Keyphrases
Peripheral Blood
100%
Activation Status
100%
Idiopathic Parkinson's Disease
100%
Bisphosphonates
100%
Leucine-rich Repeat Kinase 2 (LRRK2)
100%
Parkinson's Disease
63%
VPS35
45%
Mutation Carriers
27%
R1441C
27%
Lysosomal Disease
27%
LRRK2 G2019S mutation
18%
Cause of Disease
18%
Phosphorylation
18%
LRRK2 Kinase
18%
Monogenic
18%
Asymptomatic mutation Carriers
9%
GBA mutations
9%
GBA Variants
9%
Glucocerebrosidase
9%
Membrane Degradation
9%
Parallel Reaction Monitoring
9%
Biomarker Analysis
9%
No Significant Difference
9%
Common Risk Factors
9%
Biomarker Combination
9%
Disease-causing mutations
9%
Lipid Degradation
9%
Pathomechanism
9%
Pathway Activity
9%
Mechanistic Pathway
9%
Highly Sensitive
9%
Lysosomal Enzymes
9%
Lysosomal Storage Disease
9%
Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS)
9%
LRRK2 mutation
9%
Monocytes
9%
Rab GTPase
9%
Quantitative Immunoblotting
9%
Disease-modifying Therapy
9%
Potential Biomarkers
9%
Multiplexing
9%
Hyperphosphorylation
9%
Neutrophils
9%
Simultaneous Quantification
9%
Patient Stratification
9%
Cell Matrix
9%
Fresh Peripheral Blood
9%
Kinase Cascade
9%
Kinase Activity
9%
Unmet Needs
9%
Biochemistry, Genetics and Molecular Biology
LRRK2
100%
Isoform
100%
VPS35
31%
Mass Spectrometry
12%
Kinase
12%
Phosphotransferase
12%
Glucocerebrosidase
6%
Glucosylceramidase
6%
Lipid
6%
Cytoskeleton
6%
Enzyme
6%
Hyperphosphorylation
6%
Immunoblotting
6%