Meakin, Paul

Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Jul 2019, In : Metabolism: Clinical and Experimental. 96, p. 101-102 2 p.

Research output: Contribution to journal › Article

Insulin

Inflammation

corrigendum

125 Citations (Scopus)

376 Downloads (Pure)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In : Nature. 556, 7699, p. 113-117 5 p.

Research output: Contribution to journal › Article

Open Access

File

Alkylation

Anti-Inflammatory Agents

Interferon Type I

Cysteine

Lipopolysaccharides

10 Citations (Scopus)

34 Downloads (Pure)

Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology

Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., Hawkes, C. A. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., Macleod, M. R., Macrae, I. M., Markus, H. S., McCabe, C., McColl, B. W., Meakin, P. J., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, T. J., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R. M., Trueman, R. C., Wang, T., Williams, A., Williams, S. C. R. & Work, L. M., 30 Apr 2018, In : Clinical Science. 132, 8, p. 851-868 18 p.

Research output: Contribution to journal › Article

Open Access

File

Dementia

Chronic Disease

Cerebral Small Vessel Diseases

Education

Cerebrovascular Disorders

7 Citations (Scopus)

63 Downloads (Pure)

The beta secretase BACE1 regulates the expression of the insulin receptor in the liver

Meakin, P., Mezzapesa, A., Benabou, E., Haas, M., Bonardo, B., Grino, M., Brunel, J-M., Biddinger, S. B., Desbois-Mouthon, C., Govers, R., Ashford, M. L. J. & Peiretti, F., 3 Apr 2018, In : Nature Communications. 9, p. 1-14 14 p., 1306.

Research output: Contribution to journal › Article

Open Access

File

Amyloid Precursor Protein Secretases

insulin

Insulin Receptor

liver

Liver

29 Citations (Scopus)

151 Downloads (Pure)

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weiβ, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L. J., Trost, M. & Arthur, J. S. C., 8 Aug 2016, In : Scientific Reports. 6, p. 1-17 17 p., 31159.

Research output: Contribution to journal › Article

Open Access

File

Ubiquitin

Cytokines

Oxidants

Polyubiquitin

Autoimmunity

Activities 2013 2013

1 Participation in conference

Diabetes UK Professional Conference 2013

Paul Meakin (Participant)

13 Mar 2013 → 15 Mar 2013

Activity: Participating in or organising an event types › Participation in conference