Norcross, Neil

Dr

  • United Kingdom

  • 420 Citations
  • 9 h-Index
20102019

Research output per year

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Research Output

  • 420 Citations
  • 9 h-Index
  • 12 Article
  • 2 Patent
Article

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Luksch, T. & 44 others, Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Belén Jiménez-Díaz, M., Maria Sanz, L., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H., 18 Jun 2015, In : Nature. 522, 7556, p. 315-320 6 p.

Research output: Contribution to journalArticle

177 Citations (Scopus)

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragaña, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Luksch, T. & 44 others, Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Jiménez-Díaz, M. B., Sanz, L. M., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H., 25 May 2016, In : Nature. 537, 7618, p. 122 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

Research output: Contribution to journalArticle

Open Access
File
78 Citations (Scopus)
449 Downloads (Pure)

Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

Baragaña, B., Norcross, N. R., Wilson, C., Porzelle, A., Hallyburton, I., Grimaldi, R., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Wyatt, P. G., Delves, M. J., Meister, S., Duffy, S., Avery, V. M., Winzeler, E. A., Sinden, R. E., Wittlin, S., Frearson, J. A. & 7 others, Gray, D. W., Fairlamb, A. H., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 10 Nov 2016, In : Journal of Medicinal Chemistry. 59, 21, p. 9672-9685 14 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
198 Downloads (Pure)

Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H., Nov 2015, In : ChemMedChem. 10, 11, p. 1809-1820 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Pizarro, J. C., Hills, T., Senisterra, G., Wernimont, A. K., Mackenzie, C., Norcross, N. R., Ferguson, M. A. J., Wyatt, P. G., Gilbert, I. H. & Hui, R., 17 Oct 2013, In : PLoS Neglected Tropical Diseases. 7, 10, e2492.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
133 Downloads (Pure)

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

Cleghorn, L. A. T., Woodland, A., Collie, I. T., Torrie, L. S., Norcross, N., Luksch, T., Mpamhanga, C., Walker, R. G., Mottram, J. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G., 9 Dec 2011, In : ChemMedChem. 6, 12, p. 2214-2224 11 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
7 Downloads (Pure)
Open Access
File
33 Citations (Scopus)
98 Downloads (Pure)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J., Edwards, T. E. & 57 others, Hallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H., 2 Apr 2019, In : Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
253 Downloads (Pure)

Substituted Aminoacetamides as Novel Leads for Malaria Treatment

Norcross, N., Wilson, C., Baragana, B., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Fletcher, D., Sinden, R., Delves, M. J., Ruecker, A., Duffy, S., Meister, S., Antonova-Koch, Y., Crespo, B., de Cózar, C., Sanz, L., Gamo, F-J., Avery, V. M., Frearson, J. A. & 8 others, Gray, D., Fairlamb, A., Winzeler, E. A., Waterson, D., Campbell, S. F., Willis, P., Read, K. & Gilbert, I., 17 Jul 2019, In : ChemMedChem. 14, 14, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
51 Downloads (Pure)

Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials

Norcross, N. R., Baragana, B., Wilson, C., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Porzelle, A., Grimaldi, R., Wittlin, S., Duffy, S., Avery, V. M., Meister, S., Sanz, L., Jimenez-Diaz, B., Angulo-Barturen, I., Ferrer, S., Santos Marinez, M. & 10 others, Javier Gamo, F., Frearson, J. A., Gray, D. W., Fairlamb, A. H., Winzeler, E. A., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 14 Jul 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6101-6120 20 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
326 Downloads (Pure)

Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi

Herrera, L. J., Brand, S., Santos, A., Nohara, L. L., Harrison, J., Norcross, N. R., Thompson, S., Smith, V., Lema, C., Varela-Ramirez, A., Gilbert, I. H., Almeida, I. C. & Maldonado, R. A., 29 Apr 2016, In : PLoS Neglected Tropical Diseases. 10, 4, 20 p., e0004540.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
283 Downloads (Pure)
Patent

Anti-malarial agents

Gilbert, I., Norcross, N., Baragana, B. & Porzelle, A., 17 Oct 2013, IPC No. C07D 215/52 (2006.01), A61K 31/4725 (2006.01), A61P 33/06 (2006.01) , Patent No. PCT/GB2013/050633

Research output: Patent

N-myristoyl transferase inhibitors

Brand, S., Wyatt, P., Thompson, S., Smith, V., Bayliss, T., Harrison, J., Norcross, N., Cleghorn, L., Gilbert, I. & Brenk, R., 11 Mar 2010, IPC No. C07D 213/75 (2006.01), C07D 213/42 (2006.01), C07D 239/69 (2006.01), C07D 263/50 (2006.01), C07D 403/12 (2006.01), C07D 407/12 (2006.01), C07D 409/12 (2006.01), C07D 413/12 (2006.01), C07D 413/14 (2006.01), C07D 417/12 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01) , Patent No. PCT/GB2009/002084

Research output: Patent