Epemolu, Ola

Drug Discovery Unit

114 Citations
5 h-Index

If you made any changes in Pure these will be visible here soon.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

22 Similar Profiles

Mycobacterium tuberculosis Medicine & Life Sciences

Structure-Activity Relationship Medicine & Life Sciences

Pharmaceutical Preparations Medicine & Life Sciences

Methionine-tRNA Ligase Medicine & Life Sciences

Quinazolinones Medicine & Life Sciences

Indazoles Medicine & Life Sciences

Lysosphingolipid Receptors Medicine & Life Sciences

Polyketide Synthases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2014 2018

114 Citations
5 h-Index
13 Article

2 Citations

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

Murugesan, D., Ray, P. C., Bayliss, T., Prosser, G. A., Harrison, J. R., Green, K., Soares De Melo, C., Feng, T. S., Street, L. J., Chibale, K., Warner, D. F., Mizrahi, V., Epemolu, O., Scullion, P., Ellis, L., Riley, J., Shishikura, Y., Ferguson, L., Osuna-Cabello, M., Read, K. D. & 10 othersGreen, S. R., Lamprecht, D. A., Steyn, A. J. C., Ioerger, T. R., Sacchettini, J., Rhee, K. Y., Arora, K., Barry, C. E., Wyatt, P. G. & Boshoff, H. I. M., 8 Jun 2018, In : ACS Infectious Diseases. 4, 6, p. 954-969 16 p.

Research output: Contribution to journal › Article

Open Access

File

Quinazolinones

Structure-Activity Relationship

Mycobacterium tuberculosis

Adenosine Triphosphate

Allosteric Site

2 Citations

Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and it's newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users

McKenzie, C., Sutcliffe, O. B., Read, K., Scullion, S., Epemolu, R., Fletcher, D., Helander, A., Beck, O., Rylski, A., Antonides, L., Riley, J., Smith, S. & Nic Daeid, N., Jul 2018, In : Forensic Toxicology. 36, 2, p. 359-374 16 p.

Research output: Contribution to journal › Article

Open Access

File

Metabolites

Drug Users

Metabolism

Opioid Analgesics

Urine

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

Bell, M., Foley, D., Naylor, C., Robinson, C., Riley, J., Epemolu, R., Scullion, S., Shishikura, Y., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 30 Jul 2018, In : Bioorganic & Medicinal Chemistry Letters. 5 p.

Research output: Contribution to journal › Article

Open Access

File

Lysosphingolipid Receptors

Modulators

Esters

Plasma (human)

Butyrylcholinesterase

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Cleghorn, L., Ray, P., Odingo, J., Kumar, A., Wescott, H., Korkegian, A., Masquelin, T., Lopez Moure, A., Wilson, C., Davis, S., Huggett, M., Turner, P., Smith, A., Epemolu, R., Zuccotto, F., Riley, J., Scullion, S., Shishikura, Y., Ferguson, L., Rullas, J. & 6 othersGuijarro, L., Read, K., Green, S., Hipskind, P., Parish, T. & Wyatt, P., 26 Jun 2018, In : Journal of Medicinal Chemistry.

Research output: Contribution to journal › Article

Open Access

File

Thiophenes

Morpholinos

Mycobacterium tuberculosis

Electron Transport Complex IV

Structure-Activity Relationship

3 Citations

Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition

Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 9 Mar 2018, In : Chemical Science. 2018, 9, p. 2387-2634 18 p., 2452.

Research output: Contribution to journal › Article

Open Access

File

Benzodiazepines

Leucine

Proteins

Cell proliferation

Valine