Epemolu, Ola

Drug Discovery Unit

94 Citations
5 h-Index

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22 Similar Profiles

Mycobacterium tuberculosis Medicine & Life Sciences

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Quinazolinones Medicine & Life Sciences

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Lysosphingolipid Receptors Medicine & Life Sciences

Polyketide Synthases Medicine & Life Sciences

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Research Output 2014 2018

94 Citations
5 h-Index
13 Article

2 Citations

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

Murugesan, D., Ray, P. C., Bayliss, T., Prosser, G. A., Harrison, J. R., Green, K., Soares De Melo, C., Feng, T. S., Street, L. J., Chibale, K., Warner, D. F., Mizrahi, V., Epemolu, O., Scullion, P., Ellis, L., Riley, J., Shishikura, Y., Ferguson, L., Osuna-Cabello, M., Read, K. D. & 10 othersGreen, S. R., Lamprecht, D. A., Steyn, A. J. C., Ioerger, T. R., Sacchettini, J., Rhee, K. Y., Arora, K., Barry, C. E., Wyatt, P. G. & Boshoff, H. I. M., 8 Jun 2018, In : ACS Infectious Diseases. 4, 6, p. 954-969 16 p.

Research output: Contribution to journal › Article

Open Access

File

Quinazolinones

Structure-Activity Relationship

Mycobacterium tuberculosis

Adenosine Triphosphate

Allosteric Site

1 Citations

Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and it's newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users

McKenzie, C., Sutcliffe, O. B., Read, K., Scullion, S., Epemolu, R., Fletcher, D., Helander, A., Beck, O., Rylski, A., Antonides, L., Riley, J., Smith, S. & Nic Daeid, N., Jul 2018, In : Forensic Toxicology. 36, 2, p. 359-374 16 p.

Research output: Contribution to journal › Article

Open Access

File

Metabolites

Drug Users

Metabolism

Opioid Analgesics

Urine

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

Bell, M., Foley, D., Naylor, C., Robinson, C., Riley, J., Epemolu, R., Scullion, S., Shishikura, Y., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 30 Jul 2018, In : Bioorganic & Medicinal Chemistry Letters. 5 p.

Research output: Contribution to journal › Article

Open Access

File

Lysosphingolipid Receptors

Modulators

Esters

Plasma (human)

Butyrylcholinesterase

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Cleghorn, L., Ray, P., Odingo, J., Kumar, A., Wescott, H., Korkegian, A., Masquelin, T., Lopez Moure, A., Wilson, C., Davis, S., Huggett, M., Turner, P., Smith, A., Epemolu, R., Zuccotto, F., Riley, J., Scullion, S., Shishikura, Y., Ferguson, L., Rullas, J. & 6 othersGuijarro, L., Read, K., Green, S., Hipskind, P., Parish, T. & Wyatt, P., 26 Jun 2018, In : Journal of Medicinal Chemistry.

Research output: Contribution to journal › Article

Open Access

File

Thiophenes

Morpholinos

Mycobacterium tuberculosis

Electron Transport Complex IV

Structure-Activity Relationship

3 Citations

Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition

Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 9 Mar 2018, In : Chemical Science. 2018, 9, p. 2387-2634 18 p., 2452.

Research output: Contribution to journal › Article

Open Access

File

Benzodiazepines

Leucine

Proteins

Cell proliferation

Valine