Birch, Paul

Professor

  • United Kingdom

20012020

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2020

All roads lead to susceptibility: the many modes-of-action of fungal and oomycete intracellular effectors

He, Q., McLellan, H., Boevink, P. C. & Birch, P. R. J., 24 Apr 2020, In : Plant Communications. 100050.

Research output: Contribution to journalArticle

Open Access

Divergent Evolution of PcF/SCR74 Effectors in Oomycetes Is Associated with Distinct Recognition Patterns in Solanaceous Plants

Lin, X., Wang, S., de Rond, L., Bertolin, N., Wouters, R. H. M., Wouters, D., Domazakis, E., Bitew, M. K., Win, J., Dong, S., Visser, R. G. F., Birch, P., Kamoun, S. & Vleeshouwers, V. G. A. A., Jun 2020, In : MBio. 11, 3, 12 p., e00947-20.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)

The ubiquitin E3 ligase PUB17 positively regulates immunity by targeting a negative regulator, KH17, for degradation

McLellan, H., Chen, K., He, Q., Wu, X., Boevink, P. C., Tian, Z. & Birch, P., 13 Jul 2020, In : Plant Communications. 1, 4, 12 p., 100020.

Research output: Contribution to journalArticle

Open Access
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15 Downloads (Pure)
2019

AVR2 targets BSL family members, which act as susceptibility factors to suppress host immunity

Turnbull, D., Wang, H., Breen, S., Malec, M., Naqvi, S., Yang, L., Welsh, L., Hemsley, P. A., Zhendong, T., Brunner, F., Gilroy, E. M. & Birch, P. R. J., 1 May 2019, In : Plant Physiology. 180, 1, p. 571-581 11 p.

Research output: Contribution to journalArticle

Open Access
File
93 Downloads (Pure)

Highlights of the mini-symposium on extracellular vesicles in inter-organismal communication, held in Munich, Germany, August 2018

Bielska, E., Birch, P. R. J., Buck, A. H., Abreu-Goodger, C., Innes, R. W., Jin, H., Pfaffl, M. W., Robatzek, S., Regev-Rudzki, N., Tisserant, C., Wang, S. & Weiberg, A., 18 Mar 2019, In : Journal of Extracellular Vesicles. 8, 1, p. 1-8 8 p., 1590116.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
131 Downloads (Pure)

Pathogen enrichment sequencing (PenSeq) enables population genomic studies in oomycetes

Thilliez, G. J. A., Armstrong, M., Lim, J. T-Y., Baker, K., Jouet, A., Ward, B., Oosterhout, C. V., Jones, J. D. G., Huitema, E., Birch, P. & Hein, I., 15 Jan 2019, In : New Phytologist. 221, 3, p. 1634-1648 15 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
153 Downloads (Pure)

Phytophthora infestans effector SFI3 targets potato UBK to suppress early immune transcriptional responses

He, Q., McLellan, H., Hughes, R. K., Boevink, P. C., Armstrong, M., Lu, Y., Banfield, M. J., Tian, Z. & Birch, P. R. J., Apr 2019, In : New Phytologist. 222, 1, p. 438-454 18 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
154 Downloads (Pure)

Phytophthora infestans RXLR effectors act in concert at diverse subcellular locations to enhance host colonization

Wang, S., McLellan, H., Bukharova, T., He, Q., Murphy, F., Shi, J., Sun, S., van Weymers, P., Ren, Y., Thilliez, G., Wang, H., Chen, X., Engelhardt, S., Vleeshouwers, V., Gilroy, E. M., Whisson, S. C., Hein, I., Wang, X., Tian, Z., Birch, P. R. J. & 1 others, Boevink, P. C., 1 Jan 2019, In : Journal of Experimental Botany. 70, 1, p. 343-356 14 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
127 Downloads (Pure)

Phytophthora infestans RXLR effectors target parallel steps in an immune signal transduction pathway

Ren, Y., Armstrong, M., Qi, Y., McLellan, H., Zhong, C., Du, B., Birch, P. R. J. & Tian, Z., Aug 2019, In : Plant Physiology. 180, 4, p. 2227-2239 13 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
131 Downloads (Pure)

The oomycete microbe-associated molecular pattern Pep-13 triggers SERK3/BAK1-independent plant immunity

Wang, H., He, H., Qi, Y., McLellan, H., Tian, Z., Birch, P. R. J. & Tian, Z., Feb 2019, In : Plant Cell Reports. 38, 2, p. 173-182 10 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
95 Downloads (Pure)
2018

A potato STRUBBELIG-RECEPTOR FAMILY member, StLRPK1, associates with StSERK3A/BAK1 and activates immunity

Wang, H., Chen, Y., Wu, X., Long, Z., Sun, C., Wang, H., Wang, S., Birch, P. R. J. & Tian, Z., 1 Dec 2018, In : Journal of Experimental Botany. 69, 22, p. 5573-5586 14 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
107 Downloads (Pure)

Phytophthora infestans RXLR effector SFI5 requires association with calmodulin for PTI/MTI suppressing activity

Zheng, X., Wagener, N., McLellan, H., Boevink, P. C., Hua, C., Birch, P. R. J. & Brunner, F., 1 Sep 2018, In : New Phytologist. 219, 4, p. 1433-1446 14 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
149 Downloads (Pure)

Plant pathogen effector utilizes host susceptibility factor NRL1 to degrade the immune regulator SWAP70

He, Q., Naqvi, S., McLellan, H., Boevink, P., Champouret, N., Hein, I. & Birch, P., 14 Aug 2018, In : Proceedings of the National Academy of Sciences. 115, 33, p. E7834-E7843 10 p.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
153 Downloads (Pure)

The Phytophthora infestans Haustorium Is a Site for Secretion of Diverse Classes of Infection-Associated Proteins

Wang, S., Welsh, L., Thorpe, P., Whisson, S., Boevink, P. & Birch, P., 28 Aug 2018, In : MBio. 9, 4, p. 1-14 14 p., e01216-18.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
121 Downloads (Pure)

The Potato MAP3K StVIK Is Required for the Phytophthora infestans RXLR Effector Pi17316 to Promote Disease

Murphy, F., He, Q., Armstrong, M., Giuliani, L. M., Boevink, P. C., Zhang, W., Tian, Z., Birch, P. R. J. & Gilroy, E. M., May 2018, In : Plant Physiology. 177, 1, p. 398-410 13 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
137 Downloads (Pure)

Why did filamentous plant pathogens evolve the potential to secrete hundreds of effectors to enable disease?

Thordal-Christensen, H., Birch, P. R. J., Spanu, P. D. & Panstruga, R., 1 Apr 2018, In : Molecular Plant Pathology. 19, 4, p. 781-785 5 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
177 Downloads (Pure)
2017

A new proteinaceous pathogen-associated molecular pattern (PAMP) identified in Ascomycete fungi induces cell death in Solanaceae

Franco-Orozco, B., Berepiki, A., Ruiz, O., Gamble, L., Griffe, L. L., Wang, S., Birch, P. R. J., Kanyuka, K. & Avrova, A., Jun 2017, In : New Phytologist. 214, 4, p. 1657-1672 16 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

BTB-BACK Domain Protein POB1 Suppresses Immune Cell Death by Targeting Ubiquitin E3 ligase PUB17 for Degradation

Orosa, B., He, Q., Mesmar, J., Gilroy, E. M., McLellan, H., Yang, C., Craig, A., Bailey, M., Zhang, C., Moore, J. D., Boevink, P. C., Tian, Z., Birch, P. R. J. & Sadanandom, A., 5 Jan 2017, In : PLoS Genetics. 13, 1, p. 1-26 26 p., e1006540.

Research output: Contribution to journalArticle

Open Access
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16 Citations (Scopus)
203 Downloads (Pure)

Delivery of cytoplasmic and apoplastic effectors from Phytophthora infestans haustoria by distinct secretion pathways

Wang, S., Boevink, P. C., Welsh, L., Zhang, R., Whisson, S. C. & Birch, P. J. R., 29 Aug 2017, In : New Phytologist. 29, 8, p. 205-215 11 p.

Research output: Contribution to journalArticle

Open Access
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43 Citations (Scopus)
237 Downloads (Pure)

RXLR Effector AVR2 Up-Regulates a Brassinosteroid-Responsive bHLH Transcription Factor to Suppress Immunity

Turnbull, D., Yang, L., Naqvi, S., Breen, S., Welsh, L., Stephens, J., Morris, J., Boevink, P. C., Hedley, P. E., Zhan, J., Birch, P. R. J. & Gilroy, E. M., May 2017, In : Plant Physiology. 174, 1, p. 356-369 14 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
289 Downloads (Pure)
2016

A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease

Boevink, P. C., Wang, X., McLellan, H., He, Q., Naqvi, S., Armstrong, M. R., Zhang, W., Hein, I., Gilroy, E. M., Tian, Z. & Birch, P. R. J., 29 Jan 2016, In : Nature Communications. 7, 10311.

Research output: Contribution to journalArticle

Open Access
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47 Citations (Scopus)
301 Downloads (Pure)

Discovery and profiling of small RNAs responsive to stress conditions in the plant pathogen Pectobacterium atrosepticum

Kwenda, S., Gorshkov, V., Ramesh, A. M., Naidoo, S., Rubagotti, E., Birch, P. R. J. & Moleleki, L. N., 12 Jan 2016, In : BMC Genomics. 17, 15 p., 47.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
132 Downloads (Pure)

Genome-wide identification of potato long intergenic noncoding RNAs responsive to Pectobacterium carotovorum subspecies brasiliense infection

Kwenda, S., Birch, P. R. J. & Moleleki, L. N., 11 Aug 2016, In : BMC Genomics. 17, p. 1-14 14 p., 614.

Research output: Contribution to journalArticle

Open Access
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27 Citations (Scopus)
168 Downloads (Pure)

Oomycetes seek help from the plant : phytophthora infestans effectors target host susceptibility factors

Boevink, P. C., McLellan, H., Gilroy, E. M., Naqvi, S., He, Q., Yang, L., Wang, X., Turnbull, D., Armstrong, M. R., Tian, Z. & Birch, P. R. J., 2 May 2016, In : Molecular Plant. 9, 5, p. 636-638 3 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
158 Downloads (Pure)

Opening the effector protein toolbox for plant-parasitic cyst-nematode interactions

Eves-van den Akker, S. & Birch, P., 7 Nov 2016, In : Molecular Plant. 9, 11, p. 1451-1453 3 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
164 Downloads (Pure)

Potato NPH3/RPT2-like protein StNRL1, targeted by a Phytophthora infestans RXLR effector, is a susceptibility factor

Yang, L., McLellan, H., Naqvi, S., He, Q., Boevink, P. C., Armstrong, M., Giuliani, L. M., Zhang, W., Tian, Z., Zhan, J., Gilroy, E. M. & Birch, P. R. J., May 2016, In : Plant Physiology. 171, 1, p. 645-657 2 p.

Research output: Contribution to journalArticle

Open Access
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29 Citations (Scopus)
131 Downloads (Pure)

RNA-seq Profiling Reveals Defense Responses in a Tolerant Potato Cultivar to Stem Infection by Pectobacterium carotovorum ssp. brasiliense

Kwenda, S., Motlolometsi, T. V., Birch, P. R. J. & Moleleki, L. N., 20 Dec 2016, In : Frontiers in Plant Science. 7, p. 1-13 13 p., 1905.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
141 Downloads (Pure)

The cell biology of late blight disease

Whisson, S. C., Boevink, P. C., Wang, S. & Birch, P. R. J., Dec 2016, In : Current Opinion in Microbiology. 34, p. 127-135 9 p.

Research output: Contribution to journalArticle

Open Access
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43 Citations (Scopus)
208 Downloads (Pure)

Utilizing "Omic" technologies to identify and prioritize novel sources of resistance to the oomycete pathogen Phytophthora infestans in potato germplasm collections

Van Weymers, P. S. M., Baker, K., Chen, X., Harrower, B., Cooke, D. E. L., Gilroy, E. M., Birch, P. R. J., Thilliez, G. J. A., Lees, A. K., Lynott, J. S., Armstrong, M. R., McKenzie, G., Bryan, G. J. & Hein, I., 27 May 2016, In : Frontiers in Plant Science. 7, 11 p., 672.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
171 Downloads (Pure)
2015

A host KH RNA-binding protein is a susceptibility factor targeted by an RXLR effector to promote late blight disease

Wang, X., Boevink, P., McLellan, H., Armstrong, M., Bukharova, T., Qin, Z. & Birch, P. R. J., 7 Sep 2015, In : Molecular Plant. 8, 9, p. 1385-1395 11 p.

Research output: Contribution to journalArticle

Open Access
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25 Citations (Scopus)
172 Downloads (Pure)

A transcriptional reference map of defence hormone responses in potato

Wiesel, L., Davis, J. L., Milne, L., Redondo Fernandez, V., Herold, M. B., Middlefell Williams, J., Morris, J., Hedley, P. E., Harrower, B., Newton, A. C., Birch, P. R. J., Gilroy, E. M. & Hein, I., 19 Oct 2015, In : Scientific Reports. 5, 12 p., 15229.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
198 Downloads (Pure)

Five reasons to consider Phytophthora infestans a reemerging pathogen

Fry, W. E., Birch, P. R. J., Judelson, H. S., Grünwald, N. J., Danies, G., Everts, K. L., Gevens, A. J., Gugino, B. K., Johnson, D. A., Johnson, S. B., McGrath, M. T., Myers, K. L., Ristaino, J. B., Roberts, P. D., Secor, G. & Smart, C. D., Jul 2015, In : Phytopathology. 105, 7, p. 966-981 16 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Phytophthora infestans RXLR Effector AVR1 Interacts with Exocyst Component Sec5 to Manipulate Plant Immunity

Du, Y., Mpina, M. H., Birch, P. R. J., Bouwmeester, K. & Govers, F., Nov 2015, In : Plant Physiology. 169, 3, p. 1975-1990 16 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

The Top 10 oomycete pathogens in molecular plant pathology

Kamoun, S., Furzer, O., Jones, J. D. G., Judelson, H. S., Ali, G. S., Dalio, R. J. D., Roy, S. G., Schena, L., Zambounis, A., Panabières, F., Cahill, D., Ruocco, M., Figueiredo, A., Chen, X. R., Hulvey, J., Stam, R., Lamour, K., Gijzen, M., Tyler, B. M., Grünwald, N. J. & 14 others, Mukhtar, M. S., Tomé, D. F. A., Tör, M., Van Den Ackerveken, G., McDowell, J., Daayf, F., Fry, W. E., Lindqvist-Kreuze, H., Meijer, H. J. G., Petre, B., Ristaino, J., Yoshida, K., Birch, P. R. J. & Govers, F., May 2015, In : Molecular Plant Pathology. 16, 4, p. 413-434 22 p.

Research output: Contribution to journalArticle

249 Citations (Scopus)

U-box E3 ubiquitin ligase PUB17 acts in the nucleus to promote specific immune pathways triggered by Phytophthora infestans

He, Q., McLellan, H., Boevink, P. C., Sadanandom, A., Xie, C., Birch, P. R. J. & Tian, Z., Jun 2015, In : Journal of Experimental Botany. 66, 11, p. 3189-3199 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2014

Detection of the virulent form of AVR3a from Phytophthora infestans following artificial evolution of potato resistance gene R3a

Chapman, S., Stevens, L. J., Boevink, P. C., Engelhardt, S., Alexander, C. J., Harrower, B., Champouret, N., McGeachy, K., Van Weymers, P. S. M., Chen, X., Birch, P. R. J. & Hein, I., 23 Oct 2014, In : PLoS ONE. 9, 10, 11 p., e110158.

Research output: Contribution to journalArticle

Open Access
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23 Citations (Scopus)
198 Downloads (Pure)

Functionally Redundant RXLR Effectors from Phytophthora infestans Act at Different Steps to Suppress Early flg22-Triggered Immunity

Zheng, X., McLellan, H., Fraiture, M., Liu, X., Boevink, P. C., Gilroy, E. M., Chen, Y., Kandel, K., Sessa, G., Birch, P. R. J. & Brunner, F., 2014, In : PLoS Pathogens. 10, 4, 17 p., e1004057.

Research output: Contribution to journalArticle

Open Access
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67 Citations (Scopus)
264 Downloads (Pure)

Phytophthora infestans RXLR effector PexRD2 interacts with host MAPKKKε to suppress plant immune signaling

King, S. R. F., McLellan, H., Boevink, P. C., Armstrong, M. R., Bukharov, T., Sukarta, O., Win, J., Kamoun, S., Birch, P. R. J. & Banfield, M. J., Mar 2014, In : Plant Cell. 26, 3, p. 1345-1359 15 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Sequence diversity in the large subunit of RNA polymerase I contributes to Mefenoxam insensitivity in Phytophthora infestans

Randall, E., Young, V., Sierotzki, H., Scalliet, G., Birch, P. R. J., Cooke, D. E. L., Csukai, M. & Whisson, S. C., Sep 2014, In : Molecular Plant Pathology. 15, 7, p. 664-676 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

The zigzag model of plant-microbe interactions: is it time to move on?

Pritchard, L. & Birch, P. R. J., Dec 2014, In : Molecular Plant Pathology. 15, 9, p. 865-870 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2013

An RxLR Effector from Phytophthora infestans Prevents Re-localisation of Two Plant NAC Transcription Factors from the Endoplasmic Reticulum to the Nucleus

McLellan, H., Boevink, P., Armstrong, M., Pritchard, L., Gomez, S., Morales, J., Whisson, S. & Birch, P. R. J., 10 Oct 2013, In : PLoS Pathogens. 9, 10, e1003670.

Research output: Contribution to journalArticle

105 Citations (Scopus)

The early days of late blight

Birch, P. R. J. & Cooke, D. E. L., 2013, In : eLife. 2013, 2, e00954.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2012

Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids

Wawra, S., Agacan, M., Boddey, J. A., Davidson, I., Gachon, C. M. M., Zanda, M., Grouffaud, S., Whisson, S. C., Birch, P. R. J., Porter, A. J. & Van West, P., 2012, In : Journal of Biological Chemistry. 287, 45, p. 38101-38109 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Crops that feed the world 8: Potato: Are the trends of increased global production sustainable?

Birch, P. R. J., Bryan, G., Fenton, B., Gilroy, E. M., Hein, I., Jones, J. T., Prashar, A., Taylor, M. A., Torrance, L. & Toth, I. K., Dec 2012, In : Food Security. 4, 4, p. 477-508 32 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Genome Analyses of an Aggressive and Invasive Lineage of the Irish Potato Famine Pathogen

Cooke, D. E. L., Cano, L. M., Raffaele, S., Bain, R. A., Cooke, L. R., Etherington, G. J., Deahl, K. L., Farrer, R. A., Gilroy, E. M., Goss, E. M., Grünwald, N. J., Hein, I., MacLean, D., McNicol, J. W., Randall, E., Oliva, R. F., Pel, M. A., Shaw, D. S., Squires, J. N., Taylor, M. C. & 4 others, Vleeshouwers, V. G. A. A., Birch, P. R. J., Lees, A. K. & Kamoun, S., 4 Oct 2012, In : PLoS Pathogens. 8, 10, 14 p., e1002940.

Research output: Contribution to journalArticle

Open Access
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211 Citations (Scopus)
122 Downloads (Pure)

Host Protein BSL1 Associates with Phytophthora infestans RXLR Effector AVR2 and the Solanum demissum Immune Receptor R2 to Mediate Disease Resistance: Effector AVR2 Associates with BSL1

Saunders, D. G. O., Breen, S., Win, J., Schornack, S., Hein, I., Bozkurt, T. O., Champouret, N., Vleeshouwers, V. G. A. A., Birch, P. R. J., Gilroy, E. M. & Kamoun, S., Aug 2012, In : Plant Cell. 24, 8, p. 3420-3434 14 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Host-targeting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent manner

Wawra, S., Bain, J., Durward, E., de Bruijn, I., Minor, K. L., Matena, A., Löbach, L., Whisson, S. C., Bayer, P., Porter, A. J., Birch, P. R. J., Secombes, C. J. & van West, P., 7 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2096-2101 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Relocalization of late blight resistance protein r3a to endosomal compartments is associated with effector recognition and required for the immune response.

Engelhardt, S., Boevink, P. C., Armstrong, M. R., Ramos, M. B., Hein, I. & Birch, P. R. J., Dec 2012, In : Plant Cell. 24, 12, p. 5142-5158 16 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
2011

ADS1 encodes a MATE-transporter that negatively regulates plant disease resistance

Sun, X., Gilroy, E. M., Chini, A., Nurmberg, P. L., Hein, I., Lacomme, C., Birch, P. R. J., Hussain, A., Yun, B-W. & Loake, G. J., 2011, In : New Phytologist. 192, 2, p. 471-482 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

CMPG1-dependent cell death follows perception of diverse pathogen elicitors at the host plasma membrane and is suppressed by Phytophthora infestans RXLR effector AVR3a

Gilroy, E. M., Taylor, R. M., Hein, I., Boevink, P., Sadanandom, A. & Birch, P. R. J., 2011, In : New Phytologist. 190, 3, p. 653-666 14 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)