Clarke, Paul

Professor

1989 …2019
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Personal profile

Biography

Paul Clarke is Honorary Professor of Cancer Cell Biology at the University of Dundee and, since 2017, Director of the University of Queensland Diamantina Institute in Brisbane, Australia. He joined the University of Dundee as a Senior Lecturer in 1998 and was awarded a personal chair in 2005. He has been Research Coordinator for the Biomedical Research Centre (2002-2007), Head of Research for the College of Medicine, Dentistry and Nursing (2007-2008) and Head of the Division of Cancer Research (2011-2015). Previously he was at the University of Manchester (1994-1998) and was a research fellow in the group of Eric Karsenti at the European Molecular Biology Laboratory, Heidelberg (1991-1994). As a student, he read Biochemistry at Bristol and carried out research for his PhD with D. Grahame Hardie at Dundee. Professor Clarke has received a Royal Society-Wolfson Research Merit Award (2003-2008) and research fellowships from The Wellcome Trust and Cancer Research UK

Research

The control of cell proliferation and cell survival is critical for the normal development and tissue homeostasis of multicellular organisms. Defects in these processes underlie a number of major human diseases. Cancer is associated with loss of controls over cell division and evasion of cell death. In order to understand how cancer develops and how it may be treated more effectively, we need to understand the molecular mechanisms controlling these processes. Our goal is to understand what determines determine the balance between cell cycle controls and the induction of cell death in response to stress signals, DNA damage and during cell division. 

External positions

Director, Diamantina Institute, University of Queensland

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  • 1 Similar Profiles
Mitosis Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Cyclin B Medicine & Life Sciences
Xenopus Medicine & Life Sciences
Nuclear Envelope Medicine & Life Sciences
Karyopherins Medicine & Life Sciences
Spindle Apparatus Medicine & Life Sciences
Protein Kinases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2018

Research Output 1989 2019

18 Downloads (Pure)

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly

Guo, L., Mohd, K. S., Ren, H., Xin, G., Jiang, Q., Clarke, P. R. & Zhang, C., 23 Sep 2019, In : Journal of Cell Science. 132, 18, p. 1-12 12 p., jcs232314.

Research output: Contribution to journalArticle

Open Access
File
Karyopherins
Cyclin B1
Spindle Apparatus
Phosphorylation
Mitosis
5 Citations (Scopus)
106 Downloads (Pure)

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest

Allan, L. A., Skowyra, A., Rogers, K. I., Zeller, D. & Clarke, P. R., 3 Sep 2018, In : The EMBO Journal. 37, 17, p. 1-15 15 p., e96831.

Research output: Contribution to journalArticle

Open Access
File
Anaphase-Promoting Complex-Cyclosome
Mitosis
Degradation
Ubiquitin-Protein Ligases
Isoleucine
78 Downloads (Pure)

Timed degradation of Mcl-1 controls mitotic cell death

Clarke, P. R., Allan, L. A. & Skowyra, A., 2 Nov 2018, In : Molecular and Cellular Oncology. 5, 6, p. 1-4 4 p., e1516450.

Research output: Contribution to journalArticle

Open Access
File
Anaphase-Promoting Complex-Cyclosome
Proteasome Endopeptidase Complex
Ubiquitin
Mitosis
Proteolysis
4 Citations (Scopus)
96 Downloads (Pure)

USP9X limits mitotic checkpoint complex turnover to strengthen the spindle assembly checkpoint and guard against chromosomal instability

Skowyra, A., Allan, L., Saurin, A. & Clarke, P. R., 17 Apr 2018, In : Cell Reports. 23, 3, p. 852-865 14 p.

Research output: Contribution to journalArticle

Open Access
File
M Phase Cell Cycle Checkpoints
Chromosomal Instability
Chromosomes
Anaphase-Promoting Complex-Cyclosome
Kinetochores
5 Citations (Scopus)
98 Downloads (Pure)

Phosphorylation of XIAP by CDK1-cyclin B controls mitotic cell death

Hou, Y., Allan, L. A. & Clarke, P. R., 15 Jan 2017, In : Journal of Cell Science. 130, 2, p. 502-511 38 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclin B
Cell Death
Phosphorylation
Apoptosis
Mitosis

Thesis

Control of apoptosis in response to mitotic arrest

Author: Rogers, K. I., 2017

Supervisor: Clarke, P. R. (Supervisor)

Student thesis: Master's ThesisMaster of Philosophy

Inhibition of PLK1 by p53 and by PLK1-targeted drugs

Author: Ahmadi, M., 2018

Supervisor: Meek, D. (Supervisor), Clarke, P. R. (Supervisor) & Fuller-Pace, F. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy