Thomas, Michael

Dr

  • United Kingdom

  • 7 Citations
  • 2 h-Index
20172018
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Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 41 Similar Profiles
Parasites Medicine & Life Sciences
Chagas Disease Medicine & Life Sciences
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Nifurtimox Medicine & Life Sciences
Triazoles Medicine & Life Sciences

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Research Output 2017 2018

  • 7 Citations
  • 2 h-Index
  • 6 Article

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease

Thomas, M. G., De Rycker, M., Cotillo Torrejon, I., Thomas, J., Riley, J., Spinks, D., Read, K. D., Miles, T. J., Gilbert, I. H. & Wyatt, P. G., 1 Oct 2018, In : Bioorganic & Medicinal Chemistry Letters. 28, 18, p. 3025-3030 6 p.

Research output: Contribution to journalArticle

Chagas Disease
Parasites
Nifurtimox
Trypanosoma cruzi
Screening

Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

Wall, R., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 15 p., e00235-18.

Research output: Contribution to journalArticle

Open Access
File
Naphthyridines
Chelating Agents
Hydroxyl Radical
Metals
Trypanosoma brucei brucei
2 Citations

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 othersBerriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 25 Jul 2018, In : Nature. 560, 7717, p. 192-197 6 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Cyclin-Dependent Kinases
Pharmaceutical Preparations
Toxicology
Parasites

Development of chemical proteomics for the folateome and analysis of the kinetoplastid folateome

Webster, L., Thomas, M., Urbaniak, M., Wyllie, S., Ong, H., Tinti, M., Fairlamb, A., Boesche, M., Ghidelli-Disse, S., Drewes, G. & Gilbert, I., 2018, In : ACS Infectious Diseases. 4, 10, p. 1475-1486 12 p.

Research output: Contribution to journalArticle

Open Access
File
Folic Acid
Proteomics
Parasites
Proteins
Enzymes
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations