Schurch, Nicholas

Dr

  • 521 Citations
  • 10 h-Index
20072020
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Research Output 2007 2020

  • 521 Citations
  • 10 h-Index
  • 13 Article
  • 1 Letter
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Article
2020
15 Downloads (Pure)

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

Parker, M. T., Knop, K., Sherwood, A. V., Schurch, N. J., Mackinnon, K., Gould, P. D., Hall, A. J. W., Barton, G. J. & Simpson, G. G., 14 Jan 2020, In : eLife. 9, p. 1-35 35 p., e49658.

Research output: Contribution to journalArticle

Open Access
File
Nanopores
RNA Sequence Analysis
Arabidopsis
RNA
Messenger RNA
2019
66 Downloads (Pure)

Detection and Mitigation of Spurious Antisense RNA-seq Reads with RoSA

Mourão, K., Schurch, N. J., Lukoszek, R., Froussios, K., Mackinnon, K., Duc, C., Simpson, G. & Barton, G., 7 Jun 2019, In : F1000 Research. 8, p. 1-7 7 p., 819.

Research output: Contribution to journalArticle

Open Access
File
Antisense RNA
RNA
Gene Expression
Genes
Arabidopsis
49 Downloads (Pure)
Open Access
File
Differential Expression
Eukaryota
RNA
Gene expression
Gene Expression
1 Citation (Scopus)
61 Downloads (Pure)
Open Access
File
RNA Isoforms
Protein Isoforms
RNA
Transcriptome
Drosophila
2016
174 Citations (Scopus)
160 Downloads (Pure)

How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

Schurch, N. J., Schofield, P., Gierliński, M., Cole, C., Sherstnev, A., Singh, V., Wrobel, N., Gharbi, K., Simpson, G. G., Owen-Hughes, T., Blaxter, M. & Barton, G. J., Jun 2016, In : RNA: a Publication of the RNA Society. 22, 6, p. 839-851 13 p.

Research output: Contribution to journalArticle

Open Access
File
RNA
Genes
Research Design
Genome
Guidelines
2015
30 Citations (Scopus)
130 Downloads (Pure)

Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment

Gierlinski, M., Cole, C., Schofield, P., Schurch, N. J., Sherstnev, A., Singh, V., Wrobel, N., Gharbi, K., Simpson, G., Owen-Hughes, T., Blaxter, M. & Barton, G. J., 15 Nov 2015, In : Bioinformatics. 31, 22, p. 3625-3630 6 p.

Research output: Contribution to journalArticle

Open Access
File
2014
70 Citations (Scopus)
152 Downloads (Pure)

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Cole, C., Kroboth, K., Schurch, N. J., Sandilands, A., Sherstnev, A., O'Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D. & Brown, S. J., Jul 2014, In : Journal of Allergy and Clinical Immunology. 134, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

Open Access
File
Atopic Dermatitis
Pediatrics
Skin
Genotype
Extracellular Space
13 Citations (Scopus)
339 Downloads (Pure)
Open Access
File
RNA Sequence Analysis
Expressed Sequence Tags
3' Untranslated Regions
3' untranslated regions
sequence analysis
21 Citations (Scopus)
111 Downloads (Pure)

Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo

Olivera-Martinez, I., Schurch, N., Li, R., Song, J., Halley, P. A., Das, R. M., Burt, D. W., Barton, G. J. & Storey, K. G., Aug 2014, In : Development. 141, 16, p. 3266-3276 11 p.

Research output: Contribution to journalArticle

Open Access
File
Transcriptome
Chromatin
Cell Cycle
Genetic Epigenesis
RNA Sequence Analysis
2013
12 Citations (Scopus)

The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A., 2013, In : PLoS ONE. 8, 10, 16 p., e77537.

Research output: Contribution to journalArticle

T-cells
T-lymphocytes
Modulation
T-Lymphocytes
Down-Regulation
2012
71 Citations (Scopus)

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R., 2012, In : Science Signaling. 5, 213, p. ra18

Research output: Contribution to journalArticle

PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases
Gene expression
Tumors
Phenotype
37 Citations (Scopus)

Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

Klotz-Noack, K., McIntosh, D., Schurch, N., Pratt, N. & Blow, J. J., 15 May 2012, In : Journal of Cell Science. 125, 10, p. 2436-2445 10 p.

Research output: Contribution to journalArticle

2009
61 Citations (Scopus)

RE J1034+396: the origin of the soft X-ray excess and quasi-periodic oscillation

Middleton, M., Done, C., Ward, M., Gierliński, M. & Schurch, N., 21 Mar 2009, In : Monthly Notices of the Royal Astronomical Society. 394, 1, p. 250-260 11 p.

Research output: Contribution to journalArticle

oscillation
oscillations
x rays
active galactic nuclei
energy