Meakin, Paul

Mr, Dr

Associate Staff, Systems Medicine

Source: Scopus
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2 Not started
4 Finished

Development of a Sporadic Alzheimer's Disease Model (Vacation Scholarship)
Ashford, M. & Meakin, P.
Project: Research
A Pathological Role for BACE1 Actibity in Metabolic Disease?
Ashford, M. & Meakin, P.
Project: Research
Is Plasma Amyloid A Useful Biomarker For Metabolic Disease?
Ashford, M., Khan, F. & Meakin, P.
13/02/17 → 12/08/17
Project: Research
Can Amyloid Processing be Used as a Biomarker for Obesity-Driven Metabolic Disease in Humans
Ashford, M., Dillon, J., Meakin, P. & Palmer, C.
1/06/14 → 1/06/15
Project: Research
The Role of BACE1 in Cardiovascular Health and Disease
Ashford, M., Khan, F. & Meakin, P.
Anonymous Trust
1/06/13 → 31/05/14
Project: Research

918 Citations
9 h-Index
12 Article
1 Poster
1 Meeting abstract

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction
Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 3 Aug 2020, In: Journal of Clinical Investigation. 130, 8, p. 4104-4117 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

37 Downloads (Pure)
Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75]
Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Jul 2019, In: Metabolism: Clinical and Experimental. 96, p. 101-102 2 p.
Research output: Contribution to journal › Article › peer-review
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In: Nature. 556, 7699, p. 113-117 5 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
381 Citations (Scopus)

820 Downloads (Pure)
Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology
Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., Hawkes, C. A. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., Macleod, M. R., Macrae, I. M., Markus, H. S., McCabe, C., McColl, B. W., Meakin, P. J., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, T. J., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R. M., Trueman, R. C., Wang, T., Williams, A., Williams, S. C. R. & Work, L. M., 30 Apr 2018, In: Clinical Science. 132, 8, p. 851-868 18 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
23 Citations (Scopus)

86 Downloads (Pure)
The beta secretase BACE1 regulates the expression of the insulin receptor in the liver
Meakin, P., Mezzapesa, A., Benabou, E., Haas, M., Bonardo, B., Grino, M., Brunel, J-M., Biddinger, S. B., Desbois-Mouthon, C., Govers, R., Ashford, M. L. J. & Peiretti, F., 3 Apr 2018, In: Nature Communications. 9, p. 1-14 14 p., 1306.
Research output: Contribution to journal › Article › peer-review

Open Access
File
16 Citations (Scopus)

115 Downloads (Pure)

1 Participation in conference

Diabetes UK Professional Conference 2013
Paul Meakin (Participant)
13 Mar 2013 → 15 Mar 2013
Activity: Participating in or organising an event types › Participation in conference