Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Decoding efficacy and resistance space at a drug binding site
Altmann, S., Mendoza Martinez, C., Ridgway, M., Tinti, M., Saini, J., Ibrahim, P. E. G. F., Thomas, M., De Rycker, M., Bodkin, M. J. & Horn, D., 4 Feb 2026, (E-pub ahead of print) In: Nature Communications. 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors
Eadsforth, T. C., Torrie, L. S., Rowland, P., Edgar, E. V., MacLean, L. M., Paterson, C., Robinson, D. A., Shepherd, S. M., Thomas, J., Thomas, M., Gray, D., Postis, V. & De Rycker, M. (Lead / Corresponding author), Jan 2025, In: Journal of Biological Chemistry. 301, 1, 17 p., 108049.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)65 Downloads (Pure) -
Structure-activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi
Thomas, M., Dunne, J., Dodd, P. G., D’Oria, E., Frame, L., Garcia-Perez, A., McGonagle, K., Manzano-Chinchon, P., MacLean, L., Paterson, C., Riley, J., Thomas, J., Torrie, L. S., Wrobel, K., Read, K., Marco, M. (Lead / Corresponding author) & De Rycker, M. (Lead / Corresponding author), 1 Sept 2025, In: RSC Medicinal Chemistry. 16, 9, p. 4135-4153 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile78 Downloads (Pure) -
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis (Nature, (2018), 560, 7717, (192-197), 10.1038/s41586-018-0356-z)
Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P. & Albrecht, S. & 12 others, , 4 Jul 2023, In: Nature. 619, p. E48 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Structure Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors
Thomas, M. G., McGonagle, K., Rowland, P., Robinson, D. A., Dodd, P. G., Camino-Díaz, I., Campbell, L., Cantizani, J., Castañeda, P., Conn, D., Craggs, P. D., Edwards, D., Ferguson, L., Fosberry, A., Frame, L., Goswami, P., Hu, X., Korczynska, J., MacLean, L. & Martin, J. & 21 others, , 10 Aug 2023, In: Journal of Medicinal Chemistry. 66, 15, p. 10413-10431 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Link opens in a new tab Citations (Scopus)307 Downloads (Pure)
Prizes
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Industry and Academic Collaboration Award
De Rycker, M. (Recipient), Gilbert, I. (Recipient), Read, K. (Recipient), Wyllie, S. (Recipient), Wyatt, P. (Recipient), Gray, D. (Recipient), Thomas, M. (Recipient), Brand, S. (Recipient), McGonagle, K. (Recipient), Dodd, P. (Recipient), Dunne, J. (Recipient), MacLean, L. (Recipient), Thomas, J. (Recipient), Manthri, S. (Recipient), Paterson, C. (Recipient), Stojanovski, L. (Recipient), Pinto, E. (Recipient), Ferguson, L. (Recipient), Simeons, F. (Recipient), Torrie, L. (Recipient), Robinson, D. (Recipient), Riley, J. (Recipient), Frame, L. (Recipient), Garcia Sanchez, M. (Recipient), Da Silva Pacheco, J. (Recipient), Miles, T. (Recipient), Fiandor, J. M. (Recipient), Martin, J. J. (Recipient), Marco, M. (Recipient), Gonzalez, S. (Recipient), Cantizani, J. (Recipient), Cotillo, I. (Recipient) & Manzano, M. P. (Recipient), 12 Apr 2023
Prize: Prize (including medals and awards)
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Bonding
Floyd, A. (Host), Fong, E. (Chair), Mackintosh, A. (Host), Fairlamb, A. (Chair), Aitken, J. (Member of programme committee), Farrell, S. (Participant), Thomas, M. (Participant), Tarver, G. (Participant), Postis, V. (Participant), McGinnis, C. (Participant), Read, K. (Participant), Seizova, S. (Participant), Cleghorn, L. (Participant), Baragana, B. (Participant), Pearson, L.-A. (Participant), Bellany, F. (Participant), Pinto, E. (Participant), Simeons, F. (Participant), Godoy Magalhaes, L. (Participant), Bayliss, T. (Participant), Akwensi, J. (Participant), De Sousa Paradela, L. (Participant), Wyllie, S. (Participant), Anderson, G. (Participant), Wu, S. (Participant) & Urbanowska, A. (Participant)
16 Feb 2023 → 8 Apr 2023Activity: Participating in or organising an event types › Festival/Exhibition
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Diagnosis: Kidnapped escape game
Floyd, A. (Organiser), Hardee, E. (Organiser), Hallyburton, I. (Contributor), Niven, S. (Contributor), Cameron, A. (Contributor), Bellany, F. (Contributor), Wyllie, S. (Contributor), Torrie, L. (Contributor), Thomas, M. (Contributor) & Naylor, C. (Contributor)
16 Oct 2019 → …Activity: Other activity types › Other
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