If you made any changes in Pure these will be visible here soon.

Personal profile


Dr Witham graduated from Oxford University and worked in a number of hospitals in the south of England and Australia before discovering the delights of Scotland. He undertook his PhD in Dundee running a randomised controlled trial of exercise training for older chronic heart failure patients, before taking up post as Clinical Lecturer in Ageing and Health in 2003.

 In October 2007, he commenced an NES / CSO Clinician Scientist award, with a duration of 5 years; he completed clinical training in geriatrics and general medicine in late 2009 before taking up post as Clinical Senior Lecturer in Ageing and Health, becoming Clinical Reader in Ageing and Health in July 2013.

 Dr Witham works as an honorary consultant geriatrician with NHS Tayside, undertaking community geriatrics work, general older people’s outpatients and helps to run the Dundee Memory Clinic service. He is a member of the Health Services and Population research Committee (Chief Scientist Office, Scottish Government) and contributes to the Scottish polypharmacy guideline working group.


Pleiotropic interventions to improve the health of older people:

Multimorbidity is the norm in older people, but most interventions are tested in younger people without comorbid disease, who take few other medications. Conducting trials in typical frail older people is therefore critical if we are to build the evidence base we need to treat older people, and this forms a major focus of work in our department. Recent trials have included extensive work on the cardiovascular effects of vitamin D in different populations, the effects of exercise training in older heart failure patients, interventions for muscle weakness in older people, and a large, ongoing trial of bicarbonate for older patients with advanced CKD.

Finding interventions with multiple beneficial effects in older people (e.g. on cardiovascular disease, bone health, sarcopenia) is a key goal – such interventions could circumvent the hazard and inconvenience of polypharmacy –i.e. having to take multiple medications for each illness an older person has. By using routinely collected health, functional and social care data, we aim to find potential candidate interventions that might provide overall benefit to the health and function of older people, and use this observational data as a platform for future trials.


Dr Witham runs the third year Ageing and Health teaching and examining, and contributes to administering, marking and examining fourth year undergraduate geriatric medicine teaching. He also contributes to medical postgraduate and nursing staff teaching, and runs the Tayside StR Research training course for higher specialist medical trainee doctors. He is an associate member of the Higher Education Academy.

Education/Academic qualification

Doctor of Philosophy, University of Dundee

Bachelor of Medicine and Bachelor of Surgery, University of Oxford

Bachelor of Arts, University of Oxford

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 63 Similar Profiles
Randomized Controlled Trials Medicine & Life Sciences
Vitamin D Medicine & Life Sciences
Heart Failure Medicine & Life Sciences
Exercise Medicine & Life Sciences
Placebos Medicine & Life Sciences
Independent Living Medicine & Life Sciences
Blood Vessels Medicine & Life Sciences
Blood Pressure Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2018

Cross-sectional relationship between Haemoglobin concentration and measures of physical and cognitive function in an older rural South African population

Payne, C. F., Davies, J. I., Gomez-Olive, F. X., Hands, K. J., Kahn, K., Kobayashi, L. C., Tipping, B., Tollman, S., Wade, A. & Witham, M. 21 Apr 2018 In : Journal of Epidemiology and Community Health. 7 p.

Research output: Contribution to journalArticle

Open Access
Hand Strength

Effect of vitamin D supplementation on markers of vascular function: a systematic review and individual participant meta-analysis

Beveridge, L. , Khan, F. , Struthers, A. , Armitage, J. , Barchetta, I. , Cavallo, M. G. , Clarke, R. , Dalan, R. , Dreyer, G. , Gepner, A. D. , Forouhi, N. G. , Harris, R. A. , Hitman, G. A. , Larsen, T. , Khadgawat, R. , Marckmann, P. , Mose, F. H. , Pilz, S. , Scholze, A. , Shargorodsky, M. & 4 others Sokol, S. I., Stricker, H., Zoccali, C. & Witham, M. 30 May 2018 In : Journal of the American Heart Association. 2018, 7, p. 1-21 21 p., e008273

Research output: Contribution to journalArticle

Open Access
Vitamin D
Blood Vessels
Pulse Wave Analysis

Establishing a clinical phenotype for cachexia in end stage kidney disease: study protocol

Reid, J., Noble, H. R., Adamson, G., Davenport, A., Farrington, K., Fouque, D., Kalantar-Zadeh, K., Mallett, J., McKeaveney, C., Porter, S., Seres, D. S., Shields, J., Slee, A., Witham, M. D. & Maxwell, A. P. 13 Feb 2018 In : BMC Nephrology. 19, p. 1-6 6 p., 38

Research output: Contribution to journalArticle

Open Access
Chronic Kidney Failure

Hypertension treatment for older people-navigating between Scylla and Charybdis

Conroy, S. P., Westendorp, R. G. J. & Witham, M. D. 21 May 2018 In : Age and Ageing. 4 p.

Research output: Contribution to journalArticle

Decision Making
Blood Pressure
2 Citations

Leucine and ACE inhibitors as therapies for sarcopenia (LACE trial): study protocol for a randomised controlled trial

Band, M. M., Sumukadas, D., Struthers, A. D., Avenell, A., Donnan, P. T., Kemp, P. R., Smith, K. T., Hume, C. L., Hapca, A. & Witham, M. D. 4 Jan 2018 In : Trials. 19, p. 1-11 11 p., 6

Research output: Contribution to journalArticle

Open Access
Clinical Protocols
Angiotensin-Converting Enzyme Inhibitors
Randomized Controlled Trials

Activities 2005 2014

  • 7 Participation in conference
  • 2 Editorial activity
  • 1 Participation in workshop, seminar, course

Scottish Society of Physicians

Witham, M. (Invited speaker)
19 Sep 2014

Activity: Participation in conference

RCPE International Geriatric Medicine Course

Witham, M. (Member of programme committee)
26 May 201430 May 2014

Activity: Participation in workshop, seminar, course

Heart Failure Society of America 2014

Witham, M. (Invited speaker)
14 Sep 2014

Activity: Participation in conference

European Renal Association conference

Witham, M. (Invited speaker)
31 May 2014

Activity: Participation in conference


The effect of vitamin K On vascular health and physical function in older people with vascular disease

Author: Fulton, R., 2013

Supervisor: Witham, M. (Supervisor) & McMurdo, M. (Supervisor)

Student thesis: Master's ThesisMaster of Science


Tribal differences in the post-operative handover: a mixed-methods study

Author: Robertson, E. R., 2017

Supervisor: Witham, M. (Supervisor) & McCulloch, P. (External person) (Supervisor)

Student thesis: Doctoral ThesisDoctor of Medicine