Mohamed, H., Paine, S. M. L., Anderson, G., John Mayer, R., Lowe, J., Ellen Billett, E. & Bedford, L., Jan 2017, In : Cell Death and Disease. 8, p. 1-12 12 p., e2531.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
158 Downloads (Pure)

Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

Nielsen, S. V., Stein, A., Dinitzen, A. B., Papaleo, E., Tatham, M. H., Poulsen, E. G., Kassem, M. M., Rasmussen, L. J., Lindorff-Larsen, K. & Hartmann-Petersen, R., 19 Apr 2017, In : PLoS Genetics. 13, 4, 26 p., e1006739.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
185 Downloads (Pure)

Ufd1-Npl4 recruit Cdc48 for disassembly of ubiquitylated CMG helicase at the end of chromosome replication

Maric, M., Mukherjee, P., Tatham, M. H., Hay, R. & Labib, K., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3033-3042 10 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
206 Downloads (Pure)
2016

Identification of RNF168 as a PML nuclear body regulator

Shire, K., Wong, A. I., Tatham, M. H., Anderson, O. F., Ripsman, D., Gulstene, S., Moffat, J., Hay, R. T. & Frappier, L., 1 Feb 2016, In : Journal of Cell Science. 129, 3, p. 580-591 12 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
151 Downloads (Pure)
2015

Analysis of the SUMO2 proteome during HSV-1 Infection

Sloan, E., Tatham, M. H., Groslambert, M., Glass, M., Orr, A., Hay, R. T. & Everett, R. D., 22 Jul 2015, In : PLoS Pathogens. 11, 7, 34 p., e1005059.

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)

Global Reprogramming of Host SUMOylation during Influenza Virus Infection

Domingues, P., Golebiowski, F., Tatham, M. H., Lopes, A. M., Taggart, A., Hay, R. T. & Hale, B. G., 17 Nov 2015, In : Cell Reports. 13, 7, p. 1467-1480 14 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
145 Downloads (Pure)

Proteome-wide identification of SUMO modification sites by mass spectrometry

Tammsalu, T., Matic, I., Jaffray, E. G., Ibrahim, A. F. M., Tatham, M. H. & Hay, R. T., Sep 2015, In : Nature Protocols. 10, 9, p. 1374-1388 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H. & Hay, R. T., 15 Mar 2015, In : Biochemical Journal. 466, 3, p. 489-498 10 p.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)
2014

Dss1 is a 26S proteasome ubiquitin receptor

Paraskevopoulos, K., Kriegenburg, F., Tatham, M. H., Rösner, H. I., Medina, B., Larsen, I. B., Brandstrup, R., Hardwick, K. G., Hay, R. T., Kragelund, B. B., Hartmann-Petersen, R. & Gordon, C., 6 Nov 2014, In : Molecular Cell. 56, 3, p. 453-461 9 p.

Research output: Contribution to journalArticle

Open Access
File
47 Citations (Scopus)
137 Downloads (Pure)

Proteome-wide identification of SUMO2 modification sites

Tammsalu, T., Matic, I., Jaffray, E. G., Ibrahim, A. F. M., Tatham, M. H. & Hay, R. T., 29 Apr 2014, In : Science Signaling. 7, 323, 10 p., rs2.

Research output: Contribution to journalArticle

119 Citations (Scopus)

SUMO chain-induced dimerization activates RNF4

Rojas-Fernandez, A., Plechanovová, A., Hattersley, N., Jaffray, E., Tatham, M. H. & Hay, R. T., 20 Mar 2014, In : Molecular Cell. 53, 6, p. 880-92 13 p.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
138 Downloads (Pure)
2013

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

Tatham, M. H., Plechanovova, A., Jaffray, E. G., Salmen, H. & Hay, R. T., 2013, In : Biochemical Journal. 453, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2012

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

Plechanovová, A., Jaffray, E. G., Tatham, M. H., Naismith, J. H. & Hay, R. T., 2012, In : Nature. 489, 7414, p. 115-120 5 p.

Research output: Contribution to journalArticle

267 Citations (Scopus)
2011

Comparative proteomic analysis identifies a role for SUMO in protein quality control

Tatham, M. H., Matic, I., Mann, M. & Hay, R. T., 21 Jun 2011, In : Science Signaling. 4, 178, p. - 12 p., rs4.

Research output: Contribution to journalArticle

125 Citations (Scopus)

Purification and identification of endogenous polySUMO conjugates

Bruderer, R., Tatham, M. H., Plechanovova, A., Matic, I., Garg, A. K. & Hay, R. T., Feb 2011, In : EMBO Reports. 12, 2, p. 142-148 7 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)
2010

High-stringency tandem affinity purification of proteins conjugated to ubiquitin-like moieties

Golebiowski, F., Tatham, M. H., Nakamura, A. & Hay, R. T., 2010, In : Nature Protocols. 5, 5, p. 873-882 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

SUMOylation of the GTPase Rac1 is required for optimal cell migration

Castillo-Lluva, S., Tatham, M. H., Jones, R. C., Jaffray, E. G., Edmondson, R. D., Hay, R. T. & Malliri, A., Nov 2010, In : Nature Cell Biology. 12, 11, p. 1078-U70 21 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)
2009

Detection of protein SUMOylation in vivo

Tatham, M. H., Rodriguez, M. S., Xirodimas, D. P. & Hay, R. T., 2009, In : Nature Protocols. 4, 9, p. 1363-1371 9 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

System-wide changes to SUMO modifications in response to heat shock

Golebiowski, F., Matic, I., Tatham, M. H., Cole, C., Yin, Y., Nakamura, A., Cox, J., Barton, G. J., Mann, M. & Hay, R. T., 26 May 2009, In : Science Signaling. 2, 72, 12 p., ra24.

Research output: Contribution to journalArticle

329 Citations (Scopus)
2008

In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy

Matic, I., van Hagen, M., Schimmel, J., Macek, B., Ogg, S. C., Tatham, M. H., Hay, R. T., Lamond, A. I., Mann, M. & Vertegaal, A. C. O., 1 Jan 2008, In : Molecular & Cellular Proteomics. 7, 1, p. 132-144 13 p.

Research output: Contribution to journalArticle

198 Citations (Scopus)

Quantitative analysis of multi-protein interactions using FRET: application to the SUMO pathway

Martin, S. F., Tatham, M. H., Hay, R. T. & Samuel, I. D. W., Apr 2008, In : Protein Science. 17, 4, p. 777-784 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

Tatham, M. H., Geoffroy, M-C., Shen, L., Plechanovova, A., Hattersley, N., Jaffray, E. G., Palvimo, J. J. & Hay, R. T., May 2008, In : Nature Cell Biology. 10, 5, p. 538-546 9 p.

Research output: Contribution to journalArticle

567 Citations (Scopus)
2006

SUMO protease SENP1 induces isomerization of the scissile peptide bond

Shen, L., Tatham, M. H., Dong, C., Zagorska, A., Naismith, J. H. & Hay, R. T., Dec 2006, In : Nature Structural & Molecular Biology. 13, 12, p. 1069-1077 9 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)
2005

Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection

Tatham, M. H., Kim, S., Jaffray, E., Song, J., Chen, Y. & Hay, R. T., Jan 2005, In : Nature Structural & Molecular Biology. 12, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)